麻豆传媒

Current

My group are members of the Regenerative Medicine, Stem Cells and Transplantation Theme, Biosciences Institute, 麻豆传媒. Twitter:@IGM_YoungLab 

Qualifications

BSc, , 1989-1992
PhD, Cambridge laboratory, , Norwich ( affiliated), 1992-1996

Previous Positions

1997-1998. ARC Post-doctoral Research Assistant, , University of Manchester.
1998-2003. ARC Senior Post-doctoral Research Assistant, , University of East Anglia.
2003-2004. Dunhill Medical Trust Post-doctoral Research Assistant, , University of East Anglia.

Memberships

Member of the
Previously honorary treasurer and committee member of the British Society for Matrix Biology ()

Areas of expertise

• Cartilage biology
• Osteoarthritis
• Epigenetics
• MicroRNA

Google scholar:
ORCID:

Research Interests

We are members of the Regenerative Medicine, Stem Cells and Transplantation Theme.

My research interests include gene expression and regulation in the context of cartilage development and the main cartilage disease, osteoarthritis (OA). My laboratory focus is how these genes are epigenetically regulated; by microRNAs, DNA methylation and chromatin modifications.

Other Expertise

Main techniques: Gene expression analysis/profiling (Real-time PCR, microarray, RNA-seq). Cell signalling analysis. RNAi (siRNA, shRNA). miRNA analysis. Cas9/CRISPR. ChIP-seq, ATAC-seq. Transcription factor analysis (EMSA, mutagenesis, reporter assays). Epigenetic analysis. Models of osteoarthritis.

Current Work

Age is the major risk factor for Osteoarthritis. We are investigating the molecular mechanisms of how ageing impacts on cartilage.

Manipulating gene expression in cartilage is currently not possible therefore we have developed an interest in tissue engineering, to generate cartilage from the differentiation of stem cells. Using this model we have generated a series of -omics scale data to help understand what controls a chondrocyte phenotype.

We are developing CRISPR technology in the group both in terms of their ability to edit genes and also to regulate transcription. With collaborators we are using CRISPR to generate novel transgenics.

Post-doctoral Scientists

Clinical trainee fellow

• Adam Farrier

Past Lab members

• Jamie Soul
• Yao Hao
• Dan Hayman
• Hua Lin
• David Wilkinson
• Adrian Falconer
• Marta Radwan
• Siliva Lecci
• Bola Ajekigbe
• Dimitra Tsompani
• Heather Bromby
• Steven Woods
• Rodolfo Gomez
• Katie Crossland
• Wang Hui
• Yaobo Xu
• Catherine Bui
• Christos Gavriilidis
• Jenny Scott
• Hannah Elliott
• Martin Galler

Esteem Indicators

Previously British Society for Matrix Biology (BSMB) Honorary Treasurer

http://www.bsmb.ac.uk

Funding

Current funding is mainly from the Dunhill Medical Trust, the JGW Patterson Foundation, Versus Arthritis, 麻豆传媒 NHS Hospital Charity, and CIMA (MRC/Arthritis Research UK).

Industrial Relevance

More than 7 million adults in the UK (15% of the population) have long-term health problems due to arthritis and related conditions. In 2001 incapacity benefit alone cost the nation £2.4 billion.

Metalloproteinases are the enzymes ultimately responsible for the collagen loss to cartilage seen in arthritic diseases. The design of small molecule inhibitors of the metalloproteinases remains a major focus of the pharmaceutical industry, yet has been largely unsuccessful, probably due to a lack of specificity of the compounds and side effects. Since arthritis is a debilitating, but not fatal disease, such side effects need to be minimised. We suggest that HDACi will be chondroprotective in all destructive arthritides, including both rheumatoid arthritis and osteoarthritis (other examples include: reactive arthritis, gout/pseudogout, psoriatic arthritis). They may also show utility in cartilage engineering/transplantation to protect cartilage explants or engineered/cultured cartilage from degradation. Many pharmaceutical companies are currently testing HDACi in cancer therapy trials, therefore these molecules potentially represent the next wave of drugs to fight the arthiitis.

I regularly supervise Masters of Research and undergraduate students for laboratory projects.

I teach on the Masters of Research Biology of Ageing (MMB8011) and Tissue Engineering (MEC8060).

I am Programme and module leader for Regenerative Medicine and Stem Cells (MMB8022).

I was previously DPD for MRes projects (MMB8099).

• Articles

  • Hayman DJ, Johnson de Sousa Brito FM, Lin H, Prior A, Charlesworth G, Hao Y, Pearson RD, Soul J, Clark IM, Pirog KA, Barter MJ, van't Hof RJ, Young DA. . Bone 2025, 190, 117273.
  • Barter MJ, Turner DA, Rice SJ, Hines M, Lin H, Falconer AMD, McDonnell E, Soul J, Arques MDC, Europe-Finner GN, Rowan AD, Young DA, Wilkinson DJ. . Matrix Biology 2024, 133, 33-42.
  • Gilbert SJ, Soul J, Hao Y, Lin H, Piróg KA, Coxhead J, Patel K, Barter MJ, Young DA, Blain EJ. . Disease Models and Mechanisms 2024, 17(10), dmm050583.
  • Gomez R, Barter MJ, Alonso-Perez A, Skelton AJ, Proctor C, Herrero-Beaumont G, Young DA. . Biological Research 2023, 56(1), 9.
  • Chaudhry N, Muhammad H, Seidl C, Downes D, Young DA, Hao Y, Zhu L, Vincent TL. . Osteoarthritis and Cartilage 2022, 30(4), 596-604.
  • Barter MJ, Butcher A, Wang H, Tsompani D, Galler M, Rumsby EL, Culley KL, Clark IM, Young DA. . Scientific Reports 2022, 12(1), 6640.
  • Stadnik PS, Gilbert SJ, Tarn J, Charlton S, Skelton AJ, Barter MJ, Duance VC, Young DA, Blain EJ. . Journal of Physiology 2021, 599(1), 143-155.
  • Soul J, Barter MJ, Little CB, Young DA. . Annals of the Rheumatic Diseases 2021, 80(3), 376-383.
  • Wilkinson DJ, Falconer AMD, Wright HL, Lin H, Yamamoto K, Cheung K, Charlton SH, Arques MDC, Janciauskiene S, Refaie R, Rankin KS, Young DA, Rowan AD. . The FEBS Journal 2021, 289(1), 121-139.
  • Hayman DJ, Modebadze T, Charlton S, Cheung K, Soul J, Lin H, Hao Y, Miles CG, Tsompani D, Jackson RM, Briggs MD, Piróg KA, Clark IM, Barter MJ, Clowry GJ, LeBeau FEN, Young DA. . Scientific Reports 2021, 11(1), 10452.
  • Barter MJ, Cheung K, Falk J, Panagiotopoulos AC, Cosimini C, OBrien S, TejaPutri K, Neill G, Deehan DJ, Young DA. . Epigenetics 2021, 16(1), 106-119.
  • Patel K, Chandrasegaran S, Clark IM, Proctor CJ, Young DA, Shanley DP. . Bioinformatics 2021, 37(20), 3604–3609.
  • Le L, Niu L, Barter MJ, Young DA, Dalmay T, Clark IM, Swingler TE. . Scientific Reports 2020, 10(1), 21923.
  • Woods S, Charlton S, Cheung K, Hao Y, Soul J, Reynard LN, Crowe N, Swingler TE, Skelton AJ, Piróg KA, Miles CG, Tsompani D, Jackson RM, Dalmay T, Clark IM, Barter MJ, Young DA. . RNA 2020, 26, 1575-1588.
  • Coelho-Lima J, Mohammed A, Cormack S, Jones S, Ali A, Panahi P, Barter M, Bagnall A, Ali S, Young D, Spyridopoulos I. . Clinical Chemistry 2020, 66(1), 247-256.
  • Rice SJ, Beier F, Young DA, Loughlin J. . Nature Reviews Rheumatology 2020, 16, 268-281.
  • Cheung K, Barter MJ, Falk J, Proctor CJ, Reynard LN, Young DA. . FASEB Journal 2020, 34(4), 5317-5531.
  • Barter MJ, Bui C, Cheung K, Falk J, Gomez R, Skelton AJ, Elliott HR, Reynard LN, Young DA. . Scientific Reports 2020, 10(10), 1169.
  • Dennis EP, Edwards SM, Jackson RM, Hartley CL, Tsompani D, Capulli M, Teti A, Boot-Handford RP, Young DA, Piróg KA, Briggs MD. . Journal of Bone and Mineral Research 2020, 35(8), 1452-1469.
  • Woods S, Barter MJ, Elliott HR, McGillivray CM, Birch MA, Clark IM, Young DA. . Matrix Biology 2019, 77, 87-100.
  • Ajekigbe B, Cheung K, Xu Y, Skelton AJ, Panagiotopoulos A, Soul J, Hardingham TE, Deehan DJ, Barter MJ, Young DA. . Osteoarthritis and Cartilage 2019, 27(4), 694-702.
  • Cheung K, Burgers MJ, Young DA, Cockell S, Reynard LN. . Epigenetics 2019, 15(6-7), 594-603.
  • Barter MJ, Gomez R, Hyatt S, Cheung K, Skelton AJ, Xu Y, Clark IM, Young DA. . Development 2017, 144, 4510-4521.
  • Steinbusch MMF, Fang Y, Milner PI, Clegg PD, Young DA, Welting TJM, Peffers MJ. . Scientific Reports 2017, 7, 43558.
  • Le LTT, Swingler TE, Crowe N, Vincent TL, Barter MJ, Donell ST, Delany AM, Dalmay T, Young DA, Clark IM. . Journal of Molecular Medicine 2016, 94(5), 583-596.
  • Crowe N, Swingler TE, Le LTT, Barter MJ, Wheeler G, Pais H, Donell ST, Young DA, Dalmay T, Clark IM. . Osteoarthritis and Cartilage 2016, 24(3), 534-543.
  • Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J. . Human Molecular Genetics 2015, 24(25), 7432-7444.
  • Barter MJ, Tselepi M, Gomez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA. . Stem Cells 2015, 33(11), 3266-3280.
  • Rushton MD, Young DA, Loughlin J, Reynard LN. . Annals of the Rheumatic Diseases 2015, 74(9), 1778-1782.
  • Radwan M, Wilkinson DJ, Hui W, Destrument AP, Charlton SH, Barter MJ, Gibson B, Coulombe J, Gray DA, Rowan AD, Young DA. . Annals of the Rheumatic Diseases 2014.
  • Hui W, Young DA, Rowan AD, Xu X, Cawston TE, Proctor CJ. . Annals of the Rheumatic Diseases 2014, 1-10.
  • Litherland GJ, Hui W, Elias MS, Wilkinson DJ, Watson S, Huesa C, Young DA, Rowan AD. . Arthritis & Rheumatology 2014, 66(8), 2175-2187.
  • Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J. . Arthritis & Rheumatology 2014, 66(9), 2450-2460.
  • Purvis HA, Anderson AE, Young DA, Isaacs JD, Hilkens CMU. . Journal of Immunology 2014, 193(3), 1142-1150.
  • Syddall CM, Reynard LN, Young DA, Loughlin J. . PLoS Genetics 2013, 9(6), e1003557.
  • Gavriilidis C, Miwa S, von Zglinicki T, Taylor RW, Young DA. . Arthritis & Rheumatism 2013, 65(2), 378-387.
  • Radwan M, Gavriilidis C, Robinson JH, Davidson R, Clark IM, Rowan AD, Young DA. . Arthritis & Rheumatism 2013, 65(5), 1290-1301.
  • Barter MJ, Young DA. . Current Rheumatology Reports 2013, 15(9), 353.
  • Swingler TE, Wheeler G, Carmont V, Elliott HR, Barter MJ, Abu-Elmagd M, Donell ST, Boot-Handford RP, Hajihosseini MK, Münsterberg A, Dalmay T, Young DA, Clark IM. . Arthritis and Rheumatism 2012, 64(6), 1909-1919.
  • Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA. . Annals of the Rheumatic Diseases 2012, 71(3), 455-462.
  • Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, Santibanez-Koref M, Loughlin J, Young DA. . Osteoarthritis and Cartilage 2012, 20(9), 1029-1038.
  • Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. . FASEB Journal 2012, 26(7), 3000-3011.
  • Pratt AG, Swan DC, Richardson S, Wilson G, Hilkens C, Young DA, Isaacs JD. . Annals of the Rheumatic Diseases 2012, 71(8), 1374-1381.
  • Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J. . Human Molecular Genetics 2011, 20(17), 3450-3460.
  • Scott JL, Gabrielides C, Davidson RK, Swingler TE, Clark IM, Wallis GA, Boot-Handford RP, Kirkwood TBL, Talyor RW, Young DA. . Annals of the Rheumatic Diseases 2010, 69(8), 1502-1510.
  • Swingler TE, Kevorkian L, Culley KL, Illman SA, Young DA, Parker AE, Lohi J, Clark IM. . Biochemical Journal 2010, 427, 391-400.
  • Milner JM, Patel A, Davidson RK, Swingler TE, Desilets A, Young DA, Kelso EB, Donell ST, Cawston TE, Clark IM, Ferrell WR, Plevin R, Lockhart JC, Leduc R, Rowan AD. . Arthritis & Rheumatism 2010, 62(7), 1955-1966.
  • Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DA. . Rheumatology 2010, 49(11), 2043-2053.
  • Barter MJ, Hui W, Lakey RL, Catterall JB, Cawston TE, Young DA. . Annals of the Rheumatic Diseases 2010, 69(12), 2189-2198.
  • Barter MJ, Pybus L, Litherland GJ, Rowan AD, Clark IM, Edwards DR, Cawston TE, Young DA. . Matrix Biology 2010, 29(7), 602-612.
  • Cui Y, Yu J, Urban JPG, Young DA. . Spine 2010, 35(11), 1101-1108.

• Book Chapter

  • Cawston TE, Young DA, Rowan DD. . In: Hochberg MC; Silman AJ; Smolen JS; Weinblatt ME; Weisman MH, ed. Rheumatology: Sixth Edition. Philadelphia, PA: Elsevier Inc, 2014, pp.152-159.

• Conference Proceedings (inc. Abstracts)

  • Johnson de Sousa Brito FM, Pearson RD, Kalamajski S, Young DA, Pirog KA. . In: British Society for Matrix Biology Spring Meeting 2024: The Dynamic matrix—Mechanics, Ageing and Repair. 2024, Bristol: Wiley-Blackwell Publishing Ltd.
  • de las Heras Ruiz T, de Sousa Brito F, Farcasanu M, Howe S, Young D, Pirog KA. . In: British Society for Matrix Biology (BSMB) Autumn 2021 Autumn Meeting. 2021, 麻豆传媒 upon Tyne: Wiley.
  • Rushton MD, Young DA, Loughlin J, Reynard LN. . In: 2015 OARSI World Congress on Osteoarthritis: Celebrating 25 Years of Osteoarthritis Research. 2015, Seattle, WA, USA: Elsevier.
  • James K, Tarn JR, Al-Ali S, Hallinan J, Young DA, Ng WF. . In: Rheumatology 2014. 2014, Liverpool, UK: Oxford University Press.

• Editorial

  • Young DA. . Arthritis and Rheumatism 2013, 65(3), 555-558.

• Reviews

  • Tamblin-Hopper P, Kiss-Toth E, Sudbery I, Young D, Mark Wilkinson J. . Journal of Translational Genetics and Genomics 2024, 8(2), 225-243.
  • Young DA, Barter MJ, Soul J. . Osteoarthritis and Cartilage 2022, 30(2), 216-225.
  • Jones TL, Esa MS, Li KHC, Krishnan SRG, Elgallab GM, Pearce MS, Young DA, Birrell FN. . Bone 2021, 152, 116068.
  • Swingler TE, Niu L, Smith P, Paddy P, Le L, Barter MJ, Young DA, Clark IM. . Clinical and Experimental Rheumatology 2019, 37(5), 40-47.
  • Young DA, Barter MJ, Wilkinson DJ. . F1000Research 2019, 8, 195.
  • Young DA, Bui C, Barter MJ. . Epigenomics 2012, 4(6), 593-595.
  • Barter MJ, Bui C, Young DA. . Osteoarthritis and Cartilage 2012, 20(5), 339-349.
  • Cawston TE, Young DA. . Cell and Tissue Research 2010, 339(1), 221-235.