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Staff Profile

Dr Fiona LeBeau

Reader in Neural Networks

  • Telephone: +44 (0) 191 208 5729
  • Address: Biosciences Institute
    Â鶹´«Ã½
    Faculty of Medical Sciences
    Framlington Place
    Â鶹´«Ã½ upon Tyne.
    NE2 4HH
Background

 

Roles and Responsibilities

Member of the Faculty of Medical Sciences Impact Case Committee

 

Qualifications

BSc Physiology (1st class) Sheffield University

PhD Neuroscience (Â鶹´«Ã½)

 

Previous Positions

Post-doctoral Fellow, University of Maryland, Baltimore, MD.

Non-Clinical Scientist MRC Anatomical Neuropharmacology Unit, Oxford, UK.

Senior Post-doctoral Research Fellow, School of Biomedical Sciences, University of Leeds, UK.

 

Membership

British Neuroscience Association

The Physiological Society

Society for Neuroscience

 

Research

Research Interests

My main interests are in understanding the mechanisms involved in the generation of cortical network activity. In particularly we are keen to understand the role of different types of network oscillations e.g. theta (4-12 Hz) and gamma (30-80 Hz) frequency oscillations in the hippocampus and prefrontal cortex. These oscillations are important for many higher cognitive functions including learning, memory and attention. In the lab we focus on understanding changes in network oscillations, neuroinflammation and mitochondrial dysfunction in diseases such as dementia, schizophrenia and epilepsy.

Other Expertise

In my lab we use a combination of in vitro electrophysiological and in vivo approaches in rodents to study cortical network activity. In addition we also work closely with Neurosurgeons and are conducting studies using both acute live human tissue and human organotypic slice cultures to investigate the mechanisms underlying epilepsy/neurodegenerative diseases.

I have close collaborations with many other researchers within the Biosciences Institute and the Institute of Clinical and Translational Research including Dr. Gavin Clowry, Prof Andrew Jackson, Prof Mark Baker and Prof. Stuart Baker.


Current Work

We are currently working on a number of projects elucidating the role of network oscillations and neuroinflammation in the hippocampus and prefrontal cortex. Changes in these key brain areas are implicated in many diseases such as schizophrenia, Alzheimer's disease, and dementia with Lewy bodies and epilepsy.


Current lab members


Ms. Beth Dennis - Staff PhD with Neurexpert

Mr. Mark Turnbull - PhD student CANDO project.

Mr. Ashan Jayasakera - Epilepsy Research UK funded clinical staff PhD student.

Mrs. Ibtisam Al Musawi - PhD student.

Ms. Anastasia Dimitriou - PhD student.

Ms. Lauren O'Neill - Alzheimer's Society funded PhD student.

Dr. Connie McKenzie-Gray-Scott - Post doctoral researcher - MRC project.

Dr. Daipayan Chowdhury - Post doctoral researcher - Motor Neurone Disease Association project.

Dr. Suprawadee Srisuwan - Visiting Academic,



Past Lab members

Joanne Driver, Daniel C Haggerty, Bernadette O'Donovan, Dorcas C Eden, Claire Gillougley, Natalie Adams, Vasilis Glykos, Sabine Gretenkord, Clare Tweedy, Myrto Stylianou, Tamara Modebadze, David Koss.

Past Funding

Royal Society Research Grant; Â鶹´«Ã½ Studentship; Lena Teague Bequest Fund; BBSRC equipment grant; EPSRC studentship; BBSRC/CASE studentship; Wellcome Trust studentship; MRC Case studentship; Alzheimer's Society studentship; UK Innovate Grant. Co-I on CANDO (Wellcome Trust project).

Present Funding


Principal Investigator - Neurexpert contract. 

Principal Investigator - Alzheimer's Society PhD Studentship Award.

Co-Investigator - MRC Post-mortem and Living brain tissue grant.

Co-Investigator - Great Ormond Street Hospital Grant.

Principal Investigator - Motor Neurone Disease Association.

Teaching

I teach on the Pharmacology BSc course, 2nd and 3rd year Biomedical science neuroscience BSc modules and the Mres in Neuroscience.

I regularly supervise undergraduate and postgraduate laboratory projects.

Publications

  • Articles

    • Dennis BH, Neale SA, LeBeau FEN, Salt TE. . Pharmacology Biochemistry and Behavior 2023, 223, 173532.
    • Alhesain M, Ronan H, LeBeau FEN, Clowry GJ. . Frontiers in Neuroscience 2023, 17, 1249973.
    • Zaaimi B, Turnbull M, Hazra A, Wang Y, Gandara C, McLeod F, McDermott EE, Escobedo-Cousin E, Idil AS, Bailey RG, Tardio S, Patel A, Ponon N, Gausden J, Walsh D, Hutchings F, Kaiser M, Cunningham MO, Clowry GJ, LeBeau FEN, Constandinou TG, Baker SN, Donaldson N, Degenaar P, O'Neill A, Trevelyan AJ, Jackson A. . Nature Biomedical Engineering 2023, 7, 559-575.
    • Gee LMV, Barron-Millar B, Leslie J, Richardson C, Zaki MYW, Luli S, Burgoyne RA, Cameron RIT, Smith GR, Brain JG, Innes B, Jopson L, Dyson JK, McKay KRC, Pechlivanis A, Holmes E, Berlinguer-Palmini R, Victorelli S, Mells GF, Sandford RN, Palmer J, Kirby JA, Kiourtis C, Mokochinski J, Hall Z, Bird TG, Borthwick LA, Morris CM, Hanson PS, Jurk D, Stoll EA, LeBeau FEN, Jones DEJ, Oakley F. . American Journal of Pathology 2023, 193(1), 11-26.
    • Olkhova EA, Bradshaw C, Blain A, Alvim D, Turnbull DM, LeBeau FEN, Ng YS, Gorman GS, Lax NZ. . Communications Biology 2023, 6(1), 1078.
    • Zaaimi B, Turnbull M, Hazra A, Wang Y, Gandara C, McLeod F, McDermott EE, Escobedo-Cousin E, Shah Idil A, Bailey RG, Tardio S, Patel A, Ponon N, Walsh D, Hutchings F, Kaiser M, Cunningham MO, Clowry GJ, LeBeau FEN, Constandinou TG, Baker SN, Donaldson N, Degenaar P, O'Neill A, Trevelyan AJ, Jackson A. Closed-loop optogenetic control of the dynamics of neural activity in non-human primates. Nature Biomedical Engineering 2023, 7, 559-575.
    • Hayman DJ, Modebadze T, Charlton S, Cheung K, Soul J, Lin H, Hao Y, Miles CG, Tsompani D, Jackson RM, Briggs MD, Piróg KA, Clark IM, Barter MJ, Clowry GJ, LeBeau FEN, Young DA. . Scientific Reports 2021, 11(1), 10452.
    • Tweedy C, Kindred N, Curry J, Williams C, Taylor J-P, Atkinson P, Randall F, Erskine D, Morris CM, Reeve AK, Clowry GJ, LeBeau FEN. . Neurobiology of Disease 2021, 149, 105226.
    • Firfilionis D, Hutchings F, Tamadoni R, Walsh D, Turnbull M, Escobedo-Cousin E, Bailey RG, Gausden J, Patel A, Haci D, Liu Y, LeBeau FEN, Trevelyan A, Constandinou TG, O'Neill A, Kaiser M, Degenaar P, Jackson A. . Frontiers in Neuroscience 2021, 15, 718311.
    • Gretenkord S, Olthof BMJ, Stylianou M, Rees A, Gartside SE, LeBeau FEN. . European Journal of Neuroscience 2020, 52(2), 2915-2930.
    • Stylianou M, Zaaimi B, Thomas A, Taylor J-P, LeBeau FEN. . Frontiers in Neuroscience 2020, 14, 579867.
    • Fielder E, Tweedy C, Wilson C, Oakley F, LeBeau FEN, Passos JF, Mann DA, von Zglinicki T, Jurk D. . Aging Cell 2020, 19(10), e13188.
    • Keane PC, Hanson PS, Patterson L, Blain PG, Hepplewhite P, Khundakar AA, Judge SJ, Kahle PJ, LeBeau FEN, Morris CM. . Neuroscience Letters 2019, 711, 134437.
    • Stylianou M, Murphy N, Peraza LR, Graziadio S, Cromarty R, Killen A, O'Brien JT, Thomas AJ, LeBeau FEN, Taylor J-P. . Clinical Neurophysiology 2018, 129(6), 1209-1220.
    • Robson E, Tweedy C, Manzanza N, Taylor J-P, Atkinson P, Randall F, Reeve A, Clowry GJ, LeBeau FEN. . Neuroscience 2018, 377, 161-173.
    • Adams NE, Sherfey JS, Kopell NJ, Whittington MA, LeBeau FEN. . eNeuro 2017, 4(1).
    • Gretenkord S, Rees A, Whittington MA, Gartside SE, Lebeau FEN. . Journal of Neurophysiology 2017, 117(3), 1126-1142.
    • Glykos V, Whittington MA, LeBeau FEN. . The Journal of Physiology 2015, 593(16), 3597-3615.
    • LeBeau FEN. . Drug Discovery Today: Therapeutic Strategies 2013, 10(2), e79-e83.
    • Haggerty DC, Glykos V, Adams NE, LeBeau FE. . Neuroscience 2013, 253, 142-154.
    • Börgers C, Talei Franzesi G, LeBeau FEN, Boyden S, Kopell NJ. . PLoS Computational Biology 2012, 8(2), e1002362.
    • Bernstein HG, Johnson M, Perry RH, LeBeau FEN, Dobrowolny H, Bogerts B, Perry EK. . Neuropathology 2011, 31(1), 1-10.
    • Whittington MA, Cunningham MO, LeBeau FE, Racca C, Traub RD. . Developmental Neurobiology 2011, 71(1), 92-106.
    • Roopun AK, LeBeau FEN, Rammell J, Cunningham MO, Traub RD, Whittington MA. . Frontiers in Neural Circuits 2010, 4(1), 8.
    • Cox DJ, Racca C, LeBeau FEN. . Journal of Comparative Neurology 2008, 509(6), 551-565.
    • Fuchs EC, Zivkovic AR, Cunningham MO, Middleton S, Le Beau FEN, Bannerman DM, Rozov A, Whittington MA, Traub RD, Rawlins JNP, Monyer H. . Neuron 2007, 53(4), 591-604.
    • Driver JE, Racca C, Cunningham MO, Towers SK, Davies CH, Whittington MA, Le Beau FEN. . European Journal of Neuroscience 2007, 26(5), 1280-1288.
    • Bibbig A, Middleton S, Racca C, Gillies MJ, Garner H, Le Beau FEN, Davies CH, Whittington MA. . Journal of Neurophysiology 2007, 97(4), 2812-2823.
    • Cunningham MO, Hunt J, Middleton S, Le Beau FEN, Gillies MG, Davies CH, Maycox PR, Whittington MA, Racca C. . Journal of Neuroscience 2006, 26(10), 2767-2776.
    • Roopun AK, Middleton SJ, Cunningham MO, Le Beau FEN, Bibbig A, Whittington MA, Traub RD. . Proceedings of the National Academy of Sciences of the United States of America 2006, 103(42), 15646-15650.
    • Traub RD, Pais I, Bibbig A, Lebeau FE, Buhl EH, Garner H, Monyer H, Whittington MA. . Journal of Neurophysiology 2005, 94(2), 1225-1235.
    • Traub RD, Contreras D, Cunningham MO, Murray H, Le Beau FEN, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA. . Journal of Neurophysiology 2005, 93(4), 2194-2232.
    • Traub RD, Bibbig A, Le Beau FE, Cunningham MO, Whittington MA. . Journal of Physiology 2005, 562(1), 3-8.
    • Traub RD, Bibbig A, Le Beau FE, Buhl EH, Whittington MA. . Annu. Rev. Neurosci 2004, 27(1), 247-278.
    • Cunningham MO, Whittington MA, Bibbig A, Roopun A, Le Beau FE, Vogt A, Monyer H, Buhl EH, Traub RD. . Proceedings of the National Academy of Sciences 2004, 101(18), 7152-7157.
    • LeBeau FEN, Traub RD, Monyer H, Whittington MA, Buhl EH. . Brain Research Bulletin 2003, 62(1), 3-13.
    • Pais I, Hormuzdi SG, Monyer H, Traub RD, Wood IC, Buhl EH, Whittington MA, LeBeau FE. . Journal of Neurophysiology 2003, 89(4), 2046-2054.
    • Traub RD, Cunningham MO, Gloveli T, LeBeau FE, Bibbig A, Buhl EH, Whittington MA. . Proceedings of the National Academy of Sciences of the United States of America 2003, 100(19), 11047-11052.
    • Traub RD, Pais I, Bibbig A, LeBeau FEN, Buhl EH, Hormizdi S, Monyer H, Whittington MA. . Proceedings of the National Academy of Sciences of the United States of America 2003, 100(3), 1370-1374.
    • LeBeau FEN, Towers SK, Traub RD, Whittington MA, Buhl EH. . Journal of Physiology 2002, 542(1), 167-179.
    • LeBeau FE, Towers SK, Traub RD, Whittington MA, Buhl EH. . Journal of Physiology 2002, 542(1), 167-179.
    • Towers SK, LeBeau FEN, Gloveli T, Traub RD, Whittington MA, Buhl EH. . Journal of Neurophysiology 2002, 87(2), 1165-1168.
    • Gillies MJ, Traub RD, LeBeau FEN, Davies CH, Gloveli T, Buhl EH, Whittington MA. . Journal of Physiology 2002, 543(3), 779-793.
    • LeBeau FEN, Malmierca MS, Rees A. . Journal of Neuroscience 2001, 21(18), 7303-7312.
    • LeBeau FEN, Malmierca MS, Rees A. . The Journal of Neuroscience 2001, 15, 7303-7312.
    • Hormuzdi SG, Pais I, LeBeau FEN, Towers SK, Rozov A, Buhl EH, Whittington MA, Monyer H. . Neuron 2001, 31(3), 487-495.
    • Traub RD, Kopell N, Bibbig A, Buhl EH, LeBeau FEN, Whittington MA. . Journal of Neuroscience 2001, 21(23), 9478-9486.
    • Whittington MA, Doheny HC, Traub RD, LeBeau FEN, Buhl EH. . The Journal of Neuroscience 2001, 21(5), 1727-1738.
    • Traub RD, Whittington MA, Buhl EH, LeBeau FEN, Bibbig A, Boyd S, Cross H, Baldeweg T. . Epilepsia 2001, 42(2), 153-170.

  • Book Chapters

    • McKeith IG. . In: Kosaka K, ed. Dementia with Lewy Bodies: Clinical and Biological Aspects. Tokyo: Springer Japan, 2016, pp.59-71.
    • Taylor J-P, Collerton D, LeBeau F, Perry E. . In: Kosaka K, ed. Dementia with Lewy Bodies: Clinical and Biological Aspects. Tokyo: Springer Japan, 2016, pp.23-39.

  • Conference Proceedings (inc. Abstract)

    • Gillougley C, Rentesi G, LeBeau F, Cunningham M, Alvaro G, Large C. . In: 27th ECNP Congress. 2014, London: Elsevier BV.

  • Reviews

    • Lee B, Edling C, Ahmad S, LeBeau FEN, Tse G, Jeevaratnam K. . International Journal of Molecular Sciences 2023, 24(16), 12601.
    • Babiloni C, Blinowska K, Bonanni L, Cichocki A, De Haan W, Del Percio C, Dubois B, Escudero J, Fernandez A, Frisoni G, Guntekin B, Hajos M, Hampel H, Ifeachor E, Kilborn K, Kumar S, Johnsen K, Johannsson M, Jeong J, LeBeau F, Lizio R, Lopes da Silva F, Maestu F, McGeown WJ, McKeith I, Moretti DV, Nobili F, Olichney J, Onofrj M, Palop JJ, Rowan M, Stocchi F, Struzik ZM, Tanila H, Teipel S, Taylor JP, Weiergraber M, Yener G, Young-Pearse T, Drinkenburg WH, Randall F. . Neurobiology of Aging 2020, 85, 58-73.
    • Law ZK, Todd C, Mehraram R, Schumacher J, Baker MR, LeBeau FEN, Yarnall A, Onofrj M, Bonanni L, Thomas A, Taylor J-P. . Diagnostics 2020, 10(9), 616.
    • Le Beau FEN, El Manira A, Griller S. . Trends in Neurosciences 2005, 28(10), 552-561.
    • Silberberg G, Grillner S, Le Beau FEN, Maex R, Markram H. . Trends in Neurosciences 2005, 28(10), 541-551.
    • Grillner S, Markram H, De Schutter E, Silberberg G, Le Beau FEN. . Trends in Neurosciences 2005, 28(10), 525-533.