Breakthrough in understanding mechanism of melanoma ulceration
A ground-breaking explanation of the mechanism by which early-stage melanomas become at risk of spreading has just been published in the British Journal of Dermatology.
19 January 2022
A ground-breaking explanation of the mechanism by which early-stage melanomas become at risk of spreading has just been published in the British Journal of Dermatology.
The team at Â鶹´«Ã½, led by Professor Penny Lovat, in association with AMLo Biosciences have now described the process by which the secretion of TGFβ2 by a primary melanoma causes the reduction, or downregulation, of the proteins AMBRA1 and loricrin in the epidermis overlying the tumour. The growth factor TGFβ2 also causes the loss of claudin-1 leading to loss of the integrity of the skin thereby facilitating tumour ulceration.
This collaboration between Â鶹´«Ã½ upon Tyne Hospitals (NuTH) and Â鶹´«Ã½, harnesses the power of our biobanks, and high quality tissue-based diagnostics in NovoPath.