麻豆传媒

My roles and responsibilities

Childhood Cancer Theme Leader

Institute GM Chair

Research Fellow of the University Sains Malaysia, Penang

My research interests

Leukaemic fusion genes as initiating and driving events in leukaemogenesis

Therapeutic interference with fusion gene function

Regulation of leukaemic self-renewal

Development of non-genotoxic treatments for childhood leukaemias

Current research group (shared with Josef Vormoor)

Helen Blair, PhD                                                        

Milene Dalmina, PhD student                                   

Alex Elder, PhD                                                        

Asmida Isa, PhD student

Hasan Issa, PhD student

Lynsey McKenzie, PhD

Hesta McNeill

Shalini Moorthy, PhD student

Ryan Nelson

Deepali Pal, PhD, NC3R Training Fellow

Ricky Tirtakusuma, PhD student

Research Interests

Oncogenic fusion genes

Current Work

Role of AML1/MTG8 (RUNX1/RUNX1T1) in leukaemic persistence
Role of MLL/AF4 (MLL/MLLT2) in leukaemic persistence
Systemic delivery of antileukaemic siRNAs

Esteem Indicators

Reviewer for the Leukaemia Research Fund, Children with Leukaemia, Cancer Research UK, Yorkshire Cancer Research.
Reviewer for Blood, Journal of Drug Targeting, Angewandte Chemie, Journal of Molecular and Cellular Medicine, Oligonucleotides, Cancer Letters, Expert Opinion on Therapeutic Targets, Oncogene, Cancer Investigation.

Funding

Primitive Progenitor/Stem Cells in Philadelphia Chromosome-positive Acute Lymphoblastic Leukaemia; Leukaemia Research Fund; £140,299, 01 Dec 2008 - 30 Nov 2010

The Role of RUNX1/RUNX1T1 in Therapy Induced Leukaemia (PhD studentship); JGW Patterson Foundation; £88,381; 01 Oct 2008 - 30 Sep 2011

The role of MLL/AF4 in Leukaemic Maintenance; Leukaemia Research Fund; £212,884; 01 Sep 2008 - 31 Aug 2011

AML1/MTG8 - an addictive oncogone? Kay Kendall Leukaemia Fund; £112,028; 01 Jul 2008 - 30 Jun 2010

NECCR PhD Studentship; North of England Childrens Cancer Research Fund; £32,242.33; 01 Mar 2007 - 30 Sep 2010

Patents

Eckstein F, Pieken W, Benseler F, Olsen DB, Williams DM, Heidenreich O: Modified ribozymes. 91916858; 23.09.1991

Heidenreich O, Vornlocher H-P, Kreutzer R, Limmer S: Method for inhibiting the expression of a target gene resulting from a chromosome aberration. EP 200300608; 22.01.2003

Heidenreich O, Hadwiger P, Vornlocher H-P: RNAi modulation of MLL-AF4 and uses thereof. US Serial No. 60/635,936; 6.12.2005

• Sinclair PB, Blair HH, Ryan SL, Buechler L, Cheng J, Clayton J, Hanna R, Hollern S, Hawking Z, Bashton M, Schwab CJ, Jones L, Russell LJ, Marr H, Carey P, Halsey C, Heidenreich O, Moorman AV, Harrison CJ. . Haematologica 2018, 103, 634-644.
• Horowitz M, Schreiber H, Elder A, Heidenreich O, Vormoor J, Toffalori C, Vago L, Kroger N. . Bone Marrow Transplantation 2018, 53(11), 1379-1389.
• Fordham SE, Blair HJ, Elstob CJ, Plummer R, Drew Y, Curtin NJ, Heidenreich O, Pal D, Jamieson D, Park C, Pollard J, Fields S, Milne P, Jackson GH, Marr HJ, Menne T, Jones GJ, Allan JM. . Blood Advances 2018, 2(10), 1157-1169.
• Garrido Castro P, van Roon EHJ, Pinhancos SS, Trentin L, Schneider P, Kerstjens M, te Kronnie G, Heidenreich O, Pieters R, Stam RW. . Leukemia 2018, 32(2), 323-331.
• Meyer C, Burmeister T, Groger D, Tsaur G, Fechina L, Renneville A, Sutton R, Venn NC, Emerenciano M, Pombo-De-Oliveira MS, Barbieri Blunck C, Almeida Lopes B, Zuna J, Trka J, Ballerini P, Lapillonne H, De Braekeleer M, Cazzaniga G, Corral Abascal L, Van Der Velden VHJ, Delabesse E, Park TS, Oh SH, Silva MLM, Lund-Aho T, Juvonen V, Moore AS, Heidenreich O, Vormoor J, Zerkalenkova E, Olshanskaya Y, Bueno C, Menendez P, Teigler-Schlegel A, Zur Stadt U, Lentes J, Gohring G, Kustanovich A, Aleinikova O, Schafer BW, Kubetzko S, Madsen HO, Gruhn B, Duarte X, Gameiro P, Lippert E, Bidet A, Cayuela JM, Clappier E, Alonso CN, Zwaan CM, Van Den Heuvel-Eibrink MM, Izraeli S, Trakhtenbrot L, Archer P, Hancock J, Moricke A, Alten J, Schrappe M, Stanulla M, Strehl S, Attarbaschi A, Dworzak M, Haas OA, Panzer-Grumayer R, Sedek L, Szczepa T, Caye A, Suarez L, Cave H, Marschalek R. . Leukemia 2018, 32(2), 273-284.
• Elder A, Bomken S, Wilson I, Blair HJ, Cockell S, Ponthan F, Dormon K, Pal D, Heidenreich O, Vormoor J. . Leukemia 2017, 31, 2577-2586.
• Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA. . Cell Reports 2017, 18(2), 482-495.
• Loke J, Assi SA, Imperato MR, Ptasinska A, Cauchy P, Grabovska Y, Soria NM, Raghavan M, Delwel HR, Cockerill PN, Heidenreich O, Bonifer C. . Cell Reports 2017, 19(8), 1654-1668.
• Weiland J, Pal D, Case M, Irving J, Ponthan F, Koschmieder S, Heidenreich O, von Stackelberg A, Eckert C, Vormoor J, Elder A. . Leukemia 2016, 30(9), 1920–1923.
• Pal D, Heidenreich O, Vormoor J. . Cancer Cell 2016, 30(6), 825-826.
• Pal D, Blair HJ, Elder A, Dormon K, Rennie KJ, Coleman DJL, Weiland J, Rankin KS, Filby A, Heidenreich O, Vormoor J. . Leukemia 2016, 30, 1691-1700.
• Williams MT, Yousafzai YM, Elder A, Rehe K, Bomken S, Frishman-Levy L, Tavor S, Sinclair P, Dormon K, Masic D, Perry T, Weston VJ, Kearns P, Blair H, Russell LJ, Heidenreich O, Irving JA, Izraeli S, Vormoor J, Graham GJ, Halsey C. . Blood 2016, 127(16), 1998-2006.
• Forster VJ, Nahari MH, Martinez-Soria N, Bradburn AK, Ptasinska A, Assi SA, Fordham SE, McNeil H, Bonifer C, Heidenreich O, Allan JM. . Leukemia 2016, 30(1), 250-253.
• Goyama S, Schibler J, Gasilina A, Shrestha M, Lin S, Link KA, Chen J, Whitman SP, Bloomfield CD, Nicolet D, Assi SA, Ptasinska A, Heidenreich O, Bonifer C, Kitamura T, Nassar NN, Mulloy JC. . Leukemia 2016, 30(3), 728-739.
• Sinclair P, Cheng J, Raninga P, Hanna R, Hollern S, Enshaei A, Blair H, Nakjang S, Ryan S, Eswaran J, Buechler L, Heidenreich O, Harrison C. . In: 57th American Society of Hematology (ASH) Annual Meeting. 2015, Orlando, FL, USA: American Society of Hematology.
• Dormon K, Latif ES, Bashton M, Pal D, Selby M, Blair H, Rand V, Hall AG, Vormoor J, Heidenreich O. . In: ASH 2015 Annual Meeting. 2015, Orlando, USA: American Society of Hematology.
• Weiland J, Elder A, Forster V, Heidenreich O, Koschmieder S, Vormoor J. . Pediatric Blood & Cancer 2015, 62(7), 1144-1148.
• Yousafzai YM, Williams MTS, Bhatti S, Cousins A, Rehe K, Bomken S, Sinclair P, Weston VJ, Russell LJ, Heidenreich O, Irving JAE, Vormoor J, Graham GJ, Halsey C. . In: 55th Annual Scientific Meeting of the British Society for Haematology. 2015, Edinburgh, UK: Wiley.
• Bourquin JP, Fischer U, Forster M, Rinaldil A, Risch T, Sungalee S, Hans-Jorg W, Bornhauser B, Michael G, Christina K, Adrian S, Marc S, Catherine W, Amstislavskiy V, Baruchel A, Thies B, Giuseppe B, Gunnar C, Helene C, Dardanel D, Mauro D, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas O, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Holl J, Homhardt S, Husemann P, te Kronnie G, Lehrach H, Marovca B, Niggli F, McHardy A, Moorman A, Panzer-Grumayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schafer D, Schrappe M, Schreiber S, Schutte M, Stade B, Tchindal J, Thiele R, Vora A, Zaliova M, Zichner T, Zimmermann M, Borkhardt A, Franke A, Korbel JO, Stanulla M, Yaspo ML. . In: 20th Congress of the European Hematology Association. 2015, Vienna, Austria: Fondazione Ferrata Storti.
• Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stutz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cave H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Holl JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, te Kronnie G, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grumayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schafer D, Schrappe M, Schreiber S, Schutte M, Stade B, Thiele R, von der Weid N, Vora A, Zaliova M, Zhang LH, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML. . Nature Genetics 2015, 47(9), 1020-1029.
• Elder A, Blair H, Dormon K, Bomken S, Cockell SJ, Heidenreich O, Vormoor J. . In: 57th ASH Annual Meeting. 2015, Orlando, USA: American Society of Hematology.
• Martinez N, McKenzie LM, Nakang S, Ptasinska A, Assi SA, Bonifer C, Heidenreich O. . In: HAEMATOLOGICA. 2015, Vienna, Austria: Fondazione Ferrata Storti.
• Bell N, Blair H, Noble R, Price L, Wood K, Vormoor J, Bacon C, Rand V, Heidenreich O, Wedge S, Bomken S. . In: Fifth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell.
• Forster V, Nahari M, Martinez-Soria N, Bradburn A, Ptasinska A, Assi S, McNeill H, Bonifer C, Heidenreich O, Allan J. . In: 20th Congress of the European Hematology Association. 2015, Vienna, Austria: Fondazione Ferrata Storti.
• Eswaran J, Sinclair P, Heidenreich O, Irving J, Russell LJ, Hall A, Calado DP, Harrison CJ, Vormoor J. . Leukemia 2015, 29(8), 1623-1631.
• Vormoor B, Knizia HK, Batey MA, Almeida GS, Wilson I, Dildey P, Sharma A, Blair H, Hide IG, Heidenreich O, Vormoor J, Maxwell RJ, Bacon CM. . PLoS ONE 2014, 9(1), e85128.
• Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, Schröder A, Venturini L, Blair HJ, Vormoor J, Ottmann O, Ganser A, Pich A, Hilfiker-Kleiner D, Heidenreich O, Eder M. . Leukemia 2014, 28, 554-565.
• Ptasinska A, Assi SA, Martinez-Soria N, Imperato MR, Piper J, Cauchy P, Pickin A, James SR, Hoogenkamp M, Williamson D, Wu MC, Tenen DG, Ott S, Westhead DR, Cockerill PN, Heidenreich O, Bonifer C. . Cell Reports 2014, 8(6), 1974-1988.
• Breig O, Bras S, Soria NM, Osman D, Heidenreich O, Haenlin M, Waltzer L. . Leukemia 2014, 28(6), 1271-1279.
• Batey MA, Ponthan F, Blair HJ, Heidenreich O. . In: AACR Annual Meeting 2014. 2014, San Diego, CA: American Association for Cancer Research.
• Rehe K, Wilson K, Bomken S, Williamson D, Irving J, den Boer ML, Stanulla M, Schrappe M, Hall AG, Heidenreich O, Vormoor J. . EMBO Molecular Medicine 2013, 5(1), 38-51.
• Omedes Pujol M, Coleman DJL, Allen CD, Heidenreich O, Fulton DA. . Journal of Controlled Release 2013, 172(3), 939-945.
• Ptasinska A, Assi S, Williamson D, Cauchy P, Tenen D, Cockerill P, Westhead D, Heidenreich O, Bonifer C. . In: 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells. 2013, Vienna, Austria: Elsevier Inc.
• Bomken S, Buechler L, Rehe K, Ponthan F, Elder A, Blair H, Bacon CM, Vormoor J, Heidenreich O. . Leukemia 2013, 27(3), 718-721.
• Ray D, Kwon SY, Tagoh H, Heidenreich O, Ptasinska A, Bonifer C. . Blood 2013, 122(5), 759-769.
• van Asbeck AH, Beyerle A, McNeill H, Bovee-Geurts PHM, Lindberg S, Verdurmen WPR, Hällbrink M, Langel U, Heidenreich O, Brock R. . ACS Nano 2013, 7(5), 3797-3807.
• Meyer C, Hofmann J, Burmeister T, Groger D, Park TS, Emerenciano M, de Oliveira MP, Renneville A, Villarese P, Macintyre E, Cave H, Clappier E, Mass-Malo K, Zuna J, Trka J, De Braekeleer E, De Braekeleer M, Oh SH, Tsaur G, Fechina L, van der Velden VHJ, van Dongen JJM, Delabesse E, Binato R, Silva MLM, Kustanovich A, Aleinikova O, Harris MH, Lund-Aho T, Juvonen V, Heidenreich O, Vormoor J, Choi WWL, Jarosova M, Kolenova A, Bueno C, Menendez P, Wehner S, Eckert C, Talmant P, Tondeur S, Lippert E, Launay E, Henry C, Ballerini P, Lapillone H, Callanan MB, Cayuela JM, Herbaux C, Cazzaniga G, Kakadiya PM, Bohlander S, Ahlmann M, Choi JR, Gameiro P, Lee DS, Krauter J, Cornillet-Lefebvre P, Kronnie GT, Schafer BW, Kubetzko S, Alonso CN, Stadt UZ, Sutton R, Venn NC, Izraeli S, Trakhtenbrot L, Madsen HO, Archer P, Hancock J, Cerveira N, Teixeira MR, Lo Nigro L, Moricke A, Stanulla M, Schrappe M, Sedek L, Szczepanski T, Zwaan CM, Coenen EA, van den Heuvel-Eibrink MM, Strehl S, Dworzak M, Panzer-Grumayer R, Dingermann T, Klingebiel T, Marschalek R. . Leukemia 2013, 27(11), 2165-2176.
• Dunne J, Mannari D, Farzaneh T, Gessner A, van Delft FW, Heidenreich O, Young BD, Gascoyne DM. . Leukemia 2012, 26(5), 1131-1135.
• Ptasinska A, Assi SA, Mannari D, James SR, Williamson D, Dunne J, Hoogenkamp M, Wu M, Care M, McNeill H, Cauchy P, Cullen M, Tooze RM, Tenen DG, Young BD, Cockerill PN, Westhead DR, Heidenreich O, Bonifer C. . Leukemia 2012, 26(8), 1829-1841.
• Grinev VV, Posrednik DV, Heidenreich O. . Molecular Biology 2011, 45(2), 300-308.
• Duque-Afonso J, Yalcin A, Berg T, Abdelkarim M, Heidenreich O, Lübbert M. . Oncogene 2011, 30(27), 3062-3072.
• Dunne J, Gascoyne DM, Lister TA, Brady HJ, Heidenreich O, Young BD. . Cancer Research 2010, 70(10), 3985-3995.
• Gessner A, Thomas M, Garrido Castro P, Büchler L, Scholz A, Brümmendorf TH, Martinez Soria N, Vormoor J, Greil J, Heidenreich O. . Leukemia 2010, 24(10), 1751-1759.
• Werth D, Grassi G, Konjer N, Dapas B, Farra R, Giansante C, Kandolf R, Guarnieri G, Nordheim A, Heidenreich O. . European Journal of Cell Biology 2010, 89(2-3), 216-224.
• Bomken S, Fiser K, Heidenreich O, Vormoor J. . British Journal of Cancer 2010, 103(4), 439-445.
• Osman D, Gobert V, Ponthan FM, Heidenreich O, Haenlin M, Waltzer L. . Proceedings of the National Academy of Sciences 2009, 106(29), 12043-12048.
• Russell LJ, Capasso M, Vater I, Akasaka T, Bernard OA, Calasanz MJ, Chandrasekaran T, Chapiro E, Gesk S, Griffiths M, Guttery DS, Haferlach C, Harder L, Heidenreich O, Irving JAE, Kearney L, Nguyen-Khac F, Machado L, Minto L, Majid A, Moorman AV, Morrison H, Rand V, Strefford JC, Schwab CJ, Tonnies H, Dyer MJ, Siebert R, Harrison CJ. . Blood 2009, 114(13), 2688-2698.
• Martinez Soria N, Tussiwand R, Ziegler P, Manz MG, Heidenreich O. . Leukemia 2008, 23(1), 188-190.
• Thomas M, Gessner A, Vornlocher HP, Hadwiger P, Greil J, Heidenreich O. . Blood 2005, 106(10), 3559-3566.
• Martinez N, Drescher B, Riehle H, Cullmann C, Vornlocher HP, Ganser A, Heil G, Nordheim A, Krauter J, Heidenreich O. . BMC Cancer 2004, 4(1), 44.
• Heidenreich O, Krauter J, Riehle H, Hadwiger P, John M, Heil G, Vornlocher HP, Nordheim A. . Blood 2003, 101(8), 3157-3163.
• Scherr M, Battmer K, Winkler T, Heidenreich O, Ganser A, Eder M. . Blood 2003, 101(4), 1566-1569.