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Staff Profile

Professor Jane Endicott

Prof of Cancer Structural Biology

  • Personal Website:
  • Address: Translational and Clinical
    Research Institute
    Faculty of Medical Sciences
    Â鶹´«Ã½
    Paul O'Gorman Building
    Framlington Place
    Â鶹´«Ã½ upon Tyne
    NE2 4HH
Background

Current position

Professor of Cancer Structural Biology



Area of expertise


Cell cycle structural biology       

Phosphorylation transcription

Since October 2011, I have been Professor of Cancer Structural Biology at Â鶹´«Ã½ and a member of the Cancer Research UK Â鶹´«Ã½ Drug Discovery Group. My group is pursuing structure-function studies of protein complexes involved in regulating transcription and progression through the eukaryotic cell cycle. We are also providing structural biology support to projects within the CRUK Â鶹´«Ã½ DDG. I recently joined the Translational and Clinical Research Institute within the Faculty of Medical Sciences.

I studied Biochemistry at Corpus Christi College, the University of Oxford and then moved to the laboratory of Victor Ling at the Ontario Cancer Institute, Toronto to complete my PhD. I returned to Oxford in 1991 as a Junior Research Fellow of the National Cancer Institute of Canada to join the laboratories of Professor Paul Nurse and Professor Louise Johnson to pursue structural studies of cyclin-dependent protein kinases (CDKs) and their regulators. I was awarded a Royal Society University Research Fellowship in 1995 and appointed to a University Lecturership in the Laboratory of Molecular Biophysics, University of Oxford in 1998. During my time at Oxford I held a College Fellowship at St. Cross College, where I am now an Emeritus Fellow and a Lecturership at Trinity College. 

External research roles and memberships

2024-present Royal Society Faraday Discovery Fellowships Committee B, member

2018-present CRUK Science Committee/ Discovery Research Committee, Vice Chair (2023-present)

2016-2023 MRC Non-Clinical Training and Career Development Panel, Deputy Chair (2019-2023)

2012-present Fellow, Royal Society of Biology

2003-present Faculty of 1000

Honours and awards

2014   MRC Suffrage Science Award

Google scholar:

Research

Research interests


Structural and functional characterisation of the cyclin-dependent protein kinase (CDK) family
Development of small molecule CDK inhibitors
Biophysical assays and structure determination for anti-cancer drug design

Current work

The growth and division of cells is strictly controlled at the molecular level by a number of enzymes that include the cyclin dependent protein kinases (CDKs). CDKs 1, 2, 4 and 6 are switched on and off in an orderly sequence, to ensure that cell division starts and stops at the required time. Other members of the CDK family (for example CDKs 7, 8 and 9) are also important for the control of transcription, the process by which genes are transcribed into messenger RNA that in turn serves as the template for protein synthesis. Regulation of transcription ensures the timely expression of proteins required for cell growth and differentiation. Errors in either the control of cell cycle progression or transcription can lead to uncontrolled cell growth and proliferation.

Although CDK family members are closely related in sequence, biological studies have revealed that each has unique properties. Our work, primarily using the technique of X-ray crystallography, allows us to see the structures of CDKs and the complexes they form at atomic resolution and to learn how they differ from each other. To this end we characterise and reconstitute selected CDK-containing complexes using heterologous expression systems and then study them by structural, biochemical, biophysical and cell-based methods. Aberrant CDK activity has been linked to cancer, neurological diseases, and rheumatoid arthritis. CDK-selective inhibitors in clinical trials for the treatment of cancer act by binding to the CDK active site to block CDK activity. Compounds that block other interactions made by CDK-cyclin complexes represent an alternative target for CDK-directed therapies. Our work aims to identify CDK-cyclin protein interaction sites to further understand the regulation of this important enzyme class and to aid the further development of CDK inhibitors. 

For further details about our work, please visit our web pages:

https://research.ncl.ac.uk/cellcyclestructuralbiology/

https://research.ncl.ac.uk/drugdiscovery/

Selected Publications



Rowland, R.J., Korolchuk, S., Salamina, M., Tatum, N.J., Ault, J.R., Hart, S., Turkenburg, J.P., Blaza, J.N., Noble, M.E.M., Endicott, J.A. (2024) Cryo-EM structure of the CDK2-cyclin A-CDC25A complex. Nat Commun. 15:6807.

Salamina, M., Montefiore, B.C., Liu, M., Wood, D.J., Heath, R., Ault, J.R., Wang, L.-Z., Korolchuk, S., Baslé, A., Pastok, M.W., Reeks, J., Tatum, N.J., Sobott, F., Arold, S.T., Pagano, M., Noble, M.E.M., Endicott, J.A. (2021) Discriminative SKP2 Interactions with CDK-cyclin complexes support a cyclin A-specific role in p27KIP1 degradation. J. Mol. Biol. 433:166795.

Wood, D.J., Korolchuk, S. Tatum N.J., Wang, L.-Z. Endicott, J.A. Noble, M.E.M., Martin, M.P. (2019) Differences in the conformational energy landscape of CDK1 and CDK2 suggest a mechanism for achieving selective CDK inhibition. Cell Chem. Biol. 26:121-130.

Wood DJ, Endicott JA. (2018) Structural insights into the functional diversity of the CDK-cyclin family. Open Biol. 8(9). pii: 180112. doi: 10.1098/rsob.180112. 

Hallett, S.T., Pastok, M.W., Morgan, R.M.L., Wittner, A., Blundell, K.L.I.M., Felletar, I., Wedge, S.R., Prodromou, C., Noble, M.E.M., Pearl, L.H. and Endicott, J.A. (2017) Differential regulation of G1 CDK complexes by the Hsp90-Cdc37 chaperone system. Cell Repts, 21, 1-13.

Brown, N.R., Korolchuk, S., Martin, M., Moukhametzianov, R., Stanley, W. Noble, M.E.M. and Endicott, J.A. (2015) CDK1 structures reveal conserved and unique features of the essential cell cycle CDK. Nature Comms, 6: 6769.



Theme web pages

Discovery of Medicines


 


Teaching

Teaching and supervision

PhD and MRes student supervision

I look forward to welcoming Masters and undergraduate project students with an interest in

            Cell cycle regulation

            CDK structural biology

Undergraduate course BGM2002, Biochemistry and Genetics of Signalling and the Cell Cycle

Undergraduate course BGM2060, Proteins and Enzymes

MRes course MMB8008, Chromosome Biology and Cell Cycle Control in Health and Disease


Publications

  • Articles

    • Pastok MW, Tomlinson CWE, Turberville S, Butler AM, Basle A, Noble MEM, Endicott JA, Pohl E, Tatum NJ. . Structure 2024, 32(12), 2301-2315.e6.
    • Rowland RJ, Korolchuk S, Salamina M, Tatum NJ, Ault JR, Hart S, Turkenburg JP, Blaza JN, Noble MEM, Endicott JA. . Nature Communications 2024, 15(1), 6807.
    • al-Rawi A, Kaye E, Korolchuk S, Endicott JA, Ly T. . Cell Reports 2023, 42(3), 112139.
    • Rowland RJ, Heath R, Maskell D, Thompson RF, Ranson NA, Blaza JN, Endicott JA, Noble MEM, Salamina M. . Scientific Reports 2023, 13, 10718.
    • Miller DC, Reuillon T, Molyneux L, Blackburn T, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hardcastle I, Harnor SJ, Heptinstall A, Lochhead P, Martin MP, Martin NC, Myers S, Newell DR, Noble RA, Phillips N, Rigoreau L, Thomas H, Tucker JA, Wang L-Z, Waring MJ, Wong A-C, Wedge SR, Noble MEM, Cano C. . Journal of Medicinal Chemistry 2022, 65(9), 6513-6540.
    • Davison G, Martin MP, Turberville S, Dormen S, Heath R, Heptinstall AB, Lawson M, Miller DC, Ng YM, Sanderson JN, Hope I, Wood DJ, Cano C, Endicott JA, Hardcastle IR, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2022, 65(22), 15416-15432.
    • Salamina M, Montefiore BC, Liu M, Wood DJ, Heath R, Ault JR, Wang L-Z, Korolchuk S, Basle A, Pastok MW, Reeks J, Tatum NJ, Sobott F, Arold ST, Pagano M, Noble MEM, Endicott JA. . Journal of Molecular Biology 2021, 433(5), 166795.
    • Al-Khawaldeh I, Aldred GG, Alyassiri M, Basmadjian C, Bordoni C, Harnor SJ, Heptinstall AB, Hobson SJ, Jennings CE, Khalifa S, Lebraud H, Miller DC, Shrives HJ, de Souza JV, Stewart HL, Temple M, Totobenazara J, Tucker JA, Tudhope SJ, Wang LZ, Bronowska AK, Cano C, Endicott JA, Golding BT, Hardcastle IR, Hickson I, Wedge SR, Willmore E, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2021, 64(14), 10001-10018.
    • Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang L-Z, Wong A-C, Noble MEM, Wedge SR, Cano C. . European Journal of Medicinal Chemistry 2019, 178, 530-543.
    • Wood D, Lopez-Fernandez JD, Knight LE, Al-Khawaldeh I, Gai C, Lin S, Martin MP, Miller DC, Cano C, Endicott JA, Hardcastle IR, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2019, 62(7), 3741-3752.
    • Wood DJ, Korolchuk S, Tatum NJ, Wang L-Z, Endicott JA, Noble MEM, Martin MP. . Cell Chemical Biology 2019, 26(1), 121-130.e5.
    • Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C. . Organic and Biomolecular Chemistry 2018, 16(11), 1843-1850.
    • Martin MP, Endicott JA, Noble MEM. . Essays in Biochemistry 2017, 61(5), 439-452.
    • Hallett ST, Pastok MW, Morgan RML, Wittner A, Blundell KLIM, Felletar I, Wedge SR, Prodromou C, Noble MEM, Pearl LH, Endicott JA. . Cell Reports 2017, 21(5), 1386-1398.
    • Coxon C, Anscombe E, Harnor S, Martin M, Carbain B, Golding B, Hardcastle I, Harlow L, Korolchuk S, Matheson C, Newell D, Noble M, Sivaprakasam M, Tudhope SJ, Turner D, Wang L, Wedge SR, Wong C, Griffin R, Endicott J, Cano C. . Journal of Medicinal Chemistry 2017, 60, 1746-1767.
    • Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble MEM, Wedge SR, Endicott JA, Griffin RJ. . Chemistry & Biology 2015, 22(9), 1159-1164.
    • Brown NR, Korolchuk S, Martin MP, Stanley WA, Moukhametzianov R, Noble MEM, Endicott JA. . Nature Communications 2015, 6, 6769.
    • Echalier A, Hole AJ, Lolli G, Endicott JA, Noble MEM. . ACS Chemical Biology 2014, 9(6), 1251-1256.
    • Lu M, Zak J, Chen SO, Sanchez-Pulido L, Severson DT, Endicott J, Ponting CP, Schofield CJ, Lu X. . Cell 2014, 157(5), 1130-1145.
    • Carbain B, Paterson DJ, Anscombe E, Campbell AJ, Cano C, Echalier A, Endicott JA, Golding BT, Haggerty K, Hardcastle IR, Jewsbury PJ, Newell DR, Noble MEM, Roche C, Wang LZ, Griffin RJ. . Journal of Medicinal Chemistry 2014, 57(1), 56-70.
    • Anil B, Riedinger C, Endicott JA, Noble MEM. . Acta Crystallographica Section D: Biological Crystallography 2013, 69(8), 1358-1366.
    • Shao H, Shi SH, Huang SL, Hole AJ, Abbas AY, Baumli S, Liu XR, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang SD. . Journal of Medicinal Chemistry 2013, 56(3), 640-659.
    • Endicott JA, Noble MEM. . Biochemical Society Transactions 2013, 41(4), 1008-1016.
    • Hole AJ, Baumli S, Shao H, Shi SH, Huang SL, Pepper C, Fischer PM, Wang SD, Endicott JA, Noble ME. . Journal of Medicinal Chemistry 2013, 56(3), 660-670.
    • Medina B, Paraskevopoulos K, Boehringer J, Sznajder A, Robertson M, Endicott J, Gordon C. . Journal of Biological Chemistry 2012, 287(50), 42344-42351.
    • Baumli S, Hole AJ, Wang LZ, Noble MEM, Endicott JA. . Structure 2012, 20(10), 1788-1795.
    • Baumli S, Hole AJ, Noble MEM, Endicott JA. . ACS chemical biology 2012, 7(5), 811-816.
    • Boehringer J, Riedinger C, Paraskevopoulos K, Johnson EOD, Lowe ED, Khoudian C, Smith D, Noble MEM, Gordon C, Endicott JA. . Biochemical Journal 2012, 448(1), 55-65.
    • Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle I, Endicott JA, McDonnell JM. . Chemical Biology and Drug Design 2011, 77(5), 301-308.
    • Watson AF, Liu JF, Bennaceur K, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lu XH, McDonnell JM, Newell DR, Noble MEM, Revill CH, Riedinger C, Xu Q, Zhao Y, Lunec J, Hardcastle IR. . Bioorganic & Medicinal Chemistry Letters 2011, 21(19), 5916-5919.
    • Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J. . Journal of Medicinal Chemistry 2011, 54(5), 1233-1243.
    • Riedinger C, Boehringer J, Trempe JF, Lowe ED, Brown NR, Gehring K, Noble MEM, Gordon C, Endicott JA. . Journal of Biological Chemistry 2010, 285(44), 33992-34003.
    • Baumli S, Endicott JA, Johnson LN. . Chemistry & Biology 2010, 17(9), 931-936.
    • Bettayeb K, Baunbæk D, Delehouze C, Loaëc N, Hole AJ, Baumli S, Endicott JA, Douc-Rasy S, Bénard J, Oumata N, Galons H, Meijer L. . Genes & Cancer 2010, 1(4), 369-380.
    • Trempe JF, Brown NR, Noble MEM, Endicott JA. . Acta Crystallographica. Section F: Structural Biology and Crystallization Communications 2010, 66(9), 994-998.
    • Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble MEM. . Proceedings of the National Academy of Sciences 2009, 106(11), 4171-4176.
    • Merckx A, Echalier A, Langford K, Sicard A, Langsley G, Joore J, Doerig C, Noble M, Endicott J. . Structure 2008, 16(2), 228-238.
    • Echalier A, Bettayeb K, Ferandin Y, Lozach O, Clement M, Valette A, Liger F, Marquet B, Morris JC, Endicott JA, Joseph B, Meijer L. . Journal of Medicinal Chemistry 2008, 51(4), 737-751.
    • Bettayeb K, Oumata N, Echalier A, Ferandin Y, Endicott JA, Galons H, Meijer L. . Oncogene 2008, 27(44), 5797-5807.
    • Riedinger C, Endicott JA, Kemp SJ, Smyth LA, Watson A, Valeur E, Golding BT, Griffin RJ, Hardcastle IR, Noble ME, McDonnell JM. . Journal of the American Chemical Society 2008, 130(47), 16038-16044.
    • Marchetti F, Sayle KL, Bentley J, Clegg W, Curtin NJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Harrington RW, Mesguiche V, Newell DR, Noble MEM, Parsons RJ, Pratt DJ, Wang L, Hardcastle IR, Mesguiche V, Newell DR, Noble MEM, Parsons RJ, Pratt DJ, Wang L, Hardcastle IR. . Organic and Biomolecular Chemistry 2007, 5(10), 1577-1585.
    • Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schachtele C, Kubbutat MHG, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L. . Cancer Research 2007, 67(17), 8325-8334.
    • Welburn JPI, Tucker JA, Johnson T, Lindert L, Morgan M, Willis A, Noble MEM, Endicott JA. . Journal of Biological Chemistry 2007, 282(5), 3173-3181.
    • Lowe ED, Hasan N, Trempe JF, Fonso L, Noble MEM, Endicott JA, Johnson LN, Brown NR. . Acta Crystallographica. Section D: Biological Crystallography 2006, 62(2), 177-188.
    • Griffin RJ, Henderson A, Curtin NJ, Echalier A, Endicott J, Hardcastle IR, Newell DR, Noble M, Wang L, Golding BT. . Journal of the American Chemical Society 2006, 128(18), 6012-6013.
    • Pratt DJ, Bentley J, Jewsbury P, Boyle FT, Endicott JA, Noble MEM. . Journal of Medicinal Chemistry 2006, 49(18), 5470-5477.
    • Doerig C, Billker O, Pratt D, Endicott J. . Biochimica et biophysica acta - Proteins and Proteomics 2005, 1754(1-2), 132–150.
    • MacDonald N, Welburn JPI, Noble MEM, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC. . Molecular Cell 2005, 20(2), 199-211.
    • Trempe JF, Brown NR, Lowe ED, Gordon C, Campbell ID, Noble MEM, Endicott JA. . EMBO Journal 2005, 24(18), 3178-3189.
    • Noble M, Barrett P, Endicott J, Johnson L, McDonnell J, Robertson G, Zawaira A. . Biochimica et Biophysica Acta: Proteins and Proteomics 2005, 1754(1-2), 58-64.
    • Sasaki T, Funakoshi M, Endicott JA, Kobayashi H. . Biochemical and Biophysical Research Communications 2005, 336(2), 530-535.
    • Hardcastle IR, Arris CE, Bentley J, Boyle FT, Chen Y, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury, P., Menyerol, J., Mesguiche, V., Newell, D.R., Noble, M., Pratt, D., Wang, L., Whitfield, H.J. . Journal of Medicinal Chemistry 2004, 47(15), 3710-3722.
    • Holton S, Merckx A, Burgess D, Doerig C, Noble M, Endicott J. . Structure 2003, 11(11), 1329-1337.
    • Sayle, K., Bentley, J., Boyle, F., Calvert, A. H., Cheng, Y., Curtin, N. J., Endicott, J., Golding, B., Hardcastle, I., Jewsbury, P., Mesguiche, V., Newell, D. R., Noble, M., Parsons, R., Pratt, D., Wang, L., Griffin, R. J. . Bioorganic and Medicinal Chemistry Letters 2003, 13(18), 3079-3082.
    • Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. . Journal of Medicinal Chemistry 2003, 46(2), 222-236.
    • Mesguiche, V, Parsons, R.J., Arris, C.E., Bentley, J., Boyle, F., Curtin, N.J., Davies, T.G., Endicott, J., Gibson, A., Golding, B., Griffin, R.J., Jewsbury, P., Johnson, L.N., Newell, D.R., Noble, M.E.M., Wang, L., Hardcastle, I.R. . Bioorganic and Medicinal Chemistry Letters 2003, 13(2), 217-222.
    • Davies T, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott J, Gibson A, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J.A., Wang, L., Whitfield, H.J. . Nature Structural Biology 2002, 9(10), 745-749.
    • Gibson A, Arris CE, Bentley J, Boyle F, Curtin NJ, Davies T, Endicott J, Golding BT, Grant S, Griffin R, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J., Whitfield, H.J. . Journal of Medicinal Chemistry 2002, 45(16), 3381-3393.
    • Doerig C, Endicott J, Chakrabarti D. . International Journal for Parasitology 2002, 32(13), 1575–1585.
    • Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble MEM. . Structure 2001, 9(5), 389-397.
    • Lawrie AM, Tito P, Hernandez H, Brown NR, Robinson CV, Endicott JA, Noble MEM, Johnson LN. . Protein Expression and Purification 2001, 23(2), 252-260.
    • Bentley J, Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury PJ, Johnson LN, Noble MEM, Newell DR. . Clinical Cancer Research 2000, 6, 328.
    • Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Garman EF, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury P, Johnson LN, Lawrie AM, Newell DR, Noble MEM, Sausville EA, Schultz R, Yu W. . Journal of Medicinal Chemistry 2000, 43(15), 2797-2804.
    • Legraverend M, Tunnah P, Noble M, Ducrot P, Ludwig O, Grierson DS, Leost M, Meijer L, Endicott J. . Journal of Medicinal Chemistry 2000, 43(7), 1282-1292.
    • Brown NR, Noble MEM, Endicott JA, Johnson LN. . Nature Cell Biology 1999, 1(7), 438-443.
    • Johnson LN, Noble MEM, Barford D, Brown N, Endicott JA, Lawrie A, Owen DJ. . Journal of the Chemical Society of Pakistan 1999, 21(3), 185-201.
    • Hoessel R, Leclerc S, Endicott JA, Noble MEM, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang WC, Eisenbrand G, Meijer L. . Nature cell biology 1999, 1(1), 60-67.
    • Brown NR, Noble MEM, Lawrie AM, Morris MC, Tunnah P, Divita G, Johnson LN, Endicott JA. . Journal of Biological Chemistry 1999, 274(13), 8746-8756.
    • Endicott JA, Noble MEM, Tucker JA. . Current Opinion in Structural Biology 1999, 9(6), 738-744.
    • Endicott JA, Noble MEM. . Structure 1998, 6(5), 535-541.
    • Endicott JA, Noble ME, Garman EF, Brown N, Rasmussen B, Nurse P, Johnson LN. . EMBO Journal 1995, 14(5), 1004-1014.
    • Brown NR, Noble MEM, Endicott JA, Garman EF, Wakatsuki S, Mitchell E, Rasmussen B, Hunt T, Johnson LN. . Structure 1995, 3(11), 1235-1247.
    • Endicott JA, Nurse P. . Structure 1995, 3(4), 321-325.
    • Bourne Y, Arvai AS, Bernstein SL, Watson MH, Reed SI, Endicott JE, Noble ME, Johnson LN, Tainer JA. . Proceedings of the National Academy of Sciences 1995, 92(22), 10232-10236.
    • Endicott JA, Nurse P, Johnson LN. . Protein Engineering 1994, 7(2), 243-253.
    • Juranka P, Zhang F, Kulpa J, Endicott J, Blight M, Holland IB, Ling V. . The Journal of biological chemistry 1992, 267(6), 3764-3770.
    • Endicott JA, Sarangi F, Ling V. . DNA sequence : the journal of DNA sequencing and mapping 1991, 2(2), 89-101.
    • Endicott JA, Juranka PF, Sarangi F, Gerlach JH, Deuchars KL, Ling V. . Molecular and Cellular Biology 1987, 7(11), 4075-4081.

  • Book Chapter

    • Martin MP, Endicott JA, Noble MEM, Tatum NJ. . In: Methods in Enzymology. San Diego: Academic Press Inc, 2023, pp.211-234.

  • Conference Proceedings (inc. Abstracts)

    • Ahn M, Bevan L, Buck I, Cano C, Castro J, Cons B, Endicott J, Fazal L, Ferrari N, Hardcastle I, Hearn K, Holvey R, Howard S, Johnson C, Jennings C, Kucia-Tran J, Kyle S, Lunec J, Lyons J, Miller D, Rees D, Noble M, Newell DR, Reeks J, Saini H, St Denis J, Tamanini E, Thomas H, Thompson N, Vinkovic M, Ward G, Wallis N, Walton H, Wedge S, Williams P, Willmore E, Wilshire N, Zhao Y, Chessari G. . In: American Association for Cancer Research Annual Meeting. 2024, San Diego: AACR Journals.
    • Massa BC, Martin MP, Noble ME, Endicott JA. . In: AACR 106th Annual Meeting 2015. 2015, Philadelphia, USA: American Association for Cancer Research.
    • Martin M, Anscombe E, Meschini E, Staunton D, Geitmann M, Danielson UH, Wang LZ, Vidal RM, Reuillon T, Golding BT, Newell DR, Wedge S, Noble MEM, Endicott JA, Griffin RJ. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
    • Shouksmith AE, Evans LE, Griffin RJ, Golding BT, Newell H, Miller DC, Noble MEM, Endicott JA, Tweddle D. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, Texas: American Chemical Society.
    • Lebraud H, Golding BT, Meschini E, Cano C, Anscombe E, Wang LZ, Endicott JA, Noble MEM, Newell DR, Griffin RJ. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, Texas: American Chemical Society.
    • Anil B, Blackburn E, Blackburn T, Cully S, Liu J, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lunec J, Newell DR, Revill CH, Riedinger C, Watson AF, Xu Q, Zhao Y, Hardcastle IR, Noble MEM. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
    • Shao H, Abbas AY, Shi S, Foley D, Huang S, Bradshaw TD, Pepper C, Endicott JA, Wang S, Fischer PM. . In: 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2012, Dublin, Ireland: Pergamon.
    • Echalier A, Endicott JA, Noble MEM. . In: BBA - Proteins and Proteomics: 6th International Conference on Inhibitors of Protein Kinases (IPK). 2010, Warsaw, Poland: Elsevier BV.
    • Meschini E, Endicott JA, Golding BT, Hardcastle IR, Newell DR, Noble MEM, Wang LZ, Griffin RJ. . In: Abstracts of Papers of the American Chemical Society. 2010, American Chemical Society.
    • Echalier A, Endicott JA, Johnson LN, McDonnell J, Noble MEM. . In: European Journal of Pharmaceutical Sciences: 18th Helsinki Drug Research. 2006, Helsinki, Finland: Elsevier BV.
    • Endicott JA, Merckx A, Hofmann G, Noble MEM. . In: International Meeting on Indirubin, the Red Shade of Indigo. 2003, Musée National de Préhistoire, Les Eyzies-de-Tayac, France: Editions "Life in Progress".
    • Davies TG, Pratt DJ, Endicott JA, Johnson LN, Noble MEM. . In: Pharmacology & Therapeutics: 2nd International Confernce on Inhbitors of Protein Kinases. 2002, Warsaw, Poland: Elsevier Inc.
    • Johnson LN, DeMoliner E, Brown NR, Song HW, Barford D, Endicott JA, Noble MEM. . In: Pharmacology & Therapeutics: 2nd International Confernce on Inhbitors of Protein Kinases. 2002, Warsaw, Poland: Elsevier Inc.
    • Sayle KL, Mesguishe V, Parsons RJ, Bentley J, Davies TG, Endicott JA, Noble MEM, Wang LZ, Hardcastle IR, Golding BT. . In: European Journal of Cancer: 14th EORTC/NCI/AACR Symposium on Molecular Targets and Cancer Therapeutics. 2002, Frankfurt, Germany: Pergamon.
    • Noble MEM, Endicott JA. . In: Pharmacology & Therapeutics: 1st International Conference on Inhibitors of Protein Kinases (IPK). 1999, Warsaw, Poland: Elsevier Inc.
    • Grant S, Boyle F, Calvert AH, Curtin NJ, Endicott J, Golding BT, Griffin RJ, Johnson LN, Newell DR, Noble MEM, Robson CN. . In: 10th NCI-EORTC Symposium on New Drugs in Cancer Therapy. 1998, Amsterdam, The Netherlands: Annals of Oncology: Oxford University Press.
    • Endicott J, Noble M, Lawrie A, Tunnah P, Brown N, Johnson L, Calvert AH, Curtin NJ, Golding BT, Griffin RJ, Newell DR. . In: 10th NCI-EORTC Symposium on New Drugs in Cancer Therapy. 1998, Amsterdam, The Netherlands: Annals of Oncology: Oxford University Press.
    • Johnson LN, Brown NR, Endicott JA, Lawrie AM, Lowe ED, Noble MEM, Tunnah P. . In: FASEB Journal. 1997, Federation of American Societies for Experimental Biology.

  • Editorial

    • Trempe JF, Endicott JA. . Nature 2007, 445(7126), 375-376.

  • Letters

    • Lawrie AM, Noble MEM, Tunnah P, Brown NR, Johnson LN, Endicott JA. . Nature Structural Biology 1997, 4(10), 796-801.
    • Gerlach JH, Endicott JA, Juranka PF, Henderson G, Sarangi F, Deuchars KL, Ling V. . Nature 1986, 324(6096), 485-489.

  • Reviews

    • Watt J, Martin MP, Endicott JA, Noble MEM. . Current Opinion in Structural Biology 2025, 90, 102982.
    • Hope I, Endicott JA, Watt JE. . RSC Chemical Biology 2023, 4(2), 146-164.
    • Wood DJ, Endicott JA. . Open Biology 2018, 8(9), 180112.
    • Endicott JA, Noble MEM, Johnson LN. . Annual Review of Biochemistry 2012, 81, 587-613.
    • Welburn JPI, Endicott JA. . Seminars in Cell & Developmental Biology 2005, 16(3), 369-381.
    • Pratt DJ, Endicott JA, Noble MEM. . Current Opinion In Drug Discovery & Development 2004, 7(4), 428-436.
    • Noble MEM, Endicott JA, Johnson LN. . Science 2004, 303(5665), 1800-1805.
    • Noble MEM, Endicott JA, Brown NR, Johnson LN. . Trends in Biochemical Sciences 1997, 22(12), 482-487.
    • Endicott JA, Ling V. . Annual Review of Biochemistry 1989, 58, 137-171.