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Staff Profile

Professor Akane Kawamura

Professor of Chemical Biology

  • Address: School of Natural and Environmental Sciences, Chemistry
    Bedson Building (Room 3.11)
    Kings Road
    Â鶹´«Ã½
    Â鶹´«Ã½ Upon Tyne
    NE1 7RU
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Publications

  • Articles

    • Simelis K, Saraç H, Salah E, Nishio K, McAllister TE, Corner TP, Tumber A, Belle R, Schofield CJ, Suga H, Kawamura A. . Bioorganic & Medicinal Chemistry 2024, 99, 117597.
    • Smith TS, Bhushan B, Granata D, Kaas CS, Andersen B, Decoene KW, Ren Q, Liu H, Qu X, Yang Y, Pan J, Chen Q, Munzel M, Kawamura A. . RSC Chemical Biology 2024, 5(1), 12-18.
    • Belle R, Saraç H, Salah E, Bhushan B, Szykowska A, Roper G, Tumber A, Kriaucionis S, Burgess-Brown N, Schofield CJ, Brown T, Kawamura A. . Journal of Medicinal Chemistry 2024, 67(6), 4525–4540.
    • Bonnici J, Oueini R, Salah E, Johansson C, Schofield CJ, Kawamura A. . FEBS Letters 2023, 597(7), 933-946.
    • Miura T, Malla TR, Owen CD, Tumber A, Brewitz L, McDonough MA, Salah E, Terasaka N, Katoh T, Lukacik p, Strain-Damerell C, Mikolajek H, Walsh MA, Kawamura A, Schofield CJ, Suga H. . Nature Chemistry 2023, 15, 998-1005.
    • Salvini CLA, Darlot B, Davison J, Martin MP, Tudhope SJ, Turberville S, Kawamura A, Noble MEM, Wedge SR, Crawford JJ, Waring MJ. . Chemical Science 2023, 14(31), 8288-8294.
    • Coleman OD, Macdonald J, Thomson B, Ward JA, Stubbs CJ, McAllister TE, Clark S, Amin S, Cao Y, Abboud MI, Zhang Y, Sanganee H, Huber KVM, Claridge TDW, Kawamura A. . Chemical Science 2023, 14(26), 7136-7146.
    • Pringle TA, Coleman O, Kawamura A, Knight JC. . RSC Advances 2022, 12(43), 27716-27722.
    • Belle R, Kamps JJAG, Poater J, Kumar K, Pieters BJGE, Salah E, Claridge TDW, Paton RS, Bickelhaupt FM, Kawamura A, Schofield CJ, Mecinovic J. . Communications Chemistry 2022, 5, 27.
    • Bhushan B, Granata D, Kaas CS, Kasimova MA, Ren Q, Cramer CN, White MD, Hansen AMK, Fledelius C, Invernizzi G, Deibler K, Coleman OD, Zhao X, Qu X, Liu H, Zurmühl SS, Kodra JT, Kawamura A, Münzel M. . Chemical Science 2022, 13(11), 3256-3262.
    • McAllister TE, Coleman OC, Roper G, Kawamura A. . Peptide Science 2021, 113(1), e24204.
    • Hsu KF, Wilkins SE, Hopkinson RJ, Sekirnik R, Flashman E, Kawamura A, McCullagh JSO, Walport L, Schofield CJ. . Epigenetics 2021, 16(1), 14-27.
    • Chowdhury R, Abboud MI, McAllister TE, Banerji B, Bhushan B, Sorensen JL, Kawamura A, Schofield CJ. . Scientific Reports 2020, 10(1), 21964.
    • Sarac H, Morova T, Pires E, McCullagh J, Kaplan A, Cingoz A, Bagci-Onder T, Onder T, Kawamura A, Lack NA. . Oncogene 2020, 39, 2187–2201.
    • Reinbold R, John T, Spingardi P, Kawamura A, Schofield CJ, Hopkinson RJ. . Scientific Reports 2020, 10, 17955.
    • Josephson B, Fehl C, Isenegger PG, Nadal S, Wright TH, Poh AWJ, Bower BJ, Giltrap AM, Chen L, Batchelor-McAuley C, Roper G, Arisa O, Sap JBI, Kawamura A, Baldwin AJ, Mohammed S, Compton RG, Gouverneur V, Davis BG. . Nature 2020, 585, 530-537.
    • Darlot B, Eaton JRO, Geis-Asteggiante L, Yakala GK, Karuppanan K, Davies G, Robinson CV, Kawamura A, Bhattacharya S. . Journal of Biological Chemistry 2020, 295(32), 10926-10939.
    • Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu K-F, Wilkins SE, Yeh T-L, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, Franz H, Sippl W, Lassmann S, Diederichs S, Schleicher E, Schofield CJ, Kawamura A, Schule R, Jung M. . ACS Chemical Biology 2019, 14(8), 1737-1750.
    • Reinbold R, John T, Spingardi P, Kawamura A, Thompson AL, Schofield CJ, Hopkinson RJ. . Scientific Reports 2019, 9, 18289.
    • Vazquez-Rodriguez S, Wright M, Rogers CM, Cribbs AP, Velupillai S, Philpott M, Lee H, Dunford JE, Huber KVM, Robers MB, Vasta JD, Thezenas M-L, Bonham S, Kessler B, Bennett J, Fedorov O, Raynaud F, Donovan A, Blagg J, Bavetsias V, Oppermann U, Bountra C, Kawamura A, Brennan PE. . Angewandte Chemie - International Edition 2019, 58(2), 515-519.
    • Lee AW, Deruaz M, Lynch C, Davies G, Singh K, Alenazi Y, Eaton JRO, Kawamura A, Shaw J, Proudfoot AEI, Dias JM, Bhattacharya S. . Journal of Biological Chemistry 2019, 294(29), 11199-11212.
    • Nishio K, Belle R, Katoh T, Kawamura A, Sengoku T, Hanada K, Ohsawa N, Shirouzu M, Yokoyama S, Suga H. . ChemBioChem 2018, 19(9), 979-985.
    • Eaton JRO, Alenazi Y, Singh K, Davies G, Geis-Asteggiante L, Kessler B, Robinson CV, Kawamura A, Bhattacharya S. . Journal of Biological Chemistry 2018, 293(16), 6134-6146.
    • Guillade L, Sarno F, Tarhonskaya H, Nebbioso A, Alvarez S, Kawamura A, Schofield CJ, Altucci L, de Lera AR. . ChemMedChem 2018, 13(18), 1949-1956.
    • Passioura T, Bhushan B, Tumber A, Kawamura A, Suga H. . Bioorganic and Medicinal Chemistry 2018, 26(6), 1225-1231.
    • McAllister TE, Yeh T-L, Abboud MI, Leung IKH, Hookway ES, King ONF, Bhushan B, Williams ST, Hopkinson RJ, Munzel M, Loik ND, Chowdhury R, Oppermann U, Claridge TDW, Goto Y, Suga H, Schofield CJ, Kawamura A. . Chemical Science 2018, 9(20), 4569-4578.
    • Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ. . FEBS Letters 2018, 592(19), 3264-3273.
    • Hancock RL, Abboud MI, Smart TJ, Flashman E, Kawamura A, Schofield CJ, Hopkinson RJ. . ChemBioChem 2018, 19(9), 917-921.
    • Bonnici J, Tumber A, Kawamura A, Schofield CJ. . Philosophical Transactions of the Royal Society B: Biological Sciences 2018, 373(1748), 20170071.
    • Tarhonskaya H, Tumber A, Kawamura A, Schofield CJ. . Current Protocols in Pharmacology 2018, 80(1), 3.15.1-3.15.12.
    • Hopkinson RJ, Langley GW, Belle R, Walport LJ, Dunne K, Munzel M, Salah E, Kawamura A, Claridge TDW, Schofield CJ. . Chemical Communications 2018, 54(57), 7975-7978.
    • Alenazi Y, Singh K, Davies G, Eaton JRO, Elders P, Kawamura A, Bhattacharya S. . Scientific Reports 2018, 8, 6333.
    • Abboud MI, McAllister TE, Leung IKH, Chowdhury R, Jorgensen C, Domene C, Mecinovic J, Lippl K, Hancock RL, Hopkinson RJ, Kawamura A, Claridge TDW, Schofield CJ. . Chemical Communications 2018, 54(25), 3130-3133.
    • Singh K, Davies G, Alenazi Y, Eaton JRO, Kawamura A, Bhattacharya S. . Scientific Reports 2017, 7, 4267.
    • Hancock RL, Masson N, Dunne K, Flashman E, Kawamura A. . ACS Chemical Biology 2017, 12(4), 1011-1019.
    • Tarhonskaya H, Nowak RP, Johansson C, Szykowska A, Tumber A, Hancock RL, Lang P, Flashman E, Oppermann U, Schofield CJ, Kawamura A. . Journal of Molecular Biology 2017, 429(19), 2895-2906.
    • Hanauer T, Hopkinson RJ, Patel K, Li Y, Correddu D, Kawamura A, Sarojini V, Leung IKH, Gruber T. . Organic and Biomolecular Chemistry 2017, 15(5), 1100-1105.
    • Tumber A, Nuzzi A, Hookway ES, Hatch SB, Velupillai S, Johansson C, Kawamura A, Savitsky P, Yapp C, Szykowska A, Wu N, Bountra C, Strain-Damerell C, Burgess-Brown NA, Ruda GF, Fedorov O, Munro S, England KS, Nowak RP, Schofield CJ, La Thangue NB, Pawlyn C, Davies F, Morgan G, Athanasou N, Muller S, Oppermann U, Brennan PE. . Cell Chemical Biology 2017, 24(3), 371-380.
    • Yeh T-L, Leissing TM, Abboud MI, Thinnes CC, Atasoylu O, Holt-Martyn JP, Zhang D, Tumber A, Lippl K, Lohans CT, Leung IKH, Morcrette H, Clifton IJ, Claridge TDW, Kawamura A, Flashman E, Lu X, Ratcliffe PJ, Chowdhury R, Pugh CW, Schofield CJ. . Chemical Science 2017, 8(11), 7651-7668.
    • Dobrynin G, McAllister TE, Leszczynska KB, Ramachandran S, Krieg AJ, Kawamura A, Hammond EM. . Scientific Reports 2017, 7, 11094.
    • Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, Mill P. . Journal of Cell Biology 2017, 216(4), 999-1013.
    • Belle R, Al Temimi AHK, Kumar K, Pieters BJGE, Tumber A, Dunford JE, Johansson C, Oppermann U, Brown T, Schofield CJ, Hopkinson RJ, Paton RS, Kawamura A, Mecinovic J. . Chemical Communications 2017, 53(99), 13264-13267.
    • Kawamura A, Munzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ONF, Passioura T, Walport LJ, Hatch SB, Madden S, Muller S, Brennan PE, Chowdhury R, Hopkinson RJ, Suga H, Schofield CJ. . Nature Communications 2017, 8, 14773.
    • Gerken PA, Wolstenhulme JR, Tumber A, Hatch SB, Zhang Y, Muller S, Chandler SA, Mair B, Li F, Nijman SMB, Konietzny R, Szommer T, Yapp C, Fedorov O, Benesch JLP, Vedadi M, Kessler BM, Kawamura A, Brennan PE, Smith MD. . Angewandte Chemie - International Edition 2017, 56(49), 15555-15559.
    • Hatch SB, Yapp C, Montenegro RC, Savitsky P, Gamble V, Tumber A, Ruda GF, Bavetsias V, Fedorov O, Atrash B, Raynaud F, Lanigan R, Carmichael L, Tomlin K, Burke R, Westaway SM, Brown JA, Prinjha RK, Martinez ED, Oppermann U, Schofield CJ, Bountra C, Kawamura A, Blagg J, Brennan PE, Rossanese O, Muller S. . Epigenetics and Chromatin 2017, 10, 9.
    • Peacock H, Thinnes CC, Kawamura A, Hamilton AD. . Supramolecular Chemistry 2016, 28(5-6), 575-581.
    • Walport LJ, Hopkinson RJ, Chowdhury R, Schiller R, Ge W, Kawamura A, Schofield CJ. . Nature Communications 2016, 7, 11974.
    • Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan Y-V, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, Von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Muller S, Van Montfort RLM, Brennan PE, Blagg J. . Journal of Medicinal Chemistry 2016, 59(4), 1388-1409.
    • Chan MC, Atasoylu O, Hodson E, Tumber A, Leung IKH, Chowdhury R, Gomez-Perez V, Demetriades M, Rydzik AM, Holt-Martyn J, Tian Y-M, Bishop T, Claridge TDW, Kawamura A, Pugh CW, Ratcliffe PJ, Schofield CJ. . PLoS ONE 2015, 10(7), e0132004.
    • Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Muller S, Pugh CW, Ratcliffe PJ, Brennan PE, Kawamura A, Schofield CJ. . Chemical Communications 2015, 51(84), 15458-15461.
    • Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A. . Epigenetics 2014, 9(12), 1596-1603.
    • Brem J, Van Berkel SS, Aik W, Rydzik AM, Avison MB, Pettinati I, Umland K-D, Kawamura A, Spencer J, Claridge TDW, McDonough MA, Schofield CJ. . Nature Chemistry 2014, 6(12), 1084-1090.
    • Rotili D, Tomassi S, Conte M, Benedetti R, Tortorici M, Ciossani G, Valente S, Marrocco B, Labella D, Novellino E, Mattevi A, Altucci L, Tumber A, Yapp C, King ONF, Hopkinson RJ, Kawamura A, Schofield CJ, Mai A. . Journal of Medicinal Chemistry 2014, 57(1), 42-55.
    • England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, Von Delft F, Burgess-Brown NA, Kawamura A, Schofield CJ, Brennan PE. . MedChemComm 2014, 5(12), 1879-1886.
    • Tarhonskaya H, Rydzik AM, Leung IKH, Loik ND, Chan MC, Kawamura A, McCullagh JSO, Claridge TDW, Flashman E, Schofield CJ. . Nature Communications 2014, 5, 3423.
    • Rydzik AM, Chowdhury R, Kochan GT, Williams ST, McDonough MA, Kawamura A, Schofield CJ. . Chemical Science 2014, 5(5), 1765-1771.
    • Laurieri N, Kawamura A, Westwood IM, Varney A, Morris E, Russell AJ, Stanley LA, Sim E. . BMC Pharmacology and Toxicology 2014, 15(1), 68.
    • Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh T-L, Chan MC, Mott BT, McCullagh JSO, Maloney DJ, Schofield CJ, Kawamura A. . ChemMedChem 2014, 9(3), 566-571.
    • Chowdhury R, Candela-Lena J, Chan M, Greenald D, Yeoh K, Tian Y, McDonough M, Tumber A, Rose NR, Conejo-Garcia A, Demetriades M, Mathavan S, Kawamura A, Lee MK, vanEeden F, Pugh C, Ratcliffe PJ, Schofield CJ. Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases. ACS Chemical Biology 2013, 8, 1488-1496.
    • Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TDW, Schofield CJ. . Angewandte Chemie International Edition 2013, 55(30), 7709-7713.
    • Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N. . Journal of Medicinal Chemistry 2013, 56(18), 7222-7231.
    • Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XL, Kristensen JBL, King ON, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, Lejeune C, Rydzik AM, Rose NR, Bagg EA, Donough MA, Yue WW, Ng SS, Olse L, Brennan P, Oppermann U, Muller-Knapp S, Klose RJ, Ratcliffe PJ, Schofield CJ, Kawamura A. . Chemical Science 2013, 4(8), 3110-3117.
    • Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Danie M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, vonDelft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A. Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases. Journal of Medicinal Chemistry 2012, 55, 6639-6643.
    • Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E. Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. PLOS ONE 2012, 7(12), e52790.
    • Woon ECY, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JHY, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ. Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases. Angewandte Chemie International Ed 2012, 51, 1631-1634.
    • Yeoh KK, Chan MC, Thalhammer A, Demetriades M, Chowdhury R, Tian YM, Stolze I, McNeill LA, Lee MK, Woon EC, Mackeen MM, Kawamura A, Ratcliffe PJ, Mecinovic J, Schofield CJ. Dual-action inhibitors of HIF hydroxylases that induce binding of a second iron ion. Org Biomol Chem 2012, 11, 732-745.
    • Leung IK, Demetriades M, Hardy AP, Lejeune C, Smart TJ, Szollossi A, Kawamura A, Schofield CJ, Claridge TD. A reporter ligand NMR screening method for 2-oxogluarate inhibitors. Journal of Medicinal Chemistry 2012, 56(2), 547-555.
    • Chowdhury R, Yeoh K, Tian Y, Hillringhaus L, Bagg E, Rose NR, Leung IK, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Reports 2011, 12, 463-469.
    • Westwood IM, Kawamura A, Russell AJ, Sandy J, Davies SG, Sim E. Novel Small-Molecule Inhibitors of Arylamine N-Acetyltransferases: Drug Discovery by High Throughput Screening. Combinatorial Chemistry & High Throughput Screening 2011, 14(2), 117-24.
    • Rotili D, Altun M, Kawamura A, Wolf A, Fischer R, Leung IKH, Mackeen MM, Tian Y, Ratcliffe PJ, Mai A, Kessler BM, Schofield CJ. A Photoreactive Small-Molecule Probe for 2-Oxoglutarate. Cell Chemical Biology 2011, 18, 642-654.
    • Laurieri N, Crawford MH, Kawamura A, Westwood IM, Robinson J, Fletcher AM, Davies SG, Sim E, Russell AJ. Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker. J Am Chem Soc 2010, 132(10), 3238-9.
    • King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SN, Quinn AM, Rai G, Mott BT, Klose RJ, Oppermann U, Heightman T, Maloney DJ, Jadhav A, Schofield CJ, Simeonov A. Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors. PLOS ONE 2010, 5(11), e15535.
    • Westwood I, Bhakta S, Russell AJ, Fullam E, Anderton MC, Kawamura A, Mulvaney AW, Vickers RJ, Bhowruth V, Besra GS, Lalvani A, Davies SG, Sim E. Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars. Protein & Cell 2010, 1(1), 82-95.
    • Kawamura A, Tumber A, Rose NR, King ON, Daniel M, Oppermann U, Heightman TD, Schofield CJ. Development of homogeneous luminescence assays for histone demethylase catalysis and binding. Anal Biochem 2010, 404(1), 86-93.
    • Lack NA, Kawamura A, Fullam E, Laurieri N, Beard S, Russell AJ, Evangelopoulos D, Westwood I, Sim E. Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. Biochem J 2009, 418(2), 369-78.
    • Russell AJ, Westwood IM, Crawford MH, Robinson J, Kawamura A, Redfield C, Laurieri N, Lowe ED, Davies SG, Sim E. Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2. Bioorg Med Chem 2009, 17(2), 905-918.
    • Kawamura A, Westwood I, Wakefield L, Long H, Zhang N, Walters K, Redfield C, Sim E. Mouse N-acetyltransferase type 2, the homologue of human N-acetyltransferase type 1. Biochem Pharm 2009, 75(7), 868-878.
    • Fullam E, Kawamura A, Wilkinson H, Abuhammad A, Westwood I, Sim E. Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis. The Protein Journal 2009, 28, 281-293.
    • Wakefield L, Cornish V, Long H, Kawamura A, Zhang X, Hein DW, Sim E. Mouse arylamine N-acetyltransferase 2 (Nat2) expression in the developing neuroendocrine system. Biomarkers 2007, 13(1), 106-118.
    • Fakis G, Boukouvala S, Kawamura A, Kennedy S. Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis. Pharmacogenetics and Genomics 2007, 17(3), 181-188.
    • Wang H, Vath GM, Kawamura A, Bates CA, Sim E, Hanna PE, Wagner CR. Overexpression, Purification, and Characterization of Recombinant Human Arylamine N-Acetyltransferase 1. The Protein Journal 2005, 24, 65–77.
    • Kawamura A, Graham J, Mushtaq A, Vath GM, Hanna PE, Wagner CR, Sim E. Eukaryotic arylamine N-acetyltransferase: Investigation of substrate specificity by high-throughput screening. Biochem Pharm 2005, 69, 347-359.
    • Kawamura A, Sandy J, Upton A, Noble M, Sim E. . Protein Expression and Purification 2003, 27(1), 75-84.
    • Sandy J, Mushtaq A, Kawamura A, Sinclair J, Sim E, Noble M. The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis – an enzyme which inactivates the anti-tubercular drug, isoniazid. J Mol Biol 2002, 318, 1071-1083.

  • Book Chapters

    • Bhattacharya S, Kawamura A. . In: Advances in Protein Chemistry and Structural Biology – Inflammatory Diseases – Part A. Elsevier, 2020, pp.1-38.
    • Wright M, Brennan P, Kawamura A. . In: Antonello Mai, ed. Chemical Epigenetics. Cham: Springer International Publishing, 2020, pp.221-253.
    • Serrano L, Roper G, Kawamura A. . In: Paul Brennan, Saleta Vazquez Rodriguez, ed. The Discovery and Utility of Chemical Probes in Target Discovery. Cambridge: Royal Society of Chemistry, 2020, pp.100-123.
    • Belle R, Kawamura A, Arimondo P. . In: Antonello Mai, ed. Chemical Epigenetics. Cham: Springer Nature, 2020, pp.255-286.
    • Højrup C, Coleman O, Bukowski JP, Clausen RP, Kawamura A. . In: Wolfgang Sippl & Manfred Jung, ed. Epigenetic Drug Discovery. Weinheim: Wiley-VCH Verlag GmbH & Co. KGaA, 2019, pp.263-296.

  • Editorials

    • Conway SJ, Kawamura A, Marr TM, Platt F, Russell AJ. . Journal of Medicinal Chemistry 2022, 65(8), 5867-5869.
    • Kawamura A, Ganesan A. . Current Opinion in Chemical Biology 2020, 57, A1-A4.

  • Reviews

    • Bhushan B, Erdmann A, Zhang Y, Belle R, Johannson C, Oppermann U, Hopkinson RJ, Schofield CJ, Kawamura A. . Bioorganic and Medicinal Chemistry 2018, 26(11), 2984-2991.
    • McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ. . Journal of Medicinal Chemistry 2016, 59(4), 1308-1329.
    • Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A. . Epigenomics 2015, 7(5), 791-811.
    • Thinnes CC, England KS, Kawamura A, Chowdhury R, Schofield CJ, Hopkinson RJ. . Biochimica et Biophysica Acta - Gene Regulatory Mechanisms 2014, 1839(12), 1416-1432.
    • Kawamura A, Loenarz C, Schofield CJ. Mutations To Metabolic Enzymes In Cancer Herald A Need To Unify Genetics And Biochemistry. Cell Cycle 2011, 10(17).
    • Rose NR, McDonough MA, King OF, Kawamura A, Schofield CJ. Inhibition of 2-Oxoglutarate Dependent Oxygenases. Chemical Society Reviews 2011, 40(8), 4364-4369.
    • Sim E, Lack N, Wang C, Long H, Westwood I, Fullam E, Kawamura A. Arylamine N-acetyltransferases: Structural and Functional Implications of Polymorphisms. Toxicology 2008, 254, 170-183.
    • Westwood IM, Kawamura A, Fullam E, Russell AJ, Davies SG, Sim E. Structure and mechanism of arylamine N- acetyltransferases. Current Topics in Medicinal Chemistry 2006, 6, 1641-1654.
    • Pompeo F, Brooke E, Kawamura A, Mustaq A, Sim E. The pharmacogenetics of NAT: structural aspects. Pharmacogenomics 2002, 3(1), 19-30.