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Staff Profile

Dr Amy Anderson

Senior Research Associate

  • Telephone: +44 (0) 191 208 2754
  • Address: Musculoskeletal Research Group
    Translational and Clinical Research Institute
    Â鶹´«Ã½
    Room M3.136I, 3rd Floor William Leech Building
    Framlington Place
    Â鶹´«Ã½ upon Tyne
    NE2 4HH
Background

Introduction

I completed my PhD at Imperial College London identifying host genetic loci responsible for the outcome of Helicobacter pylori infection. After my PhD I remained at Imperial College and worked as a Research Assistant studying seasonal changes in the suppressive capacity of Tregs in hayfever sufferers. I moved to Â鶹´«Ã½ in 2006 as a Research Associate and have been working on the pathogenesis of rheumatoid arthritis ever since. In 2016 I became a Senior Research Associate.

Area of expertise

  • Tolerance induction
  • Biomarker development and disease pathogenesis in rheumatoid arthritis
Google scholar:
Research

Projects

Since coming to Â鶹´«Ã½ I have been involved in a number of projects focusing on the development of biomarkers for the diagnosis of rheumatoid arthritis, in addition to development of novel immunotherapies for rheumatoid arthritis, with a particular interest in therapeutic tolerance induction.


Biomarker development

In collaboration with Professor John Isaacs and Dr Arthur Pratt, we have identified a potential transcriptional biomarker for the early diagnosis of seronegative rheumatoid arthritis. We have demonstrated that interleukin-6 and downstream STAT3 signalling are potential therapeutic targets in the early stages of clinical disease. We are currently investigating several biomarkers linked to this pathway to determine their diagnostic and theragnostic value in rheumatoid arthritis. In addition, we are investigating several proteins linked to the transcriptional biomarker to further understand the pathogenesis of rheumatoid arthritis.


Tolerogenic dendritic cells (AuToDeCRA)

The main project I having been working on, in collaboration with Professor John Isaacs and Dr Catharien Hilkens, is the development of autologous tolerogenic dendritic cells for the treatment of rheumatoid arthritis. This project culminated in a phase I clinical trial (AuToDeCRA study, funded by Arthritis Research UK). We are now embarking on a second clinical trial using autologous tolerogenic dendritic cells, which is focused on determining the best route of administration.

 

Rheumatoid arthritis pathogenesis (BIO-FLARE)

I am currently involved in a MRC funded Experimental Medicine Challenge grant investigating factors that are involved in disease flare in rheumatoid arthritis. This is a multi-centre grant held between Â鶹´«Ã½, Glasgow University and the University of Birmingham. At Â鶹´«Ã½, in collaboration with Professor John Isaacs, Dr Arthur Pratt and Dr Catharien Hilkens, we are investigating the immune system contribution to disease flare.

 



Teaching

Postgraduate teaching

  • I currently supervise/co-supervise 7 PhD students
  • I co-supervise MRes students on an annual basis


Undergraduate teaching

  • I currently lead a number of seminar sessions for Biomedical Science and Dentistry undergraduate students
  • I co-supervise BSc students on an annual basis


Publications

  • Articles

    • Baker KF, McDonald D, Hulme G, Hussain R, Coxhead J, Swan D, Schulz AR, Mei HE, MacDonald L, Pratt AG, Filby A, Anderson AE, Isaacs JD. . Nature Communications 2024, 15, 1063.
    • Brown PM, Anderson AE, Naamane N, Lendrem DW, Morgan AW, Isaacs JD, Pratt AG. . RMD Open 2024, 10(1), e003858.
    • Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J, Smith GR, Allen B, Casement J, Diboll J, Harry R, Cooles FAH, Cope AP, Simpson G, Toward R, Noble H, Parke A, Wu W, Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T, Geissmann F, Goodyear CS, McInnes IB, Donnelly I, Gilmour A, Virlan AT, Porter D, Ponchel F, Emery P, El-Jawhari J, Parmar R, McDermott MF, Fisher BA, Young SP, Jones P, Raza K, Filer A, Pitzalis C, Barnes MR, Watson DS, Henkin R, Thorborn G, Fossati-Jimack L, Kelly S, Humby F, Bombardieri M, Rana S, Jia Z, Goldmann K, Lewis M, Ng S, Barbosa-Silva A, Tzanis E, Gallagher-Syed A, John CR, Ehrenstein MR, Altobelli G, Martins S, Nguyen D, Ali H, Ciurtin C, Buch M, Symmons D, Worthington J, Bruce IN, Sergeant JC, Verstappen SMM, Stirling F, Hughes-Morley A, Tom B, Farewell V, Zhong Y, Taylor PC, Buckley CD, Keidel S, Cuff C, Levesque M, Long A, Liu Z, Lipsky S, Harvey B, Macoritto M, Hong F, Kaymakcalan S, Tsuji W, Sabin T, Ward N, Talbot S, Padhji D, Sleeman M, Finch D, Herath A, Lindholm C, Jenkins M, Ho M, Hollis S, Marshall C, Parker G, Page M, Edwards H, Cuza A, Gozzard N, Pandis I, Rowe A, Capdevila FB, Loza MJ, Curran M, Verbeeck D, Dan Baker, Mela CM, Vranic I, Mela CT, Wright S, Rowell L, Vernon E, Joseph N, Payne N, Rao R, Binks M, Belson A, Ludbrook V, Hicks K, Tipney H, Ellis J, Hasan S, Didierlaurent A, Burny W, Haynes A, Larminie C, Harris R, Dastros-Pitei D, Carini C, Kola B, Jelinsky S, Hodge M, Maciejewski M, Ziemek D, Schulz-Knappe P, Zucht H-D, Budde P, Coles M, Butler JA, Read S. . Scientific Data 2022, 9(1), 196.
    • Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CMA, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD. . Annals of the Rheumatic Diseases 2022, 81(9), 1214-1223.
    • Cooke F, Neal M, Wood MJ, de Vries IJM, Anderson AE, Diboll J, Pratt AG, Stanway J, Nicorescu I, Moyse N, Hiles D, Caulfield D, Dickinson AM, Blamire AM, Thelwall P, Isaacs JD, Hilkens CM. . Frontiers in Immunology 2022, 13(2022), 988667.
    • Vidal-Pedrola G, Naamane N, Cameron JA, Pratt AG, Mellor AL, Isaacs JD, Scheel-Toellner D, Anderson AE. . Immunology 2023, 168(4), 640-653.
    • Maney NJ, Lemos H, Barron-Millar B, Carey C, Herron I, Anderson AE, Mellor AL, Isaacs JD, Pratt AG. . Arthritis and Rheumatology 2021, 73(10), 1820-1830.
    • Rayner F, Anderson AE, Baker KF, Buckley CD, Dyke B, Fenton S, Filer A, Goodyear CS, Hilkens CMU, Hiu S, Kerrigan S, Kurowska-Stolarska M, Matthews F, McInnes I, Ng W-F, Pratt AG, Prichard J, Raza K, Siebert S, Stocken D, Teare MD, Young S, Isaacs JD. . BMC Rheumatology 2021, 5, 22.
    • Clark AD, Nair N, Anderson AE, Thalayasingam N, Naamane N, Skelton AJ, Diboll J, Barton A, Eyre S, Isaacs JD, Pratt AG, Reynard LN. . Journal of Allergy and Clinical Immunology 2020, 145(5), 1438-1451.
    • Spiering R, Jansen MAA, Wood MJ, Fath AA, Eltherington O, Anderson AE, Pratt AG, van Eden W, Isaacs JD, Broere F, Hilkens CMU. . Journal of Translational Medicine 2019, 17, 375.
    • Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG. . Frontiers in Immunology 2019, 10, 1535.
    • Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG. . Rheumatology 2019, 58(7), 1250-1258.
    • Ridgley LA, Anderson AE, Pratt AG. . Current Opinion in Rheumatology 2018, 30(2), 207-214.
    • Cooles FAH, Anderson AE, Skelton A, Pratt AG, Kurowska-Stolarska MS, McInnes I, Hilkens CMU, Isaacs JD. . Frontiers in Immunology 2018, 9, 755.
    • Thalayasingam N, Nair N, Skelton AJ, Massey J, Anderson AE, Clark AD, Diboll J, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Isaacs JD, Barton A, Pratt AG. . Arthritis and Rheumatology 2018, 70(3), 361-370.
    • Anderson AE, Swan DJ, Wong OY, Buck M, Eltherington O, Harry RA, Patterson AM, Pratt AG, Reynolds G, Doran JP, Kirby JA, Isaacs JD, Hilkens CM. . Clinical & Experimental Immunology 2017, 187(1), 113-123.
    • Khamri W, Abeles RD, Hou TZ, Anderson AE, El-Masry A, Triantafyllou E, Bernsmeier C, Larsen FS, Singanayagam A, Kudo N, Possamai LA, Lebosse F, Auzinger G, Bernal W, Willars C, Weston CJ, Lombardi G, Wendon J, Thursz M, Antoniades CG. . Gastroenterology 2017, 153(1), 263-276.e8.
    • Bell GM, Anderson AE, Diboll J, Reece R, Eltherington O, Harry RA, Fouweather T, MacDonald C, Chadwick T, McColl EM, Dunn J, Dickinson AM, Hilkens CMU, Isaacs JD. . Annals of the Rheumatic Diseases 2017, 76(1), 227-234.
    • Lord P, Spiering R, Aguillón JC, Anderson AE, Appel S, Benitez-Ribas D, ten-Brinke A, Broere F, Cools N, Cuturi MC, Diboll J, Geissler EK, Giannoukakis N, Gregori S, van-Ham SM, Lattimer S, Marshall L, Harry RA, Hutchinson JA, Isaacs JD, Joosten I, van-Kooten C, López-Díaz-de-Cerio A, Nikolic T, Barbaros-Oral H, Sofronic-Milosavljevic L, Ritter T, Riquelme P, Thomson AW, Trucco M, Vives-Pi M, Martinez-Caceres E, Hilkens CM. . PeerJ 2016, 4, 1-14.
    • Cooles FAH, Anderson AE, Drayton T, Harry RA, Diboll J, Munro L, Thalayasingham N, Ostor AJK, Isaacs JD. . Arthritis Research & Therapy 2016, 18, 302.
    • Anderson AE, Pratt AG, Sedhom MA, Doran JP, Routledge C, Hargreaves B, Brown PB, LeCao KA, Isaacs JD, Thomas R. . Annals of the Rheumatic Diseases 2016, 75, 466-473.
    • McGovern A, Schoenfelder S, Martin P, Massey J, Duffus K, Plant D, Yarwood A, Pratt AG, Anderson AE, Isaacs JD, Diboll J, Thalayasingam N, Ospelt C, Barton A, Worthington J, Fraser P, Eyre S, Orozco G. . Genome Biology 2016, 17, 212.
    • Masca NGD, Hensor EMA, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C, Goldin RD, Harris J, Hinchliffe RF, Junaid H, Kingston S, Martin-Ruiz C, Nelson CP, Peacock J, Seed PT, Shinkins B, Staples KJ, Toombs J, Wright AKA, Dawn Teare M. . eLife 2015, 4(MAY), 1-45.
    • Purvis HA, Anderson AE, Young DA, Isaacs JD, Hilkens CMU. . Journal of Immunology 2014, 193(3), 1142-1150.
    • Anderson AE, Lorenzi AR, Pratt A, Wooldridge T, Diboll J, Hilkens CM, Isaacs JD. . Rheumatology 2012, 51(8), 1397-1406.
    • Brodlie M, McKean MC, Johnson GE, Anderson AE, Hilkens CM, Fisher AJ, Corris PA, Lordan JL, Ward C. . European Respiratory Journal 2011, 37(6), 1378-1385.
    • Purvis HA, Stoop JN, Mann J, Woods S, Kozijn AE, Hambleton S, Robinson JH, Isaacs JD, Anderson AE, Hilkens CMU. . Blood 2010, 116(23), 4829-4837.
    • Harry RA, Anderson AE, Isaacs JD, Hilkens CM. . Annals of the Rheumatic Diseases 2010, 69(11), 2042-2050.
    • Lorenzi A, Morgan TA, Anderson A, Catterall J, Patterson AM, Foster HE, Isaacs JD. . Annals of the Rheumatic Diseases 2009, 68(6), 983-900.
    • Anderson AE, Mackerness KJ, Aizen M, Carr VA, Nguyen D, Du Pre F, Durham SR, Robinson DS. . Clinical & Experimental Allergy 2009, 39(11), 1693-1699.
    • Vila J, Isaacs JD, Anderson AE. . Current Opinion in Hematology 2009, 16(4), 274-279.
    • Anderson AE, Swan DJ, Sayers BL, Harry RA, Patterson AM, von Delwig A, Robinson JH, Isaacs JD, Hilkens CM. . Journal of Leukocyte Biology 2009, 85(2), 243-250.
    • Anderson AE, Isaacs JD. . Acta Reumatológica Portuguesa 2008, 33(1), 17-33.
    • Anderson AE, Sayers BL, Haniffa MA, Swan DJ, Diboll J, Wang XN, Isaacs JD, Hilkens CMU. . Journal of Leukocyte Biology 2008, 84(1), 124-133.
    • Khamri W, Worku ML, Anderson AE, Walker MM, Hawgood S, Reid KBM, Clark HW, Thursz MR. . Helicobacter 2007, 12(2), 112-123.
    • Anderson AE, Worku ML, Khamri W, Bamford KB, Walker MM, Thursz MR. . European Journal of Immunology 2007, 37(6), 1548-1561.

  • Authored Book

    • Hilkens CMU, Diboll J, Cooke F, Anderson AE. . New York, NY: Humana/Springer, 2023.

  • Conference Proceedings (inc. Abstracts)

    • Pratt AG, Massey J, Anderson AE, Nair N, Diboll J, Skelton A, Lendrem DW, Reynard LN, Cordell HJ, Eyre S, Barton A, Isaacs JD. . In: 36th European Workshop for Rheumatology Research. 2016, York: BMJ Group.
    • Cooles FAH, Anderson AE, Hilkens C, Isaacs JD. . In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA, USA: Wiley.
    • Pratt AG, Anderson AE, Nair N, Massey J, Diboll J, Skelton A, Hargreaves B, Routledge C, Lendrem D, Brown P, Barton A, Isaacs JD. . In: Rheumatology 2015. 2015, Manchester, UK: Oxford University Press.
    • Pratt AG, Anderson AE, Lendrem DW, Skelton A, Massey J, Nair N, Diboll J, Hargreaves B, Brown PM, Barton A, Isaacs JD. . In: 2015 ACR/ARHP Annual Meeting. 2015, San Francisco, CA.
    • Khamri W, Anderson AE, Abeles RD, Auzinger G, Bernal W, Willars C, Robinson JH, Lombardi G, Thursz MR, Wendon J, Antoniades CG. . In: 2nd Digestive Disorders Federation Conference. 2015, London, UK: BMJ Publishing Group.
    • Anderson AE, Pratt AG, Sedhom M, Nair N, Massey J, Routledge C, Hargreaves B, Brown P, Barton A, Isaacs JD, Thomas R. . In: British Society for Immunology Annual Congress. 2014, Brighton, UK: Wiley-Blackwell Publishing.
    • Anderson AE, Pratt AG, Sedhom M, Nair N, Massey J, Routledge C, Hargreaves B, Brown P, Barton A, Isaacs JD, Thomas R. . In: ACR/ARHP Annual Meeting. 2014, Boston, MA, USA: John Wiley & Sons, Inc.
    • Anderson A, Routledge C, Isaacs J, Pratt A. . In: Spring Meeting for Clinician Scientists in Training. 2014, London, UK: Elsevier.
    • Anderson AE, Pratt AG, Hargreaves B, Routledge C, Doran JP, Mawson P, Isaacs JD. . In: European Workshop for Rheumatology Research. 2014, Lisbon, Portugal: BMJ Publishing Group.
    • Bell G, Anderson A, Harry R, Diboll J, McColl E, Dickinson A, Hilkens C, Isaacs JD. . In: European Workshop for Rheumatology Research. 2014, Lisbon, Portugal: BMJ Publishing Group Ltd.
    • Bell G, Anderson AE, Diboll J, Harry R, McColl E, Dickinson A, Hilkens C, Isaracs JD. . In: ACR/ARHP Annual Meeting. 2014, Boston, MA, USA: Wiley-Blackwell Publishing Ltd.
    • Patsalidou M, Anderson A, Krippner-Heidenreich A. . In: European Workshop for Rheumatology Research. 2014, Lisbon, Portugal: BMJ Publishing Group.
    • Anderson AE, Routledge C, Mawson P, Isaacs JD, Pratt AG. . In: Arthritis & Rheumatism 2013 Annual Meeting. 2013, San Diego, CA, USA: John Wiley & Sons, Inc.
    • Anderson AE, Routledge C, Mawson P, Isaacs JD, Pratt AG. . In: American College of Rheumatology. 2013, San Diego, California, USA. In Press.
    • Bell G, Anderson A, Diboll J, Harry R, McColl E, Dickinson A, Hilkens C, Isaacs J. . In: Arthritis & Rheumatism 2013 Annual Meeting. 2013, San Diego, CA, USA: John Wiley & Sons, Inc.
    • Purvis H, Anderson AE, Hilkens CMU. . In: European Congress of Immunology. 2012, Glasgow, UK: Wiley-Blackwell.
    • Bell GM, Anderson AE, Harry RA, Stoop JN, Hilkens CM, Isaacs J, Dickinson A, McColl E. . In: Annual Meeting of the British Society for Rheumatology. 2012, Glasgow, UK: Oxford University Press.
    • Purvis HA, Anderson AE, Hilkens CMU. . In: Immunology: Annual Congress of the British Society for Immunology. 2011, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
    • Purvis HA, Stoop JN, Mann J, Woods S, Kozijn AE, Hambleton S, Robinson JH, Isaacs JD, Anderson AE, Hilkens CMU. . In: IImmunology: Annual Congress of the British Society for Immunology. 2010, Liverpool, UK: Wiley-Blackwell Publishing Ltd.
    • Anderson AE, Sayers BL, Swan DJ, Isaacs JD, Hilkens CM. . In: BSR Annual Meeting and BHPR Spring Meeting. 2008, Liverpool: Oxford University Press.
    • Morgan TA, Lorenzi A, Anderson A, Catteral J, Patterson AM, Foster HE, Isaacs J. . In: Rheumatology: Annual Meeting of the British Society Rheumatology/Spring Meeting of British Health Professional in Rheumatology. 2008, Liverpool, UK: Oxford University Press.
    • Harry RA, Anderson AE, Raftery G, Wooldridge T, Isaacs JD, Hilkens CM. . In: BSR Annual Meeting and BHPR Spring Meeting. 2008, Liverpool: Oxford University Press.
    • Anderson AE, Sayers B, Diboll J, Isaacs JD, Hilkens CM. . In: 6th Global Arthritis Research Network (GARN) Meeting. 2007, Zurich, Switzerland: Arthritis Research & Therapy: BioMed Central Ltd.

  • Letters

    • Cooles FAH, Anderson AE, Lendrem DW, Norris J, Pratt AG, Hilkens CMU, Isaacs JD. . Journal of Allergy and Clinical Immunology 2017, 141(1), 445-448.e4.
    • Pratt AG, Anderson AE, Carmody RJ, Isaacs JD. . Arthritis and Rheumatology 2016, 68(3), 770-771.

  • Reviews

    • Williams KC, Gault A, Anderson AE, Stewart CJ, Lamb CA, Speight RA, Rajan N, Plummer R, Pratt AG. . Frontiers in Immunology 2023, 14, 1122430.
    • Cooles FA, Isaacs JD, Anderson AE. . Current Rheumatology Reports 2013, 15(9), 1-9.