麻豆传媒

Qualifications

BSc. - Leicester 1993
PhD. - Leicester and Heidelberg (Germany) 1998

Previous Positions

1996 to 2000 Division of Mol. Microbiology, Biozentrum, University of Basel, Basel, Switerland
2000 to 2003 Dept. of Microbiology, University of Washington, Seattle, WA, USA

Memberships

Society for General Microbiology
Society for Applied Microbiology

1) Urinary Tract Infections

Urinary tract infections (UTIs) are a common bacterial infection with symptoms that include urinary frequency, urgency to void, dysuria and abdominal pain. At present it is assumed that the relationship between an individual’s susceptibility and bacterial virulence determines the balance between tolerance of invading pathogens and the mounting of an immune response, which in turn dictates the course of infection and subsequent recurrence. The lack of specific genomic and phenotypic information makes it challenging to differentiate between uropathogenic E. coli (UPEC) and asymptomatic bacteriuria (ABU) E. coli strains. One outcome is that ABU patients, particularly the elderly, are often given antibiotics without justification due to clinical uncertainty.

This work on UTIs is a collaborative project between myself, a further university-based academic, a urological consultant surgeon and a uro-gynaecological consultant. Our partnership objectives focus on an unmet need to generate robust data on the clinical efficacy and underlying scientific mechanisms of antibiotic and non-antibiotic preventive interventions for UTIs directly in line with global antibiotic stewardship initiatives. We have developed a robust research framework integrating basic scientific research into clinical studies and trials to inform clinical decisions, impact antibiotic stewardship and importantly, improve patient well-being.

The team’s research strategy aims to:

1. Utilise clinical studies and patient material to interrogate and understand recurrent UTI;
2. Combine basic and clinical approaches for the benefit of patients suffering recurrent UTI;
3. Educate and attract young scientists and clinicians to the study of urology and UTI.

2) The bacterial flagellum

The flagellum is a unique molecular machine driving bacterial movement through liquid environments. Bacteria are propelled forward by rotation of an external long whip-like flagellar filament. Rotation of the filament is achieved via the action of a universal joint known as the hook and a basal motor anchored into the bacterial cell envelope. The flagellar filament is a major antigen recognized by hosts during bacterial infections. A significant number of bacterial species encode multiple copies of the filament building block - flagellin. A complex regulatory network controls the assembly of the flagellum and the number per cell, which varies between different species.

Our research focuses on the fundamental understanding of how bacteria regulate flagellar assembly, how a cell coordinates the assembly of unrelated molecular machines and how hosts recognise this important antigen. We have studied how bacterial species such as the pathogen Salmonella enterica maintain a discrete number of flagellar per cell during cell growth and division. We complement our study on flagellar abundance with research to understanding how a filament is assembled from multiple flagellins, a trait maintained by many bacterial species. Our in-depth knowledge of flagellar assembly and its regulation allow us to investigate the interaction of the host innate immune system during UTIs.

Expertise

My expertise utilise bacterial genetics to study fundamental aspects of the bacterial life cycle and host-microbe interactions. My laboratory uses, bacterial genetics, protein biochemistry, structural biology, bioinformatics and microscopic techniques to validate our genetic findings.

I also have a strong background in bacterial pathogenesis of both Animal and Plant Hosts. During my career I have gained valuable experience working with a range of bacterial pathogens.

Postgraduate Supervision

A wide range of projects are available.

Undergraduate Teaching

BMS3025 - Module Leader

CMB3000 - Project Supervisor

Postgraduate Teaching

MMB8048 - Module Leader

MMB8098 - Deputy Module Leader

PhD. Supervisor for 1 student

• Articles

  • Mowbray C, Tan A, Vallee M, Fisher H, Chadwick T, Brennand C, Walton KE, Pickard RS, Harding C, Aldridge PA, Hall J. . European Urology Open Science 2022, 37, 90-98.
  • Vallee M, Harding C, Hall J, Aldridge P, Tan A. . Journal of Antimicrobial Chemotherapy 2023, 78(2), 373-379.
  • Wang X, Koirala S, Aldridge PD, Rao CV. . Journal of Bacteriology 2020, 202(13), e00787-19.
  • Hamed S, Wang X, Shawky RM, Emara M, Aldridge PD, Rao CV. . BMC Microbiology 2019, 19(1), 211.
  • Mickiewicz KM, Kawai Y, Drage L, Gomes MC, Davison F, Pickard R, Hall J, Mostowy S, Aldridge PD, Errington J. . Nature Communications 2019, 10(1), 4379.
  • Drage LKL, Robson W, Mowbray C, Ali A, Perry JD, Walton KE, Harding C, Pickard R, Hall J, Aldridge PD. . Immunity and Ageing 2019, 16(1).
  • Byrne M, Singh A, Mowbray CA, Aldridge PD, Drage LKL, Ali ASM, Bates L, Hall J, Wilson C. . Journal of Surgical Research 2019, 235, 288-297.
  • Mowbray CA, Shams S, Chung G, Stanton A, Aldridge P, Suchenko A, Pickard RS, Ali ASM, Hall J. . Clinical & Translational Immunology 2018, 7(6), e1021.
  • Albanna A, Sim M, Hoskisson PA, Gillespie C, Rao CV, Aldridge PD. Driving the expression of the Salmonella enterica sv Typhimurium flagellum using flhDC from Escherichia coli results in key regulatory and cellular differences. Scientific Reports 2018, 8(1), 16705.
  • Ali ASM, Mowbray C, Lanz M, Stanton A, Bowen S, Varley CL, Hilton P, Brown K, Robson W, Southgate J, Aldridge P, Tyson-Capper A, Abraham S, Pickard RS, Hall J. . Scientific Reports 2017, 7, 11039.
  • Sim M, Koirala S, Picton D, Strahl H, Hoskissin PA, Rao CV, Gillespie CS, Aldridge PD. . Scientific Reports 2017, 7, 41189.
  • Minamino T, Morimoto YV, Hara N, Aldridge PD, Namba K. . PLoS Pathogens 2016, 12(3), e1005495.
  • Minamino T, Morimoto YV, Kinoshita M, Aldridge PD, Namba K. . Scientific Reports 2014, 4, 7579.
  • Cairns LS, Marlow VL, Kiley TB, Birchall C, Ostrowski A, Aldridge PD, Stanley-Wall NR. . Journal of Bacteriology 2014, 196(12), 2216-2226.
  • Koirala A, Mears P, Sim M, Golding I, Chemla YR, Aldridge PD, Rao CV. . mBio 2014, 5(5), e01611-14.
  • Minamino T, Kinoshita M, Hara N, Takeuchi S, Hida A, Koya S, Glenwright H, Imada K, Aldridge PD, Namba K. . Molecular Microbiology 2012, 83(4), 775-788.
  • Faulds-Pain A, Birchall C, Aldridge C, Smith WD, Grimaldi G, Nakamura S, Miyata T, Gray J, Li GL, Tang JX, Namba K, Minamino T, Aldridge PD. . Journal of Bacteriology 2011, 193(11), 2695-2707.
  • Saini S, Floess E, Aldridge C, Brown J, Aldridge PD, Rao CV. . Molecular Microbiology 2011, 79(1), 264-278.
  • Pohl S, Tu WY, Aldridge PD, Gillespie C, Hahne H, Mäder U, Read TD, Harwood CR. . Proteomics 2011, 11(15), 3036-3055.
  • Aldridge C, Poonchareon K, Saini S, Ewen T, Soloyva A, Rao CV, Imada K, Minamino T, Aldridge PD. . Molecular Microbiology 2010, 78(6), 1416-1430.
  • Saini S, Koirala S, Floess E, Mears PJ, Chemla TR, Golding I, Aldridge C, Aldridge PD, Rao CV. . Journal of Bacteriology 2010, 192(24), 6477-6481.
  • Scharf BE, Aldridge PD, Kirby JR, Crane BR. . Molecular Microbiology 2009, 73(1), 5-19.
  • Brown JD, Saini S, Aldridge C, Herbert J, Rao CV, Aldridge PD. . Molecular Microbiology 2008, 70(4), 924-937.
  • Saini S, Brown JD, Aldridge PD, Rao CV. . Journal of Bacteriology 2008, 190(14), 4979-4988.
  • Aldridge P, Gnerer J, Karlinsey JE, Hughes KT. . Journal of Bacteriology 2006, 188(12), 4487-4496.
  • Aldridge PD, Karlinsey JE, Aldridge C, Birchall C, Thompson D, Yagasaki J, Hughes KT. . Genes & Development 2006, 20(16), 2315-2326.
  • Aldridge PD, Wu C, Gnerer J, Karlinsey JE, Hughes KT, Sachs MS. . Proceedings of the National Academy of Sciences of the United States of America 2006, 103(30), 11340-11345.
  • Aldridge P, Karlinsey JE, Becker E, Chevance FFV, Hughes KT. . Molecular Microbiology 2006, 60(3), 630-642.
  • Aldridge P, Karlinsey J, Hughes KT. . Molecular Microbiology 2003, 49(5), 1333-1345.
  • Aldridge P, Paul R, Goymer P, Rainey P, Jenal U. . Molecular Microbiology 2003, 47(6), 1695-1708.
  • Fischer B, Rummel G, Aldridge P, Jenal U. . Molecular Microbiology 2002, 44(2), 461-478.
  • Aldridge P, Hughes KT. . Current Opinion in Microbiology 2002, 5(2), 160-165.
  • Hughes KT, Aldridge PD. . Nature Structural and Molecular Biology 2001, 8(2), 96-97.
  • Aldridge P, Hughes KT. . Trends in Microbiology 2001, 9(5), 209-214.
  • Aldridge P, Jenal U. . Molecular Microbiology 1999, 32(2), 379-391.
  • P. Aldridge,F. Bernhard,P. Bugert,D. L. Coplin,K. Geider. Characterization of a gene locus from Erwinia amylovora with regulatory functions in exopolysaccharide synthesis of Erwinia spp. Can J Microbiol 1998, 44(7), 657-66.
  • S. Bereswill,P. Aldridge,J.G. Janse,K. Geider. Partial characterization of natural levan deficient Erwinia amylovora strains. 51: 215-225. Physiological and Molecular Plant Pathology 1997, 51, 215-225.
  • P. Aldridge,M. Metzger,K. Geider. Genetics of sorbitol metabolism in Erwinia amylovora and its influence on bacterial virulence. Mol Gen Genet 1997, 256(6), 611-9.

• Book Chapter

  • Brown J, Faulds-Pain A, Aldridge P. . In: Jarrell KF, ed. Pili and Flagellar: Current Research and Future Trends. Norwich: Caister Academic Press, 2009, pp.99-120.

• Conference Proceedings (inc. Abstracts)

  • Drage L, Lanz M, Ali A, Birchall C, Hall J, Pickard R, Aldridge P. . In: Annual Meeting of the Society-of-Academic-and-Research-Surgery. 2014, Univ Cambridge, Robinson Coll, Cambridge, ENGLAND: John Wiley & Sons Ltd.
  • Lanz ML, Aldridge P, Birchall C, Ali A, Townes C, Walton K, Lim LY, Pickard RS, Hall J. . In: Annual Meeting of the Society of Academic and Research Surgery. 2013, Royal Soc Med (RSM), London, ENGLAND: John Wiley & Sons Ltd.
  • Aldridge PD, Gray MA, Hirst BH, Khan CMA. . In: International Symposium on Epithelial-Bacterial Pathogen Interactions. 2004, 麻豆传媒 upon Tyne, UK: Molecular Microbiology: Wiley-Blackwell.

• Note

  • Mickiewicz KM, Kawai Y, Drage L, Gomes MC, Davison F, Pickard R, Hall J, Mostowy S, Aldridge PD, Errington J. . Nature Communications 2019, 10, 5254.