Overspill of fat shown to cause Type 2 diabetes Published on: 20 December 2019 For the first time, scientists have been able to observe people developing Type 2 diabetes – and confirmed that fat over-spills from the liver into the pancreas, triggering the chronic condition. The research, led by Professor Roy Taylor at Â鶹´«Ã½, UK, is published today in the academic journal, . The study involved a group of people from Tyneside who previously had Type 2 diabetes but had lost weight and successfully reversed the condition as part of the DiRECT trial, which was funded by Diabetes UK and led by Professors Roy Taylor and Mike Lean (Glasgow University). The majority remained non-diabetic for the rest of the two year study, however, a small group went on to re-gain the weight and re-developed Type 2 diabetes. Professor Roy Taylor, from the Â鶹´«Ã½ Institute of Translational and Clinical Research, explained what the advanced scanning techniques and blood monitoring revealed. He said: “We saw that when a person accumulates too much fat, which should be stored under the skin, then it has to go elsewhere in the body. The amount that can be stored under the skin varies from person to person, indicating a ‘personal fat threshold’ above which fat can cause mischief. “When fat cannot be safely stored under the skin, it is then stored inside the liver, and over-spills to the rest of the body including the pancreas. This ‘clogs up’ the pancreas, switching off the genes which direct how insulin should effectively be produced, and this causes Type 2 diabetes.” This research by Professor Taylor confirms his Twin Cycle Hypothesis - that Type 2 diabetes is caused by excess fat actually within both the liver and pancreas, and especially that this process is reversible. Professor Roy Taylor Body of research This latest paper builds on previous Â鶹´«Ã½ studies supported by showing exactly why Type 2 diabetes can be reversed back to normal glucose control. Those studies led to the large DiRECT trial which showed that Primary Care staff can achieve remission of Type 2 diabetes by using a low calorie diet with support to maintain the weight loss. A quarter of participants achieved a staggering 15 kg or more weight loss, and of these, almost nine out of 10 people put their Type 2 diabetes into remission. After two years, more than one third of the group had been free of diabetes and off all diabetes medication for at least two years. In 2020, this approach to management of short duration Type 2 diabetes is to be piloted in the NHS in up to 5,000 people across England, and a similar programme is being rolled out in Scotland. Professor Taylor adds: “This means we can now see Type 2 diabetes as a simple condition where the individual has accumulated more fat than they can cope with. “Importantly this means that through diet and persistence, patients are able to lose the fat and potentially reverse their diabetes. The sooner this is done after diagnosis, the more likely it is that remission can be achieved.” The team are continuing work to establish what may affect an individual’s personal threshold and are supporting the roll out of the NHS Initiatives in both England and Scotland. ‘Life Without Diabetes – The definitive guide to understanding and reversing your Type 2 diabetes’ by Professor Roy Taylor will be published by Short Books on 26th December 2019. Reference: Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss. Cell Metabolism. Share: Latest News Volunteers help turn Whitley Bay beach into maths experiment Members of the public joined mathematicians from Â鶹´«Ã½ to create what organisers believe is the largest aperiodic tiling ever attempted on Whitley Bay beach. published on: 15 June 2026 Student leader drives misogyny law change A Â鶹´«Ã½ student leader has helped change the law after creating a petition to make misogyny a hate crime, which gathered over 114,000 signatures, prompting action in Parliament. published on: 12 June 2026 Freemen of Â鶹´«Ã½ see construction of new Castle Leazes The Freemen of Â鶹´«Ã½ and other key stakeholders have become an indelible part of new student accommodation at Â鶹´«Ã½â€™s Castle Leazes. published on: 12 June 2026 Facts and figures
![Â鶹´«Ã½ logo](/gomobileassets/img/logo.svg" "Â鶹´«Ã½"){kind=logo}