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Staff Profile

Dr Matt Hopkinson

Senior Lecturer in Organic Chemistry, Admissions Tutor for Chemistry Undergraduate Programmes

  • Telephone: +44 (0) 191 2080013
  • Personal Website:
  • Address: Room 2.66
    Bedson Building
    School of Natural and Environmental Sciences
    Â鶹´«Ã½
    Â鶹´«Ã½ upon Tyne, NE1 7RU
    United Kingdom
Background
I studied chemistry at the University of Oxford (Pembroke College), graduating in 2007. Having completed a Masters project under the supervision of Prof. Véronique Gouverneur, I stayed in the group for a DPhil, graduating in 2011. During this time, I worked on the development of new reaction methods for organic synthesis, focusing on gold-catalysed coupling reactions and radiofluorination chemistry for Positron Emission Tomography (PET) imaging. This project was funded through a CASE award from GlaxoSmithKline and I spent time at their Clinical Imaging Centre (CIC) radiochemistry facility at Hammersmith Hospital in London. In 2012, I moved to Germany for a Postdoc in the group of Prof. Frank Glorius at the Westfälische Wilhelms-Universität Münster. My research there was funded by a scholarship from the Alexander von Humboldt foundation and focused on transition metal- and photocatalysis. In 2016, I started my independent career as a Junior Professor at the Freie Universität Berlin, setting up a research programme centred on the fields of organofluorine chemistry, organocatalysis and photochemistry. It is these areas that my group is continuing to explore since moving to Â鶹´«Ã½ in November 2021.
Research

For more information and the latest news from our group, please visit the .

Research in the Hopkinson Group spans several areas of organic synthesis with an overall focus on developing new practical reaction methodologies. Particular areas of interest include organofluorine chemistry, photochemistry and organocatalysis.

Organofluorine Chemistry

The incorporation of fluorine or fluorine-containing groups into organic molecules can have a dramatic impact on their chemical and biological properties. In particular, fluorinated pharmaceuticals often exhibit improved potency compared to their non-fluorinated analogues and are more metabolically stable. The comparative lack of fluorine-containing natural products means that access to these compounds relies heavily on synthetic organic chemistry and new methods that offer improved efficiency and selectivity or even allow for the preparation of unprecedented classes of organofluorine compound are highly desired.

Our research is centred on the design and application of new methodologies for the synthesis of fluorine-containing organic molecules relevant as pharmaceuticals and agrochemicals. One project line concerns the synthesis, development and application of new widely applicable reagents for installing medicinally relevant fluorinated groups such as the CF3, OCF3, SCF3 and SF5 moieties. For example, in recent work, we have introduced BT-Reagents as a new class of solid reagents that enable the deoxygenative synthesis of (fluoroalkyl)thio- and seleno-substituted compounds directly from widely available alcohols and carboxylic acids.

In other projects we exploit visible light as a tool for enabling the installation and manipulation of fluorine and fluorine-containing functional groups. For example, we have developed a new radical method for preparing valuable trifluoromethoxylated compounds using bis(trifluoromethyl)peroxide (BTMP) as a practical OCF3 radical source. Initiated by our involvement in the DFG-supported Collaborative Research Centre (SFB 1349) “Fluorine-Specific Interactions”, we also investigate selective C−F activation reactions which exploit the unique interactions between fluorine atoms and Lewis acids or hydrogen bond donors. These processes enable the synthesis of valuable partially fluorinated compounds from widely available perfluorinated feedstocks.

Light Activation in Organocatalysis

Alongside our work on organofluorine chemistry, we also develop new reaction methodologies involving photoactivation. As most compounds do not themselves absorb light in the visible part of the spectrum, we take advantage of photocatalysis strategies wherein photocatalysts such as organic dyes or transition metal polypyridyl complexes like [Ru(bpy)3]2  (bpy = 2,2ʹ-bipyridine) transfer energy either directly or via electron transfer to the substrates of interest. These processes, not only allow abundant and sustainable visible light to be used as an energy source in organic synthesis, but can also lead to unprecedented and exotic reactivity by giving access to reactive radical or ionic intermediates under remarkably mild conditions (typically room temperature using household desk lamps or LEDs).

In one project line, we are focused on the development of new methodologies where light activation is combined with N-heterocyclic carbene (NHC) organocatalysis. Using such approaches, reactivities and selectivities that are complementary to existing NHC-catalysed processes can be obtained while the wide availability of chiral organocatalysts opens up opportunities for conducting otherwise challenging enantioselective photochemical reactions. In recent work, we have introduced Photo-NHC catalysis as a strategy for expanding the scope of carbonyl photochemical reactions to substrates at the carboxylic acid oxidation level. In this process, the NHC organocatalyst can be considered a “transient aryl group” that temporarily changes the absorption characteristics and excited state properties of the carbonyl function during the catalytic cycle. 

Publications

  • Articles

    • Navarro C, Hopkinson MN. . Chemistry Teacher International 2026, epub ahead of print.
    • Jakob M, Bechler N, Abdelwahab H, Weber F, Wasternack J, Kleebauer L, Götze JP, Hopkinson MN. . Beilstein Journal of Organic Chemistry 2025, 21, 1973-1983.
    • Navarro C, Hopkinson MN. . Journal of Chemical Education 2025, 102(5), 1839–1847.
    • Yang X, Davison N, Lowe ME, Waddell PG, Armstrong RJ, McMullin CL, Hopkinson MN, Lu E. . Chemical Science 2025, 16(24), 11151-11160.
    • Lowe ME, Gallant BM, Davison N, Hopkinson MN, Kubicki DJ, Lu E, Armstrong RJ. . Journal of the American Chemical Society 2025, 147(44), 40895–40899.
    • Jakob M, Steiner L, Göbel M, Götze JP, Hopkinson MN. . ACS Catalysis 2024, 14(23), 17642-17653.
    • Mass, LM, Haswell, A, Hughes, R, Hopkinson, MN. . Beilstein Journal of Organic Chemistry 2024. Submitted.
    • Haswell A, Tironi M, Wang H, Hopkinson MN. . Journal of Fluorine Chemistry 2024, 273, 110231.
    • Maas LM, Fasting C, Voßnacker P, Limberg N, Golz P, Müller C, Riedel S, Hopkinson MN. . Angewandte Chemie International Edition 2024, 63(7), e202317770.
    • Garg A, Gerwien NJ, Fasting C, Charlton A, Hopkinson MN. . Angewandte Chemie International Edition 2023, 62(25), e202302860.
    • Mavroskoufis A, Lohani M, Weber M, Hopkinson MN, Götze JP. . Chemical Science 2023, 14, 4027-4037.
    • Tironi M, Hopkinson MN. . European Journal of Organic Chemistry 2022, 18, e202101557.
    • Dix S, Golz P, Schmid JR, Riedel S, Hopkinson MN. . Chemistry - A European Journal 2021, 27(45), 11554-11558.
    • Mavroskoufis A, Rieck A, Hopkinson MN. . Tetrahedron 2021, 100, 132497.
    • Tironi M, Dix S, Hopkinson MN. . Organic Chemistry Frontiers 2021, 8(21), 6026-6031.
    • Ariamajd A, Gerwien NJ, Schwabe B, Dix S, Hopkinson MN. . Beilstein Journal of Organic Chemistry 2021, 17, 83-88.
    • Maas LM, Schmid JR, Fasting C, Vossnacker P, Mavroskoufis A, Hopkinson MN. . Tetrahedron 2021, 101, 132512.
    • Mavroskoufis A, Rajes K, Golz P, Agrawal A, Russ V, Götze JP, Hopkinson MN. . Angewandte Chemie International Edition 2020, 59(8), 3190-3194.
    • Tironi M, Maas LM, Garg A, Dix S, Götze JP, Hopkinson MN. . Organic Letters 2020, 22(22), 8925-8930.
    • Dix S, Jakob M, Hopkinson MN. . Chemistry - A European Journal 2019, 25(32), 7635-7639.
    • Teders M, Gómez-Suárez A, Pitzer L, Hopkinson MN, Glorius F. . Angewandte Chemie International Edition 2017, 56(3), 902-906.
    • Honeker R, Garza-Sanchez RA, Hopkinson MN, Glorius F. . Chemistry - A European Journal 2016, 22(13), 4395-4399.
    • Tlahuext-Aca A, Hopkinson MN, Daniliuc CG, Glorius F. . Chemistry - A European Journal 2016, 22(33), 11587-11592.
    • Tlahuext-Aca A, Hopkinson MN, Sahoo B, Glorius F. . Chemical Science 2016, 7(1), 89-93.
    • Tlahuext-Aca A, Hopkinson MN, Aleyda Garza-Sanchez R, Glorius F. . Chemistry - A European Journal 2016, 22(17), 5909-5913.
    • Hopkinson MN, Gómez-Suárez A, Teders M, Sahoo B, Glorius F. . Angewandte Chemie International Edition 2016, 55(13), 4361-4366.
    • Sahoo B, Hopkinson MN, Glorius F. . Angewandte Chemie - International Edition 2015, 54(51), 15545-15549.
    • Boultadakis-Arapinis M, Hopkinson MN, Glorius F. . Organic Letters 2014, 16(6), 1630-1633.
    • Hopkinson MN, Sahoo B, Glorius F. . Advanced Synthesis and Catalysis 2014, 356(13), 2794-2800.
    • Sahoo B, Hopkinson MN, Glorius F. . Journal of the American Chemical Society 2013, 135(15), 5505-5508.
    • Kuhl N, Hopkinson MN, Glorius F. . Angewandte Chemie - International Edition 2012, 51(33), 8230-8234.
    • Gao Z, Lim YH, Tredwell M, Li L, Verhoog S, Hopkinson M, Kaluza W, Collier TL, Passchier J, Huiban M, Gouverneur V. . Angewandte Chemie - International Edition 2012, 51(27), 6733-6737.
    • Hollingworth C, Hazari A, Hopkinson MN, Tredwell M, Benedetto E, Huiban M, Gee AD, Brown JM, Gouverneur V. . Angewandte Chemie - International Edition 2011, 50(11), 2613-2617.
    • Li L, Hopkinson MN, Yona RL, Bejot R, Gee AD, Gouverneur V. . Chemical Science 2011, 2(1), 123-131.
    • Hopkinson MN, Gee AD, Gouverneur V. . Chemistry - A European Journal 2011, 17(30), 8248-8262.
    • Hopkinson MN, Tessier A, Salisbury A, Giuffredi GT, Combettes LE, Gee AD, Gouverneur V. . Chemistry - A European Journal 2010, 16(16), 4739-4743.
    • Hopkinson MN, Giuffredi GT, Gee AD, Gouverneur V. . Synlett 2010, (18), 2737-2742.
    • Hopkinson MN, Ross JE, Giuffredi GT, Gee AD, Gouverneur V. . Organic Letters 2010, 12(21), 4904-4907.
    • Lam Y-H, Hopkinson MN, Stanway SJ, Gouverneur V. . Synlett 2007, (19), 3022-3026.

  • Book Chapters

    • Hopkinson MN. . In: Cahard, D; Ma, JA, ed. Emerging Fluorinated Motifs: Synthesis, Properties and Applications. Wiley, 2020, pp.373-402.
    • Hopkinson MN, Glorius F. . In: Biju, AT, ed. N-Heterocyclic Carbenes in Organocatalysis. Wiley, 2019, pp.1-36.
    • Dix S, Hopkinson MN. . In: König, B, ed. Science of Synthesis: Photocatalysis in Organic Synthesis. Thieme, 2018.
    • Hopkinson MN, Gouverneur V. Gold-Catalyzed Coupling Reactions. In: Organometallic Complexes of Gold (Update 3, 2011). Georg Thieme Verlag, 2011, pp.101.

  • Reviews

    • Garg A, Haswell A, Hopkinson MN. . Chemistry - A European Journal 2024, 30(20), e202304229.
    • Bellotti P, Koy M, Hopkinson MN, Glorius F. . Nature Reviews Chemistry 2021, 5(10), 711-725.
    • Hopkinson MN, Mavroskoufis A. . Synlett 2021, 32(02), 95-101.
    • Mavroskoufis A, Jakob M, Hopkinson MN. . ChemPhotoChem 2020, 4(10), 5147-5153.
    • Sahoo B, Hopkinson MN. . Angewandte Chemie International Edition 2018, 57(27), 7942-7944.
    • Gensch T, Hopkinson MN, Glorius F, Wencel-Delord J. . Chemical Society Reviews 2016, 45(10), 2900-2936.
    • Hopkinson MN, Tlahuext-Aca A, Glorius F. . Accounts of Chemical Research 2016, 49(10), 2261-2272.
    • Hopkinson MN, Sahoo B, Li J-L, Glorius F. . Chemistry - A European Journal 2014, 20(14), 3874-3886.
    • Hopkinson MN, Richter C, Schedler M, Glorius F. . Nature 2014, 510(7506), 485-496.
    • Kuhl N, Hopkinson MN, Wencel-Delord J, Glorius F. . Angewandte Chemie - International Edition 2012, 51(41), 10236-10254.
    • Hopkinson MN, Gee AD, Gouverneur V. . Israel Journal of Chemistry 2010, 50(5-6), 675-690.