麻豆传媒

Roles and Responsibilities

Professor of Molecular Diabetic Medicine, University of 麻豆传媒
Honorary Consultant Physician, 麻豆传媒 Hospitals NHS Trust and 麻豆传媒 Primary Care Trust
Former Director, 麻豆传媒 NIHR/Wellcome Trust Clinical Research Facility

Qualifications

BMedSci (1st class Hons) University of 麻豆传媒 1980
MB BS University of 麻豆传媒 1983; MRCP (UK) 1986;
MD University of 麻豆传媒 1992; FRCP London 1997.

Research Interests

Genetic and metabolic abnormalities in families with Type 2 diabetes; biochemical and genetic basis of insulin resistance in Type 2 diabetes;  mitochondrial related diabetes.

• Deshmukh HA, LundagerMadsen A, Viñuela A, Have CT, Grarup N, Tura A, Mahajan A, Heggie AJ, Koivula RW, DeMasi F, Tsirigos KK, Linneberg A, Drivsholm T, Pedersen O, Sørensen TIA, Astrup A, Gjesing AAP, Pavo I, Wood AR, Ruetten H, Jones AG, Koopman ADM, Cederberg H, Rutters F, Ridderstrale M, Laakso M, McCarthy MI, Frayling TM, Ferrannini E, Franks PW, Pearson ER, Mari A, Hansen T, Walker M. Genome-wide association analysis of pancreatic beta-cell glucose sensitivity. Journal of Clinical Endocrinology and Metabolism 2021, 106, 80-90.
• Blair HR, Tomas C, Miwa S, Heath A, Russell A, Ginkel M-V, Gunn D, Walker M. . Journal of Diabetes and its Complications 2021, 35(3), 107843.
• Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S, Brunak S, De Masi F, Dermitzakis ET, Forgie IM, Frost G, Hansen T, Hansen TH, Hattersley A, Kokkola T, Kurbasic A, Laakso M, Mari A, McDonald TJ, Pedersen O, Rutters F, Schwenk JM, Teare HJA, Thomas EL, Vinuela A, Mahajan A, McCarthy MI, Ruetten H, Walker M, Pearson E, Pavo I, Franks PW. . Diabetologia 2020, 63(4), 744-756.
• Tomas C, Elson JL, Newton JL, Walker M. . Scientific Reports 2020, 10(1), 18232.
• Koivula RW, Forgie IM, Kurbasic A, Vinuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstrale M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW. . Diabetologia 2019, 62(9), 1601-1615.
• Shah UJ, Xie W, Flyvbjerg A, Nolan JJ, Hojlund K, Walker M, Relton CL, Elliott HR. . Diabetes Research and Clinical Practice 2019, 148, 189-199.
• Yeung RO, Hannah-Shmouni F, Niederhoffer K, Walker MA. . Reviews in Endocrine and Metabolic Disorders 2018, 19(1), 35-52.
• Wood AR, Jonsson A, Jackson AU, Wang N, Van Leewen N, Palmer ND, Kobes S, Deelen J, Boquete-Vilarino L, Paananen J, Stancakova A, Boomsma DI, De Geus EJC, Eekhoff EMW, Fritsche A, Kramer M, Nijpels G, Simonis-Bik A, Van Haeften TW, Mahajan A, Boehnke M, Bergman RN, Tuomilehto J, Collins FS, Mohlke KL, Banasik K, Groves CJ, McCarthy MI, Pearson ER, Natali A, Mari A, Buchanan TA, Taylor KD, Xiang AH, Gjesing AP, Grarup N, Eiberg H, Pedersen O, Chen Y-D, Laakso M, Norris JM, Smith U, Wagenknecht LE, Baier L, Bowden DW, Hansen T, Walker M, Watanabe RM, T'Hart LM, Hanson RL, Frayling TM. . Diabetes 2017, 66(8), 2296-2309.
• Lotta LA, Gulati P, Day FR, Payne F, Ongen H, Van De Bunt M, Gaulton KJ, Eicher JD, Sharp SJ, Luan J, De Lucia Rolfe E, Stewart ID, Wheeler E, Willems SM, Adams C, Yaghootkar H, Sharp SJ, Forouhi NG, Kerrison ND, Sims M, Lucarelli DME, Deloukas P, McCarthy MI, Arriola L, Balkau B, Barricarte A, Boeing H, Franks PW, Gonzalez C, Grioni S, Kaaks R, Key TJ, Navarro C, Nilsson PM, Overvad K, Palli D, Panico S, Quiros JR, Rolandsson O, Sacerdote C, Salamanca-Fernandez E, Slimani N, Tjonneland A, Tumino R, Spijkerman AMW, Van Der A DL, Van Der Schouw YT, Riboli E, Semple RK, Stears A, George S, Walker M, Gurnell E, Maguire D, Mukhtar R, Nag S, Adler A, Soeters MR, Laji K, Watt A, Aylwin S, Johnson A, Rayman G, Hanna F, Ellard S, Ross R, Blaslov K, Duvnjak LS, Khaw K-T, Johnson AD, Frayling T, Perry JRB, Dermitzakis E, Barroso I, Wareham NJ, Savage DB, Langenberg C, O'Rahilly S, Scott RA. . Nature Genetics 2017, 49(1), 17-26.
• Brown AE, Walker M. . Current Cardiology Reports 2016, 18, 75.
• Al-bayati A, Lukka D, Brown AE, Walker M. . Journal of Diabetes and its Complications 2016, 30(7), 1209-1216.
• Brown AE, Jones DE, Walker M, Newton JL. . PLoS One 2015, 10(4), e0122982.
• Knowles JW, Xie WJ, Zhang ZY, Chennemsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YDI, Makinen VP, Ganna A, Mahajan A, Guo XQ, Abbasi F, Greenawalt DM, Lum P, Molony C, Lind L, Lindgren C, Raffel LJ, Tsao PS, Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T, RISC Relationship Insulin, EUGENE European Network Functional, GUARDIAN Genetics UndeRlying, SAPPHIRE Stanford Asian Pacific. . Journal of Clinical Investigation 2015, 125(4), 1739-1751.
• Brown AE, Palsgaard J, Borup R, Avery P, Gunn DA, De Meyts P, Yeaman SJ, Walker M. . American Journal of Physiology Endocrinology and Metabolism 2015, 308(1), E63-E70.
• Nile DL, Brown AE, Kumaheri MA, Blair HR, Heggie A, Miwa S, Cree LM, Payne B, Chinnery PF, Brown L, Gunn DA, Walker M. . PLoS One 2014, 9(12), e115433.
• Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, Ridderstrale M, Rutters F, Vestergaard H, Gupta R, Herrgard S, Heymans MW, Perry MH, Rauh S, Siloaho M, Teare HJA, Thorand B, Bell J, Brunak S, Frost G, Jablonka B, Mari A, McDonald TJ, Dekker JM, Hansen T, Hattersley A, Laakso M, Pedersen O, Koivisto V, Ruetten H, Walker M, Pearson E, Franks PW, DIRECT Consortium. . Diabetologia 2014, 57(6), 1132-1142.
• Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, Häring H, Hansen T, Pedersen O, Smith U, Laakso M, MAGIC Investigators, DIAGRAM Consortium, RISC Consortium, Dekker JM, Nolon JJ, Groop L, Ferrannini E, Adam KP, Gall WE, Frayling TM, Walker M. . Diabetes 2013, 62(6), 2141-2150.
• Gordon C, Walker M, Carrick-Sen D. . Journal of Advanced Nursing 2013, 69(12), 2726-2737.
• Schaefer AM, Walker M, Turnbull DM, Taylor RW. . Molecular and Cellular Endocrinology 2013, 379(1-2), 2-11.
• Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Magi R, Sharp S, Jackson AU, Assimes TL, Shrader P, Knowles JW, Zethelius B, Abbasi FA, Bergman RN, Bergmann A, Berne C, Boehnke M, Bonnycastle LL, Bornstein SR, Buchanan TA, Bumpstead SJ, Bottcher Y, Chines P, Collins FS, Cooper CC, Dennison EM, Erdos MR, Ferrannini E, Fox CS, Graessler J, Hao K, Isomaa B, Jameson KA, Kovacs P, Kuusisto J, Laakso M, Ladenval C, Mohlke KL, Morken MA, Narisu N, Nathan DM, Pascoe L, Payne F, Petrie JR, Sayer AA, Schwarz PEH, Scott LJ, Stringham HM, Stumvoll M, Swift AJ, Syvanen AC, Tuomi T, Tuomilehto J, Tonjes A, Valle TT, Williams GH, Lind L, Barroso I, Quertermous T, Walker M, Wareham NJ, Meigs JB, McCarthy MI, Groop L, Watanabe RM, Florez JC. . Diabetes 2010, 59(5), 1266-1275.
• Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF, Wareham NJ, Walker M, RISC Consortium. . Diabetologia 2009, 52(8), 1537-1542.
• Cree L, Patel S, Pyle A, Lynn S, Turnbull DM, Chinnery PF, Walker M. . Diabetologia 2008, 51(8), 1440-1443.
• Pascoe L, Frayling TM, Weedon MN, Mari A, Tura A, Ferrannini E, Walker M. . Diabetologia 2008, 51(11), 1989-1992.
• Young AH, Ferrier IN, Ball SG, Mohiuddin MK, Todhunter CE, Mansfield JC, members of the Wellcome Trust Case Control Consortium. . Nature 2007, 447(7145), 661-678.
• Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, Perry JRB, Elliott KS, Lango H, Rayner NW, Shields B, Harries LW, Barrett JC, Ellard S, Groves CJ, Knight B, Patch A-M, Ness AR, Ebrahim S, Lawlor DA, Ring SM, Ben-Shlomo Y, Jarvelin M-R, Sovio U, Bennett AJ, Melzer D, Ferrucci L, Loos RJF, Barroso I, Wareham NJ, Karpe F, Owen KR, Cardon LR, Walker M, Hitman GA, Palmer CNA, Doney ASF, Morris AD, Smith GD, Hattersley AT, McCarthy MI. . Science 2007, 316(5826), 889-894.
• Pascoe L, Tura A, Patel SK, Ibrahim IM, Ferrannini E, Zeggini E, Weedon MN, Mari A, Hattersley AT, McCarthy MI, Frayling TM, Walker M. . Diabetes 2007, 56(12), 3101-3104.
• Whittaker RG, Schaefer AM, McFarland R, Taylor RW, Walker M, Turnbull DM. . Diabetes Care 2007, 30(9), 2238-2239.
• Patel S, Minton JAL, Weedon MN, Frayling TM, Ricketts C, Hitman GA, McCarthy MI, Hattersley AT, Walker M, Barrett TG. . Diabetologia 2006, 49(6), 1209-1213.
• Walker M, Mari A, Jayapaul MK, Bennett SMA, Ferrannini E. . Diabetologia 2005, 48(12), 2470-2476.
• McIntyre EA, Halse R, Yeaman SJ, Walker M. . Journal of Clinical Endocrinology and Metabolism 2004, 89(7), 3440-3448.
• Mills GW, Avery PJ, McCarthy MI, Hattersley AT, Levy JC, Hitman GA, Sampson M, Walker M. . Diabetologia 2004, 47(4), 732-738.
• Hills SA, Balkau B, Coppack SW, Dekker JM, Mari A, Natali A, Walker M, Ferrannini E. . Diabetologia 2004, 47(3), 566-570.
• Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, Sampson M, O'Rahilly S, Frayling TM, Bell JI, Lathrop GM, Bennett A, Dhillon R, Fletcher C, Groves CJ, Jones E, Prestwich P, Simecek N, Rao PVS, Wishart M, Foxon R, Howell S, Smedley D, Cardon LR, Menzel S, McCarthy MI. . American Journal of Human Genetics 2001, 69(3), 553-569.
• Lynn S, Borthwick GM, Charnley RM, Walker M, Turnbull DM. . Diabetologia 2003, 46(2), 296-299.
• Hearn T, Renforth GL, Spalluto C, Hanley NA, Piper K, Brickwood S, White C, Connolly V, Taylor JFN, Russell-Eggitt I, Bonneau D, Walker M, Wilson DI. . Nature Genetics 2002, 31(1), 79-83.
• Jackson S, Bagstaff SM, Lynn S, Yeaman SJ, Turnbull DM, Walker M. . Diabetes 2000, 49(7), 1169-1177.
• Choo-Kang ATW, Lynn S, Taylor GA, Daly ME, Sihota SS, Wardell TM, Chinnery PF, Turnbull DM, Walker M. . Diabetes 2002, 51(7), 2317-2320.
• Wiltshire S, Frayling TM, Hattersley AT, Hitman GA, Walker M, Levy JC, O'Rahilly S, Groves CJ, Menzel S, Cardon LR, McCarthy MI. . American Journal of Human Genetics 2002, 70(2), 543-546.