麻豆传媒

Roles and Responsibilities

I joined the at 麻豆传媒 in February 2014 to apply my range of skills to assist in bioinformatics, data analysis, modelling and teaching in the Faculty of Medical Sciences.

Previous Positions

Research Associate, Institute for Ageing and Health, University of 麻豆传媒 upon Tyne, 2008-13

Head of Protein-Protein Interactions Group, Biosystems Informatics Institute, 麻豆传媒 upon Tyne, 2005-07

Research Fellow, Cancer Research UK London Research Institute, 2000-04

Postdoctoral Research Assistant, Laboratory of Molecular Biophysics, University of Oxford, 1995-2000

Qualifications

PhD in Physics (Edinburgh, 1995)

BSc in Natural Sciences (Cambridge, 1990)

Memberships of Professional Organisations

Biochemical Society

Other information

Main Expertise

Analysis of Next-generation sequencing data (RNA-Seq, ChIP-Seq). Wide range of bioinformatics techniques including interpretation of gene lists in term of pathways. Statistical analysis with R/Bioconductor.

Other Expertise and Interests

Kinetic modelling of metabolic and signalling pathways with Ordinary Differential Equations. Ageing. Modelling of the cardiovascular system, with application to the investigation of orthostatic symptoms in Chronic Fatigue Syndrome. Structural aspects of biomolecular interactions, especially protein-protein interactions. Homology modelling. The computational prediction of the structure and affinity of protein-protein complexes using docking and electrostatics calculations. Molecular Dynamics simulation.

• Articles

  • Dalgliesh C, Aldalaqan S, Atallah C, Best A, Scott E, Ehrmann I, Merces G, Mannion J, Badurova B, Sandher R, Illing Y, Wirth B, Wells S, Codner G, Teboul L, Smith GR, Hedley A, Herbert M, de Rooij DG, Miles C, Reynard LN, Elliott DJ. . EMBO Journal 2025, 44, 877-902.
  • Wibowo CS, Susilo R, Ernawan R, Apriyanto A, Alshaharni MO, Smith GR, Gatehouse AM, Edwards MG. . Frontiers in Plant Science 2024, 15, 1458346.
  • Moya-Molina M, Dorgau B, Flood E, Letteboer SJF, Lorentzen E, Coxhead J, Smith G, Roepman R, Nagaraja Grellscheid S, Armstrong L, Lako M. . Cell Death & Disease 2024, 15(10), 721.
  • Siachisumo C, Luzzi S, Aldalaqan S, Hysenaj G, Dalgliesh C, Cheung K, Gazzara M, Yonchev ID, James K, Kheirollahi Chadegani M, Ehrmann I, Smith GR, Cockell SJ, Munkley J, Barash Y, Wilson SA, Elliott DJ. . eLife 2024, 12, RP89705.
  • Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith GR, McGill S, Burchmore RJS, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono J, Gaughan L. . Journal of Clinical Investigation 2023, 133(22), e169200.
  • Gee LMV, Barron-Millar B, Leslie J, Richardson C, Zaki MYW, Luli S, Burgoyne RA, Cameron RIT, Smith GR, Brain JG, Innes B, Jopson L, Dyson JK, McKay KRC, Pechlivanis A, Holmes E, Berlinguer-Palmini R, Victorelli S, Mells GF, Sandford RN, Palmer J, Kirby JA, Kiourtis C, Mokochinski J, Hall Z, Bird TG, Borthwick LA, Morris CM, Hanson PS, Jurk D, Stoll EA, LeBeau FEN, Jones DEJ, Oakley F. . American Journal of Pathology 2023, 193(1), 11-26.
  • Jones DEJ, Wetten A, Barron-Millar B, Ogle L, Mells G, Flack S, Sandford R, Kirby J, Palmer J, Brotherston S, Jopson L, Brain J, Smith GR, Rushton S, Jones R, Rushbrook S, Thorburn D, Ryder SD, Hirschfield G, Dyson JK. . eBioMedicine 2022, 80, 104068.
  • Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J, Smith GR, Allen B, Casement J, Diboll J, Harry R, Cooles FAH, Cope AP, Simpson G, Toward R, Noble H, Parke A, Wu W, Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T, Geissmann F, Goodyear CS, McInnes IB, Donnelly I, Gilmour A, Virlan AT, Porter D, Ponchel F, Emery P, El-Jawhari J, Parmar R, McDermott MF, Fisher BA, Young SP, Jones P, Raza K, Filer A, Pitzalis C, Barnes MR, Watson DS, Henkin R, Thorborn G, Fossati-Jimack L, Kelly S, Humby F, Bombardieri M, Rana S, Jia Z, Goldmann K, Lewis M, Ng S, Barbosa-Silva A, Tzanis E, Gallagher-Syed A, John CR, Ehrenstein MR, Altobelli G, Martins S, Nguyen D, Ali H, Ciurtin C, Buch M, Symmons D, Worthington J, Bruce IN, Sergeant JC, Verstappen SMM, Stirling F, Hughes-Morley A, Tom B, Farewell V, Zhong Y, Taylor PC, Buckley CD, Keidel S, Cuff C, Levesque M, Long A, Liu Z, Lipsky S, Harvey B, Macoritto M, Hong F, Kaymakcalan S, Tsuji W, Sabin T, Ward N, Talbot S, Padhji D, Sleeman M, Finch D, Herath A, Lindholm C, Jenkins M, Ho M, Hollis S, Marshall C, Parker G, Page M, Edwards H, Cuza A, Gozzard N, Pandis I, Rowe A, Capdevila FB, Loza MJ, Curran M, Verbeeck D, Dan Baker, Mela CM, Vranic I, Mela CT, Wright S, Rowell L, Vernon E, Joseph N, Payne N, Rao R, Binks M, Belson A, Ludbrook V, Hicks K, Tipney H, Ellis J, Hasan S, Didierlaurent A, Burny W, Haynes A, Larminie C, Harris R, Dastros-Pitei D, Carini C, Kola B, Jelinsky S, Hodge M, Maciejewski M, Ziemek D, Schulz-Knappe P, Zucht H-D, Budde P, Coles M, Butler JA, Read S. . Scientific Data 2022, 9(1), 196.
  • Kataura T, Otten EG, Rabanal-Ruiz Y, Adriaenssens E, Urselli F, Scialo F, Fan L, Smith GR, Dawson WM, Chen X, Yue WW, Bronowska AK, Carroll B, Martens S, Lazarou M, Korolchuk VI. . EMBO Journal 2022, 42, 1-16.
  • Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CMA, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD. . Annals of the Rheumatic Diseases 2022, 81(9), 1214-1223.
  • Shmarov F, Smith GR, Weatherhead SC, Reynolds NJ, Zuliani P. . PLoS Computational Biology 2022, 18(9), e1010267.
  • Addison R, Weatherhead SC, Pawitri A, Smith GR, Rider A, Grantham HJ, Cockell SJ, Reynolds NJ. . Redox Biology 2021, 41, 101924.
  • Barron-Millar B, Ogle L, Mells G, Flack S, Badrock J, Sandford R, Kirby J, Palmer J, Jopson L, Brain J, Smith GR, Rushton S, Hegade VS, Jones R, Rushbrook S, Thorburn D, Ryder S, Hirschfield G, Dyson JK, Jones DEJ. . Hepatology 2021, 74(6), 3269-3283.
  • Worrell J, Leslie J, Smith GR, Zaki M, Paish H, Knox A, James ML, Cartwright TN, OReily S, Kania G, Distler O, Distler J, Herrick A, Jeziorska M, Borthwick LA, Fisher AJ, Mann J, Mann DA, Oakley F. . Rheumatology 2020, 59(12), 3939-3951.
  • Anderson AE, Maney NJ, Nair N, Lendrem DW, Skelton AJ, Diboll J, Brown PM, Smith GR, Carmody RJ, Barton A, Isaacs JD, Pratt AG. . Rheumatology 2019, 58(7), 1250-1258.
  • Carroll B, Otten E, Manni D, Stefanatos R, Menzies F, Smith G, Jurk D, Kenneth N, Wilkinson S, Passos J, Attems J, Veal E, Teyssou E, Seilhean D, Millecamps S, Eskelinen E-L, Bronowska A, Rubinsztein DC, Sanz A, Korolchuk V. . Nature Communications 2018, 9, 256.
  • Paish HL, Kalson NS, Smith GR, del Carpio Pons A, Baldock TE, Smith N, Swist-Szulik K, Weir DJ, Bardgett M, Deehan DJ, Mann DA, Borthwick LA. . American Journal of Pathology 2018, 188(3), 696-714.
  • Proctor CJ, Smith GR. . PLoS ONE 2017, 12(11), 0187568.
  • Tomalin LE, Day AM, Underwood ZE, Smith GR, Dalle Pezze P, Rallis C, Patel W, Dickinson BC, Bähler J, Brewer TF, Chang CJ-L, Shanley DP, Veal EA. . Free Radicals in Biology and Medicine 2016, 95, 333-348.
  • Carroll B, Maetzel D, Maddocks ODK, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI. . eLife 2016, 5, e11058.
  • Wilson CL, Jurk D, Fullard N, Banks P, Page A, Luli S, Elsharkawy AM, Gieling RG, Bagchi-Chakraborty J, Fox C, Richardson C, Callaghan K, Blair GE, Fox N, Lagnado A, Passos JF, Moore AJ, Smith GR, Tiniakos DG, Mann J, Oakley F, Mann DA. . Nature Communications 2015, 6, 6818.
  • Barter MJ, Tselepi M, Gomez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA. . Stem Cells 2015, 33(11), 3266-3280.
  • Dolan D, Nelson G, Zupanic A, Smith G, Shanley D. . PLoS One 2013, 8(2), e55190.
  • Smith GR, Shanley DP. . BMC Systems Biology 2013, 7, 41.
  • Smith GR, Shanley DP. . PLoS ONE 2010, 5(6), e11092.
  • Pellicane G, Smith GR, Sarkisov L. . Physical Review Letters 2008, 101(24), 248102.

• Conference Proceedings (inc. Abstract)

  • Moran-Salvador E, Paoli PP, Smith GR, Page A, Howarth RM, Oakley F, Mann J, Mann D. . In: The Liver Meeting 2015: 66th Annual Meeting of the American Association for the Study of Liver Diseases. 2015, San Francisco: John Wiley & Sons, Inc.