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Staff Profile

Professor Steve Wedge

Prof of Stratified Cancer Med Discovery

Publications
  • Lebraud H, Noble R, Phillips N, Hearn K, Castro J, Zhao Y, Newell DR, Lunec J, Wedge S, Heightman TD. . Bioconjugate Chemistry 2018, 29(6), 2100-2106.
  • Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C. . Organic and Biomolecular Chemistry 2018, 16(11), 1843-1850.
  • Novo SM, Wedge SR, Stark LA. . Scientific Reports 2017, 7(1), 12020.
  • West MA, Roman A, Sayan E, Primrose JN, Wedge SR, Underwood TJ, Mirnezami AH. . Critical Reviews in Oncology/Hematology 2017, 112, 80-102.
  • Tomassini S, Gentles L, Kirk C, Cross P, Thomas H, Wedge S, Curtin NJ, O'Donnell RL. . In: BASO - The Association for Cancer Surgery Annual Scientific Conference and the NCRI Cancer Conference. 2017, Liverpool: Elsevier.
  • Jones D, Noble M, Wedge SR, Robson CN, Gaughan L. . Scientific Reports 2017, 7, 40957.
  • Coxon C, Anscombe E, Harnor S, Martin M, Carbain B, Golding B, Hardcastle I, Harlow L, Korolchuk S, Matheson C, Newell D, Noble M, Sivaprakasam M, Tudhope SJ, Turner D, Wang L, Wedge SR, Wong C, Griffin R, Endicott J, Cano C. . Journal of Medicinal Chemistry 2017, 60, 1746-1767.
  • Hallett ST, Pastok MW, Morgan RML, Wittner A, Blundell KLIM, Felletar I, Wedge SR, Prodromou C, Noble MEM, Pearl LH, Endicott JA. . Cell Reports 2017, 21(5), 1386-1398.
  • Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR. . Haematologica 2017, 102(7), 1247-1257.
  • Sharma RA, Plummer R, Stock JK, Greenhalgh TA, Ataman O, Kelly S, Clay R, Adams RA, Baird RD, Billingham L, Brown SR, Buckland S, Bulbeck H, Chalmers AJ, Clack G, Cranston AN, Damstrup L, Ferraldeschi R, Forster MD, Golec J, Hagan RM, Hall E, Hanauske AR, Harrington KJ, Haswell T, Hawkins MA, Illidge T, Jones H, Kennedy AS, McDonald F, Melcher T, O'Connor JPB, Pollard JR, Saunders MP, Sebag-Montefiore D, Smitt M, Staffurth J, Stratford IJ, Wedge SR, NCRI CTRad Acad-Pharma Joint Worki. . Nature Reviews. Clinical Oncology 2016, 13(10), 627-642.
  • Lochhead PA, Clark J, Wang LZ, Gilmour L, Squires M, Gilley R, Foxton C, Newell DR, Wedge SR, Cook SJ. . Cell Cycle 2016, 15(4), 506-518.
  • O'Neill D, Jones D, Wade M, Grey J, Nakjang S, Guo W, Cork D, Davies BR, Wedge SR, Robson CN, Gaughan L. . Oncotarget 2015, 6(28), 26029-26040.
  • Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble MEM, Wedge SR, Endicott JA, Griffin RJ. . Chemistry & Biology 2015, 22(9), 1159-1164.
  • Hancox U, Cosulich S, Hanson L, Trigwell C, Lenaghan C, Ellston R, Dry H, Crafter C, Barlaam B, Fitzek M, Smith PD, Ogilvie D, D'Cruz C, Castriotta L, Wedge SR, Ward L, Powell S, Lawson M, Davies BR, Harrington EA, Foster E, Cumberbatch M, Green S, Barry ST. . Molecular Cancer Therapeutics 2015, 14(1), 48-58.
  • Bell N, Blair H, Noble R, Price L, Wood K, Vormoor J, Bacon C, Rand V, Heidenreich O, Wedge S, Bomken S. . In: Fifth International Symposium on Childhood, Adolescent and Young Adult Non-Hodgkin Lymphoma. 2015, Varese, Italy: Wiley-Blackwell.
  • Martin M, Anscombe E, Meschini E, Staunton D, Geitmann M, Danielson UH, Wang LZ, Vidal RM, Reuillon T, Golding BT, Newell DR, Wedge S, Noble MEM, Endicott JA, Griffin RJ. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
  • Smith NR, Wedge SR, Pommier A, Barry ST. . Biochemical Society Transactions 2014, 42(6), 1601-1607.
  • Tudhope S, Zhao Y, Wittner A, Wilmore E, Bertoli A, Adhikari S, Harnor SJ, Del Bello F, Piergentili A, Lunec J, Hardcastle IR, Griffin RJ, Golding BR, Cano C, Newell DR, Wedge SR. . In: AACR Annual Meeting 2014. 2014, San Diego, CA: American Association for Cancer Research.
  • Smith NR, Baker D, Farren M, Pommier A, Swann R, Wang X, Mistry S, McDaid K, Kendrew J, Womack C, Wedge SR, Barry ST. . Clinical Cancer Research 2014, 20(19), 5141.
  • Bertoli A, Adhikari S, Harnor SJ, Zhao Y, Lunec J, Wedge SR, Tudhope S, Wittner A, Golding BT, Hardcastle IR, Cano C, Newell DR, Griffin RJ. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, TX, USA: American Chemical Society.
  • Kendrew J, Odedra R, Logie A, Taylor PJ, Pearsall S, Ogilvie DJ, Wedge SR, Jurgensmeier JM. . Cancer Chemotherapy and Pharmacology 2013, 71(4), 1021-1032.
  • Loddick SA, Ross SJ, Thomason AG, Robinson DM, Walker GE, Dunkley TPJ, Brave SR, Broadbent N, Stratton NC, Trueman D, Mouchet E, Shaheen FS, Jacobs VN, Cumberbatch M, Wilson J, Jones RDO, Bradbury RH, Rabow A, Gaughan L, Womack C, Barry ST, Robson CN, Critchlow SE, Wedge SR, Brooks AN. . Molecular Cancer Therapeutics 2013, 12(9), 1715-1727.
  • Smith NR, Baker D, Farren M, Pommier AJC, Swann R, Wang X, Mistry S, McDaid K, Kendrew J, Womack C, Wedge S, Barry ST. . Clinical Cancer Research 2013, n/a, n/a.
  • Keen H, Pichler B, Kukuk D, Duchamp O, Raguin O, Shannon A, Whalley N, Jacobs V, Bales J, Gingles G, Ricketts S-A, Wedge SR. . Molecular Imaging and Biology 2012, 14(3), 355-365.
  • Farren M, Weston S, Brown H, Broadbent N, Powell S, Shaw R, Smith NR, Inglis R, Graham A, Ashton S, Wedge SR, Barry ST. . Angiogenesis 2012, 15(4), 555-568.
  • Alferez DG, Goodlad RA, Odedra R, Sini P, Crafter C, Ryan AJ, Wedge SR, Wright NA, Anderson E, Wilkinson RW. . International Journal of Oncology 2012, 41(4), 1475-1485.
  • Ataman OU, Sambrook SJ, Wilks C, Lloyd A, Taylor AE, Wedge SR. . International Journal of Radiation Oncology - Biology - Physics 2012, 84(4), e447–e454.
  • Kendrew J, Eberlein CA, Blakey DC, Wedge SR, Foltz I, Kang P, Barry ST. . Molecular Cancer Therapeutics 2011, 10(5), 770-783.
  • Brave SR, Ratcliffe K, Wilson Z, James NH, Ashton S, Wainwright A, Kendrew J, Dudley P, Broadbent N, Sproat G, Taylor S, Barnes C, Silva JC, Farnsworth CL, Hennequin L, Ogilvie DJ, Jürgensmeier JM, Shibuya M, Wedge SR, Barry ST. . Molecular Cancer Therapeutics 2011, 10(5), 861-873.
  • Senra JM, Telfer BA, Cherry KE, McCrudden CM, Hirst DG, O'Connor MJ, Wedge SR, Stratford IJ. . Molecular Cancer Therapeutics 2011, 10(10), 1949-1958.
  • Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA. . British Journal of Cancer 2010, 102(11), 1555-1577.
  • Brave SR, Eberlein C, Shibuya M, Wedge SR, Barry ST. . Angiogenesis 2010, 13(4), 337-347.
  • Bradley DP, Tessier JT, Lacey T, Scott M, Jürgensmeier JM, Odedra R, Mills J, Kilburn L, Wedge SR. . Magnetic Resonance Imaging 2009, 27(3), 377-384.
  • Harrison LRE, Ottley CJ, Pearson DG, Roche C, Wedge SR, Dolan ME, Newell DR, Tilby MJ. . Biochemical Pharmacology 2009, 77(10), 1586-1592.
  • Shannon AM, Telfer BA, Smith PD, Babur M, Logie A, Wilkinson RW, Debray C, Stratford IJ, Williams KJ, Wedge SR. . Clinical Cancer Research 2009, 15(21), 6619-6629.
  • Curwen JO, Wedge SR. . Alternatives to Laboratory Animals 2009, 37(2), 173-180.
  • Morrison MS, Ricketts SA, Barnett J, Cuthbertson A, Tessier J, Wedge SR. . The Journal of Nuclear Medicine 2009, 50(1), 116-122.
  • Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA. . Molecular Cancer Therapeutics 2008, 7(3), 590-598.
  • Bradley DP, Tessier JL, Checkley D, Kuribayashi H, Waterton JC, Kendrew J, Wedge SR. . NMR in Biomedicine 2008, 21(1), 42-52.
  • Williams KJ, Telfer BA, Shannon AM, Babur M, Stratford IJ, Wedge SR. . British Journal of Radiology 2008, 81(Special issue 1), S21-S27.
  • Curwen JO, Musgrove HL, Kendrew J, Richmond GHP, Ogilvie DJ, Wedge SR. . Clinical Cancer Research 2008, 14(10), 3124-3131.
  • Foote KM, Mortlock AA, Heron NM, Jung FH, Hill GB, Pasquet G, Brady MC, Green S, Heaton SP, Kearney S, Keen NJ, Odedra R, Wedge SR, Wilkinson RW. . Bioorganic & Medicinal Chemistry Letters 2008, 18(6), 1904-1909.
  • Heckman CA, Holopainen T, Wirzenius M, Keskitalo S, Jeltsch M, Herttuala SY, Wedge SR, Jürgensmeier JM, Alitalo K. . Cancer Research 2008, 68(12), 4754-4762.
  • Wedge SR, Jürgensmeier JM. . In: Marmé, D and Fusenig, N, ed. Tumor Angiogenesis: Basic Mechanisms and Cancer Therapy. New York: Springer, 2008, pp.395-423.
  • Smith NR, James NH, Oakley I, Wainwright A, Copley C, Kendrew J, Womersley LM, Jürgensmeier JM, Wedge SR, Barry ST. . Molecular Cancer Therapeutics 2007, 6(8), 2198-2208.
  • Conrad C, Ischenko I, Köhl G, Wiegand U, Guba M, Yezhelyev M, Ryan AJ, Barge A, Geissler EK, Wedge SR, Jauch KW, Bruns CJ. . Anti-Cancer Drugs 2007, 18(5), 569-579.
  • Wilkinson RW, Odedra R, Heaton SP, Wedge SR, Keen NJ, Crafter C, Foster JR, Brady MC, Bigley A, Brown E, Byth KF, Barrass NC, Mundt KE, Foote KM, Heron NM, Jung FH, Mortlock AA, Boyle FT, Green S. . Clinical Cancer Research 2007, 13(12), 3682-3688.
  • Williams KJ, Telfer BA, Shannon AM, Babur M, Stratford IJ, Wedge SR. . Molecular Cancer Therapeutics 2007, 6(2), 599-606.
  • Mortlock AA, Foote KM, Heron NM, Jung FH, Pasquet G, Lohmann JJ, Warin N, Renaud F, DeSavi C, Roberts NJ, Johnson T, Dousson CB, Hill GB, Perkins D, Hatter G, Wilkinson RW, Wedge SR, Heaton SP, Odedra R, Keen NJ, Crafter C, Brown E, Thompson K, Brightwell S, Khatri L, Brady MC, Kearney S, McKillop D, Rhead S, Parry T, Green S. . Journal of Medicinal Chemistry 2007, 50(9), 2213–2224.
  • Jung FH, Pasquet G, Lambert-vandeBrempt C, Lohmann JJ, Warin N, Renaud F, Germain H, DeSavi C, Roberts N, Johnson T, Dousson C, Hill GB, Mortlock AA, Heron N, Wilkinson RW, Wedge SR, Heaton SP, Odedra R, Keen NJ, Green S, Brown E, Thompson K, Brightwell S. . Journal of Medicinal Chemistry 2006, 49(3), 955–970.
  • Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, Smith NR, Mandir N, Watkins AJ, Wilkinson RW. . Carcinogenesis 2006, 27(10), 2133-2139.
  • Matsumori Y, Yano S, Goto H, Nakataki E, Wedge SR, Ryan AJ, Sone S. . Oncology Research 2006, 16(1), 15-26.
  • Ryan AJ, Wedge SR. . British Journal of Cancer 2005, 92(s1), S6-S13.
  • Nicholson B, Gulding K, Conway M, Wedge SR, Theodorescu D. . Clinical Cancer Research 2004, 10(24), 8728-8734.
  • Drevs J, Konerding MA, Wolloscheck T, Wedge SR, Ryan AJ, Ogilvie DJ, Esser N. . Angiogenesis 2004, 7(4), 347-354.
  • Williams KJ, Telfer BA, Brave S, Kendrew J, Whittaker L, Stratford IJ, Wedge SR. . Clinical Cancer Research 2004, 10(24), 8587-8593.
  • Checkley D, Tessier J, Wedge SR, Dukes M, Kendrew J, Curry B, Middleton B, Waterton JC. . Magnetic Resonance Imaging 2003, 21(5), 475-482.
  • Pradel C, Siauve N, Bruneteau G, Clement O, deBazelaire C, Frouin F, Wedge SR, Tessier JL, Robert PH, Frija G, Cuenod CA. . Magnetic Resonance Imaging 2003, 21(8), 845-851.
  • Checkley D, Tessier JJ, Kendrew J, Waterton JC, Wedge SR. . British Journal of Cancer 2003, 89(10), 1889-1895.
  • Gasmi A, Bourcier C, Aloui Z, Srairi N, Marchetti S, Gimond C, Wedge SR, Hennequin LF, Pouysségur J. . Journal of Biological Chemistry 2002, 277(33), 29992-29998.
  • Hennequin LF, Stokes ESE, Thomas AP, Johnstone C, Ogilvie DJ, Dukes M, Wedge SR, Kendrew J, Curwen JO. . Journal of Medicinal Chemistry 2002, 45(6), 1300-1312.
  • Williams KJ, Telfer BA, Stratford IJ, Wedge SR. . British Journal of Cancer 2002, 86(7), 1157-1161.
  • Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Barnes C, Musgrove HL, Graham GA, Thomas AP, Stokes ESE, Curry B, Richmond GHP, Wadsworth PF, Hennequin LF. . Cancer Research 2002, 62(16), 4645-4655.
  • Whittles CE, Pocock TM, Wedge SR, Kendrew J, Hennequin LF, Harper SJ, Bates DO. . Microcirculation 2002, 9(6), 513-522.
  • Wedge SR, Ogilvie DJ. Inhibition of VEGF signal transduction. Identification of ZD4190. Advances in Experimental Medicine and Biology 2000, 476, 305-310.
  • Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Curwen JO, Hennequin LF, Thomas AP, Stokes ESE, Curry B, Richmond GHP, Wadsworth PF. ZD4190: An orally active inhibitor of vascular endothelial growth factor signalling with broad-spectrum antitumor efficacy. Cancer Research 2000, 60(4), 970-975.
  • Hennequin LF, Thomas AP, Johnstone C, Stokes ESE, Plé PA, Lohmann JM, Ogilvie DJ, Dukes M, Wedge SR, Curwen JO, Kendrew J, Lambert-vanderBrempt C. . Journal of Medicinal Chemistry 1999, 42(26), 5369-5389.
  • Middleton MR, Lunn JM, Morris C, Rustin G, Wedge SR, Brampton MH, Lind MJ, Lee SM, Newell DR, Bleehen NM, Newlands ES, Calvert AH, Margison GP, Thatcher N. . British Journal of Cancer 1998, 78(9), 1199-1202.
  • Brock CS, Newlands ES, Wedge SR, Bower M, Evans H, Colquhoun I, Roddie M, Glaser M, Brampton MH, Rustin GJ. Phase I trial of temozolomide using an extended continuous oral schedule. Cancer Research 1998, 58(19), 4363-4367.
  • Wedge SR, Porteous JK, Glaser MG, Marcus K, Newlands ES. In vitro evaluation of temozolomide combined with X-irradiation. Anti-Cancer Drugs 1997, 8(1), 92-97.
  • Wedge SR, Porteous JK, Newlands ES. Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model. Cancer Chemotherapy and Pharmacology 1997, 40(3), 266-272.
  • Newlands ES, Stevens MFG, Wedge SR, Wheelhouse RT, Brock C. Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials. Cancer Treatment Reviews 1997, 23(1), 35-61.
  • Wedge SR, Newlands ES. O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU. British Journal of Cancer 1996, 73(9), 1049-1052.
  • Wedge SR, Porteous JK, Newlands ES. 3-Aminobenzamide and/or O6- benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment, in cell lines of varaible mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity. British Journal of Cancer 1996, 74(7), 1030-1036.
  • Laohavinij S, Wedge S, Lind M, Bailey N, Humphreys A, Proctor M, Chapman F, Simmons D, Oakley A, Robson L, Gumbrell L, Taylor G, Thomas HD, Boddy AV, Newell DR, Calvert AH. . Investigational New Drugs 1996, 14(3), 325-335.
  • Wedge SR, Porteous JK, May BL, Newlands ES. Potentiation of temozolomide and BCNU cytotoxicity by O6-benzylguanine: a comparative study in vitro. British Journal of Cancer 1996, 73(4), 482-490.
  • Wedge SR, Laohavinij S, Taylor GA, Boddy AV, Calvert AH, Newell DR. . Clinical Cancer Research 1995, 1(12), 1479-1486.
  • Wedge SR, Laohavinij S, Taylor GA, Newell DR. . Journal of Chromatography B: Biomedical Sciences and Applications 1995, 663(2), 327-335.
  • Cassidy J, Newell DR, Wedge SR, Cummings J. . Cancer Surveys 1993, 17, 315-341.
  • Duncan R, Seymour LW, O'Hare KB, Flanagan PA, Wedge SR, Hume IC, Ulbrich K, Strohalm K, Subr V, Spreafico F, Grandi M, Ripamonti M, Farao M, Suarato A. . Journal of Controlled Release 1992, 19(1-3), 331-346.
  • Wedge SR, Duncan R, Kopeckova P. Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat. British Journal of Cancer 1991, 63(4), 546-549.
  • Seymour LW, Ulbrich K, Wedge SR, Hume IC, McCormick LA, Strohalm J, Duncan R. N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice. British Journal of Cancer 1991, 63(6), 859-866.