麻豆传媒

Background

I started my career as a clinical veterinarian and became involved in medical research at the Clinical Research Centre, London, while acting as their laboratory animal veterinarian. After completing a PhD in physiology, I moved to 麻豆传媒, where I was able to develop my major interests in the science underpinning animal welfare.

Roles and Responsibilities

I stepped down as Director  of the university research animal facilities in 2017, and now have time to focus on developing e-learning resources, and delivery of training on a range of topics related to animal welfare. I am also continuing to contribute to the work of the Pain and Animal Welfare Science group.

Qualifications

MA, VetMB, PhD, DECLAM, DLAS, DECVA, (Hon) DACLAM, FRSB, (Hon) FIAT, (Hon) FRCVS

Previous Positions

MRC Non-clinical scientific staff

Memberships

AVA, ESLAV, LAVA, LASA, AALAS

Honours and Awards

1981 Winston Churchill Travelling Fellowship, 1986 Livesey Medal by the Royal College of Veterinary Surgeons for work on anaesthesia and analgesia of laboratory animals. 1991, GV-SOLAS Prize for Laboratory Animal Science.1991 Hildegard Doerenkamp and Gerhard Zbinden Foundation for Realistic Animal Protection in Scientific Research - Scientific award for 1990, 1992 Canadian Commonwealth Fellowship. 1993 Research Defence Society - SmithKline Beecham Laboratory Animal Welfare Prize. 1996 WARDS Refinement Project Award, 1997 Honorary Associate, British Laboratory Animal Veterinary Association. 2002 CAAT Recognition Award for work on anaesthesia and analgesia. 2003 Solvay Pharmaceuticals prize, 2003. BSAVA/Blue Cross JA Wight award for contributions to companion animal welfare. 2004 BVA Dalrymple-Champneys Cup and Medal for contributions to animal welfare, 2005 International Academy of Pain Management Pfizer Award, 2006 Prince Laurent Foundation Award for Research Contributions to Animal Welfare, 2006 Eurotox/HSI/P&G Animal Welfare Award, 2007, FELASA Award, 2007, ICLAS Ben Cohen Award, 2008, Honorary Diplomate, American College of Laboratory Animal Medicine, 2008, Honorary Fellowship, Royal College of Veterinary Surgeons,2007 International Committee for Laboratory Animal Science "Ben Cohen Award" for contributions to Laboratory Animal Welfare
2007 FELASA award, for research work leading to advances in pain assessment and management in laboratory animals. 2009 Markovitz Medal, for contributions to pain alleviation, Academy of Surgical Research 2009 CAAT Charles River Refinement Award, 2011 Honorary Doctorate, University of Ghent, 2012 Charles River LASA Award to research group, for contributions to Laboratory Animal Welfare, 2014 SGV prize for animal welfare research, 2017 Honorary Fellow of the Institute of Animal Technology

Informal Interests

Bird-watching, photography, walking, cookery and computer gaming

Research Interests

Welfare of animals used in biomedical research, and in particular issues associated with pain and distress. Comparative aspects of pain assessment and alleviation. Animal anaesthesia and the neurophysiogical effects of anaesthesia.

Current Work

Our research group aims to develop improved methods of analgesia and anaesthesia for use in animals. We are also interested in comparative aspects of pain and analgesia. We also disseminate this information by developing training materials for research workers.

Future Research

We aim to develop the comparative aspects of our research in pain assessment and alleviation. In particular, we are aiming to develop means of assessing the affective component of pain. We also aim to develop more humane methods of euthanasia of laboratory animals.

Esteem Indicators

Invited speaker at international conferences (eg World Congress of Veterinary Anaesthesia, World Congress of Anaesthesia, World Congress on Alternatives to Animal use in the Life Sciences). Awarded BVA Dalrymple-Champneys Cup and Medal for contributions to animal welfare (2005), International Academy of Pain Management Pfizer Award
(2006), Prince Laurent Foundation Award for Research Contributing to Animal Welfare
(2006) Eurotox/HSI/P&G Animal Welfare Award (2006)2007 International Committee for Laboratory Animal Science "Ben Cohen Award" for contributions to Laboratory Animal Welfare
2007 FELASA award, for research work leading to advances in pain assessment and management in laboratory animals.2008 Honorary Fellowship, Royal College of Veterinary Surgeons, 2008 Honorary Diplomate, American College of Laboratory Animal Medicine, 2009 Markovitz Medal, Academy of Surgical Research,2009 CAAT Charles River Refinement Award, 2011, Honorary Doctorate, University of Ghent

Funding

Funding 2007-17 Wellcome Trust (249k), BBSRC (£307k), Solvay Pharmaceuticals (£38k), UFAW (£73k), NC3Rs (£380k), Pfizer plc (£85k), NC3Rs (£245k), NC3rs (£295k), ACLAM (£39k), Swedish Agriculture Board (£29k), NC3Rs (£300k)

Industrial Relevance

Our work on novel measures of affective state has direct relevance to pharmaceutical company research in both pain and addiction.

Postgraduate Teaching

 Workshops on anaesthesia and pain management for research workers, veterinarians and others. E-learning modules for new and experienced research workers and practical workshops and seminars on anaesthesia and pain management of laboratory animals.

• Clarkson JM, Dwyer DM, Flecknell PA, Leach MC, Rowe C. . Scientific Reports 2018, 8(1), 2448.
• Bertrand HGMJ, Sandersen C, Flecknell PA. . Laboratory Animals 2018, 52(3), 292-299.
• Bertrand HGMJ, Sandersen C, Murray J, Flecknell PA. . Journal of Medical Primatology 2017, 46(6), 332-336.
• Lofgren J, Miller AL, Lee CSS, Bradshaw C, Flecknell P, Roughan JV. . Laboratory Animals 2018, 52(4), 351-364.
• Flecknell PA, Thomas AA. . In: Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. Wiley, 2017, pp.754-763.
• Bertrand HGMJ, Springer S, Burnside W, Sandersen C, Flecknell PA. . Laboratory Animals 2017, 51(5), 518-525.
• Thomas AA, Detilleux J, Sandersen CF, Flecknell PA. . Laboratory Animals 2017, 51(5), 479-489.
• Bertrand HGMJ, Sandersen CF, Flecknell PA. . Laboratory Animals 2017, 51(4), 405-411.
• Klinck MP, Mogil JS, Moreau M, Lascelles BDX, Flecknell PA, Poitte T, Troncy E. . Pain 2017, 158(9), 1633-1646.
• Bertrand HGMJ, Thomas AA, Ellen YC, Dorward RS, Flecknell PA. . BMC Veterinary Research 2016, 12, 16.
• Bertrand HGMJ, Ellen YC, O'Keefe S, Flecknell PA. . BMC Veterinary Research 2016, 12, 93.
• Thomas AA, Miller AL, Roughan JV, Malik A, Haylor KE, Sanderson C, Flecknell PA, Leach M. . PLOS One 2016, 11(10), e0163909.
• Mendl M, Bennett R, Collins L, Davies A, Flecknell P, Green L, Hurst J, Lawrence A, Statham P, Turnbull J. . Veterinary Record 2016, 178(6), 138-139.
• Ellen Y, Flecknell P, Leach M. . PLoS One 2016, 11(9), e0161941.
• Flecknell P, Clutton E, Murphy K, Bradbury G, Taylor P. . Veterinary Record 2016, 178(19), 476-476.
• Mundinano IC, Flecknell PA, Bourne JA. MRI-guided stereotaxic brain surgery in the infant and adult common marmoset. Nature Protocols 2016, 11(7), 1299–1308. In Preparation.
• Lidster K, Jefferys JG, Blumcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkanen A, Ragan I, Shah M, Simonato M, Treyelyan A, Volk H, Walker M, Yates N, Prescott MJ. . Journal of Neuroscience Methods 2016, 260, 2-25.
• Miller AL, Kitson GL, Skalkoyannis B, Flecknell PA, Leach MC. . Applied Animal Behaviour Science 2016, 181, 160-165.
• Flecknell P, Lofgren JLS, Dyson MC, Marini RR, Michael Swindle M, Wilson RP. . In: Laboratory Animal Medicine (Third Edition). Elsevier Inc, 2015, pp.1135-1200.
• Hill SL, Thomas SHL, Flecknell PA, Thomas AA, Morris CM, Henderson D, Dunn M, Blain PG. . Emergency Medicine Journal 2015, 32(8), 626-631.
• Amer AO, Probert PM, Dunn M, Knight M, Vallance AE, Flecknell PA, Oakley F, Cameron I, White SA, Blain PG, Wright MC. . PLoS ONE 2015, 10(8), e0136173.
• Coulthard MG, Crosier J, Griffiths C, Smith J, Drinnan M, Whitaker M, Beckwith R, Matthews JNS, Flecknell P, Lambert HJ. . Pediatric Nephrology 2014, 29(10), 1873-1881.
• Roughan JV, Coulter CA, Flecknell PA, Thomas HD, Sufka KJ. . PLoS One 2014, 9(8), e103362.
• Burnside WM, Flecknell PA, Cameron AI, Thomas AA. . BMC Veterinary Research 2013, 9, 48.
• Rocha GS, Roughan J, Leach M, Flecknell P, Ingram CD, Brandt K. . In: II International Symposium on Medicinal and Nutraceutical Plants. 2013, New Delhi, India: International Society for Horticultural Science.
• Wright-Williams S, Flecknell PA, Roughan JV. . PLoS ONE 2013, 8(9), e75948.
• Miller AL, Wright-Williams SL, Flecknell PA, Roughen JV. . Laboratory Animals 2012, 46(4), 304-310.
• Thomas AA, Leach MC, Flecknell PA. . Laboratory Animals 2012, 46(1), 71-76.
• Thomas AA, Flecknell PA, Golledge HDR. . PLoS One 2012, 7(3), e32290.
• Keating SCJ, Thomas AA, Flecknell PA, Leach MC. . PLoS One 2012, 7(9), e44437.
• Brieuc V, Flecknell P, Miller A, Thomas A, Leach M. . STAL 2012, 38(3), 33-45.
• Prescott MJ, Brown VJ, Flecknell PA, Garrod K, Lemon RN, Parker AJ, Ryder K, Schultz W, Scott L, Watson J, Whitfield L. . Journal of Neuroscience Methods 2012, 204(1), 206-209.
• Leach MC, Klaus K, Miller AL, Scotto di Perrotolo M, Sotocinal SG, Flecknell PA. . PloS One 2012, 7(4), e35656.
• Miller AL, Flecknell PA, Leach MC, Roughan JV. . Applied Animal Behaviour Science 2011, 131(3-4), 138-144.
• Flecknell P, Leach M, Bateson M. . Pain 2011, 152(5), 963-964.
• Leach MC, Coulter CA, Richardson CA, Flecknell PA. . PLoS One 2011, 6(3), e13347.
• Coulter CA, Flecknell PA, Leach MC, Richardson CA. . BMC Veterinary Research 2011, 7, 12.
• Golledge HDR, Lukic J, Flecknell PA. . In: Altex: 8th World Congress. 2011, Montreal, Canada: Springer Spektrum.
• Leach MC, Bailey HE, Dickinson AL, Roughan JV, Flecknell PA. . Laboratory Animals 2010, 44(1), 59-65.
• Murphy KL, Roughan JV, Baxter MG, Flecknell PA. . Veterinary Anaesthesia and Analgesia 2010, 37(3), 222-229.
• Flecknell PA. . Nature Methods 2010, 7(6), 437-439.
• Leach MC, Forrester AR, Flecknell PA. . Laboratory Animals 2010, 44(1), 54-58.
• ScottodiPerrotolo M, Miller AL, Leach MC, Flecknell PA. . STAL 2010, 36(4), 49-58.
• Allweiler S, Leach MC, Flecknell PA. . Laboratory Animals 2010, 44(2), 113-117.
• Roughan JV, Wright-Williams SL, Flecknell PA. . Laboratory Animals 2009, 43(1), 17-26.
• Leach MC, Allweiler S, Richardson C, Roughan JV, Narbe R, Flecknell PA. . Research in Veterinary Science 2009, 87(2), 336-347.
• Dickinson AL, Leach MC, Flecknell PA. . Laboratory Animals 2009, 43(1), 11-16.
• Flecknell PA. . London: Academic Press, 2009.
• Coulter CA, Flecknell PA, Richardson CA. . Laboratory Animals 2009, 43(3), 232-238.
• Stokes EL, Flecknell PA, Richardson CA. . Laboratory Animals 2009, 43(2), 149-154.
• Dickinson AL, Leach MC, Flecknell PA. . Laboratory Animals 2009, 43(4), 357-361.
• Rocha G, Roughan JV, Leach MC, Flecknell PA, Ingram CD, Brandt K. . In: Planta Medica: 57th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research. 2009, Geneva, Switzerland: Georg Thieme Verlag.
• Flecknell P. . British Journal of Anaesthesia 2008, 101(1), 121-124.
• Flecknell P, Gledhill J, Richardson C. . Altex 2007, 24, 82-83.
• Wright-Williams SL, Courade J-P, Richardson CA, Roughan JV, Flecknell PA. . Pain 2007, 130(1-2), 108-118.
• Richardson CA, Niel LE, Leach MC, Flecknell PA. . Laboratory Animals 2007, 41(1), 46-54.
• Roughan JV, Flecknell PA. . Applied Animal Behaviour Science 2006, 96(3-4), 327-342.
• Richardson CA, Flecknell PA. . ATLA Alternatives to Laboratory Animals 2005, 33(2), 119-127.
• Orr HE, Roughan JV, Flecknell PA. . Veterinary Anaesthesia and Analgesia 2005, 32(5), 271-279.
• Sabrine N, Platt MPW, Roughan JV, Flecknell PA. . Journal of Reproductive and Infant Psychology 2004, 22(3), 237.
• Flecknell PA, Roughan JV. . In: UFAW International Symposium Science in the Service of Animal Welfare. 2004, Edinburgh: Animal Welfare: Universities Federation for Animal Welfare.
• Roughan JV, Flecknell PA, Davies BR. . Laboratory Animals 2004, 38(3), 286-296.
• Roughan JV, Flecknell PA. . Behavioural Pharmacology 2004, 15(7), 461-472.
• Flecknell PA. Anaesthesia of Rodents and Rabbits. In: D. McKelvey and K.W. Hollingshead, ed. Veterinary Anaesthesia and Analgesia. 2003.
• Antunes LM, Golledge HD, Roughan JV, Flecknell PA. . Veterinary Anaesthesia and Analgesia 2003, 30(1), 15-23.
• Antunes LM, Roughan JV, Flecknell PA. . Journal of Veterinary Pharmacology and Therapeutics 2003, 26(5), 369-376.
• Roughan JV, Flecknell PA. . European Journal of Pain 2003, 7(5), 397-406.
• Antunes LM, Roughan JV, Flecknell PA. . European Journal of Anaesthesiology 2003, 20(10), 800-808.
• Rao JN, Clark SC, Ali S, Kirby J, Flecknell PA, Dark JH. . European Journal of Cardio-thoracic Surgery 2003, 23(4), 497-502.
• Roughan JV, Flecknell PA. . Laboratory Animals 2003, 37(2), 172-172.
• Hedenqvist P, Orr HE, Roughan JV, Antunes LM, Flecknell PA. . Veterinary Anaesthesia and Analgesia 2002, 29(1), 14-19.
• Roughan JV, Flecknell PA. . Laboratory Animals 2002, 36(3), 322-343.
• Laidlaw A, Flecknell P, Rees JL. . Experimental Dermatology 2002, 11(4), 285-291.
• Coulthard MG, Flecknell P, Orr H, Manas D, O'Donnell M. . Pediatric Nephrology 2002, 17(7), 481-484.
• Flecknell PA. . ALTEX 2002, 19(2), 73-78.
• Flecknell P. . In: ALTEX Alternativen zu Tierexperimenten: Symposium on Use of Animals in Research: A Science-Society Controversy. 2002, Mainz, Germany: Spektrum Akademischer Verlag GmbH.
• Levett D, Flecknell PA, Rudland PS, Barraclough R, Neal DE, Mellon JK, Davies BR. . American Journal of Pathology 2002, 160(2), 693-700.
• Flecknell PA. . Veterinary Clinics of North America: Exotic Animal Practice 2001, 4(1), 47-56.
• Roughan JV, Flecknell PA. . Pain 2001, 90(1-2), 65-74.
• Flecknell PA, Raptopoulous D, Gasthuys F, Clarke K, Taylor P. Castration of horses and analgesia [1]. Veterinary Record 2001, 149(5), 159-160.
• Aitchison JD, Orr HE, Flecknell PA, Kirby JA, Dark JH. . European Journal of Cardio-thoracic Surgery 2001, 20(1), 187-194.
• Hedenqvist P, Roughan JV, Antunes L, Orr H, Flecknell PA. . Laboratory Animals 2001, 35(2), 172-179.
• Flecknell P. . In: International Congress and Symposium Series - Royal Society of Medicine. 2001.
• Hedenqvist P, Roughan JV, Flecknell PA. . Laboratory Animals 2000, 34(2), 207-211.
• Roughan JV, Flecknell PA. . Research in Veterinary Science 2000, 69(3), 283-288.
• Flecknell PA, Waterman-Pearson AE. . United Kingdom: W.B. Saunders Co. Ltd, 2000.
• Hedenqvist P, Roughan JV, Flecknell PA. . Laboratory Animals 2000, 34(3), 244-251.
• Clowry GJ, Flecknell PA. . Laboratory Animals 2000, 34(3), 260-264.
• Hayes JH, Flecknell PA. . Laboratory Animals 1999, 33(1), 16-23.
• Clark SC, Sudarshan CD, Khanna R, Roughan JV, Flecknell PA, Dark JH. . Laboratory Animals 1999, 33(2), 135-142.
• Flecknell PA, Orr HE, Roughan JV, Stewart R. . Veterinary Record 1999, 144(3), 65-67.
• Flecknell PA, Roughan JV, Hedenqvist P. . Laboratory Animals 1999, 33(1), 41-46.
• Clark SC, Sudarshan C, Roughan J, Flecknell PA, Dark JH. . Journal of Thoracic and Cardiovascular Surgery 1999, 117(3), 556-564.
• Roughan JV, Burzaco Ojeda O, Flecknell PA. . Laboratory Animals 1999, 33(3), 234-242.
• Flecknell PA, Roughan JV, Stewart R. . Laboratory Animals 1999, 33(2), 169-174.
• FLECKNELL PA. ANESTHESIA OF GUINEA-PIGS. VETERINARY RECORD 1987, 120(8), 167-167.