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Staff Profile

Najib Naamane

Bioinformatician

  • Address: 3rd Floor, William Leech Building, M3.127
    Translational and Clinical Research Institute
    Musculoskeletal Research Group
    The Medical School, Â鶹´«Ã½
    Â鶹´«Ã½ upon Tyne NE2 4HH
Publications

  • Articles

    • Gumber L, Rayner F, Bigirumurame T, Dyke B, Melville A, Kerrigan S, McGucken A, Naamane N, Prichard J, Buckley CD, Filer A, McInnes IB, Raza K, Siebert S, Wason JMS, Ng W-F, Anderson AE, Isaacs JD, Baker KF, Pratt AG. . RMD Open 2025, 11(2), e005442.
    • Cooles FAH, Vidal Pedrola G, Naamane N, Pratt AG, Barron-Millar B, Anderson AE, Hilkens CMU, Casement J, Bondet V, Duffy D, Zhang F, Shukla R, Isaacs JD. . Arthritis and Rheumatology 2025, 77(6), 646-657.
    • Brown PM, Anderson AE, Naamane N, Lendrem DW, Morgan AW, Isaacs JD, Pratt AG. . RMD Open 2024, 10(1), e003858.
    • Vaskimo LM, Gomon G, Naamane N, Cordell HJ, Pratt A, Knevel R. . Genes 2023, 14(12), 2167.
    • Vidal-Pedrola G, Naamane N, Cameron JA, Pratt AG, Mellor AL, Isaacs JD, Scheel-Toellner D, Anderson AE. . Immunology 2023, 168(4), 640-653.
    • Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CMA, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD. . Annals of the Rheumatic Diseases 2022, 81(9), 1214-1223.
    • Howey R, Clark AD, Naamane N, Reynard LN, Pratt AG, Cordell HJ. . PLOS Genetics 2021, 17(9), e1009811.
    • Clark AD, Nair N, Anderson AE, Thalayasingam N, Naamane N, Skelton AJ, Diboll J, Barton A, Eyre S, Isaacs JD, Pratt AG, Reynard LN. . Journal of Allergy and Clinical Immunology 2020, 145(5), 1438-1451.
    • Ridgley LA, Anderson AE, Maney NJ, Naamane N, Skelton AJ, Lawson CA, Emery P, Isaacs JD, Carmody RJ, Pratt AG. . Frontiers in Immunology 2019, 10, 1535.
    • Lendrem BC, Lendrem DW, Pratt AG, Naamane N, McMeekin P, Ng W-F, Allen AJ, Power M, Isaacs JD. . Pharmaceutical Statistics 2019, 18(6), 632-635.
    • Cunha DA, Gurzov EN, Naamane N, Ortis F, Cardozo AK, Bugliani M, Marchetti P, Eizirik DL, Cnop M. . Cell Death & Differentiation 2014, 21(8), 1313-24.
    • Wolden-Kirk H, Overbergh L, Gysemans C, Brusgaard K, Naamane N, VanLommel L, Schuit F, Eizirik DL, Christesen H, Mathieu C. . Journal of Steroid Biochemistry and Molecular Biology 2013, 136, 68-79.
    • Gurzov EN, Barthson J, Marhfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, Ørntoft TF, Bakiri L, Wagner EF, Eizirik DL. Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation. Oncogene 2012, 31(13), 1723-32.
    • Volkmar M, Dedeurwaerder S, Cunha DA, Ndlovu MN, Defrance M, Deplus R, Calonne E, Volkmar U, Igoillo-Esteve M, Naamane N, Del-Guerra S, Masini M, Bugliani M, Marchetti P, Cnop M, Eizirik DL, Fuks F. DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients. EMBO J 2012, 31(6), 1405-26.
    • Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M. Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human beta-cell apoptosis. Diabetes 2012, 61(11), 2763-75.
    • Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Ørntoft TF, Eizirik DL. STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation. J Biol Chem 2011, 286(2), 929-41.
    • Liechti R, Csárdi G, Bergmann S, Schütz F, Sengstag T, Boj SF, Servitja JM, Ferrer J, Van-Lommel L, Schuit F, Klinger S, Thorens B, Naamane N, Eizirik DL, Marselli L, Bugliani M, Marchetti P, Lucas S, Holm C, Jongeneel CV, Xenarios I. EuroDia: a beta-cell gene expression resource. Database 2010, 2010, baq024.
    • Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL. Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells. Diabetes 2010, 59(2), 358-74.
    • Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL. Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia 2008, 51(7), 1213-25.
    • Naamane N, Helden JV, Eizirik DL. In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells. BMC bioinformatics 2007, 8, 55.
    • Pirot P, Naamane N, Libert F, Magnusson NE, Ørntoft TF, Cardozo AK, Eizirik DL. Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia 2007, 50(5), 1006-14.

  • Review

    • Kutlu B, Naamane N, Berthou L, Eizirik DL. New approaches for in silico identification of cytokine-modified beta cell gene networks. Annals of the New York Academy of Sciences 2004, 1037, 41-58.