麻豆传媒

Qualifications:                             

BA Mathematics, University of Cambridge, 1972.

MSc Applied Statistics, University of Oxford, 1973.

PhD Biology, University of Cambridge, 1983.

Previous positions:

2011 – 2015  Associate Dean for Ageing, 麻豆传媒

2004 – 2011  Director, Institute for Ageing and Health, 麻豆传媒

1999 – 2004  Head, Department of Gerontology, 麻豆传媒

1999 – 2015  Professor of Medicine, 麻豆传媒

1993 – 1999  Professor of Biological Gerontology, University of Manchester

1988 – 1993  Head, Laboratory of Mathematical Biology, MRC National Institute for Medical Research, London

1981 – 1988  Staff Scientist, then Senior Staff Scientist (1987), Computing Laboratory, MRC National Institute for Medical Research, London.

1973 – 1981  Scientist, then Staff Scientist (1979), Statistics Section, National Institute for Biological Standards and Control, London.

Honours and distinctions:

Karger Prize 1984 (international science prize for an article on cellular ageing)

Verzar Medal, Vienna 1994

Fellow, Institute for Advanced Study, Budapest 1997

BBC Reith Lecturer ‘The End of Age’ 2001 (www.bbc.co.uk/radio4/reith2001)

Fellow, Academy of Medical Sciences 2001

Honorary Fellow, Faculty of Actuaries 2002

Royal Institution Dale Prize 2002 (featured as an Editorial in Nature DOI: 10.1038/417471a)

Honorary Life Member, Royal Institution 2002

Honorary Doctor of Science, University of Hull 2003

Cohen Medal of the British Society for Research on Ageing 2006

Honorary Life Member, British Society for Research on Ageing 2011

National Institute for Health Research, Senior Investigator 2009

CBE (Commander of the Order of the British Empire) 2009 (from Her Majesty the Queen)

Queen’s Anniversary Prize for Higher Education 2009 (from Her Majesty the Queen; I led the research programme on ageing for which this award was made to 麻豆传媒)

Excellence with Impact Prize, BBSRC 2011 (awarded to Institute for Ageing and Health)

Ipsen Foundation Longevity Prize 2011

Fellow, Royal College of Physicians of Edinburgh 2013

Nathan Shock Award Lecture, US National Institute on Aging 2016 (chosen by vote of NIA research staff)

Paton Prize Lecture, World Congress of Physiology 2017

Advisory and professional roles:

Member, UCL Commission for Mission-Oriented Innovation and Industrial Strategy (2018-)

Trustee, Age International (2017-)

Trustee, Dunhill Medical Trust (2017-)

International Scientific Advisory Committee, McMaster Institute for Research on Aging (2017-)

Government Office for Science, Expert Group on Ageing (2014-2016)

This relates to a Foresight project providing the UK government with the evidence to develop policies to address the challenges and opportunities of population ageing.

Royal Society, Research Grants Committee (£20k) (2014-)

Chair of the Jury of the Ipsen Foundation Longevity Prize (2014-2018)

International prize for research on the science of longevity.

Trustee Director, BIG Lottery Centre for Ageing Better (2013-2015)

I was a founding trustee director for this centre; I stepped down after the grant of £50M had been secured from BIG Lottery.

AXA Research Fund, President of Scientific Board (2012-)

The AXA Research Fund supports research at the highest standard of excellence in leading academic institutions around the world; the Fund is supported by the AXA insurance group but operates its own selection processes to choose research that is independent from the company’s business; I chair the board and provide strategic leadership.

Trustee, Cumberland Lodge (King George VI and Queen Elizabeth St Catharine’s Foundation) (2007-2016)

Government Office for Science, Foresight Theme Leader “Mental Capital Through Life” (2007-9)

This was a Foresight project on Mental Capital and Wellbeing.

Mechanisms of Ageing and Development, Editor (2000-2012)

PLoS Biology, Editorial Board (2005-)

Science and Industry Council of North England (2007-9)

International Association of Gerontology, European President (Biology) (2003-7)

Trustee, International Longevity Centre – UK (2006-8)

Academy of Medical Sciences, Council Member (2002-5)

House of Lords Science & Technology Select Committee Inquiry into Ageing (2004-6)

My role as Specialist Adviser to the Select Committee was to advise the committee on its agenda, selection of witnesses and questions to be asked, and to draft the report.

Biotechnology and Biological Sciences Research Council, Council Member (2001-2004)

UK Foresight Task Force on Healthcare for Older People, Chair (1999-2001)

British Society for Research on Ageing, Chair (1992-1999)

International Biometric Society (British Region), President (1998-2000)

Research into Ageing, Trustee (1998-2000)

Research into Ageing, Research Advisory Council (1992-2000), Chair (1996-2000)

Wellcome Trust, Basic Sciences Interest Group (1992-7)

This group selects candidates from among the very best scientists in their fields to receive the highly prestigious Wellcome Trust Senior Fellowships

Wellcome Trust, Mathematical Biology Panel (1993-7)

This panel selected projects to help grow the innovative cross-disciplinary field that is now well-established bridging mathematics and biology.

Medical Research Council, Human Genome Mapping Project Committee (1991-3)

This panel selected projects to fund in the earliest stages of the human genome project.

Research Interests

Evolution and genetics of ageing

Starting in 1977, I suggested that a major contribution to understanding ageing can be achieved by linking the evolutionary and physiological approaches in a concept called the disposable soma theory.  This predicts that: (1) ageing is due to evolved limitations in investments in somatic maintenance and repair, due to competing priorities of reproduction; (2) ageing therefore results from the accumulation during life of damage in cells and tissues; (3) multiple mechanisms contribute to ageing (since there are multiple forms of somatic maintenance, all of which are subject to the same optimality process); (4) the principal genes determining longevity and rate of senescence are genes specifying the levels of maintenance functions (e.g. DNA repair genes, antioxidant enzymes, stress proteins); (5) the ageing process is intrinsically stochastic, but that longevity is programmed, on the average, through the settings of genes of the type just considered; (6) maximum life span is not clock-driven but malleable, e.g. through modifying exposure to damage or enhancing somatic maintenance functions.

I have used these ideas to explore life history evolution (eg evolution of menopause) and the optimal allocation of metabolic resources in varying environments (eg life extension through rodent calorie-restriction).  Such models are important for understanding the genetic architecture of the life history and have major relevance for genome research on longevity.  With Rudi Westendorp (University of Leiden), we reported in Nature the first evidence for a trade-off between human longevity and fertility.

In genome studies on human ageing, I pioneered novel approaches to the analysis of gene polymorphisms affecting human longevity in collaboration with Francois Schachter and Daniel Cohen (Centre d’Etude du Polymorphisme Humain), and subsequently developed models of genetic and non-genetic factors affecting human longevity.  Emerging from the disposable soma theory, there is a growing recognition that the development of the senescent phenotype is strongly affected by intrinsic stochastic factors (chance), as well as by genes and environment.  A major synthesis of this new perspective was published in collaboration with Caleb Finch (University of Southern California).

Mechanisms of cellular ageing

A central problem in experimental gerontology is to understand how cells accumulate damage during ageing and how age changes at the cell level produce age-related dysfunction and disease within tissues and organs.  In collaboration with Chris Potten (Paterson Institute for Cancer Research), I obtained some of the first direct evidence of age changes occurring within tissue stem cells in the intestinal epithelium.  These changes involve increased susceptibility to genotoxic agents (low-dose irradiation) and impaired regenerative capacity.  In a different context, I showed that primary skin fibroblasts from long-lived mammalian species have greater intrinsic capacity to withstand a variety of stresses in vitro than cells from short-lived species.  This confirmed a key prediction of the disposable soma theory and points to the central role of cell maintenance and stress response systems in ageing and longevity.

Another key prediction of the disposable soma theory is that there is no single mechanism of cell ageing, but rather that multiple mechanisms operate together.  I have developed this concept of a network theory of cellular ageing in a series of theoretical models that examined the major candidate mechanisms of cell ageing in an integrated way (collaboration with Axel Kowald, Humboldt University).  This work led the way in establishing the importance of systems-biology approaches to addressing the inherent complexity of the ageing process. Within the Centre for Integrated Systems Biology of Ageing and Nutrition, established with BBSRC funding in 2005, major programmes have examined the complex pathways responsible for phenomena such as replicative senescence, using a combination of computational and experimental approaches.

Most recently, in collaboration with the Center for Healthy Aging at the University of Copenhagen, where I have been a part-time professorship since 2016 (now affiliate professor), I am a co-investigator in a Challenge Programme funded by the Novo-Nordisk Foundation to make use of big data to examine trajectories of ageing. This involves working to connect research on systems biology of molecular mechanisms with large volumes of pathophysiological samples as well as with data collected by national bodies such as Statistics Denmark.

Ageing in human populations

In recognition of the fact that there was then limited information about the spectrum of health in the general population at advanced age, I led the establishment of the 麻豆传媒 85 Study which since 2006 has been examined in great detail the many factors that influence trajectories of health beyond age 85. Following a two year pilot study, during which the procedures were rigorously tested and refined, the main study sought to recruit as many as possible of the population of 麻豆传媒 upon Tyne and North Tyneside who had been born in 1921. The study has included a wide range of domains of assessment (e.g. health, via nurse assessment and GP record review; cognitive and physical function; sleep; sensory function; psychology; socioeconomics; biological markers; genetics).

• Bythell JC, Brown BE, Kirkwood TBL. . Biological Reviews 2018, 93(2), 1192-1202.
• Lavrencic L, Richardson C, Harrison SL, Muniz-Terrera G, Keage H, Brittain K, Kirkwood T, Jagger C, Robinson L, Stephan B. . The Journals of Gerontology: Series A 2018, 73(4), 499-505.
• Lavrencic LM, Richardson C, Harrison SL, Muniz-Terrera G, Keage HAD, Brittain K, Kirkwood TBL, Jagger C, Robinson L, Stephan BCM. . Journals of Gerontology: Series A 2018, 73(4), 499-505.
• Stephan BCM, Muniz-Terrera G, Granic A, Collerton J, Davies K, Saxby BK, Wesnes KA, Kirkwood TBL, Jagger C. . International Journal of Geriatric Psychiatry 2018, 33(2), 298-306.
• Gore PG, Kingston A, Johnson GR, Kirkwood TBL, Jagger C. . Age and Ageing 2018, 47(6), 764-768.
• Stamp C, Zupanic A, Sachdeva A, Stoll EA, Shanley DP, Mathers JC, Kirkwood TBL, Heer R, Simons BD, Turnbull DM, Greaves LC. . EBioMedicine 2018, 31, 166-173.
• Kowald A, Kirkwood TBL. . Genes 2018, 9(3), 126.
• Kirkwood TBL. . Experimental Physiology 2018, 109(9), 1067-1074.
• King AM, Kirkwood TBL, Shanley DP. . Evolution 2017, 71(10), 2280-2297.
• Granic A, Davies K, Martin-Ruiz C, Jagger C, Kirkwood TBL, von Zglinicki T, Sayer AA. . Age and Ageing 2017, 46(6), 976-982.
• van den Heuvel J, Zandveld J, Zwaan BJ, Kirkwood TBL, Shanley DP. . Experimental Gerontology 2017, 90, 34-42.
• Granic A, Davies K, Jagger C, Dodds R, Kirkwood TBL, Sayer AA. . Age and Ageing 2017, 46(6), 970-976.
• Zandveld J, van den Heuvel J, Mulder M, Brakefield PM, Kirkwood TBL, Shanley DP, Zwaan BJ. . Evolution 2017, 71(11), 2572-2583.
• Harrison SL, de Craen AJM, Kerse N, Teh R, Granic A, Davies K, Wesnes KA, den Elzen WPJ, Gussekloo J, Kirkwood TBL, Robinson L, Jagger C, Siervo M, Stephan CMB. . Journal of the American Geriatrics Society 2017, 65(2), 381-389.
• Dodds RM, Granic A, Davies K, Kirkwood TBL, Jagger C, Sayer AA. . Journal of Cachexia, Sarcopenia and Muscle 2017, 8(2), 229-237.
• Granic A, Hill TR, Davies K, Jagger C, Adamson A, Siervo M, Kirkwood TBL, Mathers JC, Sayer AA. . Nutrients 2017, 9(4), 379.
• Kowald A, Kirkwood TBL. . Aging Cell 2016, 15(6), 986-998.
• Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, Kirkwood T, von Zglinicki T. . Aging Cell 2016, 15(2), 389-392.
• Collerton J, Jagger C, Yadegarfar ME, Davies K, Parker SG, Robinson L, Kirkwood TBL. . BioMed Research International 2016, 2016, 8745670.
• Granic A, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Jagger C. . Journal of Nutrition 2016, 146(2), 265-274.
• Granic A, Jagger C, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Sayer AA. . PLOS One 2016, 11(3), e0149699.
• Granic A, Davies K, Jagger C, Kirkwood T, Syddall HE, Sayer AA. . PLoS ONE 2016, 11(9), e0163183.
• Granic A, Davies K, Jagger C, Kirkwood T, Syddal HE, Sayer AA. . In: 60th Annual Scientific Meeting Society for Social Medicine. 2016, York: BMJ Group.
• Duncan R, Kingston A, Stephan B, Birrell F, Kirkwood T, Jagger C. . In: Rheumatology 2016. 2016, Glasgow: Oxford University Press.
• Mendonça N, Hill TR, Granic A, Davies K, Collerton J, Mathers JD, Siervo M, Wrieden WL, Seal CJ, Kirkwood TBL, Jagger C, Adamson AJ. . British Journal of Nutrition 2016, 116(4), 751-761.
• Fisher AJ, Yadegarfar ME, Collerton J, Small T, Kirkwood TBL, Davies K, Jagger C, Corris PA. . Thorax 2016, 71(3), 255-266.
• Hill TR, Granic A, Davies K, Collerton J, Martin-Ruiz C, Siervo M, Mathers JC, Adamson AJ, Francis RM, Pearce SH, Razvi S, Kirkwood TBL, Jagger C. . Osteoporosis International 2016, 27(3), 1199-1208.
• Pearce SHS, Razvi S, Yadegarfar ME, Martin-Ruiz C, Kingston A, Collerton J, Visser TJ, Kirkwood TB, Jagger C. . Journal of Clinical Endocrinology & Metabolism 2016, 101(11), 4385-4394.
• van Beek JHGM, Kirkwood TBL, Bassingthwaighte JB. . Interface Focus 2016, 6(2).
• Granic A, Aspray T, Hill T, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Kirkwood TB, Mathers JC, Jagger C. . Journal of Internal Medicine 2015, 277(4), 456-467.
• Innerd P, Catt M, Collerton J, Davies K, Trenell M, Kirkwood TBL, Jagger C. . Age and ageing 2015, 44(4), 691-694.
• Thomas MG, Shanley DP, Houston AI, McNamara JM, Mace R, Kirkwood TBL. . Journal of Evolutionary Biology 2015, 28(4), 885-895.
• Veerasamy M, Edwards R, Ford G, Kirkwood T, Newton J, Jones D, Kunadian V. . Cardiology in Review 2015, 23(1), 26-32.
• Mitnitski A, Collerton J, Martin-Ruiz C, Jagger C, von Zglinicki T, Rockwood K, Kirkwood TBL. . BMC Medicine 2015, 13, 161.
• Kirkwood TBL. . Biochemist 2015, 37(4), 8-11.
• Brittain KR, Kingston A, Davies K, Collerton J, Robinson AL, Kirkwood T, Bond J, Jagger C. . Ageing and Society 2017, 37(1), 39-62.
• Peters R, Collerton J, Granic A, Davies K, Kirkwood T, Jagger C. . The Journal of Hypertension 2015, 33(10), 2156-2164.
• Kirkwood TBL. . Philosophical Transactions of the Royal Society B. Biological Sciences 2015, 370(1666), 1-8.
• Granic A, Davies K, Adamson A, Kirkwood T, Hill TR, Siervo M, Mathers JC, Jagger C. . PLoS ONE 2015, 10(10), e0139713.
• Kowald A, Kirkwood TBL. . Experimental Gerontology 2015, 71, 89-94.
• Sayer AA, Kirkwood TBL. . Lancet 2015, 386(9990), 226-227.
• Dolan DWP, Zupanic A, Nelson G, Hall P, Miwa S, Kirkwood TBL, Shanley DP. . PLoS Computational Biology 2015, 11(5), e1004246.
• Harrison SL, Stephan BCM, Siervo M, Granic A, Davies K, Wesnes KA, Kirkwood TBL, Robinson L, Jagger C. . Journal of the American Geriatrics Society 2015, 63(4), 667-675.
• Pedersen JK, Skytthe A, McGue M, Honig LS, Franceschi C, Kirkwood TBL, Passarino G, Slagboom PE, Vaupel JW, Christensen K. . Annals of Epidemiology 2015, 25(8), 569-574.
• Duncan R, Francis RM, Jagger C, Kingston A, McCloskey E, Collerton J, Robinson L, Kirkwood TBL, Birrell F. . Osteoporosis International 2015, 26(1), 123-130.
• Duncan R, Francis RM, Jagger C, Kingston A, McCloskey E, Collerton J, Robinson L, Kirkwood TBL, Birrell F. . Osteoporosis International 2015, 26(1), 123-130.
• Kirkwood TBL. . In: 12th European Nutrition Conference. 2015, Berlin: S. Karger AG.
• Speakman JR, Blount JD, Bronikowski AM, Buffenstein R, Isaksson C, Kirkwood TB, Monaghan P, Ozanne SE, Beaulieu M, Briga M, Carr SK, Christensen LL, Cochemé HM, Cram DL, Dantzer B, Harper JM, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons MJ, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M, Selman C. . Ecology and Evolution 2015, 5(24), 5745-5757.
• Granic A, Hill TR, Kirkwood TBL, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, Mathers JC, Jagger C. . European Journal of Neurology 2015, 22(1), 106-e7.
• Siervo M, Prado C, Hooper L, Munro A, Collerton J, Davies K, Kingston A, Mathers JC, Kirkwood TBL, Jagger C. . Archives of Gerontology and Geriatrics 2015, 60(1), 227-232.
• Kingston A, Davies K, Collerton J, Robinson l, Duncan R, Kirkwood TBL, Jagger C. . Archives of Gerontology and Geriatrics 2015, 60(3), 405-411.
• Harrison S, Siervo M, Granic A, Davies K, Kirkwood T, Robinson L, Jagger C, Stephan BC. . In: Gerontological Society of America 68th Annual Scientific Meeting. 2015, Washington, DC: Oxford University Press.
• Collerton J, Gautrey HE, van Otterdijk SD, Davies K, Martin-Ruiz C, von Zglinicki T, Kirkwood TBL, Jagger C, Mathers JC, Strathdee G. . Biogerontology 2014, 15(4), 317-328.
• Siervo M, Kingston A, Kirkwood T, Mathers J, Collerton J, Davies K, Jagger C. . In: Gerontological Society of America 67th Annual Scientific Meeting. 2014, Washington, DC: Oxford University Press.
• Anderson KN, Catt M, Collerton J, Davies K, von Zglinicki T, Kirkwood TBL, Jagger C. . Age and Ageing 2014, 43(1), 57-63.
• Greaves LC, Nooteboom M, Elson JL, Tuppen HAL, Taylor GA, Commane DM, Arasaradnam RP, Khrapko K, Taylor RW, Kirkwood TBL, Mathers JC, Turnbull DM. . PLoS Genetics 2014, 10(9), e1004620.
• Zupanic A, Méplan C, Grellscheid SN, Mathers JC, Kirkwood TBL, Hesketh J, Shanley D. . RNA 2014, 20(10), 1507-1518.
• Dalle Pezze P, Nelson G, Otten EG, Korolchuk VI, Kirkwood TBL, von Zglinicki T, Shanley DP. . PLoS Computational Biology 2014, 10(8), e1003728.
• Kowald A, Dawson M, Kirkwood TBL. . Journal of Theoretical Biology 2014, 349, 171-171.
• Granic A, Davies K, Adamson A, Mathers JC, Kirkwood T, Siervo M, Jagger C. . In: Gerontological Society of America 67th Annual Scientific Meeting. 2014, Washington, DC: Oxford University Press.
• Veerasamy M, Sinclair H, Newton J, Kirkwood T, Kunadian V. . In: ESC Congress 2014. 2014, Barcelona, Spain: Oxford University Press.
• Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, Tan Q, Kamatani Y, Bennet AM, Tamm R, Trompet S, Guobjartsson DF, Flachsbart F, Rose G, Viktorin A, Fischer K, Nygaard M, Cordell HJ, Crocco P, Van den Akker EB, Bohringer S, Helmer Q, Nelson CP, Saunders GI, Alver M, Andersen-Ranberg K, Breen ME, van der Breggen R, Caliebe A, Capri M, Cevenini E, Collerton JC, Dato S, Davies K, Ford I, Gampe J, Garagnani P, de Geus EJC, Harrow J, van Heemst D, Heijmans BT, Heinsen FA, Hottenga JJ, Hofman A, Jeune B, Jonsson PV, Lathrop M, Lechner D, Martin-Ruiz C, Mcnerlan SE, Mihailov E, Montesanto A, Mooijaart SP, Murphy A, Nohr EA, Paternoster L, Postmus I, Rivadeneira F, Ross OA, Salvioli S, Sattar N, Schreiber S, Stefansson H, Stott DJ, Tiemeier H, Uitterlinden AG, Westendorp RGJ, Willemsen G, Samani NJ, Galan P, Sorensen TIA, Boomsma DI, Jukema JW, Rea IM, Passarino G, de Craen AJM, Christensen K, Nebel A, Stefansson K, Metspalu A, Magnusson P, Blanche H, Christiansen L, Kirkwood TBL, van Duijn CM, Franceschi C, Houwing-Duistermaat JJ, Slagboom PE. . Human Molecular Genetics 2014, 23(16), 4420-4432.
• Dodds RM, Syddall HE, Cooper R, Benzeval M, Deary IJ, Dennison EM, Der G, Gale CR, Inskip HM, Jagger C, Kirkwood TB, Lawlor DA, Robinson SM, Starr JM, Steptoe A, Tilling K, Kuh D, Cooper C, Sayer AA. . PLoS ONE 2014, 9(12), e113637.
• Davies K, Kingston A, Robinson L, Hughes J, Hunt JM, Barker SAH, Edwards J, Collerton J, Jagger C, Kirkwood TBL. . PLoS ONE 2014, 9(10), e108370.
• Harrison S, Stephan BC, Siervo M, Granic A, Davies K, Robinson L, Kirkwood T, Jagger C. . In: Gerontological Society of America 67th Annual Scientific Meeting. 2014, Washington DC: Oxford University Press.
• Kowald A, Dawson M, Kirkwood TBL. . Journal of Theoretical Biology 2014, 340, 111-118.
• Wiley L, Ashok D, Martin-Ruiz C, Talbot DCS, Collerton J, Kingston A, Davies K, Chinnery PF, Catt M, Jagger C, Kirkwood TBL, von Zglinicki T. . PLoS ONE 2014, 9(3), e91005.
• Baines HL, Stewart JB, Stamp C, Zupanic A, Kirkwood TBL, Larsson NG, Turnbull DM, Greaves LC. . Mechanisms of Ageing and Development 2014, 139, 22-30.
• Kingston A, Davies K, Collerton J, Robinson L, Duncan R, Bond J, Kirkwood TBL, Jagger C. . PLoS ONE 2014, 9(2), e88016.
• Raule N, Sevini F, Li ST, Barbieri A, Tallaro F, Lomartire L, Vianello D, Montesanto A, Moilanen JS, Bezrukov V, Blanche H, Hervonen A, Christensen K, Deiana L, Gonos ES, Kirkwood TBL, Kristensen P, Leon A, Pelicci PG, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Stazi MA, Toussaint O, Vaupel JW, Rose G, Majamaa K, Perola M, Johnson TE, Bolund L, Yang HM, Passarino G, Franceschi C. . Aging Cell 2014, 13(3), 401-407.
• van den Heuvel J, Zandveld J, Mulder M, Brakefield PM, Kirkwood TBL, Shanley DP, Zwaan BJ. . Journal of Evolutionary Biology 2014, 27(11), 2322-2333.
• Holt IJ, Speijer D, Kirkwood TBL. . Philosophical Transactions of the Royal Society B-Biological Sciences 2014, 369(1646), 20130451.
• Wassall RR, Kingston A, Jagger C, Collerton J, Bond J, Kirkwood T, Steele J. . In: 92 General Session & Exhibition of the IADR Africa/Middle East Regional Meeting. 2014, Cape Town, South Africa.
• Kingston A, Robinson L, Kirkwood T, Collerton J, Davies K, Jagger C. . In: Gerontological Society of America 67th Annual Scientific Meeting. 2014, Washington DC: Oxford University Press.
• Kowald A, Kirkwood TBL. . Proceedings of the National Academy of Sciences of the United States of America 2014, 111(8), 2972-2977.
• Collerton J, Kingston A, Yousaf F, Davies K, Kenny A, Neely D, Martin-Ruiz C, MacGowan G, Robinson L, Kirkwood TBL, Keavney B. . BMC Cardiovascular Disorders 2014, 14, 128.
• Granic A, Kirkwood T, Davies K, Collerton J, Hill T, Martin-Ruiz C, vonZglinicki T, Aspray T, Mathers JC, Jagger C. . In: UK Molecular Epidemiology Group (MEG) Winter Meeting on The Future of Epidemiology: Biomarkers meet Populations. 2013, 麻豆传媒: Oxford University Press.
• Granic A, Hill T, Kirkwood T, Davies K, Collerton J, Mathers JC, Jagger C. . In: Nutrition Society Annual Summer Meeting. 2013, 麻豆传媒 upon Tyne, UK: Cambridge University Press.
• Collerton J, Ashok D, Martin-Ruiz C, Pyle A, Hudson G, Yadegarfar M, Davies K, Jagger C, von Zglinicki T, Kirkwood T, Chinnery P. . Neurobiology of Aging 2013, 34(12), 2889.e1-2889.e4.
• Beekman M, Blanche H, Perola M, Hervonen A, Bezrukov V, Sikora E, Flachsbart F, Christiansen L, De Craen AJM, Kirkwood TBL, Rea IM, Poulain M, Robine JM, Valensin S, Stazi MA, Passarino G, Deiana L, Gonos ES, Paternoster L, Sorensen TIA, Tan QH, Helmer Q, van den Akker EB, Deelen J, Martella F, Cordell HJ, Ayers KL, Vaupel JW, Tornwall O, Johnson TE, Schreiber S, Lathrop M, Skytthe A, Westendorp RGJ, Christensen K, Gampe J, Nebel A, Houwing-Duistermaat JJ, Slagboom PE, Franceschi C, GEHA Consortium. . Aging Cell 2013, 12(2), 184-193.
• Cevenini E, Cotichini R, Stazi MA, Toccaceli V, Scurti M, Mari V, Berardelli M, Passarino G, Jeune B, Franceschi C, Bezrukov V, Blanche H, Bolund L, Christensen K, Deiana L, Gonos E, Hervonen A, Kirkwood TBL, Kristensen P, Leon A, Pelicci PG, Perola M, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Toussaint O, Vaupel JW. . Mechanisms of Ageing and Development 2013, 134(11-12), 560-569.
• Flatt T, Amdam GV, Kirkwood TBL, Omholt SW. . Quarterly Review of Biology 2013, 88(3), 185-218.
• Kowald A, Kirkwood TBL. . Aging Cell 2013, 12(4), 728-731.
• Jefferis JM, Taylor JP, Collerton J, Jagger C, Kingston A, Davies K, Kirkwood T, Clarke MP. . Ophthalmic Epidemiology 2013, 20(2), 82–88.
• Beddington J, Cooper CL, Field J, Goswami U, Huppert FA, Jenkins R, Jones HS, Kirkwood TBL, Sahakian BJ, Thomas SM. . In: From Stress to Wellbeing. London, UK: Palgrave Macmillan, 2013, pp.271-279.
• van den Heuvel J, Saastamoinen M, Brakefield PM, Kirkwood TBL, Zwaan BJ, Shanley DP. . American Naturalist 2013, 181(2), E28-E42.
• Kirkwood TBL. . Cell Metabolism 2013, 18(3), 303-304.
• McAuley MT, Wilkinson DJ, Jones JJL, Kirkwood TBL. . BMC Systems Biology 2012, 6(1), 130.
• Proctor CJ, Pienaar IS, Elson JL, Kirkwood TBL. . Molecular Neurodegeneration 2012, 7(1), 32.
• Kirkwood TBL. . International Journal of Epidemiology 2012, 41(2), 351-352.
• Greaves LC, Elson JL, Nooteboom M, Grady JP, Taylor GA, Taylor RW, Mathers JC, Kirkwood TBL, Turnbull DM. . PLoS Genetics 2012, 8(11), e1003082.
• Rashidi A, Kirkwood TBL, Shanley DP. . In: Breitenbach, M., Jazwinski, S.M. Laun, P, ed. Aging Research in Yeast. Berlin; New York: Springer, 2012, pp.315-330.
• Collerton J, Martin-Ruiz C, Davies K, Hilkens CM, Isaacs J, Kolenda C, Parker C, Dunn M, Catt M, Jagger C, von Zglinicki T, Kirkwood TB. . Mechanisms of Ageing and Development 2012, 133(6), 456-466.
• Yousef F, Collerton J, Kingston A, Kenny A, Davies K, Jagger C, Robinson L, Kirkwood TBL, Keavney B. . Heart 2012, 98(19), 1418-1423.
• Kirkwood TBL, Kowald A. . BioEssays 2012, 34(8), 692-700.
• Jefferis JM, Collerton J, Taylor JP, Jagger c, Kingston A, Davies K, Kirkwood T, Clarke MP. . Age and Ageing 2012, 41(4), 565-568.
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• Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BFC, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. . EMBO Reports 2005, 6(11), 1006-1008.
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• Bateson P, Barker D, Clutton-Brock T, Deb D, D'Udine B, Foley RA, Gluckman P, Godfrey K, Kirkwood T, Lahr MM, McNamara J, Metcalfe NB, Monaghan P, Spencer HG, Sultan SE. . Nature 2004, 430(6998), 419-421.
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• Kirkwood TBL, Shanley DP. . Human and Experimental Toxicology 2000, 19(6), 338-339.
• Kirkwood TBL, Shanley DP. . BELLE Newsletter 2000, 8(3).
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• Kirkwood TBL. . Science in Parliament 1999, 56, 18-19.
• Kirkwood TBL. . London: Weidenfeld & Nicolson, 1999.
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• Kirkwood TBL. Alex Comfort and the measure of aging. Experimental Gerontology 1998, 33, 135-140.
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• Kirkwood TBL. What is the relationship between osteoarthritis and ageing?. Baillieres Clinical Rheumatology 1997, 11, 683-694.
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