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Staff Profile

Professor Matthew Wright

  • Address: Liver Research Group
    Translational and Clinical Research Institute
    4th Floor (M4.145), Leech Building
    Medical School
    Â鶹´«Ã½
    Â鶹´«Ã½ Upon Tyne
    NE2 4HH
Background

Introduction


For a short video about recent research work we are doing, go to: 


ResearchGate: 

 

Background

Research background in Toxicology and cytochromes P450. General interests are in the liver cell differentiation and liver disease.

Qualifications

BSc PhD

Memberships

British Toxicology Society (BTS).

Honours and Awards

British Association for the Study of the Liver – Young Investigator of the Year (2000).

Fellow of the British Toxicology Society (FBTS)

Malcolm Blackwell Award (2023)



Research

Research Interests

Liver Biology, Liver Fibrosis, Stem/Progenitor Cells and the Liver

Other Expertise

Pharmacology, Toxicology

Current Work

Role of the PXR in modulating liver fibrosis; developing imaging techniques for liver fibrosis; Hepatocyte differentiation.  Environment and liver disease.


See

Postgraduate Supervision

Currently 3 PhD Students - in Liver Biology and Disease.

Esteem Indicators

Guest Editor - Special issues for the journal Toxicology (2007-2010)

Elected to the British Association for the Study of the Liver Committee (2001-2004).

Member of the Scientific Sub-Committee of the British Toxicology Society (2003-2008).

Member of the Executive Committee of the British Toxicology Society (2009-2012).

Member of the ANS Panel, EFSA (2011-2018).

Member of the FAF Panel, EFSA (2020-present)

Associate Editor, Toxicology (2018-present)

Funding

Newton Mosharafa

Patents

Patent Application -Wright MC, Porter A. (13-10-2005). WO2005095453. Specific binding members against synaptophysin - a human antibody to hepatic stellate cells for targeting drugs / imaging agents for liver fibrosis treatment.

Teaching

Undergraduate Teaching

Pharmacology PED2001

Toxicology PED3011

Postgraduate Teaching

MRes in Toxicology - Course co-ordinator - (MMB8032)

MRes Cell cycle control and cell signalling pathways in health and disease (PGY8003)

MRes Stem cells and regenerative medicine (MMB8022)

MRes in Medical & Molecular Biosciences (PGY8003)

Publications

  • Articles

    • Abdelghany TM, Hedya SA, Charlton A, Aljehani FA, Alanazi K, Budastour AA, Marin L, Wright MC. . Food and Chemical Toxicology 2024, 188, 114681.
    • Pringle TA, Ramon-Gil E, Leslie J, Oakley F, Wright MC, Knight JC, Luli S. . Scientific Reports 2024, 14, 633.
    • Abdelghany TM, Hedya S, Charlton A, Fan L, Fazili N, Air B, Leitch AC, Cooke M, Bronowska AK, Wright MC. . Chemosphere 2024, 363, 142827.
    • Hedya S, Charlton A, Leitch AC, Aljehani FA, Pinker B, Wright MC, Abdelghany TM. . Toxicology in Vitro 2023, 88, 105550.
    • Abdelghany TM, Hedya SA, De Santis C, Abd El-Rahman SS, Gill JH, Abdelkader NF, Wright MC. . Ecotoxicology and Environmental Safety 2023, 249, 114439.
    • Younes M, Aquilina G, Castle L, Degen G, Fowler PJ, Fernandez MJF, Fürst P, Gundert-Remy U, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens-Berendsen I, Wölfle D, Wright M, Benigni R, Bolognesi C, Boon P, Chipman K, De Knecht J, Nørby K, Arcella D, Barmaz S, Carfì M, Laganaro M, Martino C, Tard A, Vianello G, Engel K-H. . EFSA Journal 2022, 20(12), e07673.
    • Moulding S, Figueiredo R, Sewpaul A, Leitch A, Bates L, Wright M, Wilson C. . Transplantation Proceedings 2022, 54(3), 600-604.
    • Leitch AC, Ibrahim I, Abdelghany TM, Charlton A, Roper C, Vidler D, Palmer JM, Wilson C, Jones DE, Blain PG, Wright MC. . Toxicology 2021, 459, 152854.
    • Leitch AC, Abdelghany TM, Probert PM, Dunn MP, Meyer SK, Palmer JM, Cooke MP, Blake LI, Morse K, Rosenmai AK, Oskarsson A, Bates L, Figueiredo RS, Ibrahim I, Wilson C, Abdelkader NF, Jones DE, Blain PG, Wright MC. . Food and Chemical Toxicology 2020, 136, 111069.
    • Leitch AC, Abdelghany TM, Charlton A, Grigalyte J, Oakley F, Borthwick LA, Reed L, Knox A, Reilly WJ, Agius L, Blain PG, Wright MC. . Ecotoxicology and Environmental Safety 2020, 202, 110902.
    • Abdelghany TM, Leitch AC, Nevjestic I, Ibrahim I, Miwa S, Wilson C, Heutz S, Wright MC. . Food and Chemical Toxicology 2020, 145, 111593.
    • Young GR, Abdelghany TM, Leitch AC, Dunn MP, Blain PG, Lanyon C, Wright MC. . PLoS ONE 2020, 15(3), 0229745.
    • Amer A, McColl K, Bouayyad S, Kanwar A, Sen G, French JJ, Wilson CH, Manas DM, Wright MC, White SA. . Clinical Transplantation 2019, 33(12), e13734.
    • Oskarsson A, Wright MC. . Environmental Science & Technology 2019, 53(18), 10539-10541.
    • Alsaeedi F, Wilson R, Candlish C, Ibrahim I, Leitch AC, Abdelghany TM, Wilson C, Armstrong L, Wright MC. . PloS One 2019, 14(6), e0218135.
    • Leitch AC, Lakey AF, Hotham WE, Agius L, Kass GE, Blain PG, Wright MC. . Biochemical and Biophysical Research Communications 2018, 503(3), 2167-2178.
    • Probert PM, Leitch AC, Dunn MP, Meyer SK, Palmer JM, Abdelghany TM, Lakey AF, Cooke MP, Talbot H, Wills C, McFarlane W, Blake LI, Rosenmai AK, Oskarsson A, Figueiredo R, Wilson C, Kass GE, Jones DE, Blain PG, Wright MC. . Journal of Hepatology 2018, 69(5), 1123-1135.
    • Fairhall EA, Leitch AC, Lakey AF, Abdelghany TM, Ibrahim I, Tosh D, Kass GE, Wilson C, Wright MC. . Biochemical and Biophysical Research Communications 2018, 503(3), 1633-1640.
    • Radwan MA, AlQuadeib BT, Siller L, Wright MC, Horrocks B. . Drug Delivery 2017, 24(1), 40-50.
    • Meyer SK, Probert PME, Lakey AF, Axon AR, Leitch AC, Williams FM, Jowsey PA, Blain PG, Kass GEN, Wright MC. . Toxicology Letters 2017, 273, 55-68.
    • Meyer SK, Probert PME, Lakey AK, Leitch A, Blake LI, Jowsey PA, Cooke MP, Blain PG, Wright MC. . Toxicological Sciences 2017, 156(1), 54-71.
    • Leitch AC, Probert PME, Shayman JA, Meyer SK, Kass GEN, Wright MC. . Toxicology 2017, 386, 120-132.
    • Probert PM, Palmer JM, Alhusainy W, Amer AO, Rietjens IMCM, White SA, Jones DE, Wright MC. . Toxicology Letters 2016, 243, 98-110.
    • Richter M, Fairhall EA, Hoffmann SA, Tröbs S, Knöspel F, Probert PM, Oakley F, Stroux A, Wright MC, Zeilinger K. . Toxicology Research 2016, 5(1), 278-290.
    • Fairhall EA, Charles MA, Probert PM, Wallace K, Gibb J, Ravindan C, Soloman M, Wright MC. . PLoS ONE 2016, 11(3), e0150959.
    • Khadem F, Gao X, Mou Z, Jia P, Movasagh H, Onyilagha C, Wright MC, Uzonna JE. . Hepatology 2016, 63(2), 620-632.
    • Luli S, Di Paolo D, Perri P, Brignole C, Hill SJ, Brown H, Leslie J, Marshall HL, Wright MC, Mann DA, Ponzoni M, Oakley F. . Journal of Hepatology 2016, 65(1), 75-83.
    • Thursz M, Forrest E, Roderick P, Day C, Austin A, O'Grady J, Ryder A, Allison M, Gleeson D, McCune A, Patch D, Wright M, Masson S, Richardson P, Hood S, MacGilchrist A, Grant A, Vale L, Mellor J, Stanton L, Bowers M, Ratcliffe I, Downs N, Kirkman S, Homer T, Ternent L, Deverill M. . Health Technology Assessment 2015, 19(102).
    • Amer AO, Probert PM, Dunn M, Knight M, Vallance AE, Flecknell PA, Oakley F, Cameron I, White SA, Blain PG, Wright MC. . PLoS ONE 2015, 10(8), e0136173.
    • AL-Quadeib BT, Radwan MA, Siller L, Horrocks B, Wright MC. . Saudi Pharmaceutical Journal 2015, 23(3), 290-302.
    • Probert PM, Chung GW, Cockell SJ, Agius L, Mosesso P, White SA, Oakley F, Brown CD, Wright MC. . Toxicological Sciences 2014, 137(2), 350-370.
    • Al-Quadeib BT, Radwan MA, Siller L, Mutch E, Horrocks B, Wright M, Alshaer A. . Biomedical Chromatography 2014, 28(12), 1652-1659.
    • Fernandez JG, Rodriguez DA, Valenzuela M, Calderon C, Urzua U, Munroe D, Rosas C, Lemus D, Diaz N, Wright MC, Leyton L, Tapia JC, Quest AFG. . Molecular Cancer 2014, 13, 209.
    • Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. . PLoS One 2014, 9(1), e83391.
    • Probert PME, Ebrahimkhani MR, Oakley F, Mann J, Burt AD, Mann DA, Wright MC. . Toxicology Research 2014, 3(2), 98-109.
    • Fairhall EA, Charles MA, Wallace K, Schwab CJ, Harrison CJ, Richter M, Hoffmann SA, Charlton KA, Zeilinger K, Wright MC. . Toxicology Research 2013, 2(5), 308-320.
    • O'Boyle G, Swidenbank I, Marshall H, Barker CE, Armstrong J, White SA, Fricker SP, Plummer R, Wright M, Lovat PE. . British Journal of Cancer 2013, 108(8), 1634-1640.
    • Noormohamed MS, Kanwar A, Ray C, Wright MC, Cowie DE, Stamp S, Talbot D, Manas D, White SA. . Journal of Surgical Research 2013, 183(2), e39-e48.
    • Fairhall EA, Wallace K, White SA, Huang GC, Shaw JA, Wright SC, Charlton KA, Burt AD, Wright MC. . Toxicology Research 2013, 2(1), 80-87.
    • Axon A, May FEB, Gaughan LE, Williams FM, Blain PG, Wright MC. . Toxicology 2012, 298(1-3), 40-51.
    • Aguilar F, Crebelli R, Dusemund B, Galtier P, Gilbert J, Gott DM, Gundert-Remy U, König J, Lambré C, Leblanc J-C, Mortensen A, Mosesso P, Parent-Massin D, Stankovic I, Tobback P, Waalkens-Berendsen I, Woutersen R, Wright MC. . EFSA Journal 2012, 10(7), 2760.
    • Ebrahimkhani MR, Oakley F, Murphy LB, Mann J, Moles A, Perugorria MJ, Ellis E, Lakey AF, Burt AD, Douglass A, Wright MC, White SA, Jaffre F, Maroteaux L, Mann DA. . Nature Medicine 2011, 17(12), 1668-U189.
    • Wallace K, Long Q, Fairhall EA, Charlton KA, Wright MC. . Journal of Cell Science 2011, 124(3), 405-413.
    • Wallace K, Cowie DE, Konstantinou DK, Hill SJ, Tjelle TE, Axon A, Koruth M, White SA, Carlsen H, Mann DA, Wright MC. . Journal of Steroid Biochemistry and Molecular Biology 2010, 120(2-3), 137-148.
    • Gieling RG, Elsharkawy AM, Caamano JH, Cowie DE, Wright MC, Ebrahimkhani MR, Burt AD, Mann J, Raychaudhuri P, Liou HC, Oakley F, Mann DA. . Hepatology 2010, 51(3), 922-931.
    • Wallace K, Marek CJ, Hoppler S, Wright MC. . Journal of Cell Science 2010, 123(12), 2102-2109.
    • Wallace K, Flecknell PA, Burt AD, Wright MC. . American Journal of Pathology 2010, 177(3), 1225-1232.
    • Marek CJ, Wallace K, Durward E, Koruth M, Leel V, Leiper LJ, Wright MC. . Comparative Hepatology 2009, 8(1), -.
    • Wallace K, Marek CJ, Currie RA, Wright MC. . Journal of Steroid Biochemistry and Molecular Biology 2009, 116(1-2), 76-85.
    • Douglass A, Wallace K, Koruth M, Barelle C, Porter AJ, Wright MC. . Hepatology International 2008, 2(4), 405-415.
    • Hagens WI, Beljaars L, Mann DA, Wright MC, Julien B, Lotersztajn S, Reker-Smit C, Poelstra K. . Journal of Pharmacology and Experimental Therapeutics 2008, 324(3), 902-910.
    • Douglass A, Wallace K, Parr R, Park J, Durward E, Broadbent I, Barelle C, Porter A, Wright MC. . Journal of Hepatology 2008, 49(1), 88-98.
    • Marek CJ, Tucker SJ, Koruth M, Wallace K, Wright MC. . FEBS Letters 2007, 581(4), 781-786.
    • Wright MC. . Biochemical Society Transactions 2006, 34(6), 1119-1123.
    • Haughton EL, Tucker SJ, Marek CJ, Durward E, Leel V, Bascal Z, Monaghan T, Koruth M, Collie-Duguid E, Mann DA, Trim JE, Wright MC. . Gastroenterology 2006, 131(1), 194-209.
    • Marek CJ, Tucker SJ, Konstantinou DK, Elrick LJ, Haefner D, Sigalas C, Murray GI, Goodwin B, Wright MC. . Biochemical Journal 2005, 387(3), 601-608.
    • Oakley F, Meso M, Iredale JP, Green K, Marek CJ, Zhou X, May MJ, Millward-Sadler H, Wright MC, Mann DA. . Gastroenterology 2005, 128(1), 108-120.
    • Elrick LJ, Leel V, Blaylock MG, Duncan L, Drever MR, Strachan G, Charlton KA, Koruth M, Porter AJ, Wright MC. . Journal of Hepatology 2005, 42(6), 888-896.
    • Orr JG, Leel V, Cameron GA, Marek CJ, Haughton EL, Elrick LJ, Trim JE, Hawksworth GM, Halestrap AP, Wright MC. . Hepatology 2004, 40(1), 232-242.
    • Leel V, Elrick LJ, Solares J, Ingram N, Charlton KA, Porter AJ, Wright MC. . Biochemical and Biophysical Research Communications 2004, 316(3), 872-877.
    • Marek CJ, Cameron GA, Elrick LJ, Hawksworth GM, Wright MC. . Biochemical Journal 2003, 370(3), 763-769.
    • Vincent KJ, Jones E, Arthur MJ, Smart DE, Trim J, Wright MC, Mann DA. . Gut 2001, 49(5), 713-719.
    • Wright MC, Issa R, Smart DE, Trim N, Murray GI, Primrose JN, Arthur MJ, Iredale JP, Mann DA. . Gastroenterology 2001, 121(3), 685-698.
    • Trim JE, Samra SK, Arthur MJ, Wright MC, McAulay M, Beri R, Mann DA. . Journal of Biological Chemistry 2000, 275(9), 6657-63.
    • Hodgkinson CP, Wright MC, Paine AJ. . Molecular Pharmacology 2000, 58(5), 976-981.
    • Harvey JL, Paine AJ, Maurel P, Wright MC. . Drug Metabolism and Disposition 2000, 28(1), 96-101.
    • Goodship J, Gill H, Carter J, Jackson A, Splitt M, Wright M. . American Journal of Human Genetics 2000, 67(2), 498-503.
    • Elsharkawy AM, Wright MC, Hay RT, Arthur MJ, Hughes T, Bahr MJ, Degitz K, Mann DA. . Hepatology 1999, 30(3), 761-769.
    • Bahr MJ, Vincent KJ, Arthur MJ, Fowler AV, Smart DE, Wright MC, Clark IM, Benyon RC, Iredale JP, Mann DA. . Hepatology 1999, 29(3), 839-848.

  • Conference Proceedings (inc. Abstracts)

    • McConnell A, O'Boyle G, Wright M, Plummer R, Lovat P. . In: Annual Meeting of the British Association of Dermatologists. 2015, Glasgow, UK: Wiley-Blackwell Publishing Ltd.
    • Amer A, Vallance A, Mccoll K, Kanwar A, Wright M, White S. . In: 17th Congress of the European Society for Organ Transplantation. 2015, Brussels, Belgium: Wiley-Blackwell.
    • Luli S, Di Paolo D, Wilson C, Wright MC, Brown H, Ponzoni M, Mann D, Oakley F. . In: The Liver Meeting 2015: 66th Annual Meeting of the American Association for the Study of Liver Diseases. 2015, San Francisco: John Wiley & Sons, Inc.
    • Amer A, Vallance A, Wright M, White S. . In: 2nd Digestive Disorders Federation Conference 2015. 2015, London, UK: BMJ Group.
    • Charles M, Wallace K, Probert P, Oakley F, Wright M. . In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
    • Meyer S, Axon A, Jowsey P, Williams F, Blain P, Wright M. . In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
    • Probert P, Alhusainy W, Rietjens I, Wright M. . In: 50th Congress of the European-Societies-of-Toxicology. 2014, Edinburgh, SCOTLAND: Elsevier Ireland Ltd.
    • Probert P, Oakley F, Tosh D, Wright M. . In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh, SCOTLAND: Elsevier Ireland Ltd.
    • Fairhall E, Wallace K, Wright M. . In: 50th Congress of the European Societies of Toxicology (EUROTOX). 2014, Edinburgh: Elsevier Ireland.
    • Luli S, Hill S, Wilson CL, Wright MC, Mann DA, Oakley F. . In: The International Liver Congress 2014: 49th Annual Meeting of the European Association for the Study of the Liver. 2014, London: Elsevier BV.
    • Fairhall EA, Schwab C, Harrison C, Charlton KA, Wallace K, Wright MC. . In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier.
    • Probert PME, Ebrahimkhani MR, Oakley F, Burt AD, Mann DA, Wright MC. . In: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, Netherlands: Elsevier BV.
    • Richter M, Fairhall EA, Hoffmann SA, Fruhwald J, Wright MC, Zeilinger K. . In: International Liver Congress 2013: 48th Annual meeting of the European Association for the Study of the Liver. 2013, Amsterdam, The Netherlands: Elsevier BV.
    • Oakley F, Murphy L, Wright M, Mann D. . In: Journal of Hepatology: 46th Annual Meeting of the European Association for the Study of the Liver (EASL). 2011, Berlin, Germany: Elsevier BV.

  • Editorial

    • Wright M. . Toxicology 2010, 278(3), 249.

  • Reviews

    • Probert PME, Meyer SK, Alsaeedi F, Axon AA, Fairhall EA, Wallace K, Charles M, Oakley F, Jowsey PA, Blain PG, Wright MC. . Toxicology Research 2015, 4(2), 203-222.
    • Wallace K, Fairhall EA, Charlton KA, Wright MC. . Toxicology 2010, 278(3), 277-287.
    • Wallace K, Burt A, Wright M. . Biochemical Journal 2008, 411(1), 1-18.
    • Axon A, Cowie DE, Mann DA, Wright MC. . Toxicology 2008, 246(1), 40-44.