麻豆传媒

Overview

My main research activities are spread across two areas (drug discovery and radical enzymes ) and two spin-out companies (NewChem Technologies and BiBerChem Research, based in the Biosphere on the 麻豆传媒 Helix site) for which I am scientific director.

I am a co-inventor of the drug rucaparib (Rubraca), approved by the FDA and EMA for treatment of BRCA-mutant ovarian cancer and available via the NHS.

I have supervised/co-supervised 100 PhD students successfully to graduation, as well as the research projects of ca. 100 master's/ERASMUS students.

Qualifications

BSc and PhD (University of Manchester); honorary DPhil (University of Stockholm).

Research Publications

Total Number of Publications: 468 including 348 research papers, 40 reviews, 10 commentaries and 4 edited books (164 research papers and 15 reviews since 2000) [data from Web of Science]. Note: published abstracts are excluded.

Total Number of Patents: 60 listed in espacenet.com mainly for drug development projects (cancer treatment, essential thrombocythemia, Alzheimer’s disease, severe pain, gastrointestinal disturbances).

Recent Awards

2019 Robert Robinson Award of the Royal Society of Chemistry, for contributions to biochemistry, microbiology and medicine.

2010 Co-winner of the 1^st Cancer Research UK ‘Translational Research Prize’, for inventing and developing potent inhibitors of polyADP-ribose polymerase-1 leading to the drug rucaparib/Rubraca.

2005 Doctor of Philosophy cum lauda (University of Stockholm, 2005) [awarded alongside J Saramago, winner of Nobel Prize for Literature 1998].

Extramural Interests

Walking/running (raising money for charities); cycling; improving animal welfare; cinema (especially Coen brothers).

Overview

Although I was trained as a synthetic organic chemist, working under Professor A Eschenmoser on the total synthesis of vitamin B12, my main interests today are the application of synthesis to the solution of problems in biology and medicine. This can mean the synthesis of isotopically labelled substrates for studying an enzyme mechanism or the synthesis of potential drugs for treating cancer. Synthesis is therefore central to all my studies and I am always looking for new ways to expedite reactions and improve methodology. Mechanistic studies are also a major focus, especially the catalytic reactions of radical enzymes. I collaborate widely in order to maximise the ability to solve interdisciplinary problems. At 麻豆传媒, besides my research studying radical enzymes, I have worked within a team of scientists developing new drugs against cancer targets. I was co-founder of this group in 1990 (with A H Calvert and D R Newell). In 2010, we were awarded the first translational research prize from Cancer Research UK for our pioneering work on inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase. I also have had many international collaborations, involving scientists in Australia, Germany, Italy, Japan, Sweden and Switzerland. My co-workers have often spent time in collaborator’s laboratories and there have been frequent visitors from abroad. My group has always been multinational with students or postdocs from e.g. China, France, Germany, India, Iran, Italy, Poland and Spain, as well as the UK. I have supervised/co-supervised more than 100 research students, all of whom obtained the PhD degree. My research has been funded by a variety of sources including the European Commission, German Research Foundation (DFG), UK Research Councils, Cancer Research UK and the pharmaceutical industry.

In addition to my academic research, I am scientific director of the spin-out companies NewChem Technologies (founded 2002) and BiBerChem Research (2017), which are housed in the Biosphere, 麻豆传媒 Helix site. NewChem has 23 employees currently, many of whom are former 麻豆传媒 chemistry graduates, and works in collaboration with pharmaceutical and academic partners to develop new therapeutic agents.

RESEARCH AREAS

 Application of chemical synthesis and mechanistic studies to the solution of problems in biology and medicine: 

Drug Discovery.- rational design of new anticancer agents based on the molecular pathology of cancer; targets include poly(ADP-ribose) polymerases, DNA-dependent protein kinase, cyclin dependent kinases and the MDM2/p53 protein-protein interaction [collaboration with colleagues in Chemistry [R J Griffin (deceased), M J Waring et al] and 麻豆传媒 Medical School (A H Calvert, D R Newell et al)]. Interdisciplinary research at 麻豆传媒 discovered the first potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) through medicinal chemistry (directed by myself and R J Griffin), cancer pharmacology and preclinical work leading to first-in-human clinical studies. This research led to the development of the drug rucaparib (trade name Rubraca), which was granted approval by the US Food & Drug Administration (2016) and European Medicines Agency (2018) for the treatment of BRCA mutant ovarian cancer and is now available via the NHS.

The importance of the 麻豆传媒 team’s contribution was recognised by the award (2010) of the first Cancer Research UK Translational Cancer Research prize to Golding and Griffin (School of Chemistry) with A H Calvert, N J Curtin, B Durkacz, D R Newell (Northern Institute for Cancer Research). This research was also the basis of School of Chemistry Impact Cases for the 2014 and 2021 Research Excellence Framework (REF) achieving a 4* rating in both.

Enzyme Mechanisms.- especially unusual or ‘impossible’ reactions including those for which radicals are intermediates, e.g. coenzyme B₁₂-dependent reactions; anaerobic functionalisation of hydrocarbons and prebiotic enzyme-like processes [partly in collaboration with: W Buckel, H Heider (Marburg); R Rabus, H Wilkes (Oldenburg); C Chatgiliagolu (Bologna)].

Synthetic Organic Chemistry.- synthesis of biologically active molecules including specifically labelled compounds; development of new methodology including protecting groups; use of 2,2,2-trifluoroethanol in synthesis; bifurcating hydrogen bonding for catalysing epoxide reactions with amine nucleophiles.

Other Research.- Molecular toxicology (atmospheric pollutants, e.g. benzene), prebiotic chemistry, hydrogen production (clean energy), carbon dioxide sequestration; environmental chemistry.

Publications

Total Number of Publications: 468 including 348 research papers, 60 patents, 40 reviews, 10 commentaries and 4 edited books (164 research papers, 57 patents, and 15 reviews since 2000) [Web of Science and espacenet.com data excluding published abstracts].

10 Highly Cited Publications since 2000

1.     White AW, Griffin RJ, Golding BT et al, Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose)polymerase (PARP), J Med Chem, 2000, 43, 4084-4097 [264 citations]

2.     Arris CE, Golding BT, Griffin RJ et al, Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles, J Med Chem, 2000, 43, 2797-2804 [200 citations]

3.     Smith DM, Golding BT, Radom L, Understanding the mechanism of B₁₂-dependent diol dehydratase: A synergistic retro-push-pull proposal, J Am Chem Soc, 2001, 123, 1664-1675 [90 citations]

4.     Davies TG, Golding BT, Griffin RJ et al, Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor, Nat Chem Biol, 2002, 9, 745-749 [196 citations]

5.     Leahy JJJ, Golding BT, Griffin RJ et al, Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries, Bioorg Med Chem Lett, 2004, 14, 6083-6087 [307 citations]

6.     Buckel W, Golding BT, Radical enzymes in anaerobes. Annu Rev Microbiol. 2006, 60, 27-49 [139 citations]

7.     Wang X, Golding BT, Scott, K et al, A polytetrafluoroethylene-quaternary 1,4-diazabicyclo-[2.2.2]-octane polysulfone composite membrane for alkaline anion exchange membrane fuel cells, Int J Hydrogen Energy, 2011, 36, 10022-10026 [71 citations]

8.     Hardcastle IR, Golding BT, Griffin RJ et al, Isoindolinone inhibitors of the murine double minute 2 (MDM2)-p53 protein-protein interaction: structure-activity studies leading to improved potency, J Med Chem, 2011, 54, 1233-1243[125 citations]

9.     Jarling R, Golding BT, Wilkes H et al, Stereochemical investigations reveal the mechanism of the bacterial activation of n-alkanes without oxygen, Angew Chem Intl Edn, 2012, 51, 1334-1338 [53 citations]

10.  Kimes NE, Callaghan AV, Golding BT et al, Metagenomic analysis and metabolite profiling of deep-sea sediments from the Gulf of Mexico following the Deepwater Horizon oil spill, Frontiers Microbiol, 2013, 4, Article no 50 [187 citations]

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Overview

I have delivered around 2000 lectures during my academic career covering most areas of orgnaic chemistry (including biological, medicinal and synthetic chemistry).

Recent Courses

Structural Chemistry - Mass Spectrometry

Bioactive Natural Products

Chemical Toxicology and Drug Metabolism

Chemical Biology

• Articles

  • Watson WP, Munter T, Golding BT. . Chemico-Biological Interactions 2023, 382, 110591.
  • Miller DC, Reuillon T, Molyneux L, Blackburn T, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hardcastle I, Harnor SJ, Heptinstall A, Lochhead P, Martin MP, Martin NC, Myers S, Newell DR, Noble RA, Phillips N, Rigoreau L, Thomas H, Tucker JA, Wang L-Z, Waring MJ, Wong A-C, Wedge SR, Noble MEM, Cano C. . Journal of Medicinal Chemistry 2022, 65(9), 6513-6540.
  • Golding BT, Abelairas-Edesa M, Tilbury RD, Wilson JP, Zhang D, Henderson AP, Bleasdale C, Clegg W, Watson WP. . Chemico-Biological Interactions 2022, 361, 109949.
  • Uguen M, Davison G, Sprenger LJ, Hunter JH, Martin MP, Turberville S, Watt JE, Golding BT, Noble MEM, Stewart HL, Waring MJ. . Journal of Medicinal Chemistry 2022, 65(16), 11322-11339.
  • Chessari G, Hardcastle IR, Ahn JS, Anil B, Anscome E, Bawn RH, Bevan LD, Blackburn TJ, Buck I, Cano C, Carbain B, Castro J, Cons B, Cully SJ, St Denis J, Endicott JA, Fazal L, Golding BT, Griffin RJ, Haggerty K, Harnor S, Hearn K, Hobson S, Holvey RS, Howard S, Jennings C, Johnson CN, Lunec J, Miller DC, Newell DR, Noble MEM, Reeks J, Revill CH, Riedinger C, Tamanini E, Thomas H, Thompson NT, Vinkovic M, Wedge SR, Williams PA, Wilsher N, Zhang B, Zhao Y. . Journal of Medicinal Chemistry 2021, 64(7), 4071-4088.
  • Mitschke N, Erucar G, Fsadni MH, Roberts AR, Sadeghi MM, Golding BT, Christoffers J, Wilkes H. . European Journal of Organic Chemistry 2021, 2021(27), 3854-3863.
  • Drozdowska M, Tromans J, Zhang B, Jarling R, Wilkes H, Golding BT. . ChemistrySelect 2021, 6(16), 3976-3981.
  • Picazo EMH, Heptinstall AB, Wilson DM, Cano C, Golding BT, Waring MJ. . Journal of Heterocyclic Chemistry 2021, 58(4), 947-951.
  • Al-Khawaldeh I, Aldred GG, Alyassiri M, Basmadjian C, Bordoni C, Harnor SJ, Heptinstall AB, Hobson SJ, Jennings CE, Khalifa S, Lebraud H, Miller DC, Shrives HJ, de Souza JV, Stewart HL, Temple M, Totobenazara J, Tucker JA, Tudhope SJ, Wang LZ, Bronowska AK, Cano C, Endicott JA, Golding BT, Hardcastle IR, Hickson I, Wedge SR, Willmore E, Noble MEM, Waring MJ. . Journal of Medicinal Chemistry 2021, 64(14), 10001-10018.
  • Al-Sheikh A, Begum M, Zhang B, Lewis RA, Allenby NEE, Waddell PG, Golding BT. . Molecules (Basel, Switzerland) 2020, 25(24), 5868.
  • Matheson CJ, Coxon CR, Bayliss R, Boxall K, Carbain B, Fry AM, Hardcastle IR, Harnor SJ, Mas-Droux C, Newell DR, Richards MW, Sivaprakasam M, Turner D, Griffin RJ, Golding BT, Cano C. . RSC Medicinal Chemistry 2020, 11(6), 707-731.
  • Newland MJ, Rea GJ, Thuner LP, Henderson AP, Golding BT, Rickard AR, Barnes I, Wenger J. . Physical Chemistry Chemical Physics 2019, 21(3), 1160-1171.
  • Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang L-Z, Wong A-C, Noble MEM, Wedge SR, Cano C. . European Journal of Medicinal Chemistry 2019, 178, 530-543.
  • Golding BT, Waring MJ. . Expert Opinion on Drug Discovery 2018, 13(7), 583-585.
  • Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C. . Organic and Biomolecular Chemistry 2018, 16(11), 1843-1850.
  • Barata-Vallejo S, Ferreri C, Golding BT, Chatgilialoglu C. . Organic Letters 2018, 20(14), 4290-4294.
  • Espiritu R, Golding BT, Scott K, Mamlouk M. . Journal of Power Sources 2018, 375, 373-386.
  • Coxon RC, Wong C, Bayliss R, Boxall K, Carr KH, Fry AM, Hardcastle IR, Matheson CJ, Newell DR, Sivaprakasam M, Thomas H, Turner D, Yeoh S, Wang LZ, Griffin RJ, Golding BT, Cano C. . Oncotarget 2017, 8, 19089-19124.
  • Coxon C, Anscombe E, Harnor S, Martin M, Carbain B, Golding B, Hardcastle I, Harlow L, Korolchuk S, Matheson C, Newell D, Noble M, Sivaprakasam M, Tudhope SJ, Turner D, Wang L, Wedge SR, Wong C, Griffin R, Endicott J, Cano C. . Journal of Medicinal Chemistry 2017, 60, 1746-1767.
  • Mullaney JC, Medcraft C, Tew DP, Lewis-Borrell L, Golding BT, Walker NR, Legon AC. . Physical Chemistry Chemical Physics 2017, 19, 25080-25085.
  • Cortese D, Konstantin C, Guglielmo S, Wang LZ, Golding BT, Cano C, Fruttero R. . ChemMedChem 2016, 11(6), 1705-1708.
  • Wang X, Wang Y, Golding BT, Yu EH, Scott K. . Chemical Engineering Transactions 2016, 51, 121-126.
  • Tommasino C, Gambardella L, Buoncervello M, Griffin RJ, Golding BT, Alberton M, Macchia D, Spada M, Cerbelli B, d'Amati G, Malorni W, Gabriele L, Giammarioli AM. . Journal of Experimental & Clinical Cancer Research 2016, 35, 137.
  • Myers SM, Bawn RH, Bisset LC, Blackburn TJ, Cottyn B, Molyneux L, Wong AC, Cano C, Clegg W, Harrington RW, Leung H, Rigoreau L, Vidot S, Golding BT, Griffin RJ, Hammonds T, Newell DR, Hardcastle IR. . ACS Combinatorial Science 2016, 18(8), 444-455.
  • Seyhan D, Friedrich P, Szaleniec M, Hilberg M, Buckel W, Golding BT, Heider J. . Angewandte Chemie International Edition 2016, 55(38), 11664-11667.
  • Reuillon T, Alhasan SF, Beale GS, Bertoli A, Brennan A, Cano C, Reeves HL, Newell DR, Golding BT, Miller DC, Griffin RJ. . Chemical Science 2016, 7(4), 2821-2826.
  • Zaytsev AV, Pickles JE, Harnor SJ, Henderson AP, Alyasiri M, Waddell PG, Cano C, Griffin RJ, Golding BT. . RSC Advances 2016, 6(59), 53955-53957.
  • Beale G, Haagensen E, Thomas H, Wang LZ, Revill C, Payne S, Golding BT, Hardcastle IR, Newell DR, Griffin RJ, Cano C. . British Journal of Cancer 2016, 115, 682-690.
  • Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PMH, Kruger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H. . Journal of Molecular Microbiology and Biotechnology 2016, 26(1-3), 5-28.
  • Rabus R, Boll M, Golding B, Wilkes H. . Journal of Molecular Microbiology and Biotechnology 2016, 26(1-3), 63-75.
  • Mitcheson DF, Bottrill AR, Carr K, Coxon CR, Cano C, Golding BT, Griffin RJ, Fry AM, Doerig C, Bayliss R, Tobin AB. . Malaria Journal 2016, 15, 535.
  • Jarling R, Kuhner S, Janke EB, Gruner A, Drozdowska M, Golding BT, Rabus R, Wilkes H. . Frontiers in Microbiology 2015, 6, 880.
  • Shouksmith AE, Evans LE, Tweddle DA, Miller DC, Willmore E, Newell DR, Golding BT, Griffin RJ. . Australian Journal of Chemistry 2015, 68(4), 660-679.
  • Zaytsev A, Dodd B, Magnani M, Ghiron C, Golding BT, Griffin RJ, Liu J, Lu X, Micco I, Newell DR, Padova A, Robertson G, Lunec J, Hardcastle IR. . Chemical Biology and Drug Discovery 2015, 86(2), 180-189.
  • Miller DC, Carbain B, Beale GS, Alhasan SF, Reeves HL, Baisch U, Newell DR, Golding BT, Griffin RJ. . Organic & Biomolecular Chemistry 2015, 13(18), 5279-5284.
  • Dragicevic I, Baric D, Kovacevic B, Golding BT, Smith DM. . Chemistry: A European Journal 2015, 21(16), 6132-6143.
  • Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann M, Danielson UH, Stanley WA, Wang LZ, Reuillon T, Golding BT, Cano C, Newell DR, Noble MEM, Wedge SR, Endicott JA, Griffin RJ. . Chemistry & Biology 2015, 22(9), 1159-1164.
  • Yamada Y, Wehrli P, Miljkovic D, Wild H-J, Buhler N, Gotschi E, Golding B, Loliger P, Gleason J, Place B, Ellis L, Hunkeler W, Schneider P, Fuhrer W, Nordmann R, Srinivasachar K, Keese R, Muller K, Neier R, Eschenmoser A. . Helvetica Chimica Acta 2015, 98(11-12), 1921-2054.
  • Carbain B, Coxon CR, Lebraud H, Elliott KJ, Matheson CJ, Meschini E, Roberts AR, Turner DM, Wong C, Cano C, Griffin RJ, Hardcastle IR, Golding BT. . Chemistry: A European Journal 2014, 20(8), 2311-2317.
  • Harnor SJ, Rennison T, Galler M, Cano C, Griffin RJ, Newell DR, Golding BT. . MedChemComm 2014, 5(7), 984-988.
  • Lebraud H, Coxon CR, Archard VS, Bawn CM, Carbain B, Matheson CJ, Turner DM, Cano C, Griffin RJ, Hardcastle IR, Baisch U, Harrington RW, Golding BT. . Organic & Biomolecular Chemistry 2014, 12, 141-148.
  • Strijkstra A, Trautwein K, Jarling R, Wohlbrand L, Dorries M, Reinhardt R, Drozdowska M, Golding BT, Wilkes H, Rabus R. . Applied and Environmental Microbiology 2014, 80(24), 7592-7603.
  • Motwani HV, Shimakoshi H, Golding BT, Tornqvist M, Hisaeda Y. . Tetrahedron Letters 2014, 55(16), 2667-2670.
  • Carbain B, Paterson DJ, Anscombe E, Campbell AJ, Cano C, Echalier A, Endicott JA, Golding BT, Haggerty K, Hardcastle IR, Jewsbury PJ, Newell DR, Noble MEM, Roche C, Wang LZ, Griffin RJ. . Journal of Medicinal Chemistry 2014, 57(1), 56-70.
  • Lebraud H, Cano C, Carbain B, Hardcastle IR, Harrington RW, Griffin RJ, Golding BT. . Organic & Biomolecular Chemistry 2013, 11(11), 1874-1878.
  • Kimes NE, Callaghan AV, Aktas DF, Smith WL, Sunner J, Golding BT, Drozdowska M, Hazen TC, Suflita JM, Morris PJ. . Frontiers in Microbiology 2013, 4, 50.
  • Blackburn TJ, Ahmed S, Coxon CR, Liu JF, Lu XH, Golding BT, Griffin RJ, Hutton C, Newell DR, Ojo S, Watson AF, Zaytzev A, Zhao Y, Lunec J, Hardcastle IR. . MedChemComm 2013, 4(9), 1297-1304.
  • Eberlein C, Johannes J, Mouttaki H, Sadeghi M, Golding BT, Boll M, Meckenstock RU. . Environmental Microbiology 2013, 15(6), 1832-1841.
  • Cano C, Saravanan K, Bailey C, Bardos J, Curtin NJ, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Menear KA, Newell DR, Richardson CJ, Shea K, Smith GCM, Thommes P, Ting A, Griffin RJ. . Journal of Medicinal Chemistry 2013, 56(16), 6386-6401.
  • Scott RB, Downey KM, Healy KP, Henderson AP, Robinson CL, Clegg W, Harrington RW, Franklin R, Golding BT. . Heterocycles 2012, 86(2), 1637-1646.
  • Jarling R, Sadeghi M, Drozdowska M, Lahme S, Buckel W, Rabus R, Widdel F, Golding BT, Wilkes H. . Angewandte Chemie: International Edition 2012, 51(6), 1334-1338.
  • Jiang D, Barata-Vallejo S, Golding BT, Ferreri C, Chatgilialoglu C. . Organic & Biomolecular Chemistry 2012, 10(5), 1102-1107.
  • Clapham KM, Rennison T, Jones G, Craven F, Bardos J, Golding BT, Griffin RJ, Haggerty K, Hardcastle IR, Thommes P, Ting A, Cano C. . Organic & Biomolecular Chemistry 2012, 10(33), 6747-6757.
  • Zhang ZL, Tian C, Zhou SX, Wang W, Guo Y, Xia J, Liu ZM, Wang BA, Wang XW, Golding BT, Griffin RJ, Du YS, Liu JY. . European Journal of Medicinal Chemistry 2012, 58, 228-236.
  • Buckel W, Friedrich P, Golding BT. . Angewandte Chemie: International Edition 2012, 51(40), 9974-9976.
  • Friedrich P, Baisch U, Harrington RW, Lyatuu F, Zhou K, Zelder F, McFarlane W, Buckel W, Golding BT. . Chemistry: A European Journal 2012, 18(50), 16114-16122.
  • Reuillon T, Bertoli A, Griffin RJ, Miller DC, Golding BT. . Organic & Biomolecular Chemistry 2012, 10(37), 7610-7617.
  • Coffey K, Blackburn TJ, Cook S, Golding BT, Griffin RJ, Hardcastle IR, Hewitt L, Huberman K, McNeill HV, Newell DR, Roche C, Ryan-Munden CA, Watson A, Robson CN. . PLoS One 2012, 7(10), e45539.
  • Rodriguez SA, Clapham KM, Barrett L, Cano C, Desage ME, Griffin RJ, Hardcastle IR, Payne SL, Rennison T, Richardson C, Golding BT. . Organic & Biomolecular Chemistry 2011, 9(17), 6066-6074.
  • Thomas HD, Wang LZ, Roche C, Bentley J, Cheng YZ, Hardcastle IR, Golding BT, Griffin RJ, Curtin NJ, Newell DR. . European Journal of Cancer 2011, 47(13), 2052-2059.
  • Saravanan K, Barlow HC, Barton M, Calvert AH, Golding BT, Newell DR, Northen JS, Curtin NJ, Thomas HD, Griffin RJ. . Journal of Medicinal Chemistry 2011, 54(6), 1847-1859.
  • Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ. . Proceedings of the National Academy of Sciences 2011, 108(45), 18260-18265.
  • Watson AF, Liu JF, Bennaceur K, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lu XH, McDonnell JM, Newell DR, Noble MEM, Revill CH, Riedinger C, Xu Q, Zhao Y, Lunec J, Hardcastle IR. . Bioorganic & Medicinal Chemistry Letters 2011, 21(19), 5916-5919.
  • Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J. . Journal of Medicinal Chemistry 2011, 54(5), 1233-1243.
  • Begemann P, Boysen G, Georgieva NI, Sangaiah R, Koshlap KM, Koc H, Zhang DP, Golding BT, Gold A, Swenberg JA. . Chemical Research in Toxicology 2011, 24(7), 1048-1061.
  • Clapham KM, Bardos J, Finlay R, Golding BT, Griffen EJ, Griffin RJ, Hardcastle IR, Menear KA, Ting A, Turner P, Young GL, Cano C. . Bioorganic & Medicinal Chemistry Letters 2011, 21(3), 966-970.
  • Motwani HV, Qiu SR, Golding BT, Kylin H, Tornqvist M. . Food and Chemical Toxicology 2011, 49(4), 750-757.
  • Wong C, Griffin RJ, Hardcastle IR, Northen JS, Wang LZ, Golding BT. . Organic & Biomolecular Chemistry 2010, 8(10), 2457-2464.
  • Marchetti F, Cano C, Curtin NJ, Golding BT, Griffin RJ, Haggerty K, Newell DR, Parsons RJ, Payne SL, Wang LZ, Hardcastle IR. . Organic & Biomolecular Chemistry 2010, 8(10), 2397-2407.
  • Golding BT, Barnes ML, Bleasdale C, Henderson AP, Jiang D, Li X, Mutlu E, Petty HJ, Sadeghi MM. . Chemico-Biological Interactions 2010, 184(1-2), 196-200.
  • Payne SL, Rodriguez-Aristegui S, Bardos J, Cano C, Golding BT, Hardcastle IR, Peacock M, Parveen N, Griffin RJ. . Bioorganic & Medicinal Chemistry Letters 2010, 20(12), 3649-3653.
  • Cano C, Barbeau OR, Bailey C, Cockcroft XL, Curtin NJ, Duggan H, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Knights C, Menear KA, Newell DR, Richardson CJ, Smith GC, Spittle B, Griffin RJ. . Journal of Medicinal Chemistry 2010, 53(24), 8498-8507.
  • Cano C, Golding BT, Haggerty K, Hardcastle IR, Peacock M, Griffin RJ. . Organic & Biomolecular Chemistry 2010, 8(8), 1922-1928.
  • Thomas HD, Saravanan K, Wang LZ, Lin MJ, Northen JS, Barlow H, Barton M, Newell DR, Griffin RJ, Golding BT, Curtin NJ. . Molecular Cancer Therapeutics 2009, 8(7), 1828-1837.
  • Velarde M, Macieira S, Hilberg M, Broker G, Tu SM, Golding BT, Pierik AJ, Buckel W, Messerschmidt A. . Journal of Molecular Biology 2009, 391(3), 609-620.
  • Motwani HV, Fred C, Hagolund J, Golding BT, Tornqvist M. . Chemical Research in Toxicology 2009, 22(9), 1509-1516.
  • Suarez D, Laval G, Tu SM, Jiang D, Robinson CL, Scott R, Golding BT. . Synthesis 2009, (11), 1807-1810.
  • Thiele B, Rieder O, Golding BT, Müller M, Boll M. . Journal of the American Chemical Society 2008, 130(43), 14050-14051.
  • Pierik AJ, Graf T, Pemberton L, Golding BT, Retey J. . ChemBioChem 2008, 9(14), 2268-2275.
  • Bauer G, Chatgilialoglu C, Gebicki JL, Gebicka L, Gescheidt G, Golding BT, Goldstein S, Kaizer J, Merenyi G, Speier G, Wardman P. . Chimia 2008, 62(9), 704-712.
  • Riedinger C, Endicott JA, Kemp SJ, Smyth LA, Watson A, Valeur E, Golding BT, Griffin RJ, Hardcastle IR, Noble ME, McDonnell JM. . Journal of the American Chemical Society 2008, 130(47), 16038-16044.
  • Murr M, Cano C, Golding BT, Hardcastle IR, Hummersome M, Frigerio M, Curtin NJ, Menear K, Richardson C, Smith G, Griffin R. . Bioorganic and Medicinal Chemistry Letters 2008, 18(17), 4885-4890.
  • Munter T, Cottrell L, Ghai R, Golding BT, Watson WP. . Chemico-Biological Interactions 2007, 166(1-3), 323-331.
  • Marchetti F, Sayle KL, Bentley J, Clegg W, Curtin NJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Harrington RW, Mesguiche V, Newell DR, Noble MEM, Parsons RJ, Pratt DJ, Wang L, Hardcastle IR, Mesguiche V, Newell DR, Noble MEM, Parsons RJ, Pratt DJ, Wang L, Hardcastle IR. . Organic and Biomolecular Chemistry 2007, 5(10), 1577-1585.
  • Barbeau OR, Cano-Soumillac C, Griffin RJ, Hardcastle IR, Smith GCM, Richardson C, Clegg W, Harrington RW, Golding BT. . Organic & Biomolecular Chemistry 2007, 5(16), 2670-2677.
  • Hollick J, Rigoreau L, Cano-Soumillac C, Cockcroft X, Curtin NJ, Frigerio M, Golding BT, Guiard S, Hardcastle IR, Hickson I, Hummersone M, Menear K, Martin N, Matthews I, Newell DR, Ord R, Richardson C, Smith G, Griffin RJ. . Journal of Medicinal Chemistry 2007, 50(8), 1958-1972.
  • Butler P, Golding BT, Laval G, Loghmani-Khouzani H, Ranjbar-Karimi R, Sadeghi MM. . Tetrahedron 2007, 63(45), 11160-11166.
  • Seeberger S, Griffin RJ, Hardcastle IR, Golding BT. . Organic & Biomolecular Chemistry 2007, 5(1), 132-138.
  • Buckel W, Kratky C, Golding BT. . Chemistry - A European Journal 2006, 12(2), 352-362.
  • Sadeghi MM, Loghmani-Khouzani H, Ranjbar-Karimi R, Golding BT. . Tetrahedron Letters 2006, 47(14), 2455-2457.
  • Hardcastle, I.R., Ahmed, S., Atkins, H., Farnie, G., Golding, B.T., Griffin, R.J., Guyenne, S., Hutton,C., Källblad, P., Kemp, S., Kitching, M.S., Newell, D.R., Norbedo, S., Northen, J.S., Reid, R.J., Saravanan, K., Willems, H., Lunec, J. . Journal of Medicinal Chemistry 2006, 49(21), 6209-6221.
  • Griffin RJ, Henderson A, Curtin NJ, Echalier A, Endicott J, Hardcastle IR, Newell DR, Noble M, Wang L, Golding BT. . Journal of the American Chemical Society 2006, 128(18), 6012-6013.
  • Buckel W, Pierik AJ, Plett S, Alhapel A, Suarez D, Tu S-M, Golding BT. . European Journal of Inorganic Chemistry 2006, (18), 3622-3626.
  • Aristegui SR, El-Murr MD, Golding BT, Griffin RJ, Hardcastle IR. . Organic Letters 2006, 8(26), 5927-5929.
  • Sandala GM, Smith DM, Coote ML, Golding BT, Radom L. . Journal of the American Chemical Society 2006, 128(10), 3433-3444.
  • Naser U, Pierik AJ, Scott R, Cinkaya I, Buckel W, Golding BT. . Bioorganic Chemistry 2005, 33(1), 53-66.
  • Griffin RJ, Fontana G, Golding BT, Guiard SL, Hardcastle IR, Leahy JJJ, Martin N, Richardson C, Rigoreau LJM, Stockley ML, Smith GCM. . Journal of Medicinal Chemistry 2005, 48(2), 569-585.
  • Pierik AJ, Ciceri D, Lopez RF, Kroll F, Broker G, Beatrix B, Buckel W, Golding BT. . Biochemistry 2005, 44(31), 10541-10551.
  • Henderson AP, Barnes ML, Bleasdale C, Cameron R, Clegg W, Heath SL, Lindstrom AB, Rappaport SM, Waidyanatha S, Watson WP, Golding BT. . Chemical Research in Toxicology 2005, 18(2), 265-270.
  • Silvari V, Haglund J, Jenssen D, Golding BT, Ehrenberg L, Tornqvist M. . Mutation Research - Genetic Toxicology and Environmental Mutagenesis 2005, 580(1-2), 91-101.
  • Nutley BP, Smith NF, Hayes A, Kelland LR, Brunton L, Golding BT, Smith GCM, Martin NMB, Workman P, Raynaud FI. . British Journal of Cancer 2005, 93(9), 1011-1018.
  • Pennati M, Campbell AJ, Curto M, Binda M, Cheng Y, Wang L, Curtin NJ, Golding BT, Griffin RJ, Hardcastle IR, Henderson A, Zaffaroni N, Newell DR. . Molecular Cancer Therapeutics 2005, 4(9), 1328-1337.
  • Hardcastle I, Ahmed S, Atkins H, Calvert AH, Curtin NJ, Farnie G, Golding BT, Griffin R, Guyenne S, Hutton C, Källblad P, Kemp S, Kitching M, Newell D, Norbedo S, Northen J, Reid R, Saravanan K, Willems H, Lunec J. . Bioorganic and Medicinal Chemistry Letters 2005, 15(5), 1515-1520.
  • Paulsson B, Rannug A, Henderson AP, Golding BT, Tornqvist M, Warholm M. . Mutation Research: Genetic Toxicology and Environmental Mutagenesis 2005, 580(1-2), 53-59.
  • Barfod R, Eriksen J, Golding BT, Hammershoi A, Jacobsen TA, Langkilde A, Larsen S, Monsted O, Sargeson AM, Sorensen HO. . Dalton Transactions 2005, (3), 491-500.
  • Henderson AP, Bleasdale C, Delaney K, Lindstrom AB, Rappaport SM, Waidyanatha S, Watson WP, Golding BT. . Bioorganic Chemistry 2005, 33(5), 363-373.
  • Hardcastle I, Cockcroft X, Curtin NJ, El-Murr M, Leahy JJJ, Stockley M, Golding BT, Rigoreau L, Richardson C, Smith G, Griffin RJ. . Journal of Medicinal Chemistry 2005, 48(24), 7829-7846.
  • Begemann P, Christova-Georgieva NI, Sangaiah R, Koc H, Zhang D, Golding BT, Gold A, Swenberg JA. . Chemical Research in Toxicology 2004, 17(7), 929-936.
  • Scott R, Naser U, Friedrich P, Selmer T, Buckel W, Golding BT. . Chemical Communications 2004, 10(10), 1210-1211.
  • Curtin, N., Barlow, H., Bowman, K., Calvert, A. H., Davison, R., Golding, B., Huang, B., Loughlin, P., Newell, D., Smith, P., Griffin, R. . Journal of Medicinal Chemistry 2004, 47(20), 4905-4922.
  • White, A., Curtin, N.J., Eastman, B., Golding, B.T., Hostomsky, Z., Kyle,S., Li, J., Maegley, K., Skalitzky, D., Webber, S., Yu, X., Griffin, R.J. . Bioorganic and Medicinal Chemistry Letters 2004, 14(10), 2433-2437.
  • Castillo-Melendez JA, Golding BT. . Synthesis 2004, (10), 1655-1663.
  • Hardcastle IR, Arris CE, Bentley J, Boyle FT, Chen Y, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Jewsbury, P., Menyerol, J., Mesguiche, V., Newell, D.R., Noble, M., Pratt, D., Wang, L., Whitfield, H.J. . Journal of Medicinal Chemistry 2004, 47(15), 3710-3722.
  • Scott R, Golding BT. . Arkivoc 2004, 2004(x), 118-133.
  • Leahy JJJ, Golding BT, Griffin RJ, Hardcastle IR, Richardson C, Rigoreau L, Smith GCM. . Bioorganic & Medicinal Chemistry Letters 2004, 14(24), 6083-6087.
  • Chetty R, Christensen PA, Golding BT, Scott K. . Applied Catalysis A: General 2004, 271(1-2), 185-194.
  • Tikhe J, Webber S, Hostomsky Z, Maegley K, Ekkers A, Li J, Yu X, Almassy R, Kumpf R, Boritzki T, Zhang C, Calabrese C, Curtin NJ, Kyle S, Thomas HD, Wang L, Calvert AH, Golding B, Griffin RJ, Newell DR. . Journal of Medicinal Chemistry 2004, 47(22), 5467-5481.
  • Speranza G, Buckel W, Golding BT. . Journal of Porphyrins and Phthalocyanines 2004, 8(1-3), 290-300.
  • Fred C, Cantillana T, Henderson AP, Golding BT, Tornqvist M. . Rapid Communications in Mass Spectrometry 2004, 18(18), 2177-2184.
  • Watson WP, Munter T, Golding BT. . Chemical Research in Toxicology 2004, 17(12), 1562-1567.
  • Henderson AP, Bleasdale C, Clegg W, Golding BT. . Chemical Research in Toxicology 2004, 17(3), 378-382.
  • Skalitzky, D., Marakovits, J., Maegley, K., Ekker, A., Yu, X., Hostomsky, Z., Webber, S., Eastman, B., Almassy, R., Li, J., Curtin, N. J., Newell, D. R., Calvert, A. H., Griffin, R. J., Golding, B. T. . Journal of Medicinal Chemistry 2003, 46(2), 210-213.
  • Sayle, K., Bentley, J., Boyle, F., Calvert, A. H., Cheng, Y., Curtin, N. J., Endicott, J., Golding, B., Hardcastle, I., Jewsbury, P., Mesguiche, V., Newell, D. R., Noble, M., Parsons, R., Pratt, D., Wang, L., Griffin, R. J. . Bioorganic and Medicinal Chemistry Letters 2003, 13(18), 3079-3082.
  • Darley DJ, Selmer T, Clegg W, Harrington RW, Buckel W, Golding BT. . Helvetica Chimica Acta 2003, 86(12), 3991-3999.
  • Golding BT, Cottrell L, Mackay D, Zhang D, Watson WP. . Chemical Research in Toxicology 2003, 16(7), 933-944.
  • Laval G, Golding BT. One-pot sequence for the decarboxylation of α-amino acids. Synlett 2003, (4), 542-546.
  • Hamilton JF, Lewis AC, Bloss C, Wagner V, Henderson AP, Golding BT, Wirtz K, Martin-Reviejo M, Pilling MJ. . ATMOSPHERIC CHEMISTRY AND PHYSICS 2003, 3, 1999-2014.
  • Paulsson B, Kotova N, Grawe J, Henderson A, Granath F, Golding B, Tornqvist M. . Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2003, 535(1), 15-24.
  • Chetty R, Christensen PA, Golding BT. . Chemical Communications 2003, 9(8), 984-985.
  • Whitfield HJ, Griffin RJ, Hardcastle IR, Henderson AP, Meneyrol J, Mesguiche V, Sayle KL, Golding BT. . Chemical Communications 2003, (22), 2802-2803.
  • Munter T, Cottrell L, Golding BT, Watson WP. . Chemical Research in Toxicology 2003, 16(10), 1287-1297.
  • Hetzel M, Brock M, Selmer T, Pierik AJ, Golding BT, Buckel W. . European Journal of Biochemistry 2003, 270(5), 902-910.
  • Mesguiche, V, Parsons, R.J., Arris, C.E., Bentley, J., Boyle, F., Curtin, N.J., Davies, T.G., Endicott, J., Gibson, A., Golding, B., Griffin, R.J., Jewsbury, P., Johnson, L.N., Newell, D.R., Noble, M.E.M., Wang, L., Hardcastle, I.R. . Bioorganic and Medicinal Chemistry Letters 2003, 13(2), 217-222.
  • Hollick JJ, Golding BT, Hardcastle IR, Martin N, Richardson C, Rigoreau LJM, Smith GCM, Griffin RJ. . Bioorganic & Medicinal Chemistry Letters 2003, 13(18), 3083-3086.
  • Carey KA, Clegg W, Elsegood MRJ, Golding BT, Maskill H. . Acta Crystallographica, Section E: Structure Reports Online 2003, E59(3), o263-o265.
  • Henderson AP, Mutlu E, Leclercq A, Bleasdale C, Clegg W, Henderson RA, Golding BT. . Chemical Communications 2002, 8(17), 1956-1957.
  • Carey KA, Clegg W, Elsegood MRJ, Golding BT, Hill MNS, Maskill H. . Journal of the Royal Chemical Society: Perkin Transactions 1 2002, (23), 2673-2679.
  • Butler PA, Crane CG, Golding BT, Hammershoi A, Hockless DC, Petersen TB, Sargeson AM, Ware DC. . Inorganica Chimica Acta 2002, 331(1), 318-321.
  • Davies T, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott J, Gibson A, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J.A., Wang, L., Whitfield, H.J. . Nature Structural Biology 2002, 9(10), 745-749.
  • Pierik AJ, Ciceri D, Broker G, Edwards CH, McFarlane W, Winter J, Buckel W, Golding BT. . Journal of the American Chemical Society 2002, 124(47), 14039-14048.
  • Gibson A, Arris CE, Bentley J, Boyle F, Curtin NJ, Davies T, Endicott J, Golding BT, Grant S, Griffin R, Jewsbury, P., Johnson, L., Mesguiche, V., Newell, D.R., Noble, M., Tucker, J., Whitfield, H.J. . Journal of Medicinal Chemistry 2002, 45(16), 3381-3393.
  • Koch SSC, Thoresen LH, Tikhe JG, Maegley KA, Almassy RJ, Li JK, Yu XH, Zook SE, Kumpf RA, Zhang C, Boritzki TJ, Mansour RN, Zhang KE, Ekker A, Calabrese CR, Curtin NJ, Kyle S, Thomas HD, Wang LZ, Calvert AH, Golding BT, Griffin RJ, Newell DR, Webber SE, Hostomsky Z. . Journal of Medicinal Chemistry 2002, 45(23), 4961-4974.
  • Munter T, Cottrell L, Hill S, Kronberg L, Watson WP, Golding BT. . Chemical Research in Toxicology 2002, 15(12), 1549-1560.
  • Haglund J, Henderson AP, Golding BT, Tornqvist M. . Chemical Research in Toxicology 2002, 15(6), 773-779.
  • Northen J, Boyle F, Clegg W, Curtin NJ, Edwards A, Griffin R, Golding B. . Journal of the Chemical Society. Perkin Transactions 1 2002, 2(1), 108-115.
  • Laval G, Clegg W, Crane CG, Hammershoi A, Sargeson AM, Golding BT. . Chemical Communications 2002, 8(17), 1874-1875.
  • Huhta MS, Ciceri D, Golding BT, Marsh ENG. . Biochemistry 2002, 41(9), 3200-3206.
  • Smith DM, Golding BT, Radom L. Understanding the mechanism of B-12-dependent diol dehydratase: A synergistic retro-push-pull proposal. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2001, 123(8), 1664-1675.
  • Stockley M, Clegg W, Fontana G, Golding BT, Martin N, Rigoreau LJM, Smith GCM, Griffin RJ. . Bioorganic & Medicinal Chemistry Letters 2001, 11(21), 2837-2841.
  • Liu JY, Ma XY, Golding BT. . Chinese Journal of Inorganic Chemistry 2001, 21(1), 71-74.
  • Davies TG, Endicott JA, Johnson LN, Noble ME, Arris CE, Bentley J, Calvert AH, Curtin NJ, Golding BT, Griffin RJ, Hardcastle IH, Mesguiche V, Newell H, Parsons RJ, Whitfield HJ, Boyle T, Jewsbury P. . Cellular and Molecular Biology Letters 2001, 6(2B), 470.
  • Davies TG, Endicott JA, Noble ME, Johnson LN, Arris CE, Bentley J, Boyle FT, Calvert AH, Curtin NJ, Jewsberry PJ, Gibson AE, Golding BT, Griffin RJ, Hardcastle I, Mesguiche V, Parsons R, Whitfield H, Newell DR. . Cellular and Molecular Biology Letters 2001, 6(2B), 514-515.
  • Wetmore SD, Smith DM, Golding BT, Radom L. . Journal of the American Chemical Society 2001, 123(33), 7963-7972.
  • Cottrell L, Golding BT, Munter T, Watson WP. . Chemical Research in Toxicology 2001, 14(11), 1552-1562.
  • Smith PG, Thomas HD, Barlow HC, Griffin RJ, Golding BT, Calvert AH, Newell DR, Curtin NJ. . Clinical Cancer Research 2001, 7(7), 2105-2113.
  • Heck R, Henderson AP, Kohler B, Retey J, Golding BT. . European Journal of Organic Chemistry 2001, (14), 2623-2627.
  • Haglund J, Rafiq A, Ehrenberg L, Golding BT, Tornqvist M. . Chemical Research in Toxicology 2000, 13(4), 253-256.
  • Zhang D, Bleasdale C, Golding BT, Watson WP. . Chemical Communications 2000, (13), 1141-1142.
  • Bentley J, Arris CE, Boyle FT, Calvert AH, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Grant S, Griffin RJ, Jewsbury PJ, Johnson LN, Noble MEM, Newell DR. . Clinical Cancer Research 2000, 6, 328.
  • Ciceri D, Pierik AJ, Hartrampf G, Broker G, Speranza G, Buckel W, Cornforth SJ, Golding BT. . Helvetica Chimica Acta 2000, 83(9), 2550-2561.
  • Barlow, H. C., Bowman, K. J., Curtin, N. J., Calvert, A. H., Golding, B. T., Huang, B., Loughlin, P. J., Newell, D. R., Smith, P. G., Griffin, R. J. . Bioorganic and Medicinal Chemistry Letters 2000, 10(6), 585-589.
  • White, A.W., Almassy, R., Calvert, A.H., Curtin, N.J., Griffin, R.J., Hostomsky, Z., Maegley, K., Newell, D.R., Srinivasan, S, Golding, B.T. . Journal of Medicinal Chemistry 2000, 43(22), 4084-4097.
  • Griffin, R. J., Arris, C. E., Bleasdale, C. , Boyle, F., Calvert, A. H., Curtin, N. J., Dalby, C., Kanugula, S., Lembicz, N., Newell, D. R., Pegg, A., Golding, B. T. . Journal of Medicinal Chemistry 2000, 43(22), 4071-4083.
  • Arris CE, Boyle FT, Calvert AH, Curtin NJ, Jewsbury P, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Johnson LN, Laurie A, Yu W, Newell DR, Noble MEM, Sausville E, Schultz R, Garman EF, Grant S. . Journal of Medicinal Chemistry 2000, 43(15), 2797-2804.
  • Andersen RJ, Ashwell S, Garnett I, Golding BT. . Journal of the Chemical Society, Perkin Transactions 1 2000, (24), 4488-4498.
  • Klotz B, Barnes I, Golding BT, Becker K-H. . Physical Chemistry Chemical Physics 2000, 2(2), 227-235.
  • Wang MF, Golding BT, Potter GA. . Synthetic Communications 2000, 30(23), 4197-4204.
  • Smith DM, Golding BT, Radom L. . Journal of the American Chemical Society 1999, 121(40), 9388-9399.
  • Smith DM, Golding BT, Radom L. . Journal of the American Chemical Society 1999, 121(24), 5700-5704.
  • Kitching MS, Clegg W, Elsegood MRJ, Griffin RJ, Golding BT. . Synlett 1999, 997-999.
  • Golding BT, Mitchinson A, Clegg W, Elsegood MRJ, Griffin RJ. . Journal of the Chemical Society - Perkin Transactions 1 1999, (3), 349-356.
  • Smith DM, Golding BT, Radom L. . Journal of the American Chemical Society 1999, 121(5), 1037-1044.
  • Watson W, Golding B. Weighing up the risks. CHEMISTRY IN BRITAIN 1998, 34(7), 45-48.
  • GOLDING BT. THE B12 MYSTERY. CHEMISTRY IN BRITAIN 1990, 26(10), 950-954.
  • GOLDING BT. SYNTHESIS AND REACTIONS OF CHIRAL C-3-UNITS. CHEMISTRY & INDUSTRY 1988, (19), 617-621.
  • GOLDING BT, OSULLIVAN MC, SMITH LL. CONVENIENT ROUTES TO ALKYL-SUBSTITUTED POLYAMINES. TETRAHEDRON LETTERS 1988, 29(50), 6651-6654.

• Conference Proceedings (inc. Abstracts)

  • Bertoli A, Adhikari S, Harnor SJ, Zhao Y, Lunec J, Wedge SR, Tudhope S, Wittner A, Golding BT, Hardcastle IR, Cano C, Newell DR, Griffin RJ. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, TX, USA: American Chemical Society.
  • Tudhope S, Zhao Y, Wittner A, Wilmore E, Bertoli A, Adhikari S, Harnor SJ, Del Bello F, Piergentili A, Lunec J, Hardcastle IR, Griffin RJ, Golding BR, Cano C, Newell DR, Wedge SR. . In: AACR Annual Meeting 2014. 2014, San Diego, CA: American Association for Cancer Research.
  • Martin M, Anscombe E, Meschini E, Staunton D, Geitmann M, Danielson UH, Wang LZ, Vidal RM, Reuillon T, Golding BT, Newell DR, Wedge S, Noble MEM, Endicott JA, Griffin RJ. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
  • Myers S, Martin N, Bawn R, Blackburn T, Barrett L, Reuillon T, Golding B, Griffin R, Hammonds T, Hardcastle I, Leung H, Newell D, Rigoreau L, Wong A, Cano C. . In: 26th EORTC – NCI – AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
  • Shouksmith AE, Evans LE, Griffin RJ, Golding BT, Newell H, Miller DC, Noble MEM, Endicott JA, Tweddle D. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, Texas: American Chemical Society.
  • Lebraud H, Golding BT, Meschini E, Cano C, Anscombe E, Wang LZ, Endicott JA, Noble MEM, Newell DR, Griffin RJ. . In: 247th ACS National Meeting and Exposition. 2014, Dallas, Texas: American Chemical Society.
  • Anil B, Blackburn E, Blackburn T, Cully S, Liu J, Drummond CJ, Endicott JA, Golding BT, Griffin RJ, Haggerty K, Lunec J, Newell DR, Revill CH, Riedinger C, Watson AF, Xu Q, Zhao Y, Hardcastle IR, Noble MEM. . In: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2014, Barcelona, Spain: Elsevier.
  • Cully SJ, Blackburn TJ, Cano C, Golding BT, Griffin RJ, Lunec J, Newell D, Noble M, Zhao Y, Hardcastle IR. . In: 245th ACS National Meeting and Exposition. 2013, New Orleans, Louisiana: American Chemical Society.
  • Barrett L, Rennison T, Clapham KM, Rodriguez-Aristegui S, Bardos J, Curtin NJ, Dennis M, Finlay R, Golding BT, Hardcastle IR, Newell DR, Young G, Cano C, Griffin RJ. . In: 245th ACS National Meeting and Exposition. 2013, New Orleans, Louisiana: American Chemical Society.
  • Myers SM, Bawn RH, Cottyn B, Golding BT, Griffin RJ, Hammonds T, Leung H, Newell D, Rigoreau L, Wong AC, Hardcastle IR, Cano C. Hit validation of ERK5 inhibitors: Expectations and challenges. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
  • Matheson CJ, Aherne W, Bayliss R, Boxall K, Cano C, Golding BT, Hardcastle IR, Mas-Droux C, Newell DR, Wang LZ, Griffin RJ. Design and synthesis of 8-substituted purines as inhibitors of Nek2 kinase. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
  • Bawn RH, Golding BT, Griffin RJ, Hammonds T, Leung H, Newell D, Rigoreau L, Wong AC, Cano C, Hardcastle IR. Development of substituted benzothiazoles as ERK5 inhibitors. In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2011, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
  • Blackburn T, Ahmed H, Coxon CR, Golding BT, Griffin RJ, Newell H, Liu J, Lu X, Lunec J, Hardcastle IR. Triarylpyrroles, dual inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions. In: EJC SUPPLEMENTS. 2010, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD.
  • Carbain B, Roche C, Endicott JA, Golding BT, Hardcastle IR, Cano C, Zhen-Wang L, Newell DR, Noble MEM, Griffin RJ. . In: European Journal of Cancer Supplements: 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. 2010, Berlin: Elsevier.
  • Meschini E, Endicott JA, Golding BT, Hardcastle IR, Newell DR, Noble MEM, Wang LZ, Griffin RJ. . In: Abstracts of Papers of the American Chemical Society. 2010, American Chemical Society.
  • Cano C, Curtin NJ, Golding BT, Haggerty K, Hardcastle IR, Hummersone M, Menear K, Richardson C, Smith GCM, Griffin RJ. Development of potent water-soluble inhibitors of the DNA-dependent protein kinase (DNA-PK). In: EJC SUPPLEMENTS. 2008, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND: PERGAMON-ELSEVIER SCIENCE LTD.
  • Marchetti F, Curtin NJ, Golding BT, Griffin RJ, Hardcastle IR, Newell DR, Wang LZ. Design and synthesis of inhibitors of cyclin-dependent kinases as potential antitumor agents. In: MOLECULAR CANCER THERAPEUTICS. 2007, 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA: AMER ASSOC CANCER RESEARCH.
  • Begemann P, Georgieva NI, Sangaiah R, Gold A, Koc H, Zhang D, Golding BT, Swenberg JA. . In: Toxicological Sciences: 42nd Annual Meeting of the Society of Toxicology. 2003, Salt Lake City, Utah, USA: Oxford University Press.
  • Sayle KL, Mesguishe V, Parsons RJ, Bentley J, Davies TG, Endicott JA, Noble MEM, Wang LZ, Hardcastle IR, Golding BT. . In: European Journal of Cancer: 14th EORTC/NCI/AACR Symposium on Molecular Targets and Cancer Therapeutics. 2002, Frankfurt, Germany: Pergamon.
  • Watson WP, Cottrell L, Zhang DP, Golding BT. . In: 38th European Congress of Toxicology. 2001, London, UK: Elsevier Ireland Ltd.
  • Golding BT, Watson WP. . In: 2nd International Conference on Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis. 1999, Heidelberg, Germany: International Agency for Research on Cancer.
  • Radom L, Smith DM, Golding BT. . In: Abstracts of Papers of the American Chemical Society. 1999, American Chemical Society.
  • GOLDING BT, NASSEREDDIN IK, OSULLIVAN MC. MOLECULAR MECHANISMS IN POLYAMINE BIOCHEMISTRY. In: BIOCHEMICAL SOCIETY TRANSACTIONS. 1990.

• Editorial

  • Golding BT. . Future Medicinal Chemistry 2015, 7(5), 549-551.

• Letter

  • Smith DM, Golding BT, Radom L. . Journal of the American Chemical Society 1999, 121(6), 1383-1384.

• Notes

  • Golding BT. . Future Medicinal Chemistry 2017, 9(3), 271-273.
  • Golding BT, Buckel W. . Angewandte Chemie International Edition 2014, 53(14), 3546-3546.

• Patents

  • Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, StDenis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DW, Mitchell DR, Griffin RJ. . WO2017055860, 2017.
  • Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, StDenis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DW, Mitchell DR, Griffin RJ. . WO/2017055859, 06/04/2017.
  • Chessari G, Howard S, Buck IM, Cons BD, Johnson CN, Holvey RS, Rees DC, St Denis JD, Tamanini E, Golding BT, Hardcastle IR, Cano CF, Miller DC, Noble MEM, Griffin RJ, Osborne JD, Peach J, Lewis A, Hirst KL, Whittaker BP, Watson DR. . PCT/GB2016/053041, 06/04/2017.
  • Reuillon T, Miller D, Myers S, Molyneux L, Cano C, Hardcastle I, Griffin R, Rigoreau L, Golding B, Noble M. . WO/2016/042341, 24/03/2016.

• Reviews

  • Heider J, Szaleniec M, Martins BM, Seyhan D, Buckel W, Golding BT. . Journal of Molecular Microbiology and Biotechnology 2016, 26(1-3), 29-44.
  • Selvaraj B, Buckel W, Golding BT, Ullmann GM, Martins BM. . Journal of Molecular Microbiology and Biotechnology 2016, 26(1-3), 76-91.
  • Wilkes H, Buckel W, Golding BT, Rabus R. . Journal of Molecular Microbiology and Biotechnology 2016, 26(1-3), 138-151.
  • Ferreri C, Golding BT, Jahn U, Ravanat JL. . Free Radical Research 2016, 50(Suppl. 1), S112-S128.
  • Zhang B, Golding BT, Hardcastle IR. . Future Medicinal Chemistry 2015, 7(5), 631-645.
  • Buckel W, Golding BT. . Annual Review of Microbiology 2006, 60, 27-49.
  • Buckel W, Martins BM, Messerschmidt A, Golding BT. . Biological Chemistry 2005, 386(10), 951-959.
  • Hardcastle IR, Golding BT, Griffin RJ. . Annual Review of Pharmacology and Toxicology 2002, 42, 325-348.