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Staff Profile

Professor Martin Noble

Prof of Biom Struct & Anticanc Drug Des

  • Personal Website:
  • Address: Â鶹´«Ã½
    Translational & Clinical Research Institute
    Paul O'Gorman Building
    Medical School
    Framlington Place
    Â鶹´«Ã½ upon Tyne
    NE2 4HH

Background

Since October 2011 I have been Professor of Biomolecular Structure and Anticancer Drug Design at Â鶹´«Ã½, initially in the Northern Institute for Cancer Research and now in the Â鶹´«Ã½ Translational and Clinical Research Institute. My group is pursuing structure-function studies of protein complexes involved in regulating transcription and progression through the eukaryotic cell cycle. 


Prior to taking up my appointment in Â鶹´«Ã½ I was a Professor at the Laboratory of Molecular Biophysics in the Department of Biochemistry, Oxford University, where I worked from 1993 as postdoc, Royal Society University Research Fellow, University Lecturer, and ultimately Head of Laboratory, after having been recruited initially to the group of Professor Dame Louise Johnson.


My main interest is in understanding the molecular recognition events that drive cellular signalling processes, and in exploiting that understanding to produce new chemical probes and potential leads for drug discovery. This interest has also lead me into the field of bionanotechnology, where protein structures can be recycled as building blocks for novel materials.

Within Â鶹´«Ã½, I am Head of Academic Structural Sciences with Cancer Research Horizons- Therapeutic Innovations, while my external commitments include being a member of the executive committee of CCP4, the principal resource for software development in macromolecular crystallography.


Area of expertise

  • Structural biology and biophysical approaches to understand regulatory process at the atomic and molecular level. 
  • Structure based drug discovery. 
  • Computational methods in macromolecular structure determination and analysis.

Google scholar:

ORCID:

 


Teaching

 

I look forward to welcoming M.Res and project students with an interest in 

  • The structural biology of cancer
  • Computational and experimental structure-based drug design 

I also co-lead and offer lectures and practicals in BGM3064 (Applied Biochemistry), and jointly run a laboratory in BGM2062


Publications

  • Articles

    • Pastok MW, Tomlinson CWE, Turberville S, Butler AM, Basle A, Noble MEM, Endicott JA, Pohl E, Tatum NJ. . Structure 2024, 32(12), 2301-2315.e6.
    • Rowland RJ, Korolchuk S, Salamina M, Tatum NJ, Ault JR, Hart S, Turkenburg JP, Blaza JN, Noble MEM, Endicott JA. . Nature Communications 2024, 15(1), 6807.
    • Agirre J, Atanasova M, Bagdonas H, Ballard CB, Basle A, Beilsten-Edmands J, Borges RJ, Brown DG, Burgos-Marmol JJ, Berrisford JM, Bond PS, Caballero I, Catapano L, Chojnowski G, Cook AG, Cowtan KD, Croll TI, Debreczeni JE, Devenish NE, Dodson EJ, Drevon TR, Emsley P, Evans G, Evans PR, Fando M, Foadi J, Fuentes-Montero L, Garman EF, Gerstel M, Gildea RJ, Hatti K, Hekkelman ML, Heuser P, Hoh SW, Hough MA, Jenkins HT, Jimenez E, Joosten RP, Keegan RM, Keep N, Krissinel EB, Kolenko P, Kovalevskiy O, Lamzin VS, Lawson DM, Lebedev AA, Leslie AGW, Lohkamp B, Long F, Maly M, McCoy AJ, McNicholas SJ, Medina A, Millan C, Murray JW, Murshudov GN, Nicholls RA, Noble MEM, Oeffner R, Pannu NS, Parkhurst JM, Pearce N, Pereira J, Perrakis A, Powell HR, Read RJ, Rigden DJ, Rochira W, Sammito M, Sanchez Rodriguez F, Sheldrick GM, Shelley KL, Simkovic F, Simpkin AJ, Skubak P, Sobolev E, Steiner RA, Stevenson K, Tews I, Thomas JMH, Thorn A, Valls JT, Uski V, Uson I, Vagin A, Velankar S, Vollmar M, Walden H, Waterman D, Wilson KS, Winn MD, Winter G, Wojdyr M, Yamashita K. . Acta crystallographica. Section D, Structural biology 2023, 79, 449-461.
    • Morese PA, Anthony N, Bodnarchuk M, Jennings C, Martin MP, Noble RA, Phillips N, Thomas HD, Wang LZ, Lister A, Noble MEM, Ward RA, Wedge SR, Stewart HL, Waring MJ. . Journal of Medicinal Chemistry 2023, 66(17), 12324-12341.
    • Salvini CLA, Darlot B, Davison J, Martin MP, Tudhope SJ, Turberville S, Kawamura A, Noble MEM, Wedge SR, Crawford JJ, Waring MJ. . Chemical Science 2023, 14(31), 8288-8294.
    • Rowland RJ, Heath R, Maskell D, Thompson RF, Ranson NA, Blaza JN, Endicott JA, Noble MEM, Salamina M. . Scientific Reports 2023, 13, 10718.
    • Miller DC, Reuillon T, Molyneux L, Blackburn T, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hardcastle I, Harnor SJ, Heptinstall A, Lochhead P, Martin MP, Martin NC, Myers S, Newell DR, Noble RA, Phillips N, Rigoreau L, Thomas H, Tucker JA, Wang L-Z, Waring MJ, Wong A-C, Wedge SR, Noble MEM, Cano C. . Journal of Medicinal Chemistry 2022, 65(9), 6513-6540.
    • Davison G, Martin MP, Turberville S, Dormen S, Heath R, Heptinstall AB, Lawson M, Miller DC, Ng YM, Sanderson JN, Hope I, Wood DJ, Cano C, Endicott JA, Hardcastle IR, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2022, 65(22), 15416-15432.
    • Martin MP, Noble MEM. . Acta Crystallographica. Section D, Structural Biology 2022, D78(11), 1294-1302.
    • Uguen M, Davison G, Sprenger LJ, Hunter JH, Martin MP, Turberville S, Watt JE, Golding BT, Noble MEM, Stewart HL, Waring MJ. . Journal of Medicinal Chemistry 2022, 65(16), 11322-11339.
    • Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscome E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, St Denis J, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor S, Hearn K, Hobson S, Holvey RS, Howard S, Jennings C, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, Tamanini E, Thomas H, Thompson NT, Vinkovic M, Wedge SR, Williams PA, Wilsher N, Zhang B, Zhao Y. . Journal of Medicinal Chemistry 2021, 64(7), 4071-4088.
    • Salamina M, Montefiore BC, Liu M, Wood DJ, Heath R, Ault JR, Wang L-Z, Korolchuk S, Basle A, Pastok MW, Reeks J, Tatum NJ, Sobott F, Arold ST, Pagano M, Noble MEM, Endicott JA. . Journal of Molecular Biology 2021, 433(5), 166795.
    • Al-Khawaldeh I, Aldred GG, Alyassiri M, Basmadjian C, Bordoni C, Harnor SJ, Heptinstall AB, Hobson SJ, Jennings CE, Khalifa S, Lebraud H, Miller DC, Shrives HJ, de Souza JV, Stewart HL, Temple M, Totobenazara J, Tucker JA, Tudhope SJ, Wang LZ, Bronowska AK, Cano C, Endicott JA, Golding BT, Hardcastle IR, Hickson I, Wedge SR, Willmore E, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2021, 64(14), 10001-10018.
    • Lochhead PA, Tucker JA, Tatum NJ, Wang J, Oxley D, Kidger AM, Johnson VP, Cassidy MA, Gray NS, Noble MEM, Cook SJ. . Nature Communications 2020, 11(1), 1383.
    • Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen CD, Resnick E, Strain-Damerell C, Aimon A, Abranyi-Balogh P, Brandao-Neto J, Carbery A, Davison G, Dias A, Downes TD, Dunnett L, Fairhead M, Firth JD, Jones SP, Keeley A, Keseru GM, Klein HF, Martin MP, Noble MEM, O'Brien P, Powell A, Reddi RN, Skyner R, Snee M, Waring MJ, Wild C, London N, von Delft F, Walsh MA. . Nature Communications 2020, 11(1), 5047.
    • Verhoork SJM, Jennings CE, Rozatian N, Reeks J, Meng J, Corlett EK, Bunglawala F, Noble MEM, Leach AG, Coxon CR. . Chemistry - A European Journal 2019, 25(1), 177-182.
    • Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang L-Z, Wong A-C, Noble MEM, Wedge SR, Cano C. . European Journal of Medicinal Chemistry 2019, 178, 530-543.
    • Wood D, Lopez-Fernandez JD, Knight LE, Al-Khawaldeh I, Gai C, Lin S, Martin MP, Miller DC, Cano C, Endicott JA, Hardcastle IR, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2019, 62(7), 3741-3752.
    • Wood DJ, Korolchuk S, Tatum NJ, Wang L-Z, Endicott JA, Noble MEM, Martin MP. . Cell Chemical Biology 2019, 26(1), 121-130.e5.
    • Unterlass JE, Baslé A, Blackburn TJ, Tucker J, Turlais F, Cano C, Noble MME, Curtin NJ. . Oncotarget 2018, 9, 13139-13153.
    • Whittaker SR, Barlow C, Martin MP, Mancusi C, Wagner S, Self A, Barrie E, Te Poele R, Sharp S, Brown N, Wilson S, Jackson W, Fischer PM, Clarke PA, Walton MI, McDonald E, Blagg J, Noble M, Garrett MD, Workman P. . Molecular Oncology 2018, 12(3), 287-304.
    • Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C. . Organic and Biomolecular Chemistry 2018, 16(11), 1843-1850.
    • Martin MP, Endicott JA, Noble MEM. . Essays in Biochemistry 2017, 61(5), 439-452.
    • Unterlass JE, Wood RJ, Basle A, Tucker J, Cano C, Noble MM, Curtin NJ. . Oncotarget 2017, 8(61), 104478-104491.
    • Hallett ST, Pastok MW, Morgan RML, Wittner A, Blundell KLIM, Felletar I, Wedge SR, Prodromou C, Noble MEM, Pearl LH, Endicott JA. . Cell Reports 2017, 21(5), 1386-1398.
    • Coxon C, Anscombe E, Harnor S, Martin M, Carbain B, Golding B, Hardcastle I, Harlow L, Korolchuk S, Matheson C, Newell D, Noble M, Sivaprakasam M, Tudhope SJ, Turner D, Wang L, Wedge SR, Wong C, Griffin R, Endicott J, Cano C. . Journal of Medicinal Chemistry 2017, 60, 1746-1767.
    • Jones D, Noble M, Wedge SR, Robson CN, Gaughan L. . Scientific Reports 2017, 7, 40957.
    • Tan YS, Reeks J, Brown CJ, Thean D, Gago FJF, Yuen TY, Goh ETL, Lee XEC, Jennings CE, Joseph TL, Lakshminarayanan R, Lane DP, Noble MEM, Verma CS. . Journal of Physical Chemistry Letters 2016, 7(17), 3452-3457.
    • Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble MEM, Wedge SR, Endicott JA, Griffin RJ. . Chemistry & Biology 2015, 22(9), 1159-1164.
    • Brown NR, Korolchuk S, Martin MP, Stanley WA, Moukhametzianov R, Noble MEM, Endicott JA. . Nature Communications 2015, 6, 6769.
    • Echalier A, Hole AJ, Lolli G, Endicott JA, Noble MEM. . ACS Chemical Biology 2014, 9(6), 1251-1256.
    • Carbain B, Paterson DJ, Anscombe E, Campbell AJ, Cano C, Echalier A, Endicott JA, Golding BT, Haggerty K, Hardcastle IR, Jewsbury PJ, Newell DR, Noble MEM, Roche C, Wang LZ, Griffin RJ. . Journal of Medicinal Chemistry 2014, 57(1), 56-70.
    • Anil B, Riedinger C, Endicott JA, Noble MEM. . Acta Crystallographica Section D: Biological Crystallography 2013, 69(8), 1358-1366.
    • Shao H, Shi SH, Huang SL, Hole AJ, Abbas AY, Baumli S, Liu XR, Lam F, Foley DW, Fischer PM, Noble M, Endicott JA, Pepper C, Wang SD. . Journal of Medicinal Chemistry 2013, 56(3), 640-659.
    • Endicott JA, Noble MEM. . Biochemical Society Transactions 2013, 41(4), 1008-1016.
    • Hole AJ, Baumli S, Shao H, Shi SH, Huang SL, Pepper C, Fischer PM, Wang SD, Endicott JA, Noble ME. . Journal of Medicinal Chemistry 2013, 56(3), 660-670.
    • Baumli S, Hole AJ, Wang LZ, Noble MEM, Endicott JA. . Structure 2012, 20(10), 1788-1795.
    • Baumli S, Hole AJ, Noble MEM, Endicott JA. . ACS chemical biology 2012, 7(5), 811-816.
    • Boehringer J, Riedinger C, Paraskevopoulos K, Johnson EOD, Lowe ED, Khoudian C, Smith D, Noble MEM, Gordon C, Endicott JA. . Biochemical Journal 2012, 448(1), 55-65.
    • Riedinger C, Noble ME, Wright DJ, Mulks F, Hardcastle I, Endicott JA, McDonnell JM. . Chemical Biology and Drug Design 2011, 77(5), 301-308.
    • Watson AF, Liu JF, Bennaceur K, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lu XH, McDonnell JM, Newell DR, Noble MEM, Revill CH, Riedinger C, Xu Q, Zhao Y, Lunec J, Hardcastle IR. . Bioorganic & Medicinal Chemistry Letters 2011, 21(19), 5916-5919.
    • Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J. . Journal of Medicinal Chemistry 2011, 54(5), 1233-1243.
    • Riedinger C, Boehringer J, Trempe JF, Lowe ED, Brown NR, Gehring K, Noble MEM, Gordon C, Endicott JA. . Journal of Biological Chemistry 2010, 285(44), 33992-34003.
    • Banerji S, Hide BRS, James JR, Noble MEM, Jackson DG. . Journal of Biological Chemistry 2010, 285(14), 10724-10735.
    • Trempe JF, Brown NR, Noble MEM, Endicott JA. . Acta Crystallographica. Section F: Structural Biology and Crystallization Communications 2010, 66(9), 994-998.
    • Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble MEM. . Proceedings of the National Academy of Sciences 2009, 106(11), 4171-4176.
    • Merckx A, Echalier A, Langford K, Sicard A, Langsley G, Joore J, Doerig C, Noble M, Endicott J. . Structure 2008, 16(2), 228-238.
    • Lack N, Lowe ED, Lui J, Eltis LD, Noble MEM, Sim E, Westwood IM. . Acta Crystallographica. Section F: Structural Biology and Crystallization Communications 2008, 64(1), 2-7.
    • Lorenz S, Vakonakis I, Lowe ED, Campbell ID, Noble MEM, Hoellerer MK. . Structure 2008, 16(10), 1521-1531.
    • Fullam E, Westwood IM, Anderton MC, Lowe ED, Sim E, Noble MEM. . Journal of Molecular Biology 2008, 375(1), 178-191.
    • Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble MEM. . Current Drug Metabolism 2008, 9(6), 510-519.
    • Riedinger C, Endicott JA, Kemp SJ, Smyth LA, Watson A, Valeur E, Golding BT, Griffin RJ, Hardcastle IR, Noble ME, McDonnell JM. . Journal of the American Chemical Society 2008, 130(47), 16038-16044.
    • Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. . Nature Structural & Molecular Biology 2007, 14(3), 234-239.
    • Marchetti F, Sayle KL, Bentley J, Clegg W, Curtin NJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Harrington RW, Mesguiche V, Newell DR, Noble MEM, Parsons RJ, Pratt DJ, Wang L, Hardcastle IR, Mesguiche V, Newell DR, Noble MEM, Parsons RJ, Pratt DJ, Wang L, Hardcastle IR. . Organic and Biomolecular Chemistry 2007, 5(10), 1577-1585.
    • Higman VA, Blundell CD, Mahoney DJ, Redfield C, Noble MEM, Day AJ. . Journal of Molecular Biology 2007, 371(3), 669-684.
    • Wang CJ, Hagemeier C, Rahman N, Lowe E, Noble MEM, Coughtrie M, Sim E, Westwood I. . Journal of Molecular Biology 2007, 373(5), 1213-1228.
    • Welburn JPI, Tucker JA, Johnson T, Lindert L, Morgan M, Willis A, Noble MEM, Endicott JA. . Journal of Biological Chemistry 2007, 282(5), 3173-3181.
    • Cheng KY, Noble MEM, Skamnaki V, Brown NR, Lowe ED, Kontogiannis L, Shen K, Cole PA, Siligardi C, Johnson LN. . Journal of Biological Chemistry 2006, 281(32), 23167-23179.
    • Lowe ED, Hasan N, Trempe JF, Fonso L, Noble MEM, Endicott JA, Johnson LN, Brown NR. . Acta Crystallographica. Section D: Biological Crystallography 2006, 62(2), 177-188.
    • Griffin RJ, Henderson A, Curtin NJ, Echalier A, Endicott J, Hardcastle IR, Newell DR, Noble M, Wang L, Golding BT. . Journal of the American Chemical Society 2006, 128(18), 6012-6013.
    • Pratt DJ, Bentley J, Jewsbury P, Boyle FT, Endicott JA, Noble MEM. . Journal of Medicinal Chemistry 2006, 49(18), 5470-5477.
    • Holton SJ, Dairou J, Sandy J, Rodrigues-Lima F, Dupret JM, Noble MEM, Sim E. . Acta Crystallographica Section F: Structural Biology and Crystallization Communications 2005, 61(1), 14-16.
    • MacDonald N, Welburn JPI, Noble MEM, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC. . Molecular Cell 2005, 20(2), 199-211.
    • Trempe JF, Brown NR, Lowe ED, Gordon C, Campbell ID, Noble MEM, Endicott JA. . EMBO Journal 2005, 24(18), 3178-3189.
    • Kemp, S.J., Hardcastle, I.R, Ahmed, S.U., Atatreh, N.A., Barrett, P., Endicott, J.A., Golding, B.T., Griffin, R.J., Gruber, J, Hutton, C., Lunec, J., Noble, M.E.M., Reid, R.J., Riedinger, C., Smyth, L.A. . Abstracts of Papers of the American Chemical Society 2005, 230, 2735-2736.
    • Sandy J, Mushtaq A, Holton SJ, Schartau P, Noble MEM, Sim E. . Biochemical Journal 2005, 390(1), 115-123.
    • Hardcastle, I.R., Ahmed, S.U., Barrett, P.A., Endicott, J.A., Golding, B.T., Griffin, R.J., Gruber, J., Hutton, C., Kemp, S.J., Lunec, J., Noble, M.E., Riedinger, C, Smyth, L.A. . Clinical Cancer Research 2005, 11(24, Supplement 2), 9053.
    • Westwood IM, Holton SJ, Rodrigues-Lima F, Dupret JM, Bhakta S, Noble MEM, Sim E. . Biochemical Journal 2005, 385(2), 605-612.
    • Noble M, Barrett P, Endicott J, Johnson L, McDonnell J, Robertson G, Zawaira A. . Biochimica et Biophysica Acta: Proteins and Proteomics 2005, 1754(1-2), 58-64.
    • Sandy J, Holton S, Fullam E, Sim E, Noble M. . Protein Science 2005, 14(3), 775-782.
    • Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG. . Molecular Cell 2004, 13(4), 483-496.
    • Hardcastle IR, Arris CE, Bentley J, Boyle FT, Chen Y, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury, P., Menyerol, J., Mesguiche, V., Newell, D.R., Noble, M., Pratt, D., Wang, L., Whitfield, H.J. . Journal of Medicinal Chemistry 2004, 47(15), 3710-3722.
    • Potterton L, McNicholas S, Krissinel E, Gruber J, Cowtan K, Emsley P, Murshudov GN, Cohen S, Perrakis A, Noble M. . Acta Crystallographica Section D: Biological Crystallography 2004, 60(part 12), 2288-2294.
    • Holton S, Merckx A, Burgess D, Doerig C, Noble M, Endicott J. . Structure 2003, 11(11), 1329-1337.
    • Sayle, K., Bentley, J., Boyle, F., Calvert, A. H., Cheng, Y., Curtin, N. J., Endicott, J., Golding, B., Hardcastle, I., Jewsbury, P., Mesguiche, V., Newell, D. R., Noble, M., Parsons, R., Pratt, D., Wang, L., Griffin, R. J. . Bioorganic and Medicinal Chemistry Letters 2003, 13(18), 3079-3082.
    • Kawamura A, Sandy J, Upton A, Noble M, Sim E. . Protein Expression and Purification 2003, 27(1), 75-84.
    • Hoellerer MK, Noble MEM, Labesse G, Campbell ID, Werner JM, Arold ST. . Structure 2003, 11(10), 1207-1217.
    • Sim E, Pinter K, Mushtaq A, Upton A, Sandy J, Bhakta S, Noble M. . Biochemical Society Transactions 2003, 31(3), 615-619.
    • Mettey Y, Gompel M, Thomas V, Garnier M, Leost M, Ceballos-Picot I, Noble M, Endicott J, Vierfond JM, Meijer L. . Journal of Medicinal Chemistry 2003, 46(2), 222-236.
    • Mesguiche, V, Parsons, R.J., Arris, C.E., Bentley, J., Boyle, F., Curtin, N.J., Davies, T.G., Endicott, J., Gibson, A., Golding, B., Griffin, R.J., Jewsbury, P., Johnson, L.N., Newell, D.R., Noble, M.E.M., Wang, L., Hardcastle, I.R. . Bioorganic and Medicinal Chemistry Letters 2003, 13(2), 217-222.
    • Sandy J, Mushtaq A, Kawamura A, Sinclair J, Sim E, Noble M. . Journal of Molecular Biology 2002, 318(4), 1071-1083.
    • Davies T, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott J, Gibson A, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J.A., Wang, L., Whitfield, H.J. . Nature Structural Biology 2002, 9(10), 745-749.
    • Lowe ED, Tews I, Cheng KY, Brown NR, Gul S, Noble MEM, Gamblin SJ, Johnson LN. . Biochemistry 2002, 41(52), 15625-15634.
    • Leng XH, Noble M, Adams PD, Qin J, Harper JW. . Molecular and Cellular Biology 2002, 22(7), 2242-2254.
    • Gibson A, Arris CE, Bentley J, Boyle F, Curtin NJ, Davies T, Endicott J, Golding BT, Grant S, Griffin R, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J., Whitfield, H.J. . Journal of Medicinal Chemistry 2002, 45(16), 3381-3393.
    • Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble MEM. . Journal of Biological Chemistry 2001, 276(20), 17199-17205.
    • Davies TG, Endicott JA, Johnson LN, Noble ME, Arris CE, Bentley J, Calvert AH, Curtin NJ, Golding BT, Griffin RJ, Hardcastle IH, Mesguiche V, Newell H, Parsons RJ, Whitfield HJ, Boyle T, Jewsbury P. . Cellular and Molecular Biology Letters 2001, 6(2B), 470.
    • Davies TG, Endicott JA, Noble ME, Johnson LN, Arris CE, Bentley J, Boyle FT, Calvert AH, Curtin NJ, Jewsberry PJ, Gibson AE, Golding BT, Griffin RJ, Hardcastle I, Mesguiche V, Parsons R, Whitfield H, Newell DR. . Cellular and Molecular Biology Letters 2001, 6(2B), 514-515.
    • Song HW, Hanlon N, Brown NR, Noble MEM, Johnson LN, Barford D. . Molecular Cell 2001, 7(3), 615-626.
    • Davies TG, Tunnah P, Meijer L, Marko D, Eisenbrand G, Endicott JA, Noble MEM. . Structure 2001, 9(5), 389-397.
    • Lawrie AM, Tito P, Hernandez H, Brown NR, Robinson CV, Endicott JA, Noble MEM, Johnson LN. . Protein Expression and Purification 2001, 23(2), 252-260.
    • Bentley J, Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury PJ, Johnson LN, Noble MEM, Newell DR. . Clinical Cancer Research 2000, 6, 328.
    • Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Garman EF, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury P, Johnson LN, Lawrie AM, Newell DR, Noble MEM, Sausville EA, Schultz R, Yu W. . Journal of Medicinal Chemistry 2000, 43(15), 2797-2804.
    • Griffin RJ, Arris CE, Calvert AH, Curtin NJ, Jewsbury P, Endicott JA, Gibson AE, Boyle FT, Golding BT, Grant S, Johnson LN, Noble MEM, Newell DR, Lawrie A. . Abstracts of Papers of the American Chemical Society 2000, 219(2), U55 296-MEDI.
    • Legraverend M, Tunnah P, Noble M, Ducrot P, Ludwig O, Grierson DS, Leost M, Meijer L, Endicott J. . Journal of Medicinal Chemistry 2000, 43(7), 1282-1292.
    • Sim E, Payton M, Noble M, Minchin R. . Human Molecular Genetics 2000, 9(16), 2435-2441.
    • Brown NR, Noble MEM, Endicott JA, Johnson LN. . Nature Cell Biology 1999, 1(7), 438-443.
    • Johnson LN, Noble MEM, Barford D, Brown N, Endicott JA, Lawrie A, Owen DJ. . Journal of the Chemical Society of Pakistan 1999, 21(3), 185-201.
    • Hoessel R, Leclerc S, Endicott JA, Noble MEM, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang WC, Eisenbrand G, Meijer L. . Nature cell biology 1999, 1(1), 60-67.
    • Arris CE, Boyle FT, Calvert AH, Curtin NJ, Dewsbury PJ, Endicott JA, Gibson AE, Golding BT, Grant S, Griffin RJ, Johnson, L. N., Noble, M. E. M., Newell, D. R., Sausville, E., Schultz, R. . British Journal of Cancer 1999, 80(Supplement 2), 11 no. 110.
    • Brown NR, Noble MEM, Lawrie AM, Morris MC, Tunnah P, Divita G, Johnson LN, Endicott JA. . Journal of Biological Chemistry 1999, 274(13), 8746-8756.
    • Endicott JA, Noble MEM, Tucker JA. . Current Opinion in Structural Biology 1999, 9(6), 738-744.
    • Skamnaki VT, Owen DJ, Noble MEM, Lowe ED, Lowe G, Oikonomakos NG, Johnson LN. . Biochemistry 1999, 38(4), 14718-14730.
    • Newell, D. R., Arris, C. E., Boyle, F. T., Calvert, A. H., Curtin, N. J., Dewsbury, P., Endicott, J. A., Garman, E. F., Gibson, A. E., Golding, B. T., Griffin, R. J., Johnson, L. N., Lawrie, A., Noble, M. E. M., Sausville, E. A., Schultz, R. . Clinical Cancer Research 1999, 5(Supplement 1), S3755 no. 124.
    • Gregoriou M, Noble MEM, Watson KA, Garman EF, Krulle TM, DelaFuente C, Fleet GWJ, Oikonomakos NG, Johnson LN. The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 angstrom resolution and 100 K: The role of the water structure and its contribution to binding. Protein Science 1998, 7(4), 915-927.
    • Johnson LN, Lowe ED, Noble MEM, Owen DJ. The structural basis for substrate recognition and control by protein kinases. FEBS Letters 1998, 430(1-2), 1-11.
    • Endicott JA, Noble MEM. . Structure 1998, 6(5), 535-541.
    • Sinclair JC, Delgoda R, Noble MEM, Jarmin S, Goh NK, Sim E. Purification, characterization, and crystallization of an N-hydroxyarylamine O-acetyltransferase from Salmonella typhimurium. Protein Expression and Purification 1998, 12(3), 371-380.
    • Lowe ED, Noble MEM, Skamnaki VT, Oikonomakos NG, Owen DJ, Johnson LN. The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. EMBO Journal 1997, 16(22), 6646-6658.
    • Owen DJ, Noble MEM, Garman EF, Papageorgiou AC, Johnson LN. Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product. Structure 1995, 3(5), 467-482.
    • Endicott JA, Noble ME, Garman EF, Brown N, Rasmussen B, Nurse P, Johnson LN. . EMBO Journal 1995, 14(5), 1004-1014.
    • Brown NR, Noble MEM, Endicott JA, Garman EF, Wakatsuki S, Mitchell E, Rasmussen B, Hunt T, Johnson LN. . Structure 1995, 3(11), 1235-1247.
    • Bourne Y, Arvai AS, Bernstein SL, Watson MH, Reed SI, Endicott JE, Noble ME, Johnson LN, Tainer JA. . Proceedings of the National Academy of Sciences 1995, 92(22), 10232-10236.
    • Kishan R, Zeelen JP, Noble MEM, Borchert TV, Mainfroid V, Goraj K, Martial JA, Wierenga RK. Modular mutagenesis of a TEM-barrel enzyme: the crystal structure of a chimeric E.coli TIM having the eighth βα-unit replaced by the equivalent unit of chicken TIM. Protein Engineering 1994, 7(8), 945-951.
    • Kishan KVR, Zeelen JP, Noble MEM, Borchert TV, Wierenga RK. Comparison of the structures and the crystal contacts of trypanosomal triosephosphate isomerase in four different crystal forms. Protein Science 1994, 3(5), 779-787.
    • Noble MEM, Cleasby A, Johnson LN, Egmond MR, Frenken LGJ. Analysis of the structure of Pseudomonas glumae lipase. Protein Engineering 1994, 7(4), 559-562.
    • Noble MEM, Cleasby A, Johnson LN, Egmond MR, Frenkenb LGJ. The crystal structure of triacylglycerol lipase from Pseudomonas glumae reveals a partially redundant catalytic aspartate. FEBS Letters 1993, 331(1-2), 123-128.
    • Noble MEM, Zeelen JP, Wierenga RK. Structures of the “open” and “closed” state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: Implications for the reaction mechanism. Proteins: Structure, Function, and Bioinformatics 1993, 16(4), 311-326.
    • Noble MEM, Zeelen JP, Wierenga RK, Mainfroid V, Goraj K, Gohimont AC, Martial JA. Structure of triosephosphate isomerase from Escherichia coli determined at 2.6 Å resolution. Acta Crystallographica Section D: Biological Crystallography 1993, 49(part 4), 403-417.
    • Mainfroid V, Goraj K, Rentierdelrue F, Houbrechts A, Loiseau A, Gohimont AC, Noble MEM, Borchert TV, Wierenga RK, Martial JA. Replacing the (βα)-unit 8 of E.coli TIM with its chicken homologue leads to a stable and active hybrid enzyme. Protein Engineering 1993, 6(8), 893-900.
    • Borchert TV, Pratt K, Zeelen JP, Callens M, Noble MEM, Opperdoes FR, Michels PAM, Wierenga RK. Overexpression of trypanosomal triosephosphate isomerase in Escherichia coli and characterisation of a dimer-interface mutant. European Journal of Biochemistry 1993, 211(3), 703-710.
    • Noble MEM, Musacchio A, Saraste M, Courtneidge SA, Wierenga RK. Crystal structure of the SH3 domain in human Fyn; comparison of the three-dimensional structures of SH3 domains in tyrosine kinases and spectrin. EMBO Journal 1993, 12(7), 2617-2624.
    • Wierenga RK, Zeelen JP, Noble MEM. Crystal transfer experiments carried out with crystals of tryanosomal triosephosphate isomerase (TIM). Journal of Crystal Growth 1992, 122(1-4), 231-234.
    • Musacchio A, Noble M, Pauptit R, Wierenga R, Saraste M. Crystal structure of a Src-homology 3 (SH3) domain. Nature 1992, 359(6398), 851-855.
    • Wierenga RK, Noble MEM, Davenport RC. Comparison of the refined crystal structures of liganded and unliganded chicken, yeast and trypanosomal triosephosphate isomerase. Journal of Molecular Biology 1992, 224(4), 1115-1126.
    • Wierenga RK, Noble MEM, Postma JPM, Groendijk H, Kalk KH, Hol WGJ, Opperdoes FR. The crystal structure of the open and the closed conformation of the flexible loop of trypanosomal triosephosphate isomerase. Proteins 1991, 10(1), 33-49.
    • Noble MEM, Wierenga RK, Lambeir AM, Opperdoes FR, Thunnissen AMWH, Kalk KH, Groenjijk H, Hol WGJ. The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of 3 different complexes. Proteins 1991, 10(1), 50-69.
    • Wierenga RK, Noble MEM, Vriend G, Nauche S, Hol WGJ. Refined 1.83 Å structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 m-ammonium sulphate: A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex. Journal of Molecular Biology 1991, 220(4), 995-1015.
    • Noble MEM, Verlinde CLMJ, Groendijk H, Kalk KH, Wierenga RK, Hol WGJ. Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate. Journal of Medicinal Chemistry 1991, 34(9), 2709-2718.
    • Verlinde CLMJ, Noble MEM, Kalk KH, Groendijk H, Wierenga RK, Hol WGJ. Anion binding at the active site of trypanosomal triosephosphate isomerase: Monohydrogen phosphate does not mimic sulphate. European Journal of Biochemistry 1991, 198(1), 53-57.

  • Book Chapter

    • Martin MP, Endicott JA, Noble MEM, Tatum NJ. . In: Methods in Enzymology. San Diego: Academic Press Inc, 2023, pp.211-234.

  • Conference Proceedings (inc. Abstracts)

    • Willmore E, Ahn M, Bevan L, Kyle S, Zhao Y, Thomas H, Rankin KS, Bevan L, Fazal L, Hearn K, Wilsher N, Kucia-Tran J, Ferrari N, Wallis N, Thompson N, Lyons J, Miller D, Cano C, Noble M, Hardcastle I, Howard S, Chessari G, Lunec J, Newell DR, Wedge S. . In: Proceedings of the American Association for Cancer Research Annual Meeting 2024. 2024, San Diego, California: AACR.
    • Ahn M, Bevan L, Buck I, Cano C, Castro J, Cons B, Endicott J, Fazal L, Ferrari N, Hardcastle I, Hearn K, Holvey R, Howard S, Johnson C, Jennings C, Kucia-Tran J, Kyle S, Lunec J, Lyons J, Miller D, Rees D, Noble M, Newell DR, Reeks J, Saini H, St Denis J, Tamanini E, Thomas H, Thompson N, Vinkovic M, Ward G, Wallis N, Walton H, Wedge S, Williams P, Willmore E, Wilshire N, Zhao Y, Chessari G. . In: American Association for Cancer Research Annual Meeting. 2024, San Diego: AACR Journals.
    • Unterlass JE, Aljufri N, Bex S, Cano C, Noble MEM, Curtin NJ. . In: AACR 106th Annual Meeting 2015. 2015, Philadelphia, PA, USA: American Association for Cancer Research.
    • Massa BC, Martin MP, Noble ME, Endicott JA. . In: AACR 106th Annual Meeting 2015. 2015, Philadelphia, USA: American Association for Cancer Research.
    • Martin M, Anscombe E, Meschini E, Staunton D, Geitmann M, Danielson UH, Wang LZ, Vidal RM, Reuillon T, Golding BT, Newell DR, Wedge S, Noble MEM, Endicott JA, Griffin RJ. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
    • Shouksmith AE, Evans LE, Griffin RJ, Golding BT, Newell H, Miller DC, Noble MEM, Endicott JA, Tweddle D. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, Texas: American Chemical Society.
    • Lebraud H, Golding BT, Meschini E, Cano C, Anscombe E, Wang LZ, Endicott JA, Noble MEM, Newell DR, Griffin RJ. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, Texas: American Chemical Society.
    • Anil B, Blackburn E, Blackburn T, Cully S, Liu J, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lunec J, Newell DR, Revill CH, Riedinger C, Watson AF, Xu Q, Zhao Y, Hardcastle IR, Noble MEM. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
    • Cully SJ, Blackburn TJ, Cano C, Golding BT, Griffin RJ, Lunec J, Newell D, Noble M, Zhao Y, Hardcastle IR. . In: 245th ACS National Meeting and Exposition. 2013, New Orleans, Louisiana: American Chemical Society.
    • Brami-Cherrier K, Gervasi N, Arsenieva D, Boutterin MC, Ortega A, Seantier B, Gasmi L, Bouceba T, Noble MEM, Girault JA, Arold ST. . In: Biophysical Society 57th Annual Meeting. 2013, Philadelphia, Pennsylvania: Cell Press.
    • Carbain B, Roche C, Endicott JA, Golding BT, Hardcastle IR, Cano C, Zhen-Wang L, Newell DR, Noble MEM, Griffin RJ. . In: European Journal of Cancer Supplements: 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2010, Berlin: Elsevier.
    • Abuhammad AM, Lowe ED, Fullam E, Noble M, Schweichler J, Garman EF, Sim E. . In: Drug Metabolism Reviews: 9th International Meeting of the International Society for the Study of Xenobiotics(ISSX). 2010, Istanbul, Turkey: Informa Healthcare.
    • Echalier A, Endicott JA, Noble MEM. . In: BBA - Proteins and Proteomics: 6th International Conference on Inhibitors of Protein Kinases (IPK). 2010, Warsaw, Poland: Elsevier BV.
    • Meschini E, Endicott JA, Golding BT, Hardcastle IR, Newell DR, Noble MEM, Wang LZ, Griffin RJ. . In: Abstracts of Papers of the American Chemical Society. 2010, American Chemical Society.
    • Watson AF, Golding BT, Griffin RJ, Hutton C, Liu JF, Lug XH, Lunec J, Newell DR, Valeur E, Hardcastle IR. . In: Abstracts of Papers of the American Chemical Society: 236th National Meeting of the American Chemical Society. 2008, Philadelphia, Pennsylvania, USA: American Chemical Society.
    • Fielder HL, Seyfried NT, Noble M, Day AJ. . In: International Journal of Experimental Pathology: Joint British Society for Matrix Biology/Biochemical Society Focused Meeting. 2007, Sheffield Hallam University, Sheffield: Blackwell Publishing.
    • Echalier A, Endicott JA, Johnson LN, McDonnell J, Noble MEM. . In: European Journal of Pharmaceutical Sciences: 18th Helsinki Drug Research. 2006, Helsinki, Finland: Elsevier BV.
    • Henderson A, Cheng YZ, Curtin NJ, Endicott JA, Golding BT, Griffin RJ, Hardcastle IR, Newell DR, Noble MEM, Wang LZ. . In: 230th National Meeting of the American Chemical Society. 2005, Washington, District of Columbia, USA: Abstracts of Papers of The American Chemical Society: American Chemical Society.
    • Griffin RJ, Henderson AJ, Cheng YZ, Curtin NJ, Endicott JA, Golding BT, Hardcastle IR, Newell DR, Noble ME, Wang LZ. . In: AACR/NCI/EORTC International Conference on Molecular Targets and Cancer Therapeutics. 2005, Philadelphia, Pennsylvania, USA: Clinical Cancer Research: American Association for Cancer Research.
    • Sandy J, Holton S, Noble MEM, Sim E. . In: Drug Metabolism Reviews: 7th European ISSX Meeting. 2004, Vancouver, Canada: Taylor & Francis.
    • Endicott JA, Merckx A, Hofmann G, Noble MEM. . In: International Meeting on Indirubin, the Red Shade of Indigo. 2003, Musée National de Préhistoire, Les Eyzies-de-Tayac, France: Editions "Life in Progress".
    • Davies TG, Pratt DJ, Endicott JA, Johnson LN, Noble MEM. . In: Pharmacology & Therapeutics: 2nd International Confernce on Inhbitors of Protein Kinases. 2002, Warsaw, Poland: Elsevier Inc.
    • Johnson LN, DeMoliner E, Brown NR, Song HW, Barford D, Endicott JA, Noble MEM. . In: Pharmacology & Therapeutics: 2nd International Confernce on Inhbitors of Protein Kinases. 2002, Warsaw, Poland: Elsevier Inc.
    • Sayle KL, Mesguishe V, Parsons RJ, Bentley J, Davies TG, Endicott JA, Noble MEM, Wang LZ, Hardcastle IR, Golding BT. . In: European Journal of Cancer: 14th EORTC/NCI/AACR Symposium on Molecular Targets and Cancer Therapeutics. 2002, Frankfurt, Germany: Pergamon.
    • Noble MEM, Endicott JA. . In: Pharmacology & Therapeutics: 1st International Conference on Inhibitors of Protein Kinases (IPK). 1999, Warsaw, Poland: Elsevier Inc.
    • Grant S, Boyle F, Calvert AH, Curtin NJ, Endicott J, Golding BT, Griffin RJ, Johnson LN, Newell DR, Noble MEM, Robson CN. . In: 10th NCI-EORTC Symposium on New Drugs in Cancer Therapy. 1998, Amsterdam, The Netherlands: Annals of Oncology: Oxford University Press.
    • Endicott J, Noble M, Lawrie A, Tunnah P, Brown N, Johnson L, Calvert AH, Curtin NJ, Golding BT, Griffin RJ, Newell DR. . In: 10th NCI-EORTC Symposium on New Drugs in Cancer Therapy. 1998, Amsterdam, The Netherlands: Annals of Oncology: Oxford University Press.
    • Johnson LN, Brown NR, Endicott JA, Lawrie AM, Lowe ED, Noble MEM, Tunnah P. . In: FASEB Journal. 1997, Federation of American Societies for Experimental Biology.
    • Johnson LN, Barford D, Owen DJ, Noble MEM, Garman EF. . In: Signal Transduction in Health and Disease: 9th International Conference on Second Messengers and Phosphoproteins. 1997, Nashville, Tennessee, USA: Lippincott Williams and Wilkins.
    • Egmond MR, Antheunisse WP, vanBemmel CJ, Ravestein P, Frenken LGJ, Noble MEM, Johnson LN. . In: Engineering of/with Lipases: NATO Advanced Study Institute on Engineering of/with Lipases. 1996, Povoa de Varzim, Portugal: Springer.
    • Wierenga RK, Borchert TV, Noble MEM. Crystallographic binding studies with triosephosphate isomerases: Conformational changes induced by substrate and substrate-analogues. In: FEBS Letters: 21st Meeting of the Federation of European Biochemical Societies. 1992, Dublin, Ireland: Elsevier BV.
    • Opperdoes FR, Wierenga RK, Noble MEM, Hol WGJ, Willson M, Kuntz DA, Callens M, Perie J. Unique properties of glycosomal enzymes. In: Parasites: Molecular Biology, Drug and Vaccine Design. 1989, Keystone, Colorado: Wiley-Liss.

  • Editorial

    • Noble M, Ladbury JE. . Current Opinion in Structural Biology 2011, 21(6), 775-776.

  • Letters

    • Adams PD, Afonine PV, Baskaran K, Berman HM, Berrisford J, Bricogne G, Brown DG, Burley SK, Chen M, Feng Z, Flensburg C, Gutmanas A, Hoch JC, Ikegawa Y, Kengaku Y, Krissinel E, Kurisu G, Liang Y, Liebschner D, Mak L, Markley JL, Moriarty NW, Murshudov GN, Noble M, Peisach E, Persikova I, Poon BK, Sobolev OV, Ulrich EL, Velankar S, Vonrhein C, Westbrook J, Wojdyr M, Yokochi M, Young JY. . Acta Crystallographica Section D: Structural Biology 2019, 75(4), 451-454.
    • Sinclair JC, Davies KM, Venien-Bryan C, Noble MEM. . Nature Nanotechnology 2012, 6(9), 558-562.
    • Sinclair JC, Sandy J, Delgoda R, Sim E, Noble MEM. . Nature Structural Biology 2000, 7(7), 560-564.
    • Lawrie AM, Noble MEM, Tunnah P, Brown NR, Johnson LN, Endicott JA. . Nature Structural Biology 1997, 4(10), 796-801.

  • Note

    • Owen DJ, Papageorgiou AC, Garman EF, Noble MEM, Johnson LN. Expression, purification and crystallisation of phosphorylase kinase catalytic domain. Journal of Molecular Biology 1995, 246(3), 374-381.

  • Patents

    • Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, StDenis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DW, Mitchell DR, Griffin RJ. . WO2017055860, 2017.
    • Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, StDenis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DW, Mitchell DR, Griffin RJ. . WO/2017055859, 06/04/2017.
    • Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, St Denis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Griffin RJ, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DR. . PCT/GB2016/053041, 06/04/2017.
    • Reuillon T, Miller D, Myers S, Molyneux L, Cano C, Hardcastle I, Griffin R, Rigoreau L, Golding B, Noble M. . WO/2016/042341, 24/03/2016.

  • Reviews

    • Watt J, Martin MP, Endicott JA, Noble MEM. . Current Opinion in Structural Biology 2025, 90, 102982.
    • Endicott JA, Noble MEM, Johnson LN. . Annual Review of Biochemistry 2012, 81, 587-613.
    • Pratt DJ, Endicott JA, Noble MEM. . Current Opinion In Drug Discovery & Development 2004, 7(4), 428-436.
    • Noble MEM, Endicott JA, Johnson LN. . Science 2004, 303(5665), 1800-1805.
    • Noble MEM, Endicott JA, Brown NR, Johnson LN. . Trends in Biochemical Sciences 1997, 22(12), 482-487.
    • Johnson LN, Noble MEM, Owen DJ. Active and inactive protein kinases: Structural basis for regulation. Cell 1996, 85(2), 149-158.