Â鶹´«Ã½

Skip to main content

Staff Profile

Professor John Simpson

Professor of Respiratory Medicine, Â鶹´«Ã½

  • Telephone: 0191 208 2788
  • Address: 3rd Floor, William Leech Building
    Medical School
    Â鶹´«Ã½
    Framlington Place
    Â鶹´«Ã½ upon Tyne
    NE2 4HH
Background

Qualifications

FMedSci

FRCP(Edin)

PhD

MBChB

BMedBiol (Hons)


Current Roles and Responsibilities

Programme Director for the MRC/NIHR Efficacy and Mechanism Evaluation (EME) programme.

Co-director of the NIHR Healthtech Research Centre (HRC) in Diagnostic and Technology Evaluation.

NIHR Senior Investigator.


Previous roles

Deputy Chair, MRC Clinical Training and Career Development Panel.

Director of the NIHR Â鶹´«Ã½ Diagnostic Evidence Co-operative (DEC) and the NIHR Â鶹´«Ã½ Medtech and In vitro diagnostics evidence Co-operative (MIC).

Dean of Translational Research, Â鶹´«Ã½, June 2015-August 2018.

Clinical Director of R&D in Â鶹´«Ã½ upon Tyne Hospitals NHS Foundation Trust, 2013-February 2016.


Background

I am part of the PRINCIPLE (Paediatric, Respiratory, INtensive Care, Immunity and PuLmonary Epithelium) Research Group in Â鶹´«Ã½. 

My research is principally interested in understanding innate immune dysfunction in the setting of critical illness, with a view to developing novel treatments and improving antibiotic stewardship. We are particularly interested in ventilator-associated pneumonia (VAP) and sepsis. Further details are found in the adjacent RESEARCH section. Selected publications are shown in the accompanying PUBLICATIONS section.


My clinical interests are in pulmonary embolism, interstitial lung disease and pneumonia. I moved to Â鶹´«Ã½ in 2010, having previously worked in the University of Edinburgh / MRC Centre for Inflammation Research, and in the Royal Infirmary of Edinburgh.




Research

Overview

Our group’s work spans discovery science, experimental medicine and randomised controlled trials (RCTs). The work focuses principally on innate immunity (with particular reference to neutrophil and monocyte function), and how this is impaired in critical illness.


We have identified mechanisms by which neutrophils become dysfunctional phagocytic capacity during critical illness. This acquired functional defect is independently associated with significantly increased risk of developing nosocomial infection in the intensive care unit (ICU). We have also described novel means by which to restore neutrophil functions to normal (for example using GM-CSF). We are currently involved in clinical trials assessing whether interferon gamma (INFINIT trial) and GM-CSF (SepTIC and INSIGHT-AM trials) can improve innate immune function in critically ill patients.


We have a longstanding programme studying acute innate immune responses (and their resolution) in humans, using carefully supervised models of inhaled and intravenous administration of bacterial lipopolysaccharide (LPS).



Collaborators outside Â鶹´«Ã½

INFINIT trial - Tony Rostron (Sunderland), Danny McAuley (Belfast), Andrew Conway Morris (Cambridge), Paul Dark and Tim Felton (Manchester), Suveer Singh (Chelsea and Westminster), Tully Redmond (Oldham), Ingeborg Welters and Ben Morton (Liverpool), Dhruv Parekh (Birmingham), Jeremy Henning (Middlesbrough), Clingen


INSIGHT-AM trial - Tony Rostron (Sunderland), Andrew Conway Morris (Cambridge), Paul Dark and Tim Felton (Manchester), Bart Lambrecht (Ghent), Partner Therapeutics, Aerogen Ltd.


SepTIC trial - Tony Gordon (chief investigatory, Imperial College).


TIPAL trial - Andrew Wilson (chief investigator, East Anglia)


CHORUS trial - Michael Gibbons (chief investigator, Exeter)


Neutrophil biology - Danny McAuley, Cecilia O'Kane and Cliff Taggart (Belfast), Adriano Rossi and David Dockrell (Edinburgh), Steve Renshaw (Sheffield), John Girkin and Anders Aufderhorst-Roberts (Durham), Sally Clayton (Birmingham)



Grants as Lead Applicant (current and selected previous)

Current

MRC DPFS. MICA: Can interferon gamma prevent infection in critically ill patients at highest risk? A phase II randomised controlled trial (the INFINIT trial).


MRC Experimental Medicine. MICA: Key mechanisms underlying inhaled GM-CSF's enhancement of phagocytosis and bacterial clearance by human alveolar macrophages (the INSIGHT-AM trial).


NIHR HTA - A randomised controlled trial of SHORT duration antibiotic thERapy for critically ill patients with sepsis: SHORTER Trial (Joint lead applicant with Dr Tom Hellyer, Â鶹´«Ã½).


NIHR Healthtech Research Centre in Diagnostic and Technology Evaluation. Co-director (with Dr Andrew Sims, Â鶹´«Ã½ upon Tyne Hospitals NHS Foundation Trust).  


Selected Previous

Wellcome Trust/Department of Health Health Innovation Challenge Fund (HICF): Rapid detection and treatment of ventilator-associated pneumonia – towards improved antibiotic stewardship.


NIHR Â鶹´«Ã½ Medtech and In Vitro Diagnostics Co-operative (MIC).


NIHR Â鶹´«Ã½ Diagnostic Evidence Co-operative (DEC). 


Sir Jules Thorn Charitable Trust Award for Biomedical Sciences 2003. Acute infective lung injury: towards cell therapy with antiprotease-infected monocytes.


Sir Jules Thorn Charitable Trust . A randomised controlled trial of monocyte depletion in acute neutrophil-mediated lung injury.


MRC Developmental Clinical Studies (DCS): Does GM-CSF restore effective neutrophil function in critically ill patients?



Teaching

In 2009 I received an Edinburgh University Students' Association Teaching Award.

I am currently an external examiner for medical finals at the Royal College of Surgeons in Ireland (RCSI) and for a BMedSci module at the University of Edinburgh. 







Publications

  • Articles

    • Lake CJ, Scott J, Ruchaud-Sparagano MH, Thompson JH, Dewar F, Yarova P, Funston W, Davidson RCH, Musgrave KM, Wright SE, Clement I, Roy AI, Sendama W, Powell J, Brooks D, Lin A, Davies K, Hellyer TP, Rostron AJ, Simpson AJ. . Thorax 2025, epub ahead of print.
    • Brooks D, Wright SE, Beattie A, McAllister N, Anderson NH, Roy AI, Gonsalves P, Yates B, Graziadio S, Mackie A, Davidson J, Gopal SV, Whittle R, Zahed A, Barton L, Elameer M, Tuckett J, Holmes R, Sutcliffe A, Santamaria N, de Lalouviere LLH, Gupta S, Subramaniam J, Pearson JA, Brandwood M, Burnham R, Rostron AJ, Simpson AJ. . Journal of Critical Care 2024, 82, 154760.
    • Pippard BJ, Neal MA, Holland CW, Maunder AM, Forrest I, Lawson RA, Fisher HF, Matthews JNS, Wild JM, Simpson AJ, Thelwall PE. . Radiology 2024, 313(3).
    • Powell J, Powell S, Mather MW, Beck L, Nelson A, Palmowski P, Porter A, Coxhead J, Hedley A, Scott J, Rostron AJ, Hellyer T, Zaidi F, Davey T, Garnett JP, Agbeko R, Ward C, Stewart CJ, Taggart CC, Brodlie M, Simpson AJ. . Thorax 2023, 78(10), 1019-1027.
    • Sendama W, Funston W, Rostron AJ, Simpson AJ. . American Journal of Respiratory and Critical Care Medicine 2023, 207(9), 1246-1249.
    • Musgrave KM, Scott J, Sendama W, Gardner AI, Dewar F, Lake CJ, Spronk HMH, van Oerle R, Visser M, ten Cate H, Kesteven P, Fuller A, McDonald D, Knill C, Hulme G, Filby A, Wright SE, Roy AI, Ruchaud-Sparagano M, Simpson AJ, Rostron AJ. . Thrombosis Research 2023, 228, 10-20.
    • Thompson S, Pang CY, Sepuru KM, Cambier S, Hellyer TP, Scott J, Simpson AJ, Proost P, Kirby JA, Rajarathnan K, Sheerin NS, Ali S. . Cellular and Molecular Life Sciences 2023, 80, 35.
    • Legg J, Allen J-L, Andrew M, Annesley C, Chatwin M, Crawford H, Elverson J, Forton J, Oulton K, Renton K, Tavare A, Tedd H, Simpson AJ. . Thorax 2023, 78(Suppl. 1), s1-31.
    • Simpson AJ, Allen J-L, Chatwin M, Crawford H, Elverson J, Ewan V, Forton J, McMullan R, Plevris J, Renton K, Tedd H, Thomas R, Legg J. . Thorax 2023, 78(Suppl. 1), s3-s21.
    • Scott J, Trevi L, McNeil H, Ewen T, Mawson P, McDonald D, Filby A, Lall R, Booth K, Boschman G, Melkebeek V, Perkins G, McMullan R, McAuley DF, McCullagh IJ, Walsh T, Rostron A, Shankar-Hari M, Dark P, Simpson AJ, Conway Morris A, Hellyer TP. . BMJ Open 2022, 12(12), e068321.
    • Conway Morris A, Navapurkar V, Bartholdson Scott J, Maes M, Hellyer TP, Higginson E, Forrest S, Pereira-Dias J, Parmar S, Heasman-Hunt E, Polgarova P, Brown J, Titti L, Smith WPW, Scott J, Rostron A, Routledge M, Sapsford D, Torok ME, McMullan R, Enoch DA, Wong V, Curran MD, Brown NM, Simpson AJ, Herre J, Dougan G. . Wellcome Open Research 2022, 6, 256.
    • Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM. . European Respiratory Journal 2022, 59(4), 2052559.
    • Funston W, Ruchaud-Sparagano M-H, Scott J, Powell J, Cooles FAH, Shelmerdine L, McDowell C, O'Leary D, Booth KL, Clark SC, Ledingham SJ, Rostron AJ, Dark JH, Simpson AJ. . PLoS ONE 2022, 17(7), e0271958.
    • Hirani N, MacKinnon AC, Nicol L, Ford P, Schambye H, Pedersen A, Nilsson UJ, Leffler H, Sethi T, Tantawi S, Gravelle L, Slack RJ, Mills R, Karmakar U, Humphries D, Zetterberg F, Keeling L, Paul L, Molyneaux PL, Li F, Funston W, Forrest IA, Simpson AJ, Gibbons MA, Maher TM. . European Respiratory Journal 2021, 57, 2002559.
    • Pippard BJ, Neal MA, Maunder AM, Hollingsworth KG, Biancardi A, Lawson RA, Fisher H, Matthews JNS, Simpson AJ, Wild JM, Thelwall PE. . Magnetic Resonance in Medicine 2021, 85(6), 3343-3352.
    • Scott J, Ruchaud-Sparagano M-H, Musgrave K, Roy AI, Wright SE, Perry JD, Morris AC, Rostron AJ, Simpson AJ. . Journal of Immunology 2021, 207(7), 1776-1784.
    • Hatton CF, Botting RA, Duenas ME, Haq IJ, Verdon B, Thompson BJ, Spegarova JS, Gothe F, Stephenson E, Gardner AI, Murphy S, Scott J, Garnett JP, Carrie S, Powell J, Khan CMA, Huang L, Hussain R, Coxhead J, Davey T, Simpson AJ, Haniffa M, Hambleton S, Brodlie M, Ward C, Trost M, Reynolds G, Duncan CJA. . Nature Communications 2021, 12(1), 7092.
    • Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee E-C, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jorgensen SB, Coll AP, Breen DM, O'Rahilly S. . Proceedings of the National Academy of Sciences of the United States of America 2021, 118(27), e2106868118.
    • Macfarlane JG, Dorward DA, Ruchaud-Sparagano M-H, Scott J, Lucas CD, Rossi AG, Simpson AJ. . Journal of Inflammation 2020, 17, 34.
    • Gardner AI, Haq IJ, Simpson AJ, Becker KA, Gallagher J, Saint-Criq V, Verdon B, Mavin E, Trigg A, Gray MA, Koulman A, McDonnell MJ, Fisher AJ, Kramer EL, Clancy JP, Ward C, Schuchman EH, Gulbins E, Brodlie M. . American Journal of Respiratory and Critical Care Medicine 2020, 202(8), 1133-1145.
    • Loughlin L, Hellyer TP, White PL, McAuley DF, Conway Morris A, Posso RB, Richardson MD, Denning DW, Simpson AJ, McMullan R. . American Journal of Respiratory and Critical Care Medicine 2020, 202(8), 1125-1132.
    • Neal MA, Pippard BJ, Simpson AJ, Thelwall PE. . Magnetic Resonance in Medicine 2020, 83(2), 452-461.
    • Jardine L, Cytlak U, Gunawan M, Reynolds G, Green K, Wang XN, Pagan S, Paramitha M, Lamb CA, Long A, Hurst E, Nair S, Jackson GH, Publicover A, Bigley V, Haniffa M, Simpson AJ, Collin M. . The Journal of Clinical Investigation 2020, 130(9), 4574-4586.
    • Wood AJ, Vassallo AM, Ruchaud-Sparagano M-H, Scott J, Zinnato C, Gonzalez-Tejedo C, Kishore K, D'Santos CS, Simpson AJ, Menon DK, Summers C, Chilvers ER, Okkenhaug K, Morris AC. . JCI insight 2020, 5(15), e137029.
    • Hellyer TP, McAuley DF, Walsh TS, Anderson N, Conway Morris A, Singh S, Dark P, Roy AI, Perkins GD, McMullan R, Emerson LM, Blackwood B, Wright SE, Kefala K, O'Kane CM, Baudouin SV, Paterson RL, Rostron AJ, Agus A, Bannard-Smith J, Robin NM, Welters ID, Bassford C, Yates B, Spencer C, Laha SK, Hulme J, Bonner S, Linnett V, Sonksen J, Van Den Broeck T, Boschman G, Keenan DWJ, Scott J, Allen AJ, Phair G, Parker J, Bowett SA, Simpson AJ. . The Lancet Respiratory Medicine 2020, 8(2), 182-191.
    • Dutta P, Funston W, Mossop H, Ryan V, Jones R, Forbes R, Sen S, Pearson J, Griffin SM, Smith J, Ward C, Forrest IA, Simpson AJ. . Thorax 2019, 74(4), 346-353.
    • Neal MA, Pippard BJ, Simpson AJ, Thelwall PE. . Magnetic Resonance in Medicine 2019, 82(4), 1301-1311.
    • Jardine L, Wiscombe S, Reynolds G, McDonald D, Fuller A, Green K, Filby A, Forrest I, Ruchaud-Sparagano MH, Scott J, Collin M, Haniffa M, Simpson AJ. . Nature Communications 2019, 10, 1999.
    • Pinder EM, Rostron AJ, Hellyer TP, Ruchaud-Sparagano MH, Scott J, Macfarlane JG, Wiscombe S, Widdrington JD, Roy AI, Linnett VC, Baudouin SV, Wright SE, Chadwick T, Fouweather T, Juss JK, Chilvers ER, Bowett SA, Parker J, McAuley DF, Conway Morris A, Simpson AJ. . Thorax 2018, 73(10), 918-925.
    • Echevarria C, Gray J, Hartley T, Steer J, Miller J, Simpson AJ, Gibson GJ, Bourke SC. . Thorax 2018, 73(8), 713-722.
    • Widdrington JD, Gomez-Duran A, Pyle A, Ruchaud-Sparagano M-H, Scott J, Baudouin SV, Rostron AJ, Lovat PE, Chinnery PF, Simpson AJ. . Frontiers in immunology 2018, 9, 2217.
    • Powell J, Garnett JP, Mather MW, Cooles FAH, Nelson A, Verdon B, Scott J, Jiwa K, Ruchaud-Sparagano MH, Cummings SP, Perry JD, Wright SE, Wilson JA, Pearson J, Ward C, Simpson AJ. . American Journal of Respiratory and Critical Care Medicine 2018, 198(3), 340-349.
    • Shankar-Hari M, Datta D, Wilson J, Assi V, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Felton J, Warner N, Judge K, Keenan J, Wang W, Burpee T, Brown AK, Lewis SM, Mare T, Roy AI, Wright J, Hulme G, Dimmick I, Gray A, Rossi AG, Simpson AJ, Conway Morris A, Walsh TS. . Intensive Care Medicine 2018, 44(11), 1836-1848.
    • Conway Morris A, Datta D, Shankar-Hari M, Stephen J, Weir CJ, Rennie J, Antonelli J, Bateman A, Warner N, Judge K, Keenan J, Wang A, Burpee T, Brown KA, Lewis SM, Mare T, Roy AI, Hulme G, Dimmick I, Rossi AG, Simpson AJ, Walsh TS. . Intensive Care Medicine 2018, 44(5), 627-635.
    • Bigley V, Maisuria S, Cytlak U, Jardine L, Care MA, Green K, Gunawan M, Milne P, Dickinson R, Wiscombe S, Parry D, Doffinger R, Laurence A, Fonseca C, Stoevesandt O, Gennery A, Cant A, Tooze R, Simpson AJ, Hambleton S, Savic S, Doody G, Collin M. . Journal of Allergy and Clinical Immunology 2018, 141(6), 2234-2248.
    • Echevarria C, Steer J, Heslop-Marshall K, Stenton SC, Hickey PM, Hughes R, Wijesinghe M, Harrison RN, Steen N, Simpson AJ, Gibson GJ, Bourke SC. . Thorax 2017, 72(8), 686-693.
    • Widdrington JD, Gomez-Duran A, Steyn JS, Pyle A, Ruchaud-Sparagano M-H, Scott J, Baudouin SV, Rostron AJ, Simpson J, Chinnery PF. . Journal of Allergy and Clinical Immunology 2017, 140(5), 1461-1464.e8.
    • Ewan VC, Witham MD, Kiernan M, Simpson AJ. . The Lancet Respiratory Medicine 2017, 5(10), 771-772.
    • Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM. . Thorax 2017, 72, 971-980.
    • Morris AC, Gadsby N, McKenna JP, Hellyer TP, Dark P, Singh S, Walsh TS, McAuley DF, Templeton K, Simpson AJ, McMullan R. . Thorax 2017, 72(11), 1046-1048.
    • Echevarria C, Steer J, Heslop-Marshall K, Stenton SC, Hickey PM, Hughes R, Wijesinghe M, Harrison RN, Steen N, Simpson AJ, Gibson GJ, Bourke SC. . Thorax 2016, 71(2), 133-140.
    • Hellyer TP, Ewan V, Wilson P, Simpson AJ. . Journal of the Intensive Care Society 2016, 17(3), 238-243.
    • Nolan TJ, Gadsby N, Hellyer TP, Templeton K, McMullan R, McKenna J, Rennie J, Robb CT, Walsh TS, Rossi AG, Conway Morris A, Simpson AJ. . Thorax 2016, 71(7), 594-600.
    • Scott J, Harris GJ, Pinder EM, Macfarlane JG, Hellyer TP, Rostron AJ, Morris AC, Thickett DR, Perkins GD, McAuley DF, Widdrington JD, Wiscombe S, Baudouin SV, Roy AI, Linnett VC, Wright SE, Ruchaud-Sparagano MH, Simpson AJ. . Journal of Allergy and Clinical Immunology 2016, 137(2), 535-544.
    • Hellyer TP, Anderson NH, Parker J, Dark P, Van-Den-Broeck T, Singh S, McMullan R, Agus AM, Emerson LM, Blackwood B, Gossain S, Walsh TS, Perkins GD, Conway-Morris A, McAuley DF, Simpson AJ. . Trials 2016, 17, 318.
    • Hellyer TP, Morris AC, McAuley DF, Walsh TS, Anderson NH, Singh S, Dark P, Roy AI, Baudouin SV, Wright SE, Perkins GD, Kefala K, Jeffels M, McMullan R, O'Kane CM, Spencer C, Laha S, Robin N, Gossain S, Gould K, Ruchaud-Sparagano MH, Scott J, Browne EM, MacFarlane JG, Wiscombe S, Widdrington JD, Dimmick I, Laurenson IF, Nauwelaers F, Simpson AJ. . Thorax 2015, 70(1), 41-47.
    • Browne E, Hellyer TP, Baudouin SV, Morris AC, Linnett V, McAuley DF, Perkins GD, Simpson AJ. . BMJ Open Respiratory Research 2014, 1(1), e000066.
    • O'Dwyer DN, Armstrong ME, Trujillo G, Cooke G, Keane MP, Fallon PG, Simpson AJ, Millar AB, McGrath EE, Whyte MK, Hirani N, Hogaboam CM, Donnelly SC. . American Journal of Respiratory and Critical Care Medicine 2013, 188(12), 1442-1450.
    • Kerrin A, Weldon S, Chung AHK, Craig T, Simpson AJ, O'Kane CM, McAuley DF, Taggart CC. . Thorax 2013, 68(4), 315-321.
    • Morris AC, Anderson N, Brittan M, Wilkinson TS, McAuley DF, Antonelli J, McCulloch C, Barr LC, Dhaliwal K, Jones RO, Haslett C, Hay AW, Swann DG, Laurenson IF, Davidson DJ, Rossi AG, Walsh TS, Simpson AJ. . British Journal of Anaesthesia 2013, 111(5), 778-787.
    • Barr LC, Brittan M, Conway Morris A, McAuley DF, McCormack C, Fletcher AM, Richardson H, Connell M, Patel D, Wallace WA, Rossi AG, Davidson DJ, Manson L, Turner M, Hirani N, Walsh TS, Anderson NH, Dhaliwal K, Simpson AJ. . American Journal of Respiratory and Critical Care Medicine 2013, 188(4), 449-455.
    • Wilkinson TS, Morris AC, Kefala K, O'Kane CM, Moore NR, Booth NA, McAuley DE, Dhaliwal K, Walsh TS, Haslett C, Sallenave JM, Simpson AJ. . Chest 2012, 142(6), 1425-1432.
    • MacKinnon AC, Gibbons MA, Farnworth SL, Leffler H, Nilsson UJ, Delaine T, Simpson AJ, Forbes SJ, Hirani N, Gauldie J, Sethi T. . American Journal of Respiratory and Critical Care Medicine 2012, 185(5), 537-546.
    • Dhaliwal K, Scholefield E, Ferenbach D, Gibbons M, Duffin R, Dorward DA, Morris AC, Humphries D, Mackinnon A, Wilkinson TS, Wallace WA, vanRooijen N, Mack N, Rossi AG, Davidson DJ, Hirani N, Hughes J, Haslett C, Simpson AJ. . American Journal of Respiratory and Critical Care Medicine 2012, 186(6), 514-524.
    • Brittan M, Barr L, Conway Morris A, Duffin R, Rossi F, Johnston S, Monro G, Anderson N, Rossi AG, McAuley DF, Haslett C, Hirani N, Dhaliwal K, Simpson AJ. . European Respiratory Journal 2012, 40(1), 206-214.
    • Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, Van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ. . American Journal of Respiratory and Critical Care Medicine 2011, 184(5), 569-581.
    • Morris AC, Brittan M, Wilkinson TS, McAuley DF, Antonelli J, McCulloch C, Barr LC, McDonald NA, Dhaliwal K, Jones RO, Mackellar A, Haslett C, Hay AW, Swann DG, Anderson N, Laurenson IF, Davidson DJ, Rossi AG, Walsh TS, Simpson AJ. . Blood 2011, 117(19), 5178-5188.
    • Murray MP, Govan JRW, Doherty CJ, Simpson AJ, Wilkinson TS, Chalmers JD, Greening AP, Haslett C, Hill AT. . American Journal of Respiratory and Critical Care Medicine 2011, 183(4), 491-499.
    • Barlow PG, Cosseau C, Beaumont PE, Mackellar A, Wilkinson TS, Hancock REW, Govan JRW, Haslett C, Simpson AJ, Davidson DJ. . American Journal of Respiratory Molecular and Cell Biology 2010, 43(6), 692-702.
    • Conway Morris A, Kefala K, Wilkinson TS, Moncayo Nieto OL, Dhaliwal K, Farrell L, Walsh TS, Mackenzie SJ, Swann DJ, Andrews PJD, Anderson N, Govan JRW, Laurenson IF, Reid H, Davidson DJ, Haslett C, Sallenave JM, Simpson AJ. . Thorax 2010, 65(3), 201-207.
    • Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Haslett C, Govan JRW, Gregory CD, Sallenave JM, Simpson AJ. . American Journal of Pathology 2009, 174(4), 1338-1346.
    • Li HN, Barlow PG, Bylund J, Mackellar A, Bjorstad A, Conlon J, Hiemstra PS, Haslett C, Gray M, Simpson AJ, Rossi AG, Davidson DJ. . Journal of Leukocyte Biology 2009, 86(4), 891-902.
    • Lowder BV, Guinane CM, BenZakour NL, Weinert LA, ConwayMorris A, Cartwright RA, Simpson AJ, Rambaut A, Nübel U, Fitzgerald JR. . Proceedings of the National Academy of Sciences 2009, 106(46), 19545-19550.
    • Conway Morris A, Kefala K, Simpson AJ, Everingham K, Kerslake D, Raby S, Laurenson IF, Swann DJ, Walsh TS. . Thorax 2009, 64(6), 516-522.
    • ConwayMorris A, Kefala D, Wilkinson TS, Dhaliwal K, Rossi AG, Farrell L, Walsh TS, Mackenzie SJ, Reid H, Davidson DJ, Haslett C, Sallenave JM, Simpson AJ. . American Journal of Respiratory and Critical Care Medicine 2009, 180(1), 19-28.
    • Marriott HM, Jackson LE, Wilkinson TS, Simpson AJ, Mitchell TJ, Buttle DJ, Cross SS, Ince PG, Hellewell PG, Whyte MKB, Dockrell DH. . American Journal of Respiratory and Critical Care Medicine 2008, 177(8), 887-895.
    • Farnworth SL, Henderson NC, Mackinnon AC, Atkinson KM, Wilkinson T, Dhaliwal K, Hayashi K, Simpson AJ, Rossi AG, Haslett C, Sethi T. . American Journal of Pathology 2008, 172(2), 395-405.
    • Simpson AJ, Cunningham GA, Porteous DJ, Haslett C, Sallenave JM. . Human Gene Therapy 2001, 12(11), 1395-1407.
    • Simpson AJ, Wallace WAH, Marsden ME, Govan JRW, Porteous DJ, Haslett C, Sallenave JM. . Journal of Immunology 2001, 167(3), 1778-1786.

  • Conference Proceedings (inc. Abstracts)

    • Rafique C, Mitchell D, Ewart J, Forrest I, Funston W, Palmer E, Sendama W, Simpson AJ, Wiscombe S. . In: British Thoracic Society Winter Meeting. 2024, London: BMJ Group.
    • Neal M, Pippard B, Hollingsworth K, Simpson AJ, Thelwall P. . In: International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition. 2021, Virtual.
    • Neal M, Pippard B, Forrest I, Lawson R, Fisher HF, Matthews JNS, Hollingsworth K, Simpson AJ, Wild J, Thelwall P. . In: International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition. 2021, Virtual.

  • Editorials

    • Simpson AJ. . Thorax 2014, 69(2), 105-107.
    • Walsh TS, Morris AC, Simpson AJ. . British Journal of Anaesthesia 2013, 111(3), 333-337.

  • Letters

    • Thompson JH, Reddy K, Matthay MA, McAuley DF, Simpson AJ, Rostron AJ. . British Journal of Anaesthesia 2024, 133(3), 700-703.
    • Simpson AJ, Maxwell AI, Govan JRW, Haslett C, Sallenave JM. . FEBS 1999, 452(3), 309-313.

  • Reviews

    • Brooks D, Barr LC, Wiscombe S, McAuley DF, Simpson AJ, Rostron AJ. . The European Respiratory Journal 2020, 56(1), 1901298.
    • Hulse EJ, Davies JOJ, Simpson AJ, Sciuto AM, Eddleston M. . American Journal of Respiratory and Critical Care Medicine 2014, 190(12), 1342-1354.