麻豆传媒

I am a Full Professor at the Faculty of Medical Sciences at 麻豆传媒 (20% position), and I am also Full Professor at the University Medical Center Goettingen (UMG), in Goettingen, Germany.

My areas of expertise are protein misfolding, Parkinson's disease, Alzheimer's disease, alpha-synuclein, tau and amyloid-beta.

Research Focus

My research interests are focused on understanding the molecular basis of protein misfolding diseases using a variety of model organisms, from yeast to mice and rats. Our primary focus is on the molecular basis of neurodegenerative disorders. My team has developed key tools and assays for the study of protein-protein interactions that are at the root of protein aggregation, a key event in neurodegeneration. We are now using human brain tissue to investigate molecular signatures associated with disease, to translate our findings into laboratory model systems where we can test novel strategies for therapeutic intervention.

Qualifications

BSc in Biochemistry, University of Porto, Portugal

PhD in Biomedical Sciences, MIT, USA and University of Porto, Portugal

Postdoctoral Research in Neurobiology, MGH, Harvard Medical School, USA

Keywords

Protein misfolding, neurodegeneration, Parkinson's disease, Dementia with Lewy bodies, alpha-synuclein, tau, amyloids.

Google Scholar:

SCOPUS:

Research Interests and Contributions

1. Yeast as a model to define the molecular basis of neurodegeneration. I started my scientific career at the University of Leeds, studying the yeast vacuolar ATPase complex. This training was very useful and enabled me to then undertake an ambitious project during my PhD, where I developed the first yeast model of synucleinopathies. This was published in a landmark paper, in Science. Since then, I have continued to use yeast as a toolbox to investigate the basic molecular mechanisms associated with neurodegeneration in Parkinson’s and Huntington’s diseases. In particular, we have recently studied the effect of posttranslational modifications on alpha-synuclein aggregation and toxicity in yeast. Some representative publications include:

a.     Outeiro TF, Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science. 2003 Dec 5;302(5651):1772-5.

b.     Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7012-7.

c.     Fernandes JT, Tenreiro S, Gameiro A, Chu V, Conde JP*, Outeiro TF*. Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator. Lab Chip. 2014 Oct 21;14(20):3949-57. *Co-corresponding authors.

d.     Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF. Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. PLoS Genet. 2014 May 8;10(5):e1004302.

2. Sirtuins and the intersection between aging and neurodegeneration. During my postdoctoral work, I found that pharmacological or genetic inhibition of sirtuin 2, a member of the aging-associated family of sirtuin proteins, was protective in cell and animal of Parkinson’s disease. This was a landmark study published in Science. In my own lab, we have extended those studies and discovered sirtuin 2 can regulate microglial activation and brain inflammation, and we are heavily investigating the molecular mechanisms mediating the effects observed in models of Parkinson’s disease. Representative publications include:

a.     Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9.

b.     Pais TF, Szegő ÉM, Marques O, Miller-Fleming L, Antas P, Guerreiro P, de Oliveira RM, Kasapoglu B, Outeiro TF. The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J. 2013 Oct 2;32(19):2603-16.

c.     Donmez G, Outeiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. EMBO Mol Med. 2013 Mar;5(3):344-52.

3. Defining the mechanisms of toxicity associated with protein aggregation. A major interest in the field is the definition of the mechanisms of proteotoxicity. My work in yeast and mammalian cell and animal models laid the foundation for studies where we developed novel assays to visualize and measure the effects of protein aggregation in living cells and organisms. Several highly cited articles include:

a.     Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One. 2008 Apr 2;3(4):e1867.

b.     Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF. Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. J Neurosci. 2012 Aug 22;32(34):11750-62.

c.     Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF. Mutant huntingtin alters Tau phosphorylation and subcellular distribution. Hum Mol Genet. 2015 Jan 1;24(1):76-85.

d.     Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity. Proc Natl Acad Sci U S A. 2016 Oct 5.

e.     Ferreira DG, Temido-Ferreira M, Miranda HV, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF. α-synuclein interacts with PrP(C) to induce cognitive impairment through mGluR5 and NMDAR2B. Nat Neurosci. 2017 Nov;20(11):1569-1579.

4. Defining the contribution of epigenetic regulation in neurodegeneration. The interplay between the environment and genetics is thought to explain the vast majority of cases of Parkinson’s and other neurodegenerative disorders. In addition, the complexity of these disorders suggests additional mechanisms need also be considered. Among these, epigenetic regulation of gene expression, and transcriptional deregulation, appear as major possibilities. I was the senior researcher on several studies already published, and we are further pursuing these lines of research. As examples, I highlight the following articles:

a.     Marques SC, Lemos R, Ferreiro E, Martins M, de Mendonça A, Santana I, Pereira CM*, Outeiro TF*. Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice. Neuroscience. 2012 Sep 18;220:256-66. *Co-corresponding authors.

b.     Marques S, Batalha VL, Lopes LV, Outeiro TF. Modulating Alzheimer's disease through caffeine: a putative link to epigenetics. J Alzheimers Dis. 2011;24 Suppl 2:161-71.

c.     Pavlou MA, Pinho R, Paiva I, Outeiro TF. The yin and yang of α-synuclein-associated epigenetics in Parkinson's disease. Brain. 2016 Aug 31.

d.     Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF. Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles. PLoS One. 2016 Jun 20;11(6):e0157852.

Postgraduate Teaching

I teach regularly in various international Master and PhD programs (Germany, Portugal, Brazil, Croatia, etc.).

• Articles

  • Aubrey LD, Ninkina N, Ulamec SM, Abramycheva NY, Vasili E, Devine OO, Wilkinson M, MacKinnon E, Limorenko G, Walko M, Muwanga S, Amadio L, Peters OM, Illarioshkin SN, Outeiro TF, Ranson NA, Brockwell DJ, Buchman VL, Radford SE. . Proceedings of the National Academy of Sciences of the United States of America 2024, 121(2), e2309700120.
  • Jebali A, Rashidi M, Keikha R, Daliri K, Outeiro TF. . Neurologia 2024, 39(4), 321-328.
  • Galka D, Ali TT, Bast A, Niederleithinger M, Gerhardt E, Motosugi R, Sakata E, Knop M, Outeiro TF, Popova B, Braus GH. . Aging Cell 2024, 23(5), e14128.
  • da Silva ANR, Pereira GRC, Bonet LFS, Outeiro TF, De Mesquita JF. . Journal of Cellular Biochemistry 2024, 125(3), e30523.
  • Shvachiy L, Amaro-Leal A, Machado F, Rocha I, Outeiro TF, Geraldes V. . Biomedicines 2024, 12(4), 711.
  • Bosbach C, Gatzemeier LM, Bloch von Blottnitz KI, Konig A, Diederichsen U, Steinem C, Outeiro TF. . Organic and Biomolecular Chemistry 2024, 22(13), 2670-2676.
  • Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin C-H, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P. . Movement Disorders 2024, 39(6), 929-933.
  • Placido E, Koss DJ, Outeiro TF, Brocardo PS. . Journal of Neurochemistry 2024, 168(8), 1514-1526.
  • Lamtar Mohammadi E, Keikha R, Outeiro TF, Jebali A. . Cellulose 2024, 31, 3797-3804.
  • Gelain DP, Bittencourt RR, Bastos Mendes LF, Moreira JCF, Outeiro TF. . Journal of Parkinson's Disease 2023, 13(5), 717-728.
  • Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bahr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P. . Journal of Neurochemistry 2023, 166(5), 862-874.
  • Hassanzadeh K, Morrone C, Akhtari K, Gerhardt E, Zaccagnini L, Outeiro TF, Feligioni M. . Mechanisms of Ageing and Development 2023, 209, 111759.
  • Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF. . Journal of Parkinson's Disease 2023, 13(2), 179-196.
  • Shvachiy L, Amaro-Leal A, Outeiro TF, Rocha I, Geraldes V. . Cells 2023, 12(5), 818.
  • Quesnel A, Coles N, Angione C, Dey P, Polvikoski TM, Outeiro TF, Islam M, Khundakar AA, Filippou PS. . BMC Cancer 2023, 23(1), 174.
  • Rosado-Ramos R, Pocas GM, Marques D, Foito A, Sevillano DM, Lopes-da-Silva M, Goncalves LG, Menezes R, Ottens M, Stewart D, Ibanez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN. . Nature Communications 2023, 14(1), 1918.
  • Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A. . International Journal of Molecular Sciences 2023, 24(17), 13435.
  • Placido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS. . International Journal of Molecular Sciences 2023, 24(16), 12607.
  • Ghanem SS, Majbour NK, Vaikath NN, Ardah MT, Erskine D, Jensen NM, Fayyad M, Sudhakaran IP, Vasili E, Melachroinou K, Abdi IY, Poggiolini I, Santos P, Dorn A, Carloni P, Vekrellis K, Attems J, McKeith I, Outeiro TF, JEnsen PH, El-Agnaf OMA. . Proceedings of the National Academy of Sciences 2022, 119(15), e2109617119.
  • Al-Azzani M, Konig A, Outeiro TF. . Biomolecules 2022, 12(2), 324.
  • Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, International DLB Genetics Consortium, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D. . Brain 2022, 145(4), 1257-1263.
  • Koss DJ, Erskine D, Porter A, Palmoski P, Menon H, Todd OGJ, Leite M, Attems J, Outeiro TF. . Acta Neuropathologica Communications 2022, 10, 98.
  • Lassen LB, Thomsen MS, Basso E, Fuchtbauer E-M, Fuchtbauer A, Outeiro TF, Jensen PH, Moos T. . Cells 2022, 11(22), 3673.
  • Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Bras IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li J-Y. . Scientific Reports 2022, 12(1), 2987.
  • Bras IC, Khani MH, Vasili E, Mobius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF. . Journal of Parkinson's Disease 2022, 12(8), 2397-2422.
  • Swaih AM, Breda C, Sathyasaikumar KV, Allcock N, Collier MEW, Mason RP, Feasby A, Herrera F, Outeiro TF, Schwarcz R, Repici M, Giorgini F. . Biomedicines 2022, 10(9), 2294.
  • Santos CC, Cardim-Pires TR, Shvachiy L, Fonseca-Fonseca LA, Munoz P, Almeida AMAN, Costa ACS, Teles-Souza J, Ochoa-Rodriguez E, de Fatima Dias Costa M, Palhano FL, Segura-Aguilar J, Barbosa DB, do Bomfim MR, dos Santos Junior MC, Leite FHA, da Rocha Pita SS, Costa SL, Nunez-Figueredo Y, Outeiro TF, Foguel D, Silva VDA. . Neurotoxicity Research 2022, 40, 2135-2147.
  • Magalhaes RSS, Boechat FC, Brasil AA, Neto JRM, Ribeiro GD, Paranhos LH, Neves de Souza N, Vieira T, Outeiro TF, Neves BC, Eleutherio ECA. . Journal of Cellular Biochemistry 2022, 123(11), 1808-1816.
  • Chegao A, Guarda M, Alexandre BM, Shvachiy L, Temido-Ferreira M, Marques-Morgado I, Fernandes Gomes B, Matthiesen R, Lopes LV, Florindo PR, Gomes RA, Gomes-Alves P, Coelho JE, Outeiro TF, Vicente Miranda H. . npj Parkinson's Disease 2022, 8(1), 51.
  • Farzadfard A, Konig A, Petersen SV, Nielsen J, Vasili E, Dominguez-Meijide A, Buell AK, Outeiro TF, Otzen DE. . Journal of Biological Chemistry 2022, 298(5), 101848.
  • Shvachiy L, Amaro-Leal A, Outeiro TF, Rocha I, Geraldes V. . Biology 2022, 11(8), 1164.
  • Vasili E, Dominguez-Meijide A, Flores-Leon M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF. . Molecular Neurobiology 2022, 59, 1273–1284.
  • Bras IC, Khani MH, Riedel D, Parfentev I, Gerhardt E, van Riesen C, Urlaub H, Gollisch T, Outeiro TF. . Journal of Proteomics 2022, 269, 104721.
  • Thom T, Schmitz M, Fischer A-L, Correia A, Correia S, Llorens F, Pique A-V, Mobius W, Domingues R, Zafar S, Stoops E, Silva CJ, Fischer A, Outeiro TF, Zerr I. . Movement Disorders 2022, 37(1), 39-51.
  • Queiroz DD, Ribeiro TDP, Goncalves JM, Mattos LMM, Gerhardt E, Freitas J, Palhano FL, Frases S, Pinheiro AS, McCann M, Knox A, Devereux M, Outeiro TF, Pereira MD. . Biochimica et Biophysica Acta - Molecular Basis of Disease 2022, 1868(10), 166475.
  • Rosado-Ramos R, Godinho-Pereira J, Marques D, Figueira I, Outeiro TF, Menezes R, Dos Santos CN. . Molecules 2021, 26(11), 3353.
  • Koss DJ, Bondarevaite O, Adams S, Leite M, Giorgini F, Attems J, Outeiro TF. . Brain Pathology 2021, 31(1), 120-132.
  • Wong-Guerra M, Montano-Peguero Y, Ramirez-Sanchez J, Jimenez-Martin J, Fonseca-Fonseca LA, Hernandez-Ensenat D, Nonose Y, Valdes O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto del Valle RM, Pardo-Andreu G, Outeiro TF, Padron-Yaquis AS, Martimbianco de Assis A, O Souza D, Nunez-Figueredo Y. . NeuroToxicology 2021, 87, 70-85.
  • Fonseca-Fonseca LA, da Silva VDA, Wong-Guerra M, Ramirez-Sanchez J, Yaquis ASP, Ochoa-Rodriguez E, Verdecia-Reyes Y, de Araujo FM, Santana RC, Outeiro TF, Costa SL, Nunez-Figueredo Y. . NeuroToxicology 2021, 82, 89-98.
  • Flores-Leon M, Lazaro DF, Shvachiy L, Krisko A, Outeiro TF. . Biochimica et Biophysica Acta - Proteins and Proteomics 2021, 1869(10), 140693.
  • Popova B, Wang D, Rajavel A, Dhamotharan K, Lazaro DF, Gerke J, Uhrig JF, Hoppert M, Outeiro TF, Braus GH. . Frontiers in Molecular Neuroscience 2021, 14, 59926.
  • Medina L, Gonzalez-Lizarraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori M-S, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehin R, Socias SB. . Frontiers in Aging Neuroscience 2021, 13, 635760.
  • Dominguez-Meijide A, Parrales V, Vasili E, Gonzalez-Lizarraga F, Konig A, Lazaro DF, Lannuzel A, Haik S, Del Bel E, Chehin R, Raisman-Vozari R, Michel PP, Bizat N, Outeiro TF. . Neurobiology of Disease 2021, 151, 105256.
  • Popova B, Wang D, Patz C, Akkermann D, Lazaro DF, Galka D, Kolog Gulko M, Bohnsack MT, Mobius W, Bohnsack KE, Outeiro TF, Braus GH. . PLoS Genetics 2021, 17(3), e1009407.
  • Albert K, Raymundo DP, Panhelainen A, Eesmaa A, Shvachiy L, Araujo GR, Chmielarz P, Yan X, Singh A, Cordeiro Y, Palhano FL, Foguel D, Luk KC, Domanskyi A, Voutilainen MH, Huttunen HJ, Outeiro TF, Saarma M, Almeida MS, Airavaara M. . Molecular Therapy 2021, 29(9), 2821-2840.
  • Filippou P, Outeiro TF. . Movement Disorders 2021, 36(2), 340-346.
  • Masaracchia C, Konig A, Valiente-Gabioud AA, Peralta P, Favretto F, Strohaker T, Lazaro DF, Zweckstetter M, Fernandez CO, Outeiro TF. . Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2020, 1868(1), 140298.
  • Hentrich T, Wassouf Z, Ehrhardt C, Haas E, Mills JD, Casadei N, Outeiro TF, Hubener-Schmid J, Riess O, Casadei N, Schulze-Hentrich JM. . Aging 2020, 12(19), 18889-18906.
  • Vaz RL, Sousa S, Chapela D, van der Linde HC, Willemsen R, Correia AD, Outeiro TF, Afonso ND. . Pharmacology Biochemistry and Behavior 2020, 189, 172828.
  • Vicente Miranda H, Chegao A, Oliveira MS, Fernandes Gomes B, Enguita FJ, Outeiro TF. . FASEB Journal 2020, 34(5), 6718-6728.
  • Outeiro TF, Heutink P, Bezard E, Cenci AM. . Movement Disorders 2020, 36(4), 832-841.
  • Dominguez-Meijide A, Vasili E, Konig A, Cima-Omori M-S, Ibanez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF. . Scientific Reports 2020, 10(1), 12827.
  • Menezes R, Foito A, Jardim C, Costa I, Garcia G, Rosado-Ramos R, Freitag S, Alexander CJ, Outeiro TF, Stewart D, Santos CN. . Antioxidants 2020, 9(9), 789.
  • Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buee-Scherrer V, Faivre E, Baqi Y, Muller CE, Pimentel J, Schiffmann SN, Buee L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV. . Molecular Psychiatry 2020, 25, 1876-1900.
  • Vale N, Alves C, Sharma V, Lazaro DF, Silva S, Gomes P, Outeiro TF. . Pharmacological Reports 2020, 72, 456-464.
  • Ferreira C, Couceiro J, Familia C, Jardim C, Antas P, Santos CN, Outeiro TF, Tenreiro S, Quintas A. . FEMS Yeast Research 2019, 19(5), foz042.
  • Repici M, Hassanjani M, Maddison DC, Garcao P, Cimini S, Patel B, Szego EM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F. . Molecular Neurobiology 2019, 56(1), 61-77.
  • Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL. . Bioorganic and Medicinal Chemistry 2019, 27(1), 79-91.
  • Vasili E, Dominguez-Meijide A, Outeiro TF. . Frontiers in Molecular Neuroscience 2019, 12, 107.
  • Candelise N, Schmitz M, Llorens F, Villar‐Piqué A, Cramm M, Thom T, da Silva Correia SM, da Cunha JEG, Möbius W, Outeiro TF, Álvarez VG, Banchelli M, D'Andrea C, de Angelis M, Zafar S, Rabano A, Matteini P, Zerr I. . Annals of Neurology 2019, 85(5), 691-703.
  • Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Pique A, Szego E, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kugler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF. . Human Molecular Genetics 2019, 28(1), 31-50.
  • Prasad V, Wasser Y, Hans F, Goswami A, Katona I, Outeiro TF, Kahle PJ, Schulz JB, Voigt A. . The FASEB Journal 2019, 33(2), 2116-2131.
  • Outeiro TF, Koss DJ, Erskine D, Walker L, Kurzawa-Akanbi M, Burn DJ, Donaghy P, Morris CM, Taylor JP, Thomas AJ, Attems J, McKeith IG. . Molecular Neurodegeneration 2019, 14, 5.
  • Szego EM, Dominguez-Meijide A, Gerhardt E, Konig A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, Villar-Pique A, Thom T, Rizzoli S, Schmitz M, Li J, Zerr I, Attems J, Jahn O, Outeiro TF. . Cell Reports 2019, 28(1), 65-77.e6.
  • Brasil AA, de Carvalho MDC, Gerhardt E, Queiroz DD, Pereira MD, Outeiro TF, Eleutherio ECA. . Proceedings of the National Academy of Sciences of the United States of America 2019, 116(51), 25991-26000.
  • Carija A, Pinheiro F, Pujols J, Bras IC, Lazaro DF, Santambrogio C, Grandori R, Outeiro TF, Navarro S, Ventura S. . Redox Biology 2019, 22, 101135.
  • Paiva I, Carvalho K, Santos P, Cellai L, Pavlou MAS, Jain G, Gnad T, Pfeifer A, Vieau D, Fischer A, Buee L, Outeiro TF, Blum D. . GLIA 2019, 67(12), 2329-2342.
  • Pujols J, Pena-Diaz S, Lazaro DF, Peccati F, Pinheiro F, Gonzalez D, Carija A, Navarro S, Conde-Gimenez M, Garcia J, Guardiola S, Giralt E, Salvatella X, Sancho J, Sodupe M, Outeiro TF, Dalfo E, Ventura S. . Proceedings of the National Academy of Sciences of the United States of America 2018, 115(41), 10481-10486.
  • Bras IC, Lopes LV, Outeiro TF. . Movement Disorders 2018, 33(11), 1675-1684.
  • Gustafsson G, Loov C, Persson E, Lazaro DF, Takeda S, Bergstrom J, Erlandsson A, Sehlin D, Balaj L, Gyorgy B, Hallbeck M, Outeiro TF, Breakefield XO, Hyman BT, Ingelsson M. . Cellular and Molecular Neurobiology 2018, 38(8), 1539-1550.
  • Brasil AA, Magalhães RSS, de Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA. . Molecular Neurobiology 2018, 55(6), 5269-5281.
  • Bras IC, Tenreiro S, Silva AM, Outeiro TF. . FEMS Yeast Research 2018, 18(8), foy108.
  • Biosa A, Outeiro TF, Bubacco L, Bisaglia M. . Molecular Neurobiology 2018, 55(11), 8754-8763.
  • Paiva I, Jain G, Lazaro DF, Jercic KG, Hentrich T, Kerimoglu C, Pinho R, Szego EM, Burkhardt S, Capece V, Halder R, Islam R, Xylaki M, Caldi Gomes LA, Roser A-E, Lingor P, Schulze-Hentrich JM, Borovecki F, Fischer A, Outeiro TF. . Neurobiology of Disease 2018, 119, 121-135.
  • Ferreira DG, Temido-Ferreira M, Miranda HV, Batalha VL, Coelho JE, Szego EM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF. . Nature Neuroscience 2017, 20(11), 1569-1579.
  • Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D. . Proceedings of the National Academy of Sciences of the United States of America 2017, 114(25), E4971-E4977.
  • Pavlou MAS, Pinho R, Paiva I, Outeiro TF. . Brain 2017, 140(4), 878-886.
  • Lemos V, de Oliveira RM, Naia L, Szego E, Ramos E, Pinho S, Magro F, Cavadas C, Cristina Rego A, Costa V, Outeiro TF, Gomes P. . Human Molecular Genetics 2017, 26(21), 4105-4117.
  • de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szego EM, Martinho R, Munari F, Lazaro DF, Moniot S, Guerreiro P, Fonseca L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kugler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF. . PLoS Biology 2017, 15(3), e2000374.
  • Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D. . Journal of Experimental Medicine 2017, 214(8), 2257-2269.
  • Morais GR, Palma E, Marques F, Gano L, Oliveira MC, Abrunhosa A, Miranda HV, Outeiro TF, Santos I, Paulo A. . Journal of Heterocyclic Chemistry 2017, 54(1), 255-267.
  • Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz A-L, Rajput A, Szego EM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF. . Human Molecular Genetics 2017, 26(12), 2231-2246.
  • Szego EM, Gerhardt E, Outeiro TF. . Neurobiology of Aging 2017, 56, 7-16.
  • Guedes LC, Chan RB, Gomes MA, Conceição VA, Machado RB, Soares T, Xu Y, Gaspar P, Carriço JA, Alcalay RN, Ferreira JJ, Outeiro TF, Miltenberger-Miltenyi G. . Parkinsonism and Related Disorders 2017, 44, 58-65.
  • Branco-Santos J, Herrera F, Pocas GM, Pires-Afonso Y, Giorgini F, Domingos PM, Outeiro TF. . Human Molecular Genetics 2017, 26(19), 3763-3775.
  • Miranda HV, Cássio R, Correia-Guedes L, Gomes MA, Chegão A, Miranda E, Soares T, Coelho M, Rosa MM, Ferreira JJ, Outeiro TF. . Scientific Reports 2017, 7, 13713.
  • Macedo D, Bertolin TE, Oro T, Backes LTH, Brás IC, Santos CN, Tenreiro S, Outeiro TF. . Journal of Functional Foods 2017, 38(Part A), 553-560.
  • Moreira S, Fonseca I, Nunes MJ, Rosa A, Lemos L, Rodrigues E, Carvalho AN, Outeiro TF, Rodrigues CMP, Gama MJ, Castro-Caldas M. . Experimental Neurology 2017, 295, 77-87.
  • Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF. . NeuroMolecular Medicine 2017, 19(1), 113-121.
  • Pardo J, Abba MC, Lacunza E, Francelle L, Morel GR, Outeiro TF, Goya RG. . Hippocampus 2017, 27(4), 435-449.
  • Richter KN, Revelo NH, Seitz KJ, Helm MS, Sarkar D, Saleeb RS, D'Este E, Eberle J, Wagner E, Vogl C, Lazaro DF, Richter F, Coy-Vergara J, Coceano G, Boyden ES, Duncan RR, Hell SW, Lauterbach MA, Lehnart SE, Moser T, Outeiro T, Rehling P, Schwappach B, Testa I, Zapiec B, Rizzoli SO. . EMBO Journal 2017, e201695709.
  • Vicente Miranda H, Szegő EM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF. . Brain 2017, 140(5), 1399-1419.
  • Francelle L, Lotz C, Outeiro T, Brouillet E, Merienne K. . Frontiers in Human Neuroscience 2017, 11, 17.
  • Gustafsson G, Eriksson F, Moller C, da Fonseca TL, Outeiro TF, Lannfelt L, Bergstrom J, Ingelsson M. . Cellular and Molecular Neurobiology 2017, 37(1), 121-131.
  • Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlotzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, Von Arnim CAF, Xiang W, Winkler J, Klucken J. . Scientific Reports 2017, 7, 42942.
  • Ferreira DG, Batalha VL, Miranda HV, Coelho JE, Gomes R, Goncalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV. . Cerebral Cortex 2017, 27(1), 718-730.
  • Cukierman DS, Pinheiro AB, Castiñeiras-Filho SLP, da Silva ASP, Miotto MC, De Falco A, de P Ribeiro T, Maisonette S, da Cunha ALMC, Hauser-Davis RA, Landeira-Fernandez J, Aucélio RQ, Outeiro TF, Pereira MD, Fernández CO, Rey NA. . Journal of Inorganic Biochemistry 2017, 170, 160-168.
  • Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. . Human Molecular Genetics 2016, 25(9), 1677-1689.
  • Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhaes F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF. . Human Molecular Genetics 2016, 25(2), 275-290.
  • Lazaro DF, Dias MC, Carija A, Navarro S, Madaleno CS, Tenreiro S, Ventura S, Outeiro TF. . Acta neuropathologica communications 2016, 4, 128.
  • Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buee L, Muller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV. . Scientific Reports 2016, 6, 31493.
  • Goncalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF. . PLoS Genetics 2016, 12(4), e1005995.
  • Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bahr M, Outeiro TF, Eckermann K. . Molecular Neurobiology 2016, 53(5), 3124-3135.
  • Pardo J, Uriarte M, Console GM, Reggiani PC, Outeiro TF, Morel GR, Goya RG. . European Journal of Neuroscience 2016, 44(4), 2120-2128.
  • Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lazaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF. . Scientific Reports 2016, 6, 36798.
  • Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Goncalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltenyi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF. . PLoS ONE 2016, 11(6), e0157852.
  • Tatenhorst L, Eckermann K, Dambeck V, Fonseca-Ornelas L, Walle H, Lopes da Fonseca T, Koch JC, Becker S, Tonges L, Bahr M, Outeiro TF, Zweckstetter M, Lingor P. . Acta Neuropathologica Communications 2016, 4, 39.
  • Villar-Pique A, Da Fonseca TL, Sant'Anna R, Szego EM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Gonzalez EA, Rossetti G, Carloni P, Fernandez CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF. . Proceedings of the National Academy of Sciences of the United States of America 2016, 113(42), E6506-E6515.
  • Letra-Vilela R, Sanchez-Sanchez AM, Rocha AM, Martin V, Branco-Santos J, Puente-Moncada N, Santa-Marta M, Outeiro TF, Antolin I, Rodriguez C, Herrera F. . Molecular and Cellular Endocrinology 2016, 434, 238-249.
  • Kleinknecht A, Popova B, Lazaro DF, Pinho R, Valerius O, Outeiro TF, Braus GH. . PLoS Genetics 2016, 12(6), e1006098.
  • Fernandes JTS, Chutna O, Chu V, Conde JP, Outeiro TF. . Frontiers in Neuroscience 2016, 10, 511.
  • Fonseca TL, Pinho R, Outeiro TF. . Human Molecular Genetics 2016, 25(14), 2959-2971.
  • Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. . PLoS ONE 2015, 10(1), e0116919.
  • Vreja IC, Nikic I, Gottfert F, Bates M, Krohnert K, Outeiro TF, Hell SW, Lemke EA, Rizzoli SO. . ACS Nano 2015, 9(11), 11034-11041.
  • Moree B, Yin G, Lazaro DF, Munari F, Strohaker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J. . Journal of Biological Chemistry 2015, 290(46), 27582-27593.
  • Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F. . Human Molecular Genetics 2015, 24(4), 1077-1091.
  • Mbefo MK, Fares M-B, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA. . Journal of Biological Chemistry 2015, 290(15), 9412-9427.
  • Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF. . Human Molecular Genetics 2015, 24(1), 76-85.
  • Krey L, Luhder F, Kusch K, Czech-Zechmeister B, Konnecke B, Outeiro TF, Trendelenburg G. . Journal of Cerebral Blood Flow and Metabolism 2015, 35(12), 2080-2088.
  • Nunes P, Morais GR, Palma E, Silva F, Oliveira MC, Ferreira VFC, Mendes F, Gano L, Miranda HV, Outeiro TF, Santos I, Paulo A. . Organic and Biomolecular Chemistry 2015, 13(18), 5182-5194.
  • Oliveira LMA, Falomir-Lockhart LJ, Botelho MG, Lin K-H, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schule B, Arndt-Jovin DJ, Jovin TM. . Cell Death and Disease 2015, 6(11), e1994.
  • Ducic T, Carboni E, Lai B, Chen S, Michalke B, Lazaro DF, Outeiro TF, Bahr M, Barski E, Lingor P. . ACS Chemical Neuroscience 2015, 6(10), 1769-1779.
  • Macedo D, Tavares L, McDougall GJ, Vicente Miranda H, Stewart D, Ferreira RB, Tenreiro S, Outeiro TF, Santos CN. . Human Molecular Genetics 2015, 24(6), 1717-1732.
  • Pocas GM, Branco-Santos J, Herrera F, Outeiro TF, Domingos PM. . Human Molecular Genetics 2014, 24(7), 1898-1907.
  • Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szego TM, Guerreiro P, Lazaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M. . Neurobiology of Disease 2014, 70, 149-161.
  • Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF. . Proceedings of the National Academy of Sciences of the United States of America 2014, 111(19), 7012-7017.
  • Chutna O, Goncalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF. . Human molecular genetics 2014, 23(25), 6732-6745.
  • Lazaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Krohnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF. . PLoS Genetics 2014, 10(11), e1004741.
  • Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernandez CO, Outeiro TF, Becker S, Zweckstetter M. . Nature communications 2014, 5, 5857.
  • Tenreiro S, Reimao-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhaes F, Gomes A, Santos CN, Kaganovich D, Outeiro TF. . PLoS Genetics 2014, 10(5), e1004302.
  • Fernandes JTS, Tenreiro S, Gameiro A, Chu V, Outeiro TF, Conde JP. . Lab on a Chip 2014, 14(20), 3949-3957.
  • McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha J-HJ, Outeiro TF, Sadri-Vakili G. . Human Molecular Genetics 2014, 23(4), 1036-1044.
  • Perfeito R, Lazaro DF, Outeiro TF, Rego AC. . Molecular and Cellular Neuroscience 2014, 62, 51-59.
  • Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH. . Journal of Biological Chemistry 2014, 289(45), 31224-31240.
  • Fernandes JTS, Tenreiro S, Pedrosa CR, Gameiro A, Chu V, Outeiro TF, Conde JP. . Procedia Engineering 2014, 87, 92-95.
  • Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A. . Human Molecular Genetics 2014, 23(3), 755-766.
  • Zondler L, Miller-Fleming L, Repici M, Goncalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF. . Cell Death and Disease 2014, 5(7), e1350.
  • Vittori A, Breda C, Repici M, Orth M, Roos RAC, Outeiro TF, Giorgini F, Hollox EJ. . Human Molecular Genetics 2014, 23(12), 3129-3137.
  • Poehler A-M, Xiang W, Spitzer P, May VEL, Meixner H, Rockenstein E, Chutna O, Outeiro TF, Winkler J, Masliah E, Klucken J. . Autophagy 2014, 10(12), 2171-2192.
  • Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bahr M, Zweckstetter M, Kugler S. . Annals of Neurology 2013, 74(1), 109-118.
  • Vittori A, Orth M, Roos RAC, Outeiro TF, Giorgini F, Hollox EJ, Bachoud-Levi A-C, Bentivoglio AR, Biunno I, Bonelli RM, Burgunder J-M, Dunnett SB, Ferreira JJ, Heiberg A, Illmann T, Landwehrmeyer GB, Levey J, Martinez-Jaurrieta MD, Nielsen JE, Pro Koivisto S, Paivarinta M, Rojo Sebastian A, Tabrizi SJ, Vandenberghe W, Verellen-Dumoulin C, Zaremba J, Uhrova T, Wahlstrom J, Barth K, Correia-Guedes L, Finisterra A-M, Bascunana Garde M, Betz S, Bos R, Ecker D, Handley OJ, Held C, Koppers K, Laura M, Martinez Descals A, Mestre T, Monza D, Townhill J, Padieu H, Paterski L, Peppa N, Rialland A, Roren N, Sasinkova P, Trigo Cubillo P, van Walsem M, Witjes-Ane M-N, Yudina E, Zielonka D, Zielonka E, Zinzi P, Bonelli RM, Herranhof B, Hodl A, Kapfhammer H-P, Koppitz M, Magnet M, Otti D, Painold A, Reisinge K, Scheibl M, Hecht K, Lilek S, Muller N, Schoggl H, Ullah J, Ribai P, Verellen-Dumoulin C, Klempir J, Majerova V, Roth J, Hjermind LE, Jakobsen O, Vinthev-Jensen T, Larsen IU, Nielsen JE, Stokholm J, Hiivola H, Martikainen K, Tuuha K, Santala M, Milkereit E, Kosinski CM, Probst D, Reetz K, Sass C, Schiefer J, Schlangen C, Werner CJ, Andrich J, Ellrichmann G, Hoffmann R, Kaminski B, Saft C, Stamm C, Lange H, Lohle M, Schmidt S, Storch A, Wolz A, Wolz M, Capetian P, Lambeck J, Zucker B, Boelmans K, Ganos C, Hidding U, Lewerenz J, Munchau A, Schmalfeld J, Stubbe L, Zittel S, Heinicke W, Ribbat M, Longinus B, Muhlau M, Peinemann A, Stadtler M, Weindl A, Winkelmann J, Ziegler C, Bechtel N, Beckmann H, Bohlen S, Holzner E, Reilmann R, Rohm S, Rumpf S, Schepers S, Dose M, Leythaeuser G, Marquard R, Raab T, Schrenk C, Schuierer M, Barth K, Buck A, Ecker D, Eschenbach C, Held C, Landwehrmeyer B, Lezius F, Nepper S, Niess A, Schwenk D, Sussmuth S, Trautmann S, Weydt P, Cormio C, de Tommaso M, Sciruicchio V, Serpino C, Ghelli E, Ginestroni A, Bertini E, Massaro F, Mechi C, Paganini M, Piacentini S, Pradella S, Romoli AM, Sorbi S, Abbruzzese G, di Poggio Giovanna Ferrandes MB, Di Maria E, Ferrandes G, Mandich P, Marchese R, Di Donato S, Gellera C, Genitrini S, Mariotti C, Nanetti L, Monza D, Soliveri P, Tomasello C, De Michele G, Di Maio L, Massarelli M, Rinaldi C, Roca A, Rossi F, Russo CV, Salvatore E, Sorrentino P, Tucci T, De Nicola A, Elifani F, Petrollini M, Martino T, Lovo F, Squitieri F, Bentivoglio AR, Catalli C, Di Giacopo R, Fasano A, Frontali M, Guidubaldi A, Ialongo T, Jacopini G, Loria G, Piano C, Piccininni C, Quaranta D, Romano S, Soleti F, Spadaro M, Zinzi P, van Hout MSE, van Vugt JPP, Marit de Weert A, Bolwijn JJW, Dekker M, Leenders KL, van Oostrom JCH, Bos R, Dumas EM, Jurgens CK, van den Bogaard SJA, 't Hart EP, Kremer B, Verstappen CCP, Heiberg A, van Walsem MR, Frich J, Aaserud O, Wehus R, Bjorgo K, Fannemel M, Gorvell P, Lorentzen E, Koivisto SP, Retterstol L, Stokke B, Bjornevoll I, Sando SB, Dziadkiewicz A, Nowak M, Robowski P, Sitek E, Slawek J, Soltan W, Szinwelski M, Blaszczyk M, Boczarska-Jedynak M, Ciach-Wysocka E, Gorzkowska A, Jasinska-Myga B, Opala G, Klodowska-Duda G, Stompel D, Banaszkiewicz K, Bocwinska D, Bojakowska-Jaremek K, Dec M, Krawczyk M, Rudzinska M, Szczudlik A, Szczygiel E, Wasielewska A, Wojcik M, Bryl A, Ciesielska A, Klimberg A, Marcinkowski J, Samara H, Sempolowicz J, Zielonka D, Janik P, Kalbarczyk A, Kwiecinski H, Jamrozik Z, Antczak J, Jachinska K, Krysa W, Rakowicz M, Richter P, Rola R, Ryglewicz D, Sienkiewicz-Jarosz H, Stepniak I, Sulek A, Witkowski G, Zdzienicka E, Zaremba J, Zieora-Jakutowicz K, Coelho M, Correia-Guedes L, Ferreira JJ, Mestre T, Mendes T, Valadas A, Andrade C, Gago M, Garrett C, Guerra MR, Solis P, Herrera CD, Garcia PM, Cubo E, Mariscal N, Sanchez J, Barrero FJ, Morales B, Alonso-Frech F, Perez MR, Fenollar M, Garcia R, Quiroga PP, Rivera SV, Villanueva C, Alegre J, Bascunana M, Ventura MF, Yebenes JG, Ribas GG, Moreno JLL-S, Cubillo PT, Ruiz PJG, Frech FA, Guerrero R, Martinez-Descals A, Artiga MJS, Sanchez V, Alcaraz LF, Manzanares S, Perea MFN, Reinante G, Torres MMA, Moreau LV, Barbera MA, Guia DB, Hernanz LC, Catena JL, Sebastian AR, Ferrer PQ, Carruesco GT, Bas J, Busquets N, Calopa M, Buongiorno MT, Munoz E, Elorza MD, Lopez CD-A, Terol SD-S, Robert MF, Ruiz BG, Casado AG, Martinez IH, Viladrich CM, Cardenas RP, Roca E, Llesoy JR, Idiago JMR, Vergara MR, Garcia SS, Riballo AV, Hoglund A, Palhagen SE, Paucar M, Sandstrom B, Svenningsson P, Reza-Soltani TW, Burgunder J-M, Kaelin A, Romero I, Schupbach M, Stebler Y, Zaugg SW, Akhtar S, Crooks J, Curtis A, de Souza J, Rickards H, Wright J, Barker RA, Di Pietro A, Fisher K, Goodman AOG, Hill S, Kershaw A, Mason S, O'Keefe D, Swain R, Guzman NV, Busse M, Butcher C, Clenaghan C, Dunnett S, Fullam R, Jones L, Jones U, Khalil H, Minster S, Owen M, Hunt S, Price K, Rosser A, Townhill J, Edwards M, Ho C, McGill M, Pearson P, Porteous M, Brockie P, Foster J, Johns N, McKenzie S, Rothery J, Thomas G, Yates S, Burrows L, Chu C, Fletcher A, Gallantrae D, Harding A, Hamer S, Kraus A, Laver F, Longthorpe M, Markova I, Raman A, Silva M, Thomson A, Wild S, Yardumian P, Hobson E, Jamieson S, Musgrave H, Rowett L, Toscano J, Clayton C, Dipple H, Middleton J, Patino D, Andrews T, Dougherty A, Kavalier F, Golding C, Laing H, Lashwood A, Robertson D, Ruddy D, Whaite A, Santhouse A, Bruno S, Doherty K, Lahiri N, Novak M, Patel A, Rosser E, Tabrizi S, Taylor R, Warner T, Wild E, Arran N, Bek J, Callaghan J, Craufurd D, Howard L, Hare M, Huson S, Johnson L, Jones M, Murphy H, Oughton E, Partington-Jones L, Rogers D, Snowden J, Sollom A, Stopford C, Thompson J, Trender-Gerhard I, Verstraelen N, Westmoreland L, Nemeth AH, Siuda G, Harrison D, Hughes M, Parkinson A, Soltysiak B, Bandmann O, Bradbury A, Fairtlough H, Fillingham K, Foustanos I, Gill P, Kazoka M, O'Donovan K, Peppa N, Quarrell O, Taylor C, Tidswell K. . Journal of Huntington's Disease 2013, 2(1), 107-124.
  • Lopes da Fonseca T, Correia A, Hasselaar W, van der Linde HC, Willemsen R, Outeiro TF. . Brain Research Bulletin 2013, 90(1), 118-126.
  • Pais TF, Szego EM, Marques O, Miller-Fleming L, Antas P, Guerreiro P, De Oliveira RM, Kasapoglu B, Outeiro TF. . EMBO Journal 2013, 32(19), 2603-2616.
  • Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. . Nature 2013, 496(7445), 382-385.
  • Donmez G, Outeiro TF. . EMBO Molecular Medicine 2013, 5(3), 344-352.
  • Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F. . Journal of Molecular Medicine 2013, 91(5), 599-611.
  • Fagerqvist T, Nasstrom T, Ihse E, Lindstrom V, Sahlin C, Fangmark Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergstrom J. . Amyloid 2013, 20(4), 233-244.
  • Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM. . Journal of Molecular Medicine 2013, 91(4), 513-522.
  • Amaral JD, Herrera F, Rodrigues PM, Dionisio PA, Outeiro TF, Rodrigues CMP. . Biochemical Pharmacology 2013, 85(6), 745-752.
  • Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H. . Biochimica et Biophysica Acta - General Subjects 2013, 1830(8), 4065-4072.
  • Szego EM, Outeiro TF, Kermer P, Schulz JB. . Neurobiology of Aging 2013, 34(2), 589-601.
  • Vicente Miranda H, Xiang W, De Oliveira RM, Simoes T, Pimentel J, Klucken J, Penque D, Outeiro TF. . Journal of Neurochemistry 2013, 126(5), 673-684.
  • Goncalves S, Outeiro TF. . Molecular Neurobiology 2013, 47(3), 1081-1092.
  • Herrera F, Outeiro TF. . FEBS Letters 2012, 586(1), 7-12.
  • Sancenon V, Lee S-A, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ. . Human Molecular Genetics 2012, 21(11), 2432-2449.
  • Sampaio-Marques B, Felgueiras C, Silva A, Rodrigues M, Tenreiro S, Franssens V, Reichert AS, Outeiro TF, Winderickx J, Ludovico P. . Autophagy 2012, 8(10), 1494-1509.
  • de Oliveira RM, Sarkander J, Kazantsev AG, Outeiro TF. . Frontiers in Pharmacology 2012, 3, 82.
  • Kemppainen S, Rantamaki T, Jeronimo-Santos A, Lavasseur G, Autio H, Karpova N, Karkkainen E, Staven S, Miranda HV, Outeiro TF, Diogenes MJ, Laroche S, Davis S, Sebastiao AM, Castren E, Tanila H. . Neurobiology of Aging 2012, 33(6), 1122.e23-1122.e39.
  • Rosa P, Tenreiro S, Chu V, Outeiro TF, Conde JP. . Biomicrofluidics 2012, 6, 014109.
  • Diogenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Nasstrom T, Franquelim HG, Oliveira LMA, Castanho MARB, Lannfelt L, Bergstrom J, Ingelsson M, Quintas A, Sebastiao AM, Lopes LV, Outeiro TF. . Journal of Neuroscience 2012, 32(34), 11750-11762.
  • Marques SCF, Lemos R, Ferreiro E, Martins M, de Mendonca A, Santana I, Outeiro TF, Pereira CMF. . Neuroscience 2012, 220, 256-266.
  • Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetters M, Outeiro TF, Braus GH. . Journal of Biological Chemistry 2012, 287(33), 27567-27579.

• Book Chapters

  • Lazaro DF, Outeiro TF. . In: Advances in experimental medicine and biology. Springer, 2020, pp.223-236.
  • Bras IC, Xylaki M, Outeiro TF. . In: Progress in Brain Research. Elsevier, 2020, pp.91-129.
  • Peelaerts W, Outeiro TF. . In: Veerle Baekelandt and Evy Lobbestael, ed. Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies. London: Academic Press, 2017, pp.21-47.
  • Pavlou MAS, Outeiro TF. . In: Raul Delgado-Morales, ed. Neuroepigenomics in Aging and Disease. New York: Springer, 2017, pp.363-390.
  • Tenreiro S, Macedo D, Marijanovic Z, Outeiro TF. . In: Rune Matthiesen, ed. Proteostasis: Methods and Protocols. New York: Humana Press, 2016, pp.331-339.
  • Herrera F, Goncalves S, Branco dos Santos J, Fleming Outeiro T. . In: Bio-nanoimaging: Protein Misfolding and Aggregation. Elsevier Inc, 2014, pp.133-145.
  • Herrera F, Gonalves S, Outeiro TF. . In: Imaging and Spectroscopic Analysis of Living Cells: Imaging Live Cells in Health and Disease. London: Academic Press, 2012, pp.157-174.

• Editorials

  • Fernandes JB, Baixinho C, Outeiro TF, Godinho C. . Frontiers in Psychiatry 2024, 15, 1399709.
  • Outeiro TF, El-Agnaf OM. . Neurobiology of Disease 2023, 177, 105995.
  • Fernandes JB, Godinho C, Outeiro TF, Baixinho CL. . Frontiers in Human Neuroscience 2023, 17, 1216902.
  • Outeiro TF. . Journal of Neurochemistry 2021, 157(4), 889-890.
  • Outeiro TF, Mestre TA. . Journal of Neurochemistry 2019, 150(5), 462-466.
  • Roodveldt C, Outeiro TF, Braun JEA. . Frontiers in Neuroscience 2017, 11, 565.
  • Kazantsev AG, Outeiro TF. . Frontiers in Pharmacology 2012, 3, 71.

• Letters

  • Outeiro TF, Vieira TCRG. . Prion 2024, 18(1), 68-71.
  • Outeiro TF, Krisko A. . Movement Disorders 2021, 36(2), 278-279.
  • Outeiro TF, Krisko A. . Movement Disorders 2020, 35(7), 1106-1107.

• Notes

  • Klein AD, Outeiro TF. . Nature Communications 2023, 14(1), 6383.
  • Wong-Guerra M, Montano-Peguero Y, Ramirez-Sanchez J, Jimenez-Martin J, Fonseca-Fonseca LA, Hernandez-Ensenat D, Nonose Y, Valdes O, Mondelo-Rodriguez A, Ortiz-Miranda Y, Bergado G, Carmenate T, Soto del Valle RM, Pardo-Andreu G, Outeiro TF, Padron-Yaquis AS, de Assis AM, Souza DO, Nunez-Figueredo Y. . NeuroToxicology 2023, 99, 10-13.
  • Outeiro TF. . EMBO Reports 2020, 21(3), e50124.
  • Goncalves SA, Outeiro TF. . Small GTPases 2017, 8(2), 78-84.
  • Correia Guedes L, Reimao S, Paulino P, Nunes RG, Bouca-Machado R, Abreu D, Goncalves N, Soares T, Fabbri M, Godinho C, Pita Lobo P, Neutel D, Quadri M, Coelho M, Rosa MM, Campos J, Outeiro TF, Sampaio C, Bonifati V, Ferreira JJ. . Movement Disorders 2017, 32(9), 1331-1333.
  • Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, Belmonte C, Bertocchi I, Betz H, Blakemore C, Blanke O, Boehm-Sturm P, Bonhoeffer T, Bonifazi P, Brose N, Campolongo P, Celikel T, Chang CC, Chang T-Y, Citri A, Cline HT, Cortes JM, Cullen K, Dean K, Delgado-Garcia JM, Desroches M, Disterhoft JF, Dowling JE, Draguhn A, El-Khamisy SF, El Manira A, Enam SA, Encinas JM, Erramuzpe A, Esteban JA, Farinas I, Fischer E, Fukunaga I, Gabilondo I, Ganten D, Gidon A, Gomez-Esteban JC, Greengard P, Grinevich V, Gruart A, Guillemin R, Hariri AR, Hassan B, Hausser M, Hayashi Y, Hussain NK, Jabbar AA, Jaber M, Jahn R, Janahi EM, Kabbaj M, Kettenmann H, Kindt M, Knafo S, Kohr G, Komai S, Krugers H, Kuhn B, Ghazal NL, Larkum ME, London M, Lutz B, Matute C, Martinez-Millan L, Maroun M, McGaugh J, Moustafa AA, Nasim A, Nave K-A, Neher E, Nikolich K, Outeiro T, Palmer LM, Penagarikano O, Perez-Otano I, Pfaff DW, Poucet B, Rahman A-U, Ramos-Cabrer P, Rashidy-Pour A, Roberts RJ, Rodrigues S, Sanes JR, Schaefer AT, Segal M, Segev I, Shafqat S, Siddiqui NA, Soreq H, Soriano-Garcia E, Spanagel R, Sprengel R, Stuart G, Sudhof TC, Tonnesen J, Trevino M, Uthman BM, Venter JC, Verkhratsky A, Weiss C, Wiesel TN, Yaksi E, Yizhar O, Young LJ, Young P, Zawia NH, Zugaza JL, Hasan MT. . Neuron 2017, 96(4), 730-735.

• Reviews

  • Chopra A, Lang AE, Hoglinger G, Outeiro TF. . Parkinsonism and Related Disorders 2024, 122, 106078.
  • Thirupathi A, Marqueze LF, Outeiro TF, Radak Z, Pinho RA. . Neurochemical Research 2024, 49, 1643-1654.
  • Hoglinger GU, Adler CH, Berg D, Klein C, Outeiro TF, Poewe W, Postuma R, Stoessl AJ, Lang AE. . The Lancet. Neurology 2024, 23(2), 191-204.
  • Shvachiy L, Geraldes V, Outeiro TF. . Antioxidants & Redox Signaling 2023, 39(4-6), 321-335.
  • Cullinane PW, de Pablo Fernandez E, Konig A, Outeiro TF, Jaunmuktane Z, Warner TT. . Movement Disorders 2023, 38(2), 162-177.
  • Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP. . Chemical Reviews 2023, 123(14), 9094-9138.
  • Vieira TCRG, Barros CA, Domingues R, Outeiro TF. . Journal of Neurochemistry 2024, 168(8), 1625-1639.
  • Flores-Leon M, Outeiro TF. . Acta Neuropathologica 2023, 146, 369-385.
  • Xylaki M, Chopra A, Weber S, Bartl M, Outeiro TF, Mollenhauer B. . Movement Disorders 2023, 38(9), 1585-1597.
  • Outeiro TF, Alcalay RN, Antonini A, Attems J, Bonifati V, Cardoso F, Chesselet M-F, Hardy J, Madeo G, McKeith I, Mollenhauer B, Moore DJ, Rascol O, Schlossmacher MG, Soreq H, Stefanis L, Ferreira JJ. . Movement Disorders 2023, 38(7), 1127-1142.
  • Erskine D, Koss D, Korolchuk VI, Outeiro TF, Attems J, McKeith I. . Acta Neuropathologica 2021, 141, 511-526.
  • Koss DJ, Campesan S, Giorgini F, Outeiro TF. . Movement Disorders 2021, 36(8), 1744-1758.
  • Bras IC, Outeiro TF. . Cells 2021, 10(2), 375.
  • Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF. . npj Parkinson's Disease 2021, 7(1), 65.
  • Outeiro TF. . Molecular Neurobiology 2021, 58, 2202-2203.
  • Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schule B. . International Journal of Molecular Sciences 2020, 21(16), 5724.
  • Bras IC, Dominguez-Meijide A, Gerhardt E, Koss D, Lazaro DF, Santos PI, Vasili E, Xylaki M, Outeiro TF. . Journal of Neurochemistry 2020, 153(4), 433-454.
  • Domingues R, Lippi A, Setz C, Outeiro TF, Krisko A. . Aging 2020, 12(18), 18778-18789.
  • Santos PI, Outeiro TF. . FEBS Journal 2020, 287(24), 5294-5303.
  • Dominguez-Meijide A, Vasili E, Outeiro TF. . Brain Sciences 2020, 10(11), 858.
  • Correia Guedes L, Mestre T, Outeiro TF, Ferreira JJ. . Journal of Neurochemistry 2020, 152(5), 515-522.
  • Harvey K, Outeiro TF. . Biochemical Society Transactions 2019, 47(1), 197-207.
  • Rossetti G, Kless A, Lai L, Outeiro TF, Carloni P. . Biochemical Society transactions 2019, 47(3), 909-918.
  • Bras IC, Konig A, Outeiro TF. . Journal of Huntington's Disease 2019, 8(3), 245-256.
  • Xylaki M, Atzler B, Outeiro TF. . Current Neurology and Neuroscience Reports 2019, 19(10), 72.
  • Marvian AT, Koss DJ, Aliakbari F, Morshedi D, Outeiro TF. . Journal of Neurochemistry 2019, 150(5), 535-565.
  • Vaz RL, Outeiro TF, Ferreira JJ. . Frontiers in Neurology 2018, 9, 347.
  • Konig A, Miranda HV, Outeiro TF. . Journal of Parkinson's Disease 2018, 8(1), 33-43.
  • Tenreiro S, Franssens V, Winderickx J, Outeiro TF. . Current Opinion in Genetics and Development 2017, 44, 74-83.
  • Villar-Piqué A, Rossetti G, Ventura S, Carloni P, Fernández CO, Outeiro TF. . Communicative and Integrative Biology 2017, 10(1), e1270484.
  • Lázaro DF, Pavlou MAS, Outeiro TF. . Experimental Neurology 2017, 298(Part B), 162-171.
  • Lopez-Leon M, Outeiro TF, Goya RG. . Ageing Research Reviews 2017, 40, 168-181.
  • Villar-Pique A, Lopes da Fonseca T, Outeiro TF. . Journal of Neurochemistry 2016, 139(S1), 240-255.
  • Vicente Miranda H, El-Agnaf OMA, Outeiro TF. . Movement Disorders 2016, 31(6), 782-790.
  • da Fonseca TL, Villar-Piqué A, Outeiro TF. . Biomolecules 2015, 5(2), 435-471.
  • Amen T, Lázaro DF, Outeiro TF, Kaganovich D. . Israel Journal of Chemistry 2015, 55(11-12), 1252-1259.
  • Gomes P, Outeiro TF, Cavadas C. . Trends in Pharmacological Sciences 2015, 36(11), 756-768.
  • Tenreiro S, Eckermann K, Outeiro TF. . Frontiers in Molecular Neuroscience 2014, 7, 42.
  • Rodrigues TM, Jeronimo-Santos A, Outeiro TF, Sebastiao AM, Diogenes MJ. . Drugs and Aging 2014, 31(4), 239-261.
  • Amaral M, Outeiro TF, Scrutton NS, Giorgini F. . Journal of Molecular Medicine 2013, 91(6), 705-713.
  • Basso E, Antas P, Marijanovic Z, Goncalves S, Tenreiro S, Outeiro TF. . Molecular Neurobiology 2013, 48(3), 854-862.
  • Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M. . Journal of Neurochemistry 2013, 125(4), 491-511.
  • Wales P, Lazaro DF, Pinho R, Outeiro TF. . Journal of Parkinson's Disease 2013, 3(4), 415-459.
  • Tenreiro S, Munder MC, Alberti S, Outeiro TF. . Journal of Neurochemistry 2013, 127(4), 438-452.
  • Marques S, Outeiro TF. . SubCellular Biochemistry 2013, 61, 507-525.
  • Eisbach SE, Outeiro TF. . Journal of Molecular Medicine 2013, 91(6), 693-703.
  • Marques O, Outeiro TF. . Cell Death and Disease 2012, 3(7), e350.