麻豆传媒

Currently a Senior Research Associate based in the Cancer Research Horizons Therapeutic Innovation and NU Centre for Cancer Medicinal Chemistry Labs, working as part of the multi-disciplinary, anti-cancer drug discovery programme. Working in close conjunction with internal and external collaborators, I play a role in the design and synthesis of small-molecule antitumour agents and am active in the co-supervision of medicinal chemistry team members. 



SCOPUS: ; ORCID ID:0000-0003-1646-593X

GOOGLE SCHOLAR:

Qualifications:

PhD in Organic Chemistry (University of Glasgow)

Studies Towards the Synthesis of LL-Z1640-2 and Spirocyclic Systems.

• Established and optimised a synthetic route to the 14-membered macrocycle, LL-Z1640-2. The challenge of the total synthesis was addressed by the development of a flexible, economic and efficient synthesis.
• A concise method towards highly functionalised spirocyclic piperidine units was achieved using the regioselective aza-Achmatowicz oxidative rearrangement.

MSc by Research in Carbohydrate Chemistry (University of Dundee)  

Synthesis of Di- and Tri-Saccharide Fragments of a GPI Anchor from Leishmania.    

• Synthetic targets were fragments of the GPI anchor of Leishmania lipophosphoglycan, containing β-D-Galf at the terminus. Chemical syntheses of neutral disaccharides and trisaccharides, as well as the preparation of phosphorylated trisaccharides, were undertaken.

BSc (Hons) in Chemistry with Pharmacology (University of Dundee)                            

Synthesis of (1R, 2R)-2-O-(2,3,4,6-Tetra-O-benzoyl-α-D-mannopyranosyl-cyclohexanol.

Area of expertise:

• Medicinal Chemistry
• Synthetic Organic Chemistry

• Articles

  • Miller DC, Reuillon T, Molyneux L, Blackburn T, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hardcastle I, Harnor SJ, Heptinstall A, Lochhead P, Martin MP, Martin NC, Myers S, Newell DR, Noble RA, Phillips N, Rigoreau L, Thomas H, Tucker JA, Wang L-Z, Waring MJ, Wong A-C, Wedge SR, Noble MEM, Cano C. . Journal of Medicinal Chemistry 2022, 65(9), 6513-6540.
  • Gai C, Harnor SJ, Zhang S, Cano C, Zhuang C, Zhao Q. . RSC Medicinal Chemistry 2022, 13(12), 1460-1475.
  • Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscome E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, St Denis J, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor S, Hearn K, Hobson S, Holvey RS, Howard S, Jennings C, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, Tamanini E, Thomas H, Thompson NT, Vinkovic M, Wedge SR, Williams PA, Wilsher N, Zhang B, Zhao Y. . Journal of Medicinal Chemistry 2021, 64(7), 4071-4088.
  • Al-Khawaldeh I, Aldred GG, Alyassiri M, Basmadjian C, Bordoni C, Harnor SJ, Heptinstall AB, Hobson SJ, Jennings CE, Khalifa S, Lebraud H, Miller DC, Shrives HJ, de Souza JV, Stewart HL, Temple M, Totobenazara J, Tucker JA, Tudhope SJ, Wang LZ, Bronowska AK, Cano C, Endicott JA, Golding BT, Hardcastle IR, Hickson I, Wedge SR, Willmore E, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2021, 64(14), 10001-10018.
  • Ford BE, Chachra SS, Alshawi A, Brennan A, Harnor S, Cano C, Baker DJ, Smith DM, Fairclough RJ, Agius L. . Diabetes, Obesity and Metabolism 2020, 22(11), 1985-1994.
  • Matheson CJ, Coxon CR, Bayliss R, Boxall K, Carbain B, Fry AM, Hardcastle IR, Harnor SJ, Mas-Droux C, Newell DR, Richards MW, Sivaprakasam M, Turner D, Griffin RJ, Golding BT, Cano C. . RSC Medicinal Chemistry 2020, 11(6), 707-731.
  • Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang L-Z, Wong A-C, Noble MEM, Wedge SR, Cano C. . European Journal of Medicinal Chemistry 2019, 178, 530-543.
  • Hill SL, Dunn M, Cano C, Harnor SJ, Hardcastle IR, Grundlingh J, Dargan PI, Wood DM, Tucker S, Bartram T, Thomas SHL. . Clinical Chemistry 2018, 64(2), 346-354.
  • Harnor S, Brennan A, Cano C. . ChemMedChem 2017, 12(12), 895-900.
  • Harnor SJ, Brennan A, Cano C. . Medicinal Chemistry 2017, 7, 172-177.
  • Coxon C, Anscombe E, Harnor S, Martin M, Carbain B, Golding B, Hardcastle I, Harlow L, Korolchuk S, Matheson C, Newell D, Noble M, Sivaprakasam M, Tudhope SJ, Turner D, Wang L, Wedge SR, Wong C, Griffin R, Endicott J, Cano C. . Journal of Medicinal Chemistry 2017, 60, 1746-1767.
  • Zaytsev AV, Pickles JE, Harnor SJ, Henderson AP, Alyasiri M, Waddell PG, Cano C, Griffin RJ, Golding BT. . RSC Advances 2016, 6(59), 53955-53957.
  • Harnor SJ, Rennison T, Galler M, Cano C, Griffin RJ, Newell DR, Golding BT. . MedChemComm 2014, 5(7), 984-988.
  • Haagensen EJ, Thomas HD, Wilson I, Harnor SJ, Payne SL, Rennison T, Smith KM, Maxwell RJ, Newell DR. . PLoS ONE 2013, 8(12), e81763.

• Book Chapters

  • Cano C, Harnor SJ, Willmore E, Wedge SR. . In: Pollard J; Curtin N, ed. Targeting the DNA Damage Response for Anti-Cancer Therapy. New York: Humana Press Inc, 2018, pp.339-357.
  • Harnor S, Pickles J, Cano C. . In: Waring M, ed. Topics in Medicinal Chemistry. Springer, 2017, pp.1-38.

• Conference Proceedings (inc. Abstracts)

  • Bertoli A, Adhikari S, Harnor SJ, Zhao Y, Lunec J, Wedge SR, Tudhope S, Wittner A, Golding BT, Hardcastle IR, Cano C, Newell DR, Griffin RJ. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, TX, USA: American Chemical Society.
  • Tudhope S, Zhao Y, Wittner A, Wilmore E, Bertoli A, Adhikari S, Harnor SJ, Del Bello F, Piergentili A, Lunec J, Hardcastle IR, Griffin RJ, Golding BR, Cano C, Newell DR, Wedge SR. . In: AACR Annual Meeting 2014. 2014, San Diego, CA: American Association for Cancer Research.

• Review

  • Miller DC, Harnor SJ, Martin MP, Noble RA, Wedge SR, Cano C. . Journal of Medicinal Chemistry 2023, 66(7), 4491-4502.